Gene

KWMTBOMO04625  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005500

Annotation

PREDICTED:_beta-glucuronidase_[Bombyx_mori]

Location

Bomo_Chr8(+):11026931-11074005      View in EpiBrowser

Full name

Beta-glucuronidase      

Location in the cell

PlasmaMembrane   Reliability : 1.477

CDS

ATGATAAAGCCGAGATTTGCTTTCGCGCTTCTGCTAATATGCATAGTGTCCGTGACGATAGCAGTGGTGCCGCTGTCGTCTAGCTCAAATGAAATCAACCAATTGTATAAAAGAAAATTACCAAGCAACGGAGGCGCATTGTACCCACGTGCTACAGAAACCAGGGACTTAAGAACCCTAGATGGGATATGGAGTTTTCGGCCATCGCCTGCCGACCCAGAATTCGGCTATAGAAATGGCTGGTATGCGCAAGATCTTGAAAAGACAGGCTCTGTGATACACATGCCTGTGCCTTCTTCATATAATGACGTGGGCGAAGACGCCTCTCTTCGGGACCATGTAGGCTTGGTGTGGTACGACAGGAGGTTCCACGTTCCGCCGTGGTGGCAGACGGCGAAACAACGGGTCTGGGTGCGGTTCAGCAGCGTTCACTATGCCGCCGAAGTGTTTGTAAACGGCAAATCAGTGACATATCACGAGATAGGTCACTTACCGTTCGAAGTAGAGATCACGGATGTAGTGAATTACAATACGAGCAATCTCCTCACTGTTGCGGTCGACAACACCCTACTAAGCGATACTGTACCACAGGGATATGTCAAACAAATTATCGATTTTGATAAAGTGCGACAGGAGCAAACATACACGTTTGATTTTTTCAATTACGCTGGTATTCATAGGACTGTATTCTTATATTCAACGCCCCAAGTTTATATTGACGATGTTATTGTTAACACCGACATTCAAGGATTCACAGGATTCGTGGTATACAACGTAACTCACAAGGGGCCGACCACAGAAGACGTTCTCTGCCTCATTCAAGTGTTCGATAAGTCGGACACACAAGTCGTGGCCTCAAACGAGTGCGCCGGCCTATTGGAAATAGCGAATGCTAGATTCTGGTGGCCTTACCTCATGAACCCCGAGCCGGGATACTTGTACACTTTTAGGGCTTCTCTAATAAGTAGACGCGGAGATATAATCGACACTTACAGTCAGAAGATCGGTATTAGAACGGTCACGTGGACAAATACAACCATATACTTGAATTCGAAACCATTATATCTGAGGGGATTTGGGATGCACGAAGACTCGGATCTCAGAGGCAAAGGATGGGACCCAGTTTTGTGGGTGAAGAATTTTAACTTGATCAAATGGATCGGAGCGAACGCGTTCCGGACATCGCATTATCCGTACGCTGAGGAAATATACCAGTTGGCCGACGAATATGGGATAATGATCATTGATGAGTGTCCCAGCGGAGACACAGACATCTTCACGCAGTCTCTACTGAATAAGCACAAACAATCACTGACGGAGCTCATCAGACGCGACAAGAATCACCCGAGCGTCATCATGTGGTCCATCTCCAACGAGCCGCGGTCTGCCAAACAACAGGCCGATGCCTATTTCGCTGAAGTAGTGAAACACGTGAAGTCCATGGACCTCTCCAGACCCGTCACCATCGCGATCTCGCAATATTACAACACTGATAGAGCAGGACAACACTTAGACGTCATCTGCTTCAACCGTTACAACGGCTGGTACCAAAACACCGGCGACTTGAACTACATCGTCAGTAAGGTGGTGGAAGAAGCCACCGAGTTCCACCGGCGACACAACAAGCCGGTCATCATGACCGAATATGGCGCTGACACTGTTGCCGGCCTACACTTTATTCCAGAATATGTGTGGTCTGAAGAATACCAAGTGGCGCTGATGTCAGAACATTTCAAAGCGTTCGATAAACTGAGACAGACCGGCTTCTTCGCTGGCGAGTTCATATGGAATTTCGCGGATTTCAAAACAGCGCAAACGATAACCCGCGTCGGCGGCAACAGGAAAGGTATATTCACTCGGTCGCGGCAGCCTAAAGCGTCCGCGCACCACCTCCGCACGCGCTATCTGTCGCTCGCTGTCGCCGACGGCGCCGCCAATATACCGGACCCAACGTACTACATCTCCGACAACAAGCCCACCCTACACGAAGATCTATAA

Protein

MIKPRFAFALLLICIVSVTIAVVPLSSSSNEINQLYKRKLPSNGGALYPRATETRDLRTLDGIWSFRPSPADPEFGYRNGWYAQDLEKTGSVIHMPVPSSYNDVGEDASLRDHVGLVWYDRRFHVPPWWQTAKQRVWVRFSSVHYAAEVFVNGKSVTYHEIGHLPFEVEITDVVNYNTSNLLTVAVDNTLLSDTVPQGYVKQIIDFDKVRQEQTYTFDFFNYAGIHRTVFLYSTPQVYIDDVIVNTDIQGFTGFVVYNVTHKGPTTEDVLCLIQVFDKSDTQVVASNECAGLLEIANARFWWPYLMNPEPGYLYTFRASLISRRGDIIDTYSQKIGIRTVTWTNTTIYLNSKPLYLRGFGMHEDSDLRGKGWDPVLWVKNFNLIKWIGANAFRTSHYPYAEEIYQLADEYGIMIIDECPSGDTDIFTQSLLNKHKQSLTELIRRDKNHPSVIMWSISNEPRSAKQQADAYFAEVVKHVKSMDLSRPVTIAISQYYNTDRAGQHLDVICFNRYNGWYQNTGDLNYIVSKVVEEATEFHRRHNKPVIMTEYGADTVAGLHFIPEYVWSEEYQVALMSEHFKAFDKLRQTGFFAGEFIWNFADFKTAQTITRVGGNRKGIFTRSRQPKASAHHLRTRYLSLAVADGAANIPDPTYYISDNKPTLHEDL

Description

Plays an important role in the degradation of dermatan and keratan sulfates.

Catalytic Activity

a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate

Subunit

Homotetramer.

Similarity

Belongs to the glycosyl hydrolase 2 family.

Feature

chain  Beta-glucuronidase

Uniprot

H9J7K8   A0A212FK42   A0A194QSP8   A0A194PRN5   A0A2H1VVM2   A0A2J7QP48   + More
A0A067QW61   A0A1W4WJ63   A0A1Y1NAJ6   A0A084WIR1   D6WYY8   A0A1S4G6Y4   A0A0P4VLU9   A0A182QNR6   A0A1B0CV53   J9HEW9   A0A1I8M8H2   A0A182RRY1   A0A1L8E1S4   A0A1L8E203   A0A023EVQ3   A0A1L8E1Q0   A0A1I8M8I1   T1HP51   B4KU73   A0A0Q9X8T4   A0A2H8TWI1   A0A1J1I8L2   A0A0V0G5X7   N6TPQ9   A0A0A1WSE6   A0A182N3Z2   A0A1J1I4S8   A0A0A1XQ59   J9K812   A0A0A1X7P8   A0A0Q9XB98   A0A182JHB8   A0A0R3NQ73   A0A0P8XQ24   A0A3B0JJC2   A0A3B0JNB6   A0A2S2QLY1   A0A3B0J1I2   A0A3B0JH71   A0A3B0IY96   A0A0R3NVC0   Q28WJ8   A0A182WDW6   A0A182WDW7   A0A182WDW8   A0A3B0JBP6   A0A0R3NWJ6   B4H723   B3MCH6   A0A182WDW5   A0A0P8XQ09   A0A0R3NQG8   A0A182XGU9   A0A0P9AFR9   A0A182L502   W5JQR0   A0A0Q9XG25   A0A034WSD2   W8B1E3   A0A182V7U1   A0A0Q5VYG2   A0A0K8VYY1   A0A034WPW2   B3NKF1   A0A182HHG9   A0A1Q3FG12   W8BNG7   D6WYY7   A0A0M5IZS1   A0A182MGY9   A0A1Q3FG15   A0A1W4V6D4   A0A1W4VIQ9   A0A1I8PMS8   A0A1I8PMW3   W8B8D4   A0A1W4VJI7   A0A0K8SX62   A0A1I8PMR1   A0A182PUA5   E2AGJ7   A0A1I8PMW5   A0A0J9U5U1   A0A0J9RG28   A0A0A9XSU5   A0A182Y9D5   A0A0J9RGD8   A0A0J9RGD0   B4QDL7   C8VV29   A0A0A9Z159   A0A0Q9WVL5   A0A0K8SMX2  

EC Number

3.2.1.31

Pubmed

19121390    22118469    26354079    24845553    28004739    24438588    + More
18362917    19820115    17510324    27129103    25315136    24945155    26483478    17994087    23537049    25830018    15632085    18057021    20966253    20920257    23761445    25348373    24495485    20798317    22936249    25401762    25244985   

EMBL

BABH01013989    AGBW02008170    OWR54070.1    KQ461154    KPJ08543.1    KQ459595    + More
KPI95613.1    ODYU01004702    SOQ44863.1    NEVH01012097    PNF30365.1    KK853297    KDR08779.1    GEZM01013355    GEZM01013354    JAV92627.1    ATLV01023944    KE525347    KFB50105.1    KQ971363    EFA07841.1    GDKW01001145    JAI55450.1    AXCN02001092    AJWK01030100    CH477201    EJY57347.1    GFDF01001426    JAV12658.1    GFDF01001425    JAV12659.1    JXUM01129069    GAPW01000441    KQ567397    JAC13157.1    KXJ69450.1    GFDF01001424    JAV12660.1    ACPB03008079    CH933808    EDW09669.2    KRG04843.1    GFXV01006802    MBW18607.1    CVRI01000041    CRK95286.1    GECL01002723    JAP03401.1    APGK01056970    KB741277    ENN71225.1    GBXI01012530    JAD01762.1    CRK95285.1    GBXI01001136    JAD13156.1    ABLF02036573    GBXI01007584    JAD06708.1    KRG04841.1    CM000071    KRT03297.1    CH902619    KPU76703.1    OUUW01000001    SPP72701.1    SPP72698.1    GGMS01009562    MBY78765.1    SPP72702.1    SPP72699.1    SPP72697.1    KRT03295.1    EAL26669.3    SPP72700.1    KRT03296.1    CH479216    EDW33659.1    EDV37300.1    KPU76701.1    KRT03298.1    KPU76702.1    ADMH02000720    ETN65250.1    KRG04842.1    GAKP01002284    JAC56668.1    GAMC01011630    JAB94925.1    CH954179    KQS62122.1    GDHF01008544    JAI43770.1    GAKP01002283    JAC56669.1    EDV55173.1    APCN01002410    GFDL01008562    JAV26483.1    GAMC01011629    JAB94926.1    EFA07842.1    CP012524    ALC42124.1    AXCM01008037    GFDL01008547    JAV26498.1    GAMC01011631    GAMC01011628    GAMC01011627    JAB94927.1    GBRD01008070    JAG57751.1    GL439316    EFN67454.1    CM002911    KMY94985.1    KMY94983.1    GBHO01020565    JAG23039.1    KMY94986.1    KMY94982.1    CM000362    EDX07773.1    KMY94981.1    BT099775    ACV88434.1    GBHO01004593    GBHO01004592    JAG39011.1    JAG39012.1    CH940659    KRF85729.1    GBRD01011360    JAG54464.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000235965    UP000027135    + More
UP000192223    UP000030765    UP000007266    UP000075886    UP000092461    UP000008820    UP000095301    UP000075900    UP000069940    UP000249989    UP000015103    UP000009192    UP000183832    UP000019118    UP000075884    UP000007819    UP000075880    UP000001819    UP000007801    UP000268350    UP000075920    UP000008744    UP000076407    UP000075882    UP000000673    UP000075903    UP000008711    UP000075840    UP000092553    UP000075883    UP000192221    UP000095300    UP000075885    UP000000311    UP000076408    UP000000304    UP000008792   

PRIDE

H9J7K8    C8VV29   

Pfam

PF02837   Glyco_hydro_2_N        + More
PF00703   Glyco_hydro_2
PF02836   Glyco_hydro_2_C

Interpro

IPR023232   Glyco_hydro_2_AS        + More
IPR036156   Beta-gal/glucu_dom_sf       
IPR017853   Glycoside_hydrolase_SF       
IPR006103   Glyco_hydro_2_cat       
IPR023230   Glyco_hydro_2_CS       
IPR006101   Glyco_hydro_2       
IPR013783   Ig-like_fold       
IPR008979   Galactose-bd-like_sf       
IPR006102   Glyco_hydro_2_Ig-like       
IPR006104   Glyco_hydro_2_N       

SUPFAM

SSF49785   SSF49785        + More
SSF49303   SSF49303       
SSF51445   SSF51445       

Gene 3D

2.60.120.260     2.60.40.10    

ProteinModelPortal

H9J7K8   A0A212FK42   A0A194QSP8   A0A194PRN5   A0A2H1VVM2   A0A2J7QP48   + More
A0A067QW61   A0A1W4WJ63   A0A1Y1NAJ6   A0A084WIR1   D6WYY8   A0A1S4G6Y4   A0A0P4VLU9   A0A182QNR6   A0A1B0CV53   J9HEW9   A0A1I8M8H2   A0A182RRY1   A0A1L8E1S4   A0A1L8E203   A0A023EVQ3   A0A1L8E1Q0   A0A1I8M8I1   T1HP51   B4KU73   A0A0Q9X8T4   A0A2H8TWI1   A0A1J1I8L2   A0A0V0G5X7   N6TPQ9   A0A0A1WSE6   A0A182N3Z2   A0A1J1I4S8   A0A0A1XQ59   J9K812   A0A0A1X7P8   A0A0Q9XB98   A0A182JHB8   A0A0R3NQ73   A0A0P8XQ24   A0A3B0JJC2   A0A3B0JNB6   A0A2S2QLY1   A0A3B0J1I2   A0A3B0JH71   A0A3B0IY96   A0A0R3NVC0   Q28WJ8   A0A182WDW6   A0A182WDW7   A0A182WDW8   A0A3B0JBP6   A0A0R3NWJ6   B4H723   B3MCH6   A0A182WDW5   A0A0P8XQ09   A0A0R3NQG8   A0A182XGU9   A0A0P9AFR9   A0A182L502   W5JQR0   A0A0Q9XG25   A0A034WSD2   W8B1E3   A0A182V7U1   A0A0Q5VYG2   A0A0K8VYY1   A0A034WPW2   B3NKF1   A0A182HHG9   A0A1Q3FG12   W8BNG7   D6WYY7   A0A0M5IZS1   A0A182MGY9   A0A1Q3FG15   A0A1W4V6D4   A0A1W4VIQ9   A0A1I8PMS8   A0A1I8PMW3   W8B8D4   A0A1W4VJI7   A0A0K8SX62   A0A1I8PMR1   A0A182PUA5   E2AGJ7   A0A1I8PMW5   A0A0J9U5U1   A0A0J9RG28   A0A0A9XSU5   A0A182Y9D5   A0A0J9RGD8   A0A0J9RGD0   B4QDL7   C8VV29   A0A0A9Z159   A0A0Q9WVL5   A0A0K8SMX2  

PDB

3HN3     E-value=2.73564e-146,     Score=1332

KEGG

101736859    K01195 beta-glucuronidase [EC:3.2.1.31] | (RefSeq) beta-glucuronidase

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0004566   GO:0005764   GO:0005975   GO:0004553   GO:0030246   GO:0019391   GO:0016021   GO:0006508   GO:0008270   GO:0031012   GO:0005089   GO:0035023   GO:0005515   GO:0016742   GO:0003824  

SignalP

Position:   1 - 21,         Likelihood:  0.872973

 

 

Length:

665

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.2527899999999

Exp number, first 60 AAs:

21.24357

Total prob of N-in:

0.98703

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  665

 

 

Pi

202.409412

Theta

150.996145

Tajima's D

0.669917

CLR

0.738249

CSRT

0.565471726413679

Interpretation

Uncertain