Gene

KWMTBOMO04632  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005503

Annotation

PREDICTED:_lissencephaly-1_homolog_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr8(+):11193701-11220761      View in EpiBrowser

Full name

Lissencephaly-1 homolog      

Location in the cell

Cytoplasmic   Reliability : 2.105

CDS

ATGGTGTTGTCACAACGGCAACGAGAGGAGCTGAACAAAGCGATTGCCGATTATCTAGGCAGTAACGGTTACAATGACGCGCTGGAAGCGTTCAAGAAAGAAGCCGACATGACCGGCGAGATGGATCGCAAGTTCGGTGGCCTCTTGGAGAAGAAATGGACCTCCGTCATCAGACTTCAGAAAAAGGTTATGGAACTGGAATCTAAATTGTCGGAGGCTCAGAAGGAATTCATCGAGGGTGCTCCAACGCGAGCTAAGCGCACTCCAACAGAATGGATTCCGCGTCCACCCGAGAAGTTTTGTCTCACTGGACACAGGGCCACTATTACTAAGGTAATATTTCACCCCGTGTTCAGCTTGATGGTGTCCTCGAGCGAGGACGCAACCATAAAAGTTTGGGACTTTGAGAGCGGCGAGTACGAACGAACATTGAAGGGTCACACCGACTCCGTACAGGACATTGCATTCGACCACCATGGAAAATTACTTGTGTCTTGCAGCGCCGACATGTCGATCAAGCTGTGGGATTTCAATCAGACGTTCGAGTGCATCAAGACTATGCACGGACACGACCACAACGTCTCCTCGGTGGCTTTCTCTCCTAGCGGCGACATCGTGTACTCCGCCAGTCGGGATAAAACTATCAAAGCCTGGGAGGTCGCCACTGGGTACTGCATCAAGACATACAAAGGTCACCGCGAGTGGGTGCGTATGGTGCGCGTGTCGCCGGACGGGACCCTGCTCGCTTCCTGCTCAAACGATCAGACCGTGCGCATATGGAACGCGGACACTAATGAATGCAAGATGGAACTTCGCGAACATGAGCACGTGGTGGAGTGCGTGTCGTGGGCCCCCGAGGCTGCCGCCGCCGCCATCAACGAGGCCGCCGGAGGAGACAACCGCCGCGCCAACCACACCGGACCCTTCCTCGCCAGCGGCTCGAGGGACAAGTCCGTTAAGATCTGGGAGGTGAGCACGGGCCAGTGCCTGGCGACGCTGGTGGGGCACGACAACTGGGTGCGCGGCGCGGCGTGGCACCCCGGCGGCCGCTACCTGCTCACCGCCTCCGACGACAAGACCCTGCGCGTCTGGGACGTCGCGCACACGCGCTGCCTCAAGACCCTCTATGCGCATCACCACTTCGCCACCAGCCTCGATTTCCACAGAAGCTTGCCATACGTGATATCGGGCAGCGTAGATCAGACCGTCAAAGTTTGGGAGTGTCGCTAG

Protein

MVLSQRQREELNKAIADYLGSNGYNDALEAFKKEADMTGEMDRKFGGLLEKKWTSVIRLQKKVMELESKLSEAQKEFIEGAPTRAKRTPTEWIPRPPEKFCLTGHRATITKVIFHPVFSLMVSSSEDATIKVWDFESGEYERTLKGHTDSVQDIAFDHHGKLLVSCSADMSIKLWDFNQTFECIKTMHGHDHNVSSVAFSPSGDIVYSASRDKTIKAWEVATGYCIKTYKGHREWVRMVRVSPDGTLLASCSNDQTVRIWNADTNECKMELREHEHVVECVSWAPEAAAAAINEAAGGDNRRANHTGPFLASGSRDKSVKIWEVSTGQCLATLVGHDNWVRGAAWHPGGRYLLTASDDKTLRVWDVAHTRCLKTLYAHHHFATSLDFHRSLPYVISGSVDQTVKVWECR

Description

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, branching and maturation and axonal transport. Required for synchronized cell divisions in the germline, fusome integrity and oocyte differentiation. Acts together with BicD, Egl, dynein and microtubules to determine oocyte identity during oogenesis. Also required for nurse cell to oocyte transport during oocyte growth and for the positioning of the nucleus in the oocyte.

Subunit

Interacts with dynein and dynactin. Does not interact with Paf-A-Halpha.

Similarity

Belongs to the WD repeat LIS1/nudF family.

Keywords

Cell cycle   Cell division   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Microtubule   Mitosis   Reference proteome   Repeat   Transport   WD repeat   Centromere   Chromosome   Developmental protein   Differentiation   Kinetochore   Neurogenesis   Oogenesis  

Feature

chain  Lissencephaly-1 homolog

Uniprot

S4P8P6   A0A212EZB5   A0A194PQ99   A0A067R135   A0A0K8TLD2   A0A2J7QP70   + More
A0A1Q3FXW0   A0A1L8DGT9   A0A023ERS9   A0A1Y1KG88   A0A0A1XNU9   A0A1B6JG88   B4JWA1   A0A2M4A7H2   A0A182WDV8   T1EAA4   A0A2M3Z2V7   T1JLY0   A0A0L0C579   A0A0Q9WFX2   B4LQ21   A0A0B4K812   A0A0J9RF48   B4QHG6   B4HSL3   Q7KNS3   B4P6P9   B3NPW0   A0A1W4VE83   A0A1B6GFL5   A0A034V8V1   A0A0C9RE06   A0A0K8VYB4   A0A0J7L5G5   B4MY65   V9IM73   A0A0M4E7L5   B0W2S3   Q291L9   B4GAJ1   A0A2M4CT38   A0A1J1J4Q6   A0A1I8P606   K7ISU2   A0A2M4CT74   T1E2P2   A0A2M4CUL0   A0A195DXP3   F4WZK2   A0A158NGQ5   E0VTU7   A0A3B0J1S7   A0A232EZ94   B3MEY6   D6WXZ5   A0A3L8DTQ1   A0A0Q9XK39   B4KT48   W8BZW4   A0A139WCW0   A0A3R7QF82   Q17N69   U5EK48   A0A0P4VLY4   R4G8S1   A0A0V0G4G0   A0A182R4P5   A0A182Y9C9   A0A023FAP8   A0A2P2I600   A0A0A9W554   A0A2A3EB81   A0A0P4WAS1   A0A069DTY7   A0A182XGU4   A0A182M9N9   A0A224XR20   A0A182SSU6   T1PB55   Q7PZD3   A0A336MVK7   A0A0M9A373   A0A182TKA7   A0A1S3HCA1   A0A1A9VIP8   A0A182FUY3   D3TLL6   A0A224YY15   A0A131YKM9   A0A131XMS1   E1ZV56   A0A0P6HIX2   A0A0P5PF19   A0A154PAS0   A0A0P6BNS6   E2BDA6   A0A087UGC6   A0A0L7R710   E9G923   A0A1W7RA85  

Pubmed

23622113    22118469    26354079    24845553    26369729    24945155    + More
28004739    25830018    17994087    26108605    18057021    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    10498683    10559989    10737922    12537569    10993674    11056531    16105886    16107559    25348373    15632085    20075255    24330624    21719571    21347285    20566863    28648823    18362917    19820115    30249741    24495485    17510324    27129103    25244985    25474469    25401762    26823975    26334808    25315136    12364791    20353571    28797301    26830274    28049606    20798317    21292972   

EMBL

GAIX01004099    JAA88461.1    AGBW02011316    OWR46832.1    KQ459595    KPI95621.1    + More
KK853109    KDR11242.1    GDAI01002632    JAI14971.1    NEVH01012097    PNF30386.1    GFDL01002719    JAV32326.1    GFDF01008415    JAV05669.1    GAPW01001705    JAC11893.1    GEZM01087877    JAV58426.1    GBXI01001670    JAD12622.1    GECU01009509    JAS98197.1    CH916375    GGFK01003371    MBW36692.1    GAMD01001183    JAB00408.1    GGFM01002037    MBW22788.1    JH431506    JRES01000883    KNC27558.1    CH940648    KRF79376.1    AE013599    AFH08114.1    CM002911    KMY94194.1    CM000362    CH480816    AF152419    AF117606    AF098070    AY089600    BT021404    CM000158    CH954179    GECZ01008524    JAS61245.1    GAKP01020400    JAC38552.1    GBYB01006585    JAG76352.1    GDHF01021528    GDHF01008488    GDHF01008359    GDHF01000202    JAI30786.1    JAI43826.1    JAI43955.1    JAI52112.1    LBMM01000692    KMQ97734.1    CH963894    JR052154    AEY61631.1    CP012524    ALC42716.1    DS231828    EDS29826.1    CM000071    CH479181    GGFL01004338    MBW68516.1    CVRI01000070    CRL07397.1    AAZX01006436    GGFL01004349    MBW68527.1    GALA01001115    JAA93737.1    GGFL01004350    MBW68528.1    KQ980107    KYN17643.1    GL888480    EGI60277.1    ADTU01015169    DS235773    EEB16803.1    OUUW01000001    SPP72813.1    NNAY01001525    OXU23685.1    CH902619    KQ971362    EFA07920.2    QOIP01000004    RLU23682.1    CH933808    KRG04737.1    GAMC01007669    JAB98886.1    KYB25744.1    QCYY01001590    ROT76930.1    CH477201    GANO01001951    JAB57920.1    GDKW01001090    JAI55505.1    GAHY01000482    JAA77028.1    GECL01003209    JAP02915.1    GBBI01000598    JAC18114.1    IACF01003827    LAB69435.1    GBHO01040655    GBRD01008809    GDHC01009346    JAG02949.1    JAG57012.1    JAQ09283.1    KZ288311    PBC28552.1    GDRN01078161    JAI62628.1    GBGD01001653    JAC87236.1    AXCM01005331    GFTR01005975    JAW10451.1    KA645971    AFP60600.1    AAAB01008986    EAA00102.3    UFQT01001977    SSX32277.1    KQ435762    KOX75516.1    EZ422318    GFPF01009463    MAA20609.1    GEDV01008704    JAP79853.1    GEFH01000674    JAP67907.1    GL434441    EFN74915.1    GDIQ01027359    JAN67378.1    GDIQ01131690    JAL20036.1    KQ434847    KZC08474.1    GDIP01018668    JAM85047.1    GL447585    EFN86334.1    KK119688    KFM76415.1    KQ414645    KOC66633.1    GL732535    EFX84172.1    GFAH01000329    JAV48060.1   

Proteomes

UP000007151    UP000053268    UP000027135    UP000235965    UP000001070    UP000075920    + More
UP000037069    UP000008792    UP000000803    UP000000304    UP000001292    UP000002282    UP000008711    UP000192221    UP000036403    UP000007798    UP000092553    UP000002320    UP000001819    UP000008744    UP000183832    UP000095300    UP000002358    UP000078492    UP000007755    UP000005205    UP000009046    UP000268350    UP000215335    UP000007801    UP000007266    UP000279307    UP000009192    UP000283509    UP000008820    UP000075900    UP000076408    UP000242457    UP000076407    UP000075883    UP000075901    UP000095301    UP000007062    UP000053105    UP000075902    UP000085678    UP000078200    UP000069272    UP000092444    UP000000311    UP000076502    UP000008237    UP000054359    UP000053825    UP000000305   

PRIDE

B4JWA1    B4LQ21    Q7KNS3    B3NPW0    B4MY65    B4GAJ1    + More
B3MEY6    B4KT48   

Pfam

PF08513   LisH        + More
PF00400   WD40

Interpro

IPR020472   G-protein_beta_WD-40_rep        + More
IPR019775   WD40_repeat_CS       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017252   Dynein_regulator_LIS1       
IPR036322   WD40_repeat_dom_sf       
IPR037190   LIS1_N       
IPR006594   LisH       
IPR017986   WD40_repeat_dom       

SUPFAM

SSF109925   SSF109925        + More
SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

S4P8P6   A0A212EZB5   A0A194PQ99   A0A067R135   A0A0K8TLD2   A0A2J7QP70   + More
A0A1Q3FXW0   A0A1L8DGT9   A0A023ERS9   A0A1Y1KG88   A0A0A1XNU9   A0A1B6JG88   B4JWA1   A0A2M4A7H2   A0A182WDV8   T1EAA4   A0A2M3Z2V7   T1JLY0   A0A0L0C579   A0A0Q9WFX2   B4LQ21   A0A0B4K812   A0A0J9RF48   B4QHG6   B4HSL3   Q7KNS3   B4P6P9   B3NPW0   A0A1W4VE83   A0A1B6GFL5   A0A034V8V1   A0A0C9RE06   A0A0K8VYB4   A0A0J7L5G5   B4MY65   V9IM73   A0A0M4E7L5   B0W2S3   Q291L9   B4GAJ1   A0A2M4CT38   A0A1J1J4Q6   A0A1I8P606   K7ISU2   A0A2M4CT74   T1E2P2   A0A2M4CUL0   A0A195DXP3   F4WZK2   A0A158NGQ5   E0VTU7   A0A3B0J1S7   A0A232EZ94   B3MEY6   D6WXZ5   A0A3L8DTQ1   A0A0Q9XK39   B4KT48   W8BZW4   A0A139WCW0   A0A3R7QF82   Q17N69   U5EK48   A0A0P4VLY4   R4G8S1   A0A0V0G4G0   A0A182R4P5   A0A182Y9C9   A0A023FAP8   A0A2P2I600   A0A0A9W554   A0A2A3EB81   A0A0P4WAS1   A0A069DTY7   A0A182XGU4   A0A182M9N9   A0A224XR20   A0A182SSU6   T1PB55   Q7PZD3   A0A336MVK7   A0A0M9A373   A0A182TKA7   A0A1S3HCA1   A0A1A9VIP8   A0A182FUY3   D3TLL6   A0A224YY15   A0A131YKM9   A0A131XMS1   E1ZV56   A0A0P6HIX2   A0A0P5PF19   A0A154PAS0   A0A0P6BNS6   E2BDA6   A0A087UGC6   A0A0L7R710   E9G923   A0A1W7RA85  

PDB

1VYH     E-value=3.72658e-174,     Score=1570

KEGG

101736689    K16794 platelet-activating factor acetylhydrolase IB subunit alpha | (RefSeq) lissencephaly-1 homolo

PATHWAY

00565    Ether lipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005875   GO:0051012   GO:0051301   GO:0000132   GO:0070840   GO:0005874   GO:0005737   GO:0005815   GO:0007049   GO:0016787   GO:0043143   GO:0072499   GO:0043025   GO:0016319   GO:0005829   GO:0034501   GO:0051383   GO:0030286   GO:0030723   GO:0007312   GO:0051299   GO:0007298   GO:0005938   GO:0007303   GO:0048813   GO:0048142   GO:0005869   GO:0031616   GO:0008090   GO:0030381   GO:0007405   GO:0000776   GO:0048814   GO:0007283   GO:0008298   GO:0019827   GO:0007093   GO:0030426   GO:0061883   GO:0030425   GO:0042052   GO:0030473   GO:0005828   GO:0007294   GO:0050772   GO:0046843   GO:0051225   GO:1904115   GO:0006886   GO:0046716   GO:0051642   GO:0030510   GO:0030716   GO:0030706   GO:0008088   GO:0048477   GO:0005813   GO:0098930   GO:0030424   GO:0045478   GO:0051647   GO:0007018   GO:0000777   GO:0000922   GO:0042623   GO:0008104   GO:0007097   GO:0048135   GO:0010970   GO:0016358   GO:0016740   GO:0043005   GO:0005881   GO:0048854   GO:0051010   GO:0047496   GO:2000574   GO:0005635   GO:0031023   GO:0005515   GO:0000166   GO:0006508   GO:0008270   GO:0031012   GO:0005089   GO:0035023   GO:0016742   GO:0003824  

Subcellular location

Cytoplasm   Localizes to the plus end of microtubules and to the centrosome.   With evidence from 1 publications.
Cytoskeleton   Localizes to the plus end of microtubules and to the centrosome.   With evidence from 1 publications.
Microtubule organizing center   Localizes to the plus end of microtubules and to the centrosome.   With evidence from 1 publications.
Centrosome   Localizes to the plus end of microtubules and to the centrosome.   With evidence from 1 publications.
  
Spindle pole  
Chromosome  
Centromere  
Kinetochore  

Length:

409

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00256

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01600

outside

1  -  409

 

 

Pi

173.223587

Theta

164.191227

Tajima's D

0.692

CLR

0.287246

CSRT

0.569371531423429

Interpretation

Uncertain