Gene

KWMTBOMO04611  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005496

Annotation

cytochrome_P450?_family_315?_subfamily_a?_polypeptide_1_[Bombyx_mori]

Location

Bomo_Chr8(+):10667447-10685733      View in EpiBrowser

Full name

Cytochrome P450 315a1, mitochondrial      

Alternative Name

CYPCCCXVA1
Protein shadow

Location in the cell

Mitochondrial   Reliability : 2.578

CDS

ATGCATCGTTTCCCGTCGATGTCTTCCATTAGATCCGCTGTTAGGAGTCGTAACAGTAATCGATGTTCAATGTCAACTAAGCCTCATAAATCTCTACGTACCATAGATGAGATGCCACATAAGAAATCATTACCAATCATAGGAACAAAATTTGACTTATTTTCTGCAGGTGGAGGAAAAAACTTACACAAATATATCGACATGCGTCACAAGCAATTAGGACCTATATTCTACGAGAGATTAACAGGAAAGACAAAACTTGTCTTTATCAGCGACCCAACTCACATGAAAAGTTTATTCTTAAATTTAGAAGGAAAATATCCGGCACATATTTTACCAGAACCGTGGGTACTATATGAAAAATTATACGGATCAAAAAGAGGACTTTTCTTTATGGACGGAGAGGATTGGTTGATTAATCGACGAATTATGAACAAACATCTACTCAGAGAAGATTCAGATGTATGGTTACGAGCTCCTATAAGAACAGCTGTGTTTCACTTTATATGTAACTGGAAACTTAGAGCTCAAAGTGGCAACTTCTCTCCTAACTTGGAATCTGAGTTTTATAGATTTTCCACTGACGTTATTTTAGCAGTTCTTCAGGGGAATAGTGCACTATTAAAGCCCACGCCAGAATACGAGATGTTATTGTTACTGTTTTCTGAGGCTGTCAAGAAAATATTCTCAACAACTACAAAATTATATGCTTTACCCGTAGAATTCTGCCAACGATGGAATTTAAAAGTGTGGAGAAATTTCAAACAATCCGTTGATGATTCCATCTCTATCGCTCAGAAAATTGTATACGAAATGTTGCACACAAAAGACGCTGGTGACGGTTTGGTAAAAAGACTAAAGGATGAAAATATGTCTGATGAATTAATAACAAGAATTGTTGCTGACTTTGTCATCGCCGCTGGAGATACGACAGCTTATACATCACTTTGGATATTATTTTTACTTTCAAATAATACTGAAATCTTAACTGAAATGAACGACAACGACCAATACGTGAAAAATGTTGTTAAAGAGGCAATGAGATTATATCCTGTAGCACCATTTCTTACAAGAATTTTACCCAAACAATGTGTTTTGGGACCTTATTTGCTCGAGGAAGGGACTCCAGTAATAGCTTCAATCTATACATCGGGTCGAGACGAACAAAATTTTAGCAAAGCAGACCAATTTTTGCCTTATCGATGGGACAGGAACGATCAACGAAAGAAGGATTTAGTAAATCATGTACCATCTGCCACACTGCCATTTGCCTTCGGCGCCAGATCATGTATCGGTAAAAAGATGGCTATGCTACAAATGACAGAATTAATCAGTCAGATTGTGAAAAATTTTGACCTGAAATCTATGAACAATTCTGATGTGGATGCTGTAACTTCACAGGTGTTAGTGCCGAACAAAGACATCAAAGTTTTAATACTACCGCGTTCAATTTCTAAGTAA

Protein

MHRFPSMSSIRSAVRSRNSNRCSMSTKPHKSLRTIDEMPHKKSLPIIGTKFDLFSAGGGKNLHKYIDMRHKQLGPIFYERLTGKTKLVFISDPTHMKSLFLNLEGKYPAHILPEPWVLYEKLYGSKRGLFFMDGEDWLINRRIMNKHLLREDSDVWLRAPIRTAVFHFICNWKLRAQSGNFSPNLESEFYRFSTDVILAVLQGNSALLKPTPEYEMLLLLFSEAVKKIFSTTTKLYALPVEFCQRWNLKVWRNFKQSVDDSISIAQKIVYEMLHTKDAGDGLVKRLKDENMSDELITRIVADFVIAAGDTTAYTSLWILFLLSNNTEILTEMNDNDQYVKNVVKEAMRLYPVAPFLTRILPKQCVLGPYLLEEGTPVIASIYTSGRDEQNFSKADQFLPYRWDRNDQRKKDLVNHVPSATLPFAFGARSCIGKKMAMLQMTELISQIVKNFDLKSMNNSDVDAVTSQVLVPNKDIKVLILPRSISK

Description

Required for CNS development: midline glial cells. Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.

Cofactor

heme

Miscellaneous

Member of the Halloween gene group.

Similarity

Belongs to the cytochrome P450 family.
Belongs to the OXA1/ALB3/YidC family.

Keywords

Complete proteome   Heme   Iron   Membrane   Metal-binding   Mitochondrion   Monooxygenase   Oxidoreductase   Reference proteome   Transit peptide  

Feature

chain  Cytochrome P450 315a1, mitochondrial

Uniprot

Q6I6M8   L0N6K4   L0N747   L0N7B2   Q2HZZ4   A0A0P0HKS9   + More
S6B478   A0A3S2NLQ3   D1GEJ6   A0A248QEJ3   A0A2H1VI64   A0A0L7LLN4   A0A067RDD3   A0A1Y1MMR8   A0A0T6AXK2   D6WKZ9   A0A2J7PGM2   V5K5L7   A0A1W6L1B8   A0A1A9V720   A0A1A9ZL34   B4NK58   A0A1I8N6Z5   A0A034VQK8   A0A088APZ6   A0A0A1X8D5   A0A0L0CBJ1   A0A0L7R8B6   T1HQU7   A0A232F4V0   A0A0K8U898   A0A1I8Q149   B4PTF1   A0A3B0KBX2   A0A2A3EJT6   A0A224XQA4   A0A195C616   Q295B9   Q16NV1   B4GMB6   A0A023F0S2   A0A0P6IXI5   A0A075BFL1   B4HHW3   A0A146M3K4   A0A1B6CUW2   B3P4E3   Q563C5   Q9VGH1   A0A0M4EJV6   B4QTK3   K7IRZ9   A0A1B0CLM4   A0A2H8TGC2   E0VMW9   A0A146LLE3   A0A026W166   A0A1W4WC86   B3MTT6   A0A1A9X2R5   T1JAE9   A0A034VPJ7   B4K9Z0   B4JG07   A0A151WSX3   A0A1A9XW33   A0A1B0BDP7   A0A182N8F3   A0A1J1IJC8   A0A195E966   A0A1B6FRJ4   A0A158NF50   X1WI94   A0A182YH61   B4LXY5   E9ID25   T1J337   E2B079   A0A195FL49   A0A195AUU7   A0A087TZR9   A0A182RHK3   A9Q617   F4WEI7   A0A182MK14   A0A182U3F5   Q7QF34   A0A224XHL4   A0A2S2QD38   A0A0K0LB69   A0A0J7KK56   A0A182QLY6   A0A182KCS5   A0A182VHA7  

EC Number

1.14.99.-

Pubmed

15197185    16503480    19682519    28881445    26227816    24845553    + More
28004739    18362917    19820115    24267698    17994087    25315136    25348373    25830018    26108605    28648823    17550304    15632085    17510324    25474469    26999592    26823975    15804580    12177427    10731132    12537572    14610274    20075255    20566863    24508170    21347285    25244985    21282665    20798317    19060216    21719571    12364791    14747013    17210077   

EMBL

AB167737    BAD23845.1    AK289335    BAM73862.1    AK289334    BAM73861.1    + More
AK289333    BAM73860.1    DQ357068    ABC96070.1    KP764855    ALJ84053.1    AB649119    BAN66313.1    RSAL01000041    RVE50862.1    FJ844407    ACY92454.1    KX443478    ASO98053.1    ODYU01002692    SOQ40527.1    JTDY01000648    KOB76340.1    KK852775    KDR16797.1    GEZM01029690    JAV85990.1    LJIG01022600    KRT79716.1    KQ971343    EFA04669.1    NEVH01025175    PNF15482.1    KF044272    AGT57844.1    KX609520    ARN17927.1    CH964272    EDW85100.1    GAKP01014550    GAKP01014545    JAC44402.1    GBXI01007364    JAD06928.1    JRES01000630    KNC29778.1    KQ414632    KOC67115.1    ACPB03000489    NNAY01001009    OXU25500.1    GDHF01029511    JAI22803.1    CM000160    EDW97650.1    OUUW01000008    SPP83639.1    KZ288232    PBC31522.1    GFTR01006245    JAW10181.1    KQ978287    KYM95608.1    CM000070    EAL28793.2    CH477807    EAT36035.2    CH479185    EDW37990.1    GBBI01004133    JAC14579.1    GDUN01000232    JAN95687.1    KC515377    AGF44568.1    CH480815    EDW42545.1    GDHC01005469    JAQ13160.1    GEDC01020137    JAS17161.1    CH954181    EDV49458.1    AY947551    AAX85207.1    AY079170    AE014297    BT016061    CP012526    ALC47308.1    CM000364    EDX13308.1    AJWK01017455    GFXV01001329    MBW13134.1    DS235327    EEB14725.1    GDHC01010983    JAQ07646.1    KK107522    EZA49326.1    CH902623    EDV30217.1    JH431998    GAKP01014548    GAKP01014542    JAC44404.1    CH933806    EDW15638.1    CH916369    EDV92546.1    KQ982769    KYQ50946.1    JXJN01012594    CVRI01000054    CRL00351.1    KQ979479    KYN21367.1    GECZ01016961    GECZ01000749    JAS52808.1    JAS69020.1    ADTU01013744    ABLF02022089    CH940650    EDW66851.1    GL762454    EFZ21475.1    JH431820    GL444420    EFN60908.1    KQ981490    KYN41395.1    KQ976736    KYM76013.1    KK117489    KFM70608.1    EF546764    ABU42524.1    GL888103    EGI67350.1    AXCM01004618    AAAB01008846    EAA06503.5    GFTR01005892    JAW10534.1    GGMS01006436    MBY75639.1    KM216998    AIW79961.1    LBMM01006459    KMQ90601.1    AXCN02002153   

Proteomes

UP000283053    UP000037510    UP000027135    UP000007266    UP000235965    UP000078200    + More
UP000092445    UP000007798    UP000095301    UP000005203    UP000037069    UP000053825    UP000015103    UP000215335    UP000095300    UP000002282    UP000268350    UP000242457    UP000078542    UP000001819    UP000008820    UP000008744    UP000001292    UP000008711    UP000000803    UP000092553    UP000000304    UP000002358    UP000092461    UP000009046    UP000053097    UP000192221    UP000007801    UP000091820    UP000009192    UP000001070    UP000075809    UP000092443    UP000092460    UP000075884    UP000183832    UP000078492    UP000005205    UP000007819    UP000076408    UP000008792    UP000000311    UP000078541    UP000078540    UP000054359    UP000075900    UP000007755    UP000075883    UP000075902    UP000007062    UP000036403    UP000075886    UP000075881    UP000075903   

PRIDE

Q6I6M8    L0N6K4    L0N747    L0N7B2    Q9VGH1   

Pfam

PF00067   p450        + More
PF02096   60KD_IMP

Interpro

IPR001128   Cyt_P450        + More
IPR002401   Cyt_P450_E_grp-I       
IPR036396   Cyt_P450_sf       
IPR002403   Cyt_P450_E_grp-IV       
IPR001708   YidC/ALB3/OXA1/COX18       
IPR017972   Cyt_P450_CS       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

Q6I6M8   L0N6K4   L0N747   L0N7B2   Q2HZZ4   A0A0P0HKS9   + More
S6B478   A0A3S2NLQ3   D1GEJ6   A0A248QEJ3   A0A2H1VI64   A0A0L7LLN4   A0A067RDD3   A0A1Y1MMR8   A0A0T6AXK2   D6WKZ9   A0A2J7PGM2   V5K5L7   A0A1W6L1B8   A0A1A9V720   A0A1A9ZL34   B4NK58   A0A1I8N6Z5   A0A034VQK8   A0A088APZ6   A0A0A1X8D5   A0A0L0CBJ1   A0A0L7R8B6   T1HQU7   A0A232F4V0   A0A0K8U898   A0A1I8Q149   B4PTF1   A0A3B0KBX2   A0A2A3EJT6   A0A224XQA4   A0A195C616   Q295B9   Q16NV1   B4GMB6   A0A023F0S2   A0A0P6IXI5   A0A075BFL1   B4HHW3   A0A146M3K4   A0A1B6CUW2   B3P4E3   Q563C5   Q9VGH1   A0A0M4EJV6   B4QTK3   K7IRZ9   A0A1B0CLM4   A0A2H8TGC2   E0VMW9   A0A146LLE3   A0A026W166   A0A1W4WC86   B3MTT6   A0A1A9X2R5   T1JAE9   A0A034VPJ7   B4K9Z0   B4JG07   A0A151WSX3   A0A1A9XW33   A0A1B0BDP7   A0A182N8F3   A0A1J1IJC8   A0A195E966   A0A1B6FRJ4   A0A158NF50   X1WI94   A0A182YH61   B4LXY5   E9ID25   T1J337   E2B079   A0A195FL49   A0A195AUU7   A0A087TZR9   A0A182RHK3   A9Q617   F4WEI7   A0A182MK14   A0A182U3F5   Q7QF34   A0A224XHL4   A0A2S2QD38   A0A0K0LB69   A0A0J7KK56   A0A182QLY6   A0A182KCS5   A0A182VHA7  

PDB

3K9Y     E-value=3.28311e-46,     Score=467

KEGG

100127120    K10722 ecdysteroid 2-hydroxylase | (RefSeq) Cyp315a1; cytochrome P450

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005506   GO:0016705   GO:0020037   GO:0004497   GO:0032977   GO:0016021   GO:0008258   GO:0007417   GO:0042768   GO:0007391   GO:0007494   GO:0005739   GO:0006697   GO:0008045   GO:0031966   GO:0008386   GO:0042176   GO:0016491   GO:0007165   GO:0015031   GO:0016020   GO:0016742   GO:0003824   GO:0055114  

Subcellular location

Membrane  
Mitochondrion membrane  

Length:

486

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.832939999999999

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00360

outside

1  -  486

 

 

Pi

265.974022

Theta

190.589539

Tajima's D

1.618701

CLR

0.115263

CSRT

0.812609369531523

Interpretation

Uncertain