Gene

KWMTBOMO04616  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005312

Annotation

PREDICTED:_notchless_protein_homolog_1_[Amyelois_transitella]

Location

Bomo_Chr8(-):10739658-10746556      View in EpiBrowser

Full name

Notchless protein homolog 1       + More
Protein Notchless      

Location in the cell

Cytoplasmic   Reliability : 1.394 Extracellular   Reliability : 1.669

CDS

ATGGAGGTAGATTCACCGAGCTGTATTCAAGCTAAATTTAAATCTGACACTGGAGAAGAAACGGGAAGTCCATTGGATTTGCCCCTAAATATAACCAAAGATCAACTTCAACTGATATGTAATGCACTTTTACAAGAGGAAGATAAACCATTCCTCTTTTTTGTGAAAGATGTTGAAATAACAACCACAATAAAGGATGCATTGGACCTAAAGACCTTGAATAGTGAAGAGGTTGTAGAGATAATATATCAACAACAGGCTGTATTTAGAGTTAGACCAGTCACAAGGTGTACTAGTTCAATACCAGGTCATGCGGAAGCAGTGATATCTACGTGCTTTAGCCCTTCCGGGAAGAAACTGGCTAGTGGCTCAGGTGACACTACTGTCAGATTTTGGGATCTGAACACACAGACACCTCTACATGTATGTAAAGGACATAGTAATTGGGTACTCTGTATAAGTTGGTCGCCAGATGGAAAAAAACTGGCATCAGCATGCAAACAAGGAAGAATTATTTTATGGGATCCATCAACTGGTAATCAAATTGGTAAACCTATGCTTGGACACAAACAGTGGGTAACAGCTCTGGCCTGGGAACCTTACCACAGAAACCCAGAATGTAGAAAACTTGCCAGTTCATCCAAAGATGGTGATGTTAGGATATGGGACACGGTAACATGTCTAACATTGTTGAGCTTGACTGGACATTCCAAAGCTGTAACTTCGGTGAAATGGGGTGGTAATGGTTTAATCTACACATCTTCTCAGGACAGGACAATCAAGGTGTGGAGGGCAGATGATGGGGTGTTATGCAGGACATTAGAAGGTCATGCTCATTGGGTTAACACTTTAGCACTAAACACGGATTATGTGTTACGTACTGGACCTTTTCATCCTGTCATGGACAATAACGCATATAGTGATGATAAGAATGTTCTCCAGCAAAGAGCATTGGACAGGTATAATGCAGTGTGCCAACAAGGAGCTGAACGTTTAGTTTCTGGTTCAGATGATTTTACATTATTTCTCTGGCTACCAGAAAAAGAAAAGAAGCCTCTGGCTAGAATGACTGGACATCAACAACTTATAAATGATGTGAAATTTTCACCAGATACAAGGATTATAGCGTCTGCTTCATTTGACAAATCTGTGAAATTATGGGAAGCAGCAAGTGGGAAGTTTATAACAACATTAAGGGGACATGTTCAAGCTGTATACATGGTTGCATGGTCTGCAGATTCTAGACTACTATTAAGTTCTAGTGCTGATTCTACACTGAAAGTTTGGAGTATGAAAACAAAGAAGTTAGAGTTGGATCTTCCAGGTCATGCAGATGAAGTGTATGCTGTCGATTGGTCCCCAGATGGAGCTTATGTGGCATCAGGAGGAAAAGATAAAGTGTTGAAGTTGTGGCAGCATTGA

Protein

MEVDSPSCIQAKFKSDTGEETGSPLDLPLNITKDQLQLICNALLQEEDKPFLFFVKDVEITTTIKDALDLKTLNSEEVVEIIYQQQAVFRVRPVTRCTSSIPGHAEAVISTCFSPSGKKLASGSGDTTVRFWDLNTQTPLHVCKGHSNWVLCISWSPDGKKLASACKQGRIILWDPSTGNQIGKPMLGHKQWVTALAWEPYHRNPECRKLASSSKDGDVRIWDTVTCLTLLSLTGHSKAVTSVKWGGNGLIYTSSQDRTIKVWRADDGVLCRTLEGHAHWVNTLALNTDYVLRTGPFHPVMDNNAYSDDKNVLQQRALDRYNAVCQQGAERLVSGSDDFTLFLWLPEKEKKPLARMTGHQQLINDVKFSPDTRIIASASFDKSVKLWEAASGKFITTLRGHVQAVYMVAWSADSRLLLSSSADSTLKVWSMKTKKLELDLPGHADEVYAVDWSPDGAYVASGGKDKVLKLWQH

Description

Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required for normal embryogenesis (By similarity). Plays a role in regulating Notch activity.
Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).
Plays a role in regulating Notch activity.

Subunit

Associates with the pre-60S ribosomal particle. Interacts (via WD repeats) with uL18 (By similarity). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (By similarity).
Interacts with Notch (via cytoplasmic domain) (PubMed:9857191). Associates with the pre-60S ribosomal particle (By similarity).
Associates with the pre-60S ribosomal particle. Interacts (via WD repeats) with uL18 (By similarity). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (PubMed:26601951).

Miscellaneous

The name 'Notchless' derives from the ability to suppress the wing notching caused by some Notch mutant alleles.

Similarity

Belongs to the NLE1/RSA4 family.

Keywords

Notch signaling pathway   Nucleus   Repeat   WD repeat   Complete proteome   Phosphoprotein   Reference proteome   Acetylation   Alternative splicing   Direct protein sequencing   Polymorphism  

Feature

chain  Notchless protein homolog 1
splice variant  In isoform 2.
sequence variant  In dbSNP:rs1471615.

Uniprot

H9J720   A0A2H1V0Q1   A0A1E1WD31   A0A3S2TNH8   A0A2A4J2B7   A0A194PQM6   + More
A0A194QY83   S4NNP5   A0A212EYS4   A0A0T6B410   A0A1Y1JU29   A0A1W4WF11   A0A067QEW1   A0A2J7QXN3   A0A1B6CNS1   U4U3B9   A0A0P5B0P2   A0A0P6CUL8   A0A0P5E6A5   A0A0K8U036   A0A0N7ZQD1   A0A0P5ZCM1   E9HFT7   A0A0P6CI94   A0A034WDM4   A0A0K8WFQ0   A0A1B6GE01   W8BDS3   D6X557   A0A154PV51   K7J2R3   A0A1I8NEG9   A0A1S3D021   T1PIJ4   A0A0U2K782   A0A0V0G8D6   A0A146LXZ6   A0A182FB76   A0A1L8H809   A0A0N0BH53   A0A232F1K0   Q7ZXK9   A0A1A9VBQ2   A0A2M4BLN3   A0A1I8NN00   A0A0L0BXN3   A0A1B0G8B6   A0A023F589   E0VIV5   Q0D2B0   A0A151IFH4   W5JU99   A0A0C9S352   A0A2M4BLM9   B4KFG7   F4WZK7   A0A1A9WN04   Q58D20   A0A3Q1N213   I3M7E4   A0A0D9R1W1   A0A0J9TCL7   A0A195DXP8   A0A1A9XXQ7   B4P2G2   B3N7S2   Q9VPR4   H0X1H4   B4Q658   J9JTX5   A0A195FEH4   A0A091DT08   A0A1S3JDQ8   B3MLP8   A0A2K6QQG7   A0A2I2V019   A0A1S3W3K9   F7GHQ8   G3VN49   A0A3Q0DL33   U3DX50   E9ILD0   Q9NVX2   H0VN00   A0A2K6LFA1   A0A287A8X1   M3VUD4   A0A2K5RDR6   G2HGH5   A0A1D5R0W2   B4ICZ0   V9KP55   A0A2K5MYU0   A0A1B0APF9   A0A287ACH7   A0A096P3W2   A0A182VBH9   A0A182HZJ3   Q7PTK2   B2GV82  

Pubmed

19121390    26354079    23622113    22118469    28004739    24845553    + More
23537049    21292972    25348373    24495485    18362917    19820115    20075255    25315136    26580012    26823975    27762356    28648823    9857191    26108605    25474469    20566863    20920257    23761445    17994087    21719571    16305752    19393038    22936249    17550304    10731132    12537572    12537569    25362486    17975172    21709235    25243066    21282665    14702039    16625196    15489334    11124703    12429849    17525332    19413330    21269460    22223895    22814378    26601951    16959974    21993624    16136131    21484476    17431167    25319552    24402279    12364791    14747013    17210077    15057822   

EMBL

BABH01013963    ODYU01000113    SOQ34336.1    GDQN01006160    JAT84894.1    RSAL01000041    + More
RVE50866.1    NWSH01003775    PCG65828.1    KQ459595    KPI95607.1    KQ461154    KPJ08536.1    GAIX01013846    JAA78714.1    AGBW02011442    OWR46648.1    LJIG01015965    KRT82020.1    GEZM01102989    JAV51638.1    KK853689    KDQ97268.1    NEVH01009378    PNF33341.1    GEDC01022265    GEDC01021364    JAS15033.1    JAS15934.1    KB631581    ERL84480.1    GDIP01191686    JAJ31716.1    GDIQ01087187    JAN07550.1    GDIP01146187    JAJ77215.1    GDHF01032634    JAI19680.1    GDIP01222889    JAJ00513.1    GDIP01045716    JAM57999.1    GL732637    EFX69411.1    GDIQ01090749    JAN03988.1    GAKP01006747    GAKP01006745    JAC52205.1    GDHF01002402    JAI49912.1    GECZ01009101    JAS60668.1    GAMC01011422    JAB95133.1    KQ971382    EEZ97691.1    KQ435210    KZC15080.1    KA648474    AFP63103.1    KT984270    ALR88667.1    GECL01001832    JAP04292.1    GDHC01008545    GDHC01007399    JAQ10084.1    JAQ11230.1    CM004469    OCT92242.1    KQ435762    KOX75548.1    NNAY01001258    OXU24594.1    AF069737    BC044710    AAC62236.1    AAH44710.1    GGFJ01004849    MBW53990.1    JRES01001179    KNC24760.1    CCAG010000229    GBBI01002463    JAC16249.1    DS235206    EEB13311.1    BC122040    AAI22041.1    KQ977793    KYM99658.1    ADMH02000120    ETN67716.1    GBYB01015346    JAG85113.1    GGFJ01004848    MBW53989.1    CH933807    EDW13082.2    GL888480    EGI60282.1    BT021777    AGTP01050539    AQIB01146960    CM002910    KMY87340.1    KQ980107    KYN17648.1    CM000157    EDW87158.2    CH954177    EDV57248.1    AE014134    AY089286    AJ012588    AAF51479.2    AAL90024.1    CAA10070.1    AAQR03133423    AAQR03133424    CM000361    EDX03242.1    ABLF02031542    KQ981625    KYN39080.1    KN123290    KFO25941.1    CH902620    EDV30769.1    AANG04004035    AEFK01177033    AEFK01177034    GAMQ01005039    JAB36812.1    GL764074    EFZ18631.1    AK001320    AB209111    AC022916    BC002884    BC012075    AJ005257    AAKN02033115    AEMK02000080    AACZ04043901    AK305839    NBAG03000289    BAK62833.1    PNI47334.1    JSUE03016471    JSUE03016472    JU476081    AFH32885.1    CH480829    EDW45416.1    JW867903    AFP00421.1    JXJN01001399    AHZZ02010044    APCN01001981    AAAB01008799    EAA03804.5    AC095947    BC166567    AAI66567.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    + More
UP000192223    UP000027135    UP000235965    UP000030742    UP000000305    UP000007266    UP000076502    UP000002358    UP000095301    UP000079169    UP000069272    UP000186698    UP000053105    UP000215335    UP000078200    UP000095300    UP000037069    UP000092444    UP000009046    UP000078542    UP000000673    UP000009192    UP000007755    UP000091820    UP000009136    UP000005215    UP000029965    UP000078492    UP000092443    UP000002282    UP000008711    UP000000803    UP000005225    UP000000304    UP000007819    UP000078541    UP000028990    UP000085678    UP000007801    UP000233200    UP000011712    UP000079721    UP000008225    UP000007648    UP000189704    UP000005640    UP000005447    UP000233180    UP000008227    UP000233040    UP000002277    UP000006718    UP000001292    UP000233060    UP000092460    UP000028761    UP000075903    UP000075840    UP000007062    UP000002494   

PRIDE

H9J720    Q7ZXK9    Q58D20    Q9VPR4    Q9NVX2   

Pfam

PF00400   WD40        + More
PF08154   NLE
PF00060   Lig_chan
PF12894   ANAPC4_WD40

Interpro

IPR017986   WD40_repeat_dom        + More
IPR001680   WD40_repeat       
IPR001632   Gprotein_B       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR019775   WD40_repeat_CS       
IPR036322   WD40_repeat_dom_sf       
IPR020472   G-protein_beta_WD-40_rep       
IPR012972   NLE       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR001320   Iontro_rcpt       
IPR024977   Apc4_WD40_dom       
IPR011041   Quinoprot_gluc/sorb_DH       

SUPFAM

SSF50978   SSF50978        + More
SSF50998   SSF50998       
SSF50952   SSF50952       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9J720   A0A2H1V0Q1   A0A1E1WD31   A0A3S2TNH8   A0A2A4J2B7   A0A194PQM6   + More
A0A194QY83   S4NNP5   A0A212EYS4   A0A0T6B410   A0A1Y1JU29   A0A1W4WF11   A0A067QEW1   A0A2J7QXN3   A0A1B6CNS1   U4U3B9   A0A0P5B0P2   A0A0P6CUL8   A0A0P5E6A5   A0A0K8U036   A0A0N7ZQD1   A0A0P5ZCM1   E9HFT7   A0A0P6CI94   A0A034WDM4   A0A0K8WFQ0   A0A1B6GE01   W8BDS3   D6X557   A0A154PV51   K7J2R3   A0A1I8NEG9   A0A1S3D021   T1PIJ4   A0A0U2K782   A0A0V0G8D6   A0A146LXZ6   A0A182FB76   A0A1L8H809   A0A0N0BH53   A0A232F1K0   Q7ZXK9   A0A1A9VBQ2   A0A2M4BLN3   A0A1I8NN00   A0A0L0BXN3   A0A1B0G8B6   A0A023F589   E0VIV5   Q0D2B0   A0A151IFH4   W5JU99   A0A0C9S352   A0A2M4BLM9   B4KFG7   F4WZK7   A0A1A9WN04   Q58D20   A0A3Q1N213   I3M7E4   A0A0D9R1W1   A0A0J9TCL7   A0A195DXP8   A0A1A9XXQ7   B4P2G2   B3N7S2   Q9VPR4   H0X1H4   B4Q658   J9JTX5   A0A195FEH4   A0A091DT08   A0A1S3JDQ8   B3MLP8   A0A2K6QQG7   A0A2I2V019   A0A1S3W3K9   F7GHQ8   G3VN49   A0A3Q0DL33   U3DX50   E9ILD0   Q9NVX2   H0VN00   A0A2K6LFA1   A0A287A8X1   M3VUD4   A0A2K5RDR6   G2HGH5   A0A1D5R0W2   B4ICZ0   V9KP55   A0A2K5MYU0   A0A1B0APF9   A0A287ACH7   A0A096P3W2   A0A182VBH9   A0A182HZJ3   Q7PTK2   B2GV82  

PDB

6FT6     E-value=6.30214e-121,     Score=1112

KEGG

101735350    K14855 ribosome assembly protein 4 | (RefSeq) notchless protein homolog 1

GO

GO:0005730   GO:0003743   GO:0042254   GO:0016021   GO:0004970   GO:0000027   GO:0007219   GO:0003824   GO:0045746   GO:0005112   GO:0045747   GO:0090263   GO:2001268   GO:0001826   GO:0042273   GO:0048705   GO:0061484   GO:0045930   GO:0001756   GO:0001822   GO:0005634   GO:0005515   GO:0005509   GO:0006468   GO:0007165   GO:0005085   GO:0005089   GO:0035023   GO:0016742  

Subcellular location

  

Length:

473

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00243

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00251

outside

1  -  473

 

 

Pi

190.568241

Theta

196.655772

Tajima's D

-0.30665

CLR

2.564053

CSRT

0.294685265736713

Interpretation

Uncertain