Gene

KWMTBOMO04610  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005315

Annotation

PREDICTED:_26S_proteasome_non-ATPase_regulatory_subunit_2_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr8(-):10651485-10662826      View in EpiBrowser

Full name

26S proteasome non-ATPase regulatory subunit 2      

Location in the cell

Cytoplasmic   Reliability : 1.863

CDS

ATGACTGTGAAAAATAAAACTGAAGAGCCAAAGAAGGAAAAAGCTGAGCCCGCAGTGGCTCCAAATGATGATCTTTCCGAGGAAGACAAACGCCTACAGGAGGAATTGAATATGCTAGTCGATAAGCTTTTGGGCAATGAAGTCGATTTATATTTTCCAGCATTACAAATGCTAAGTAATCTCATTCGGACGTCAACAACATCTATGACTTCTGTACCTAAACCTCTAAAATTCCTAAGGGAACATTATCCAGCATTGAAACAAGTATATGAAAAAATTACAGATGAAAAAACAAAAAAATTCTGTGCTGATGTTATCTCTGTCTTAGCGATGGGCGTAAGCGGTACTCTGGAAGTTGCAGAAAAGAGAGAGTGTTTGAAGTATTGTCTTCTGGGAACATTGTCAAATGTAGGTGATTGGGGACATGAATATGTTAGGCAATTGGAAGGTGAAATTGCTGAAGAATGGAATATAGAAAACATGGATTCACTTTTGCCACTAGTACGTGATGTTATCACATTTGACATGAAACACTCAGCTGAGATCCAGGCTTGTGATCTGTTAATGGAAATTGATAGACTTGATCTGCTGACCCAACATATGGACCAGAGCAACTACCCAAGAGTCTGTCTTTATCTTATTGGATGTGCAAGTTATGTTGTTGAGCCTGAGTCAACACAAATACTACAAGGTGTCTTAGATACATACCTTCGTTTTGGAGAGTACCCAAGAGCAATGCTTGTAGCTATGCAACTTCATGAGAAAGCTAAATGTGAAGAAGTGTTCAATGCCTGTAATGATCCTTTAATAAAAAAGCAACTGTGCTACTTACTTGCACGTCAATACATACCATTAGAAGTGGATGACGAAGATCTGCGCACAATTCTACTGAACGCTCATATCAATGATCATTTTCTAAGTCTGGCAAGAGAGCTTGATATTATGGAACCGAAAACTCCAGAAGAAGTTTATAAAACATGGTTAGAGTCGGCCGGATCAGCTCTTCGTCCATCTTTACTGACTGAACATCCTGTAGACTCTGCTAGACAGAACCTGTCAGCTACATTTGTGAACGCCTTTGTGAATGCCGGGTTTGGCCGAGACAAACTTGTCACAACCGATGATGGGAACAAATGGATGTACAAAAATAAGGATCATGGTATGCTCTCAGCGGCCGCGTCCCTTGGTATGATTCACTTGTGGGATGTAGACGGTGGTCTAACGCCTATCGACAAATACCTGTATACCGCCGACGAGCACATCAAGGCTGGTGCCCTACTGGCTTTAGGTCTCGTGAACTGCGGTGTCAGGAACGAGTGTGATCCAGCCTTAGCTCTGCTCTCCGATTATGTTCTGCATTCCAGTTCCAATCTCAGGATCGGAAGTGTTTTGGGTCTAGGTATTGCATATGCGGGAACACAACGAGAAGATGTGCTGTCCCACTTGCTTCCCGTGCTCAACGACACGACCGCCCCGGCCGAGATCTGCGCACTCGCCGCCATCTCCTGCGGGCTCATCGCCGTTGGATCGTGCAATGGCGATGTGTCTTGTGCAATCATTCAGCGATTGATTGACGATAACAAGGATTTGCACTCGTCTACTTACGCCAGGTTCCTGCATTTGGGACTCGGGCTGTGTTTCTTAGGCTGCAAGGAGCGCACGGAGGCGACGATGGCCGCGTTGGAAGTACTTCCGGAGCCGCAGCAGTCGCTCTGCCAGACCACGCTGTCCATGTGCGCGTACGCCGGCACCGGGGACGTGCTCGTGGTGCAACAGATGCTGCACATCTGCTCCAAGCACTACGAAACCGATAATGAACAATCGTCAACTGAAGACACAGCTTTTAAGAAACAAGACAAGAAGGACGCAAAAGAAACTACAGCAACTCCGAGCAGTTCAAAGGACGACAAATCCAAAGGTAAATCATCAAAAGACAGCAAAAACAAGGAAAAGGATAAGGAAAAGGAAGCCAACAAGGAGCTGTCCTCGGTGCAAGCCGTGGCGACCCTTGGCGTCGCGGTCATCGCATTGGCCGAGGAAACGGGCGCCGAAATGTGCACCCGCATCTTCGGACAACTGGGTAGGTACGGGGAGCCGGCAGTGCGGCGCGCCGTGCCGCTCGCCATCGCCCTGTGCTCCGTGTCCAACCCGCAGCTCTCCGTCATCGACGTGCTCAATAAATACTCCCACGATTCTGATAACGACGTCGCTTACAACGCCATATTCGCCATGGGACTCGTGGGCGCCGGCACTAACAACGCAAGACTGGCGACGATGCTGCGTGCGCTGGCGCTGTACCACGGCAAGTCTCCGGTGCACCTGTTCATGGTGCGGCTGGCGCAGGGGCTGTGTCACGCCGGCAAGGGCACGGTGACCCTGTGTCCCGCGCACGCGGACCGGCGCCTGCTCAACCAGCCCGCGCTCGCCGGCCTGCTCGTCGTGCTCACCGCCTTCCTCGACTGCAAGACCATAATCCTCGGCAAATCCCACTACTTGCTGTACGTATTGGCGACTGCGATGCAACCCCGCTGGCTGGTCACCCTCGACGAAAATCTTCAGCCCTTGAACGTCAGCGTGCGTGTGGGACAGGCTGTGGATGTTATCGGAAAAGCCGGTACACCGAAGACAATAGCCGGTTCCCACACTCACACGACGCCGGTGCTGCTGTCCTTCGGCGAGCGAGCAGAACTGGCGACTGACGAGTACATACCACTCTCGCCGATAATGGAGGGATTCGTGATTCTCAAGAAAAACGAGGATAGCGTCATGGCCTCTGTTCAATAA

Protein

MTVKNKTEEPKKEKAEPAVAPNDDLSEEDKRLQEELNMLVDKLLGNEVDLYFPALQMLSNLIRTSTTSMTSVPKPLKFLREHYPALKQVYEKITDEKTKKFCADVISVLAMGVSGTLEVAEKRECLKYCLLGTLSNVGDWGHEYVRQLEGEIAEEWNIENMDSLLPLVRDVITFDMKHSAEIQACDLLMEIDRLDLLTQHMDQSNYPRVCLYLIGCASYVVEPESTQILQGVLDTYLRFGEYPRAMLVAMQLHEKAKCEEVFNACNDPLIKKQLCYLLARQYIPLEVDDEDLRTILLNAHINDHFLSLARELDIMEPKTPEEVYKTWLESAGSALRPSLLTEHPVDSARQNLSATFVNAFVNAGFGRDKLVTTDDGNKWMYKNKDHGMLSAAASLGMIHLWDVDGGLTPIDKYLYTADEHIKAGALLALGLVNCGVRNECDPALALLSDYVLHSSSNLRIGSVLGLGIAYAGTQREDVLSHLLPVLNDTTAPAEICALAAISCGLIAVGSCNGDVSCAIIQRLIDDNKDLHSSTYARFLHLGLGLCFLGCKERTEATMAALEVLPEPQQSLCQTTLSMCAYAGTGDVLVVQQMLHICSKHYETDNEQSSTEDTAFKKQDKKDAKETTATPSSSKDDKSKGKSSKDSKNKEKDKEKEANKELSSVQAVATLGVAVIALAEETGAEMCTRIFGQLGRYGEPAVRRAVPLAIALCSVSNPQLSVIDVLNKYSHDSDNDVAYNAIFAMGLVGAGTNNARLATMLRALALYHGKSPVHLFMVRLAQGLCHAGKGTVTLCPAHADRRLLNQPALAGLLVVLTAFLDCKTIILGKSHYLLYVLATAMQPRWLVTLDENLQPLNVSVRVGQAVDVIGKAGTPKTIAGSHTHTTPVLLSFGERAELATDEYIPLSPIMEGFVILKKNEDSVMASVQ

Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Subunit

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).

Similarity

Belongs to the proteasome subunit S2 family.

Uniprot

H9J723   A0A2H1VIA1   A0A194PS70   A0A1E1WRU9   A0A194QSM7   S4NSS4   + More
A0A1E1WMN7   T1HNA1   R4G4X6   A0A224X6X3   A0A0V0G3B6   A0A069DXQ6   A0A0A9XG19   A0A023F919   R4WTN1   A0A1S3D648   A0A1B6BXI5   A0A2H8TF17   A0A2S2P6A3   J9KAY2   V5HKA2   A0A1W4ZV99   A0A3B4DP07   A0A3B4BVP6   D6W687   T1JGZ6   A0A3Q3FT65   A0A2U9B5X4   A0A3B3SLU7   A0A1A7Z6M3   H2M068   A0A3P9IP80   A0A1A7WEI5   A0A3P9MJH0   A0A096MCN6   A0A1Y1LJJ1   A0A224YI86   F4WP73   E2BBF9   A0A060XQT1   C0H8V2   A0A195EV76   A0A1E1X2C0   A0A151WM61   Q5EB37   A0A1A8GYR1   W5MQF1   A0A3B3STW8   A0A3Q3M3J9   A0A060XNU2   A0A151ILX6   A0A131Z5I7   J3JXN2   A0A026WK09   A0A1S3T1T4   A0A3S2PEK4   A0A3Q1F3H4   F7CS21   A0A1A8HZY7   A0A3Q3G638   A0A195B112   A0A158NQW6   A0A3B3ST70   L7M501   A0A3B3TJA5   A0A131XMY5   A0A087Y778   A0A3B3DU11   A0A1A8C9D0   A0A1A8AKB1   A0A1A8RI97   A0A195E6A8   A0A195CMA8   A0A1E1XST9   A0A3Q3KNA7   A0A1A8MWD8   Q6PHK7   A0A023G054   R4GC62   K1PEY4   H9G5W8   K9J3W5   A0A2Y9DW10   A0A1S3A5Y3   A0A0L7QUA5   A0A2Y9F9K6   U3BFK1   A0A2R5LP41   E2RCP9   A0A2D0STZ9   A0A1S3GI88   W5U7P5   A0A0J7KMY8   A0A232F732   I6L5A0   F7EGU4   K7J2M6   A0A2L2XZG3   A0A0M9A0L6  

Pubmed

19121390    26354079    23622113    26334808    25401762    26823975    + More
25474469    23691247    25765539    18362917    19820115    29240929    17554307    28004739    28797301    21719571    20798317    24755649    20433749    28503490    26830274    22516182    23537049    24508170    30249741    20431018    21347285    25576852    28049606    29451363    29209593    21881562    22992520    25243066    16341006    23127152    28648823    17495919    20075255    26561354   

EMBL

BABH01013950    BABH01013951    ODYU01002692    SOQ40526.1    KQ459595    KPI95599.1    + More
GDQN01001305    JAT89749.1    KQ461154    KPJ08528.1    GAIX01013937    JAA78623.1    GDQN01002867    JAT88187.1    ACPB03007651    GAHY01000990    JAA76520.1    GFTR01008250    JAW08176.1    GECL01003513    JAP02611.1    GBGD01000402    JAC88487.1    GBHO01023952    GBRD01009718    GDHC01011656    JAG19652.1    JAG56106.1    JAQ06973.1    GBBI01000751    JAC17961.1    AK418052    BAN21267.1    GEDC01031578    JAS05720.1    GFXV01000888    MBW12693.1    GGMR01012370    MBY24989.1    ABLF02033855    GANP01000328    JAB84140.1    KQ971306    EFA11079.1    JH432213    CP026245    AWO99245.1    HADX01015896    SBP38128.1    HADW01003002    SBP04402.1    AYCK01009338    AYCK01009339    GEZM01054149    JAV73819.1    GFPF01005529    MAA16675.1    GL888243    EGI64004.1    GL447043    EFN86966.1    FR905425    CDQ79230.1    BT058758    ACN10471.1    KQ981965    KYN31789.1    GFAC01005781    JAT93407.1    KQ982944    KYQ48954.1    BC090101    AAH90101.1    HAEB01018051    HAEC01008220    SBQ76358.1    AHAT01034287    FR905725    CDQ81233.1    KQ977085    KYN05887.1    GEDV01003176    JAP85381.1    APGK01047258    BT128002    KB741077    AEE62964.1    ENN74289.1    KK107182    QOIP01000003    EZA55991.1    RLU24575.1    CM012449    RVE64743.1    AAMC01042067    HAED01004959    HAEE01011452    SBQ90989.1    KQ976691    KYM77980.1    ADTU01023676    GACK01006870    JAA58164.1    GEFH01001670    JAP66911.1    HADZ01011460    HAEA01008187    SBP75401.1    HADY01017137    HAEJ01007360    SBP55622.1    HAEH01017201    HAEI01011234    SBS05746.1    KQ979608    KYN20412.1    KQ977574    KYN01825.1    GFAA01001365    JAU02070.1    HAEF01019655    HAEG01012876    SBR60814.1    BC056516    AAH56516.1    GBBL01000927    JAC26393.1    AAWZ02021625    JH818817    EKC22447.1    GABZ01000629    JAA52896.1    KQ414735    KOC62200.1    GAMT01000288    GAMR01000919    GAMP01003346    JAB11573.1    JAB33013.1    JAB49409.1    GGLE01006951    MBY11077.1    AAEX03017275    JT406941    AHH37790.1    LBMM01005329    KMQ91604.1    NNAY01000831    OXU26290.1    ABGA01216381    ABGA01216382    ABGA01216383    IAAA01002438    IAAA01002439    IAAA01002440    IAAA01002441    LAA01117.1    KQ435776    KOX74910.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000015103    UP000079169    UP000007819    + More
UP000192224    UP000261440    UP000007266    UP000261660    UP000246464    UP000261540    UP000001038    UP000265200    UP000265180    UP000028760    UP000007755    UP000008237    UP000193380    UP000087266    UP000078541    UP000075809    UP000018468    UP000261640    UP000078542    UP000019118    UP000053097    UP000279307    UP000257200    UP000008143    UP000264800    UP000078540    UP000005205    UP000261500    UP000261560    UP000078492    UP000261600    UP000001646    UP000005408    UP000248480    UP000079721    UP000053825    UP000008225    UP000002254    UP000221080    UP000081671    UP000036403    UP000215335    UP000001595    UP000002280    UP000002358    UP000053105   

PRIDE

H9J723    V5HKA2    L7M501    Q6PHK7    E2RCP9   

Pfam

PF18051   RPN1_C        + More
PF01851   PC_rep
PF17781   RPN1_RPN2_N
PF00629   MAM

Interpro

IPR002015   Proteasome/cyclosome_rpt        + More
IPR041433   RPN1_C       
IPR016643   26S_Psome_Rpn1       
IPR016024   ARM-type_fold       
IPR040892   RPN1_RPN2_N       
IPR011989   ARM-like       
IPR000998   MAM_dom       
IPR013320   ConA-like_dom_sf       

SUPFAM

SSF48371   SSF48371        + More
SSF49899   SSF49899       

Gene 3D

1.25.10.10    

CDD

cd06263  MAM

ProteinModelPortal

H9J723   A0A2H1VIA1   A0A194PS70   A0A1E1WRU9   A0A194QSM7   S4NSS4   + More
A0A1E1WMN7   T1HNA1   R4G4X6   A0A224X6X3   A0A0V0G3B6   A0A069DXQ6   A0A0A9XG19   A0A023F919   R4WTN1   A0A1S3D648   A0A1B6BXI5   A0A2H8TF17   A0A2S2P6A3   J9KAY2   V5HKA2   A0A1W4ZV99   A0A3B4DP07   A0A3B4BVP6   D6W687   T1JGZ6   A0A3Q3FT65   A0A2U9B5X4   A0A3B3SLU7   A0A1A7Z6M3   H2M068   A0A3P9IP80   A0A1A7WEI5   A0A3P9MJH0   A0A096MCN6   A0A1Y1LJJ1   A0A224YI86   F4WP73   E2BBF9   A0A060XQT1   C0H8V2   A0A195EV76   A0A1E1X2C0   A0A151WM61   Q5EB37   A0A1A8GYR1   W5MQF1   A0A3B3STW8   A0A3Q3M3J9   A0A060XNU2   A0A151ILX6   A0A131Z5I7   J3JXN2   A0A026WK09   A0A1S3T1T4   A0A3S2PEK4   A0A3Q1F3H4   F7CS21   A0A1A8HZY7   A0A3Q3G638   A0A195B112   A0A158NQW6   A0A3B3ST70   L7M501   A0A3B3TJA5   A0A131XMY5   A0A087Y778   A0A3B3DU11   A0A1A8C9D0   A0A1A8AKB1   A0A1A8RI97   A0A195E6A8   A0A195CMA8   A0A1E1XST9   A0A3Q3KNA7   A0A1A8MWD8   Q6PHK7   A0A023G054   R4GC62   K1PEY4   H9G5W8   K9J3W5   A0A2Y9DW10   A0A1S3A5Y3   A0A0L7QUA5   A0A2Y9F9K6   U3BFK1   A0A2R5LP41   E2RCP9   A0A2D0STZ9   A0A1S3GI88   W5U7P5   A0A0J7KMY8   A0A232F732   I6L5A0   F7EGU4   K7J2M6   A0A2L2XZG3   A0A0M9A0L6  

PDB

6MSD     E-value=0,     Score=2463

KEGG

101736337    K03028 26S proteasome regulatory subunit N1 | (RefSeq) 26S proteasome non-ATPase regulatory subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0008540   GO:0042176   GO:0030234   GO:0000502   GO:0043161   GO:0005634   GO:0034515   GO:0016020   GO:0005488   GO:0016491   GO:0007165   GO:0015031   GO:0016742   GO:0003824  

PANTHER

PTHR10943:SF11  

Length:

927

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.04302

Exp number, first 60 AAs:

0.00218

Total prob of N-in:

0.00612

outside

1  -  927

 

 

Pi

249.41129

Theta

151.315049

Tajima's D

1.582094

CLR

0.008827

CSRT

0.810559472026399

Interpretation

Uncertain