Gene

KWMTBOMO04624

Annotation

Matrix_metalloproteinase-16_[Papilio_machaon]

Location

Bomo_Chr8(-):10902196-10903316      View in EpiBrowser

Full name

Matrix metalloproteinase-2      

Location in the cell

Nuclear   Reliability : 2.757

CDS

ATGGACGGAAACGAGCAATCTTACGAAGACGATTTCCGGATCGCGATCAAAACTTTACAAGAATTCGGAGGTATTCCTGTCACAGGGGAGCTAGACGCAGCGACAAGAAATTTAATGAAACAAAAGCGGTGTGGTAGACCAGACAGAGAAGAACAGGATCACGAAAATCGAAGATCGAAGAGATTTGCCGTCCAGGGAGCGAAGTGGAAACACACCAATTTAACATGGAGGTAA

Protein

MDGNEQSYEDDFRIAIKTLQEFGGIPVTGELDAATRNLMKQKRCGRPDREEQDHENRRSKRFAVQGAKWKHTNLTWR

Description

Has metalloproteinase activity (PubMed:11967260). Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue (PubMed:12530966). Required for growth of the dorsal air sac primordium and development of the dorsal air sacs (PubMed:19751719). Promotes embryonic motor axon fasciculation (PubMed:18045838). Cleaves and activates frac to promote motor axon bundling during outgrowth (PubMed:21471368). Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow (PubMed:20412776). Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation (PubMed:25267296). Plays a role in wound healing (PubMed:22262460). Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions (PubMed:25520167). Required for posterior follicle cell degradation and ovulation (PubMed:25695427).

Cofactor

Zn(2+)
Ca(2+)

Similarity

Belongs to the peptidase M10A family.

Keywords

Alternative splicing   Calcium   Cell membrane   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hydrolase   Membrane   Metal-binding   Metalloprotease   Protease   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix   Zinc   Zymogen  

Feature

propeptide  Activation peptide
chain  Matrix metalloproteinase-2
splice variant  In isoform C.

Uniprot

A0A2A4IWM9   A0A2H1VB64   A0A194QU76   A0A194PQM8   A0A212FGS1   A0A0L7LT68   + More
A0A336N0B2   A0A0J7L3C7   E9IWG0   A0A336MJP8   E2BGY0   E2AGJ9   A0A195FKY6   A0A087ZQ14   A0A1Y1LH94   A0A2A3EGV3   T1KNP2   A0A2S2NLZ5   A0A151IPY0   A0A0P5H5I2   A0A1A9V8N5   A0A183IHM5   A0A2H8TRK4   A0A158NET9   A0A195AV09   A0A348G5Y9   A0A232FL65   A0A151XIP8   A0A1B0G123   A0A3L8DAM3   A0A1B0ARG3   A0A195E8Z7   A0A1B0AD89   A0A1A9W7U8   A0A1J1I9A7   A0A0M3HUN9   A0A1B0GI40   A0A1A9YH87   A0A1S3DAR8   A0A0T6B4Y1   A0A164KHU5   A0A0L7R185   H2ZEY6   A0A1B6E667   D6WYY9   A0A147BPY1   A0A2S2Q4U3   T2M4Y7   A0A1I8MCL0   A0A0P4ZTH9   A0A0P5BVX1   A0A0P6BPJ7   X1WIM9   A0A1W4WJ61   B7QD72   B4HT26   A0A0P6IFT8   A0A0P6F6M4   F6RRU7   A0A0S3Q290   A0A1B6G040   A0A087USP2   A0A1W2W5Z1   A0A3M6V0B5   E0V8V4   A0A0V1N7S9   A0A0V1HWH9   Q8MPP3   E0VM71   A0A0L0BR13   A0A0V1EZ73   A0A0V1HWB5   A0A0V1JCY4   A0A0V0YC80   A0A0N5D346   A0A0V1EYX9   A0A0V1JD56   A0A1B0EX88   A0A1S3IGL5   T2M2R4   B4QHP4   Q9U9P0   E9GW38   H2ZEY7   A0A3P6UHJ2   A0A1W0XBN1   A0A3B3E0A3   A0A3B0JKN2   A0A0J9RA38   A0A1D1VJZ5   A0A0J9R8Z6   A0A1I7VM22   A0A1B0GPG4   A0A1B6HAB5   A0A2P6L761   A0A3Q0HIT9   A0A0C9QWS2   A0A0V0SA94   W8AXQ9   A0A2P2I1R8  

EC Number

3.4.24.-

Pubmed

26354079    22118469    26227816    21282665    20798317    28004739    + More
21347285    28648823    30249741    18362917    19820115    29652888    24065732    25315136    17994087    12481130    15114417    30382153    20566863    11967260    10731132    12537572    12530966    18045838    19751719    20412776    21471368    22262460    25267296    25520167    25695427    26108605    10648248    21292972    29451363    22936249    27649274    25217238    24495485   

EMBL

NWSH01006225    PCG63582.1    ODYU01001602    SOQ38051.1    KQ461154    KPJ08540.1    + More
KQ459595    KPI95612.1    AGBW02008605    OWR52927.1    JTDY01000150    KOB78584.1    UFQS01005597    UFQT01005597    SSX16855.1    SSX36032.1    LBMM01001098    KMQ96929.1    GL766526    EFZ15070.1    UFQT01001129    SSX29063.1    GL448228    EFN85112.1    GL439316    EFN67456.1    KQ981490    KYN41330.1    GEZM01055573    JAV73019.1    KZ288254    PBC30704.1    CAEY01000277    GGMR01005590    MBY18209.1    KQ976806    KYN08207.1    GDIQ01254645    JAJ97079.1    UZAM01007580    VDP00079.1    GFXV01005022    MBW16827.1    ADTU01013670    ADTU01013671    ADTU01013672    ADTU01013673    ADTU01013674    ADTU01013675    ADTU01013676    ADTU01013677    ADTU01013678    ADTU01013679    KQ976736    KYM76078.1    FX985527    BBF97862.1    NNAY01000055    OXU31481.1    KQ982080    KYQ60201.1    CCAG010005036    QOIP01000010    RLU17361.1    JXJN01002410    KQ979479    KYN21302.1    CVRI01000044    CRK96840.1    AJWK01011259    AJWK01011260    LJIG01009817    KRT82321.1    LRGB01003325    KZS03275.1    KQ414668    KOC64604.1    GEDC01025185    GEDC01003893    JAS12113.1    JAS33405.1    KQ971363    EFA09264.2    GEGO01002587    JAR92817.1    GGMS01003418    MBY72621.1    HAAD01000947    CDG67179.1    GDIP01208779    JAJ14623.1    GDIP01179180    JAJ44222.1    GDIP01012120    JAM91595.1    ABLF02036564    ABLF02036569    ABLF02036574    ABJB010380367    ABJB010586123    DS911299    EEC16794.1    CH480816    EDW47136.1    GDIQ01005176    JAN89561.1    GDIQ01064753    JAN29984.1    EAAA01000357    LC056002    BAT62454.1    GECZ01014096    JAS55673.1    KK121385    KFM80381.1    RCHS01000379    RMX59317.1    DS234986    EEB09810.1    JYDO01000004    KRZ80010.1    JYDP01000022    KRZ14720.1    AJ289232    AE013599    BT021212    BT150239    AAX33360.1    AGV77141.1    CAC81969.1    DS235291    EEB14477.1    JRES01001487    KNC22520.1    JYDR01000003    KRY78876.1    KRZ14721.1    JYDS01000013    JYDV01000001    KRZ32835.1    KRZ46247.1    JYDU01000025    KRX98046.1    UYYF01004496    VDN04767.1    KRY78875.1    KRZ32836.1    AJWK01011251    AJWK01011252    AJWK01011253    AJWK01011254    HAAD01000070    CDG66302.1    CM000362    EDX06378.1    AF162688    AAD45804.1    GL732569    EFX76334.1    UYRX01000250    VDK78558.1    MTYJ01000005    OQV24830.1    OUUW01000001    SPP74029.1    CM002911    KMY92554.1    BDGG01000005    GAU98818.1    KMY92553.1    JH712088    EJD76154.1    AJVK01015207    AJVK01015208    AJVK01015209    GECU01036129    JAS71577.1    MWRG01001283    PRD34414.1    GBYB01005122    JAG74889.1    JYDL01000025    KRX23301.1    GAMC01016967    JAB89588.1    IACF01002329    LAB67987.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    UP000036403    + More
UP000008237    UP000000311    UP000078541    UP000005203    UP000242457    UP000015104    UP000078542    UP000078200    UP000050793    UP000005205    UP000078540    UP000215335    UP000075809    UP000092444    UP000279307    UP000092460    UP000078492    UP000092445    UP000091820    UP000183832    UP000036681    UP000092461    UP000092443    UP000079169    UP000076858    UP000053825    UP000007875    UP000007266    UP000095301    UP000007819    UP000192223    UP000001555    UP000001292    UP000008144    UP000054359    UP000275408    UP000009046    UP000054843    UP000055024    UP000000803    UP000037069    UP000054632    UP000054805    UP000054826    UP000054815    UP000046394    UP000276776    UP000085678    UP000000304    UP000000305    UP000277928    UP000261560    UP000268350    UP000186922    UP000095285    UP000092462    UP000189705    UP000054630   

PRIDE

Q8MPP3   

Pfam

PF01471   PG_binding_1        + More
PF00413   Peptidase_M10
PF00045   Hemopexin
PF01549   ShK

Interpro

IPR002477   Peptidoglycan-bd-like        + More
IPR024079   MetalloPept_cat_dom_sf       
IPR036365   PGBD-like_sf       
IPR028729   MMP15       
IPR021158   Pept_M10A_Zn_BS       
IPR001818   Pept_M10_metallopeptidase       
IPR033739   M10A_MMP       
IPR021190   Pept_M10A       
IPR006026   Peptidase_Metallo       
IPR036375   Hemopexin-like_dom_sf       
IPR000585   Hemopexin-like_dom       
IPR018487   Hemopexin-like_repeat       
IPR028733   MMP25       
IPR003582   ShKT_dom       
IPR018486   Hemopexin_CS       
IPR028726   MMP17       
IPR028723   MMP24       

SUPFAM

SSF47090   SSF47090        + More
SSF50923   SSF50923       

Gene 3D

3.40.390.10     2.110.10.10    

CDD

cd04278  ZnMc_MMP
cd00094  HX

ProteinModelPortal

A0A2A4IWM9   A0A2H1VB64   A0A194QU76   A0A194PQM8   A0A212FGS1   A0A0L7LT68   + More
A0A336N0B2   A0A0J7L3C7   E9IWG0   A0A336MJP8   E2BGY0   E2AGJ9   A0A195FKY6   A0A087ZQ14   A0A1Y1LH94   A0A2A3EGV3   T1KNP2   A0A2S2NLZ5   A0A151IPY0   A0A0P5H5I2   A0A1A9V8N5   A0A183IHM5   A0A2H8TRK4   A0A158NET9   A0A195AV09   A0A348G5Y9   A0A232FL65   A0A151XIP8   A0A1B0G123   A0A3L8DAM3   A0A1B0ARG3   A0A195E8Z7   A0A1B0AD89   A0A1A9W7U8   A0A1J1I9A7   A0A0M3HUN9   A0A1B0GI40   A0A1A9YH87   A0A1S3DAR8   A0A0T6B4Y1   A0A164KHU5   A0A0L7R185   H2ZEY6   A0A1B6E667   D6WYY9   A0A147BPY1   A0A2S2Q4U3   T2M4Y7   A0A1I8MCL0   A0A0P4ZTH9   A0A0P5BVX1   A0A0P6BPJ7   X1WIM9   A0A1W4WJ61   B7QD72   B4HT26   A0A0P6IFT8   A0A0P6F6M4   F6RRU7   A0A0S3Q290   A0A1B6G040   A0A087USP2   A0A1W2W5Z1   A0A3M6V0B5   E0V8V4   A0A0V1N7S9   A0A0V1HWH9   Q8MPP3   E0VM71   A0A0L0BR13   A0A0V1EZ73   A0A0V1HWB5   A0A0V1JCY4   A0A0V0YC80   A0A0N5D346   A0A0V1EYX9   A0A0V1JD56   A0A1B0EX88   A0A1S3IGL5   T2M2R4   B4QHP4   Q9U9P0   E9GW38   H2ZEY7   A0A3P6UHJ2   A0A1W0XBN1   A0A3B3E0A3   A0A3B0JKN2   A0A0J9RA38   A0A1D1VJZ5   A0A0J9R8Z6   A0A1I7VM22   A0A1B0GPG4   A0A1B6HAB5   A0A2P6L761   A0A3Q0HIT9   A0A0C9QWS2   A0A0V0SA94   W8AXQ9   A0A2P2I1R8  

PDB

1SU3     E-value=9.43157e-05,     Score=102

KEGG

101736589    K08002 matrix metalloproteinase-24 (membrane-inserted) [EC:3.4.24.-] | (RefSeq) matrix metalloprotei

GO

GO:0008237   GO:0031012   GO:0004222   GO:0008270   GO:0016021   GO:0030574   GO:0030198   GO:0005615   GO:0045216   GO:0016485   GO:0007426   GO:0040037   GO:0030728   GO:0009897   GO:0007561   GO:1901202   GO:0008045   GO:0097156   GO:0006929   GO:0034769   GO:0090090   GO:0007505   GO:0002218   GO:0030425   GO:0046529   GO:0003319   GO:0003144   GO:0035202   GO:0042060   GO:0007419   GO:0046331   GO:2000647   GO:0046872   GO:0005886   GO:0004175   GO:0071711   GO:0007424   GO:0006508   GO:0005089   GO:0035023   GO:0005515   GO:0016742   GO:0003824  

PANTHER

PTHR10201:SF25   PTHR10201:SF142   PTHR10201:SF21   PTHR10201:SF138  

Subcellular location

Cell membrane  

Length:

77

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00921

Exp number, first 60 AAs:

0.00921

Total prob of N-in:

0.40654

outside

1  -  77

 

 

Pi

191.773493

Theta

169.378994

Tajima's D

0.417975

CLR

0.051958

CSRT

0.491825408729564

Interpretation

Uncertain