Gene

KWMTBOMO04589  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005326

Annotation

PREDICTED:_exportin-6_[Bombyx_mori]

Location

Bomo_Chr8(-):10434030-10445679      View in EpiBrowser

Full name

Exportin-6      

Alternative Name

Ran-binding protein 20

Location in the cell

PlasmaMembrane   Reliability : 1.391

CDS

ATGACCGAACAACATATCGACGAGGCTTTAGCCTCTTTGGATATTCTCATGTCGGAGTTTTTTGCTCCGACGACAACTAATATAAGAAAACGTGAAATTGAAAGCATGCTGGAAGACTTTTCAAATCGCAGAGACTCGTGGAAACATTGTCTCCTATTTCTTCAAAAGTCACAGAATCAGTATGTTTTGATGTTCTCTCTAACGACGTTAGAGAACACTATCAACAGACAATGGATTGGTATATCAGATGAAAACAAGACAGAGATCAGGTTAACACTATGGAATGAATTAATGGCAAAACATGAAATTATGTTATACTTCATAAGAAACAAAATGGCCCACCTTATGGTTTCAATAGCCAAATATGATTGGCCACATTTATATGAGGATTTCTTTAGTAATATTGTCGAGTTAATAAAACGTGAAGGCCGAGAGTGCTTACTAGGTCTCATACTAGCACAGGCTGCAAGCGAAGAATTAGGAGTTGCACGTGATACTGGTGTACTGTTGCCTTCTGCTAGGAGGAATCAATTAGAGCGACTAATGCTGAAAGGAATGCCACAGATGCTGGCAGCCCTTAGTGCAATTTTAGAGAAAAACGCTCAGAAAGAAGGTCAATCCAATCCTCCACCATCACCCACAAATGGTGCTCCACAGACTTCAGCTCTCCCAGACCTATTAGCAAATGCTCACGAAATACAAGCTGTAGATAAGTGTCTGAATATGGAAAATGTAGTGAAGTGTTTGACTACATTACAGCATTTATTTTCATGGTTACCACTATCTTCCCATGTGCCGCCTTCTCTTGTTACCACAGTATTCTATTGGGGGAGTATAGCCACACAGTCAATGAGCGGGGAGGCAGCGCTGGCGGGGTTGGGGGGTGTGTGCGAGTTGTTGTACCGACGTTACGCGCCGCCCTCGTCGGCTGCCACGGCGCTGCGGCTGCATCACGCCGCGTTGCGTTTGCTTCGGCACCTCACGCACGCACCTCATCAACTACCACACCTACATCACGATTATTTGAATAAACTAGCGGAGTTCCTAAAACTATTTGTGTCATTACATTTCAAGAGATTGGAGGCAGAACCTGAATTCGATGCCCTAGAATTCCTTTCCTATTTATTCCAATACACATTCCAGGTGCCTACATGTGCTATATTTGTAAATTGTTTAGACATTTGGATACAGTTCATTGACATATTGAAACCAGAGGATATACCTAAATATTGGGAAGCATTACAAGCCTTAGTTAATGGTGTGTTGAATAAAATACAATTCCAGCATAATAAAGCACAACTACAACATTTGGATAATGATCTGTGTGATGATGATGGTGAAACAGAATATCAGACATTCCTGAAACATTGCATTGAATGTGTGGCGAGAGTGGCTGATTTGGCGCCCTTGGACGTATTCACTTGTGTCTTGGAGCGGTGGCAGTGCCTGGTGGGCGTGCACGGGCGCGCGGCGTGGCGGGCGGGCGCGGCGGCGGGCGCGGAGGGGGAGCGCCTGCTCGTGGCGCTGCTCGACCTCGCCGTGCTCACCCGCGTGCTCGGACGACTCGCTCCTGCGCTGCTTTCCGAGTCTGAGAGCGGACGGCGCGTGTCGGCGGTGCAGCTCGGCGGCGTGCTGCTGGAGCGCGCGGGCGCCGCCCTCGCCGCGCCGCCCCTCGCCCGCGGCCACCCTCCGCACTACGCACGTGCTCTACTGCATATTCACGCCGAGATGTTCGCGTGCATGGGCGCTTGGTGCTGTTACGCGACCGACTGCGGCGTGCCCGTACAAACTATGGAAGGCCTGTTCTCGTCTACGGTGCCTTTTCTGCTACCTCGTGATATCCCTGAACCTCCGTTACTGTGCCAAGCGGCTGCGCAGCTGCTATTGAGTTTATCGAAAAACGTTAAGTTGACAAGTGATCCCATGTCGCTCGTCGGCGAACTGTACAATCACGCGCAACGCTCCCTGCACTACCTGGAACCGAAAGTGAGATATCGTTTATAA

Protein

MTEQHIDEALASLDILMSEFFAPTTTNIRKREIESMLEDFSNRRDSWKHCLLFLQKSQNQYVLMFSLTTLENTINRQWIGISDENKTEIRLTLWNELMAKHEIMLYFIRNKMAHLMVSIAKYDWPHLYEDFFSNIVELIKREGRECLLGLILAQAASEELGVARDTGVLLPSARRNQLERLMLKGMPQMLAALSAILEKNAQKEGQSNPPPSPTNGAPQTSALPDLLANAHEIQAVDKCLNMENVVKCLTTLQHLFSWLPLSSHVPPSLVTTVFYWGSIATQSMSGEAALAGLGGVCELLYRRYAPPSSAATALRLHHAALRLLRHLTHAPHQLPHLHHDYLNKLAEFLKLFVSLHFKRLEAEPEFDALEFLSYLFQYTFQVPTCAIFVNCLDIWIQFIDILKPEDIPKYWEALQALVNGVLNKIQFQHNKAQLQHLDNDLCDDDGETEYQTFLKHCIECVARVADLAPLDVFTCVLERWQCLVGVHGRAAWRAGAAAGAEGERLLVALLDLAVLTRVLGRLAPALLSESESGRRVSAVQLGGVLLERAGAALAAPPLARGHPPHYARALLHIHAEMFACMGAWCCYATDCGVPVQTMEGLFSSTVPFLLPRDIPEPPLLCQAAAQLLLSLSKNVKLTSDPMSLVGELYNHAQRSLHYLEPKVRYRL

Description

Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Subunit

Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB (PubMed:14592989). Interacts with ACTB in a RanGTP-dependent manner (PubMed:14592989).
Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.

Similarity

Belongs to the exportin family.

Keywords

Acetylation   Alternative splicing   Complete proteome   Cytoplasm   Nucleus   Phosphoprotein   Polymorphism   Protein transport   Reference proteome   Transport  

Feature

chain  Exportin-6
splice variant  In isoform 2.
sequence variant  In dbSNP:rs14672.

Uniprot

A0A3S2NH06   A0A2H1VLE0   A0A194QT65   V5HJN4   A0A067R0K4   A0A131XZF0   + More
A0A147BCU1   A0A2J7Q0D7   A0A1S3GYH4   B7Q989   A0A1S3ITZ6   V3YVJ7   A0A1W4X8A3   R7U8G1   A0A3Q4BB91   A0A3Q1BZZ2   A0A3P8TIE2   A0A3P9M9Z9   H3BET1   A0A3B4ZUM0   A0A3P8WA05   A7S0X1   A0A3Q3K7P5   C3Z7U1   A0A3Q3GG94   A0A3Q1HEM0   A0A3P8XV62   A0A210Q338   G3V858   A0A3B3UCB3   A0A093BBZ1   A0A341BCS7   A0A341BB52   A0A2U4A8M7   A0A2Y9PN22   A0A3B4FKQ4   A0A2Y9PFT7   G3WLI9   F6VYP1   F1RFG5   A0A2Y9ERI3   G1RLJ3   A0A3B3YX66   G1PLR1   A0A2Y9E596   A0A2K6BA70   A0A2K5VRV6   A0A2K5Y6A4   A0A096NHJ9   A0A2K5M6N0   H9FRV4   U3DFH2   G3WLI8   F7HX34   A0A2J8TJT7   Q96QU8   G3UKR7   A0A2R9AZ27   H2QAT9   G3QS71   B7ZM10   W5NS68   G3T8H8   A0A384AGD8   A0A2K5E3W3   A0A3P9BW10   L8IQ84   A0A3P8P010   F6Y1V2   F1MI29   A0A3B4X6W1   S7PHR5   H0X7V2   A0A3Q7STZ1   F1PV75   A0A286ZTA7   A0A1S3ESV0   A0A287D026   A0A2K6FF59   G5AJV1   I3MIP4   A0A3Q2L596   M3WD24   A0A2K6TSD7   A0A2K6TS26   G1SI70   A0A1S3A1T8   Q924Z6   A0A3Q7TNE9   A0A2Y9L8B6   M3YNB4   A0A1V4KTA2   A0A2K6KV57  

Pubmed

26354079    25765539    24845553    29652888    23254933    17554307    + More
9215903    24487278    17615350    18563158    25069045    28812685    15057822    15632090    22673903    21709235    17495919    30723633    21993624    17431167    25319552    25243066    14592989    9205841    12168954    14702039    15616553    15489334    18691976    18669648    19413330    19690332    21269460    21406692    22223895    22814378    23186163    22722832    16136131    22398555    20809919    25186727    22751099    19892987    19393038    16341006    21993625    17975172    16141072    21183079    22323606   

EMBL

RSAL01000041    RVE50843.1    ODYU01003194    SOQ41621.1    KQ461154    KPJ08509.1    + More
GANP01010760    JAB73708.1    KK852824    KDR15433.1    GEFM01004211    JAP71585.1    GEGO01006811    JAR88593.1    NEVH01019969    PNF22047.1    ABJB010146788    ABJB010295153    ABJB010309990    ABJB010357166    ABJB010410600    ABJB010493063    ABJB010530649    ABJB010653108    ABJB011048346    ABJB011065817    DS887784    EEC15411.1    KB204066    ESO82003.1    AMQN01001653    KB304239    ELU02274.1    AFYH01027836    AFYH01027837    AFYH01027838    AFYH01027839    AFYH01027840    AFYH01027841    AFYH01027842    AFYH01027843    AFYH01027844    AFYH01027845    DS469562    EDO42656.1    GG666591    EEN51446.1    NEDP02005157    OWF43168.1    AABR07005773    AABR07071985    AC126892    CH473956    EDM17499.1    KN126143    KFU86744.1    AEFK01080670    AEFK01080671    AEFK01080672    AEFK01080673    AEFK01080674    AEFK01080675    AEFK01080676    AEFK01080677    AEFK01080678    AEFK01080679    AEMK02000016    DQIR01096756    DQIR01097973    DQIR01168113    DQIR01169611    DQIR01231851    DQIR01268227    DQIR01269895    DQIR01271244    DQIR01273321    DQIR01274897    HDA52232.1    HDB87328.1    ADFV01196833    ADFV01196834    ADFV01196835    ADFV01196836    ADFV01196837    ADFV01196838    ADFV01196839    AAPE02053929    AAPE02053930    AAPE02053931    AAPE02053932    AAPE02053933    AAPE02053934    AQIA01042494    AQIA01042495    AQIA01042496    AQIA01042497    AHZZ02018557    JSUE03025981    JSUE03025982    JSUE03025983    JSUE03025984    JU333608    JV046545    AFE77363.1    AFI36616.1    GAMQ01004458    JAB37393.1    GAMT01000024    GAMT01000023    GAMS01002746    GAMR01007737    GAMP01000791    JAB11837.1    JAB20390.1    JAB26195.1    JAB51964.1    NDHI03003494    PNJ33203.1    AY026388    AB002368    AK123846    AC136611    CH471145    BC004403    BC014071    BC078674    BC108286    BC130304    AK223043    AJFE02022945    AJFE02022946    AJFE02022947    AJFE02022948    AJFE02022949    AACZ04059639    AACZ04059640    GABC01000770    GABF01003938    GABD01005497    NBAG03000444    JAA10568.1    JAA18207.1    JAA27603.1    PNI23973.1    CABD030099955    CABD030099956    CABD030099957    CABD030099958    CABD030099959    CABD030099960    CABD030099961    CABD030099962    CABD030099963    CABD030099964    BC144189    AAI44190.1    AMGL01068998    AMGL01068999    JH881011    ELR57267.1    KE162966    EPQ10243.1    AAQR03123031    AAQR03123032    AAQR03123033    AAQR03123034    AAQR03123035    AAQR03123036    AAQR03123037    AAEX03004417    AGTP01031067    AGTP01031068    AGTP01031069    AGTP01031070    AGTP01031071    JH165533    EHA97311.1    AANG04002788    AAGW02069692    AAGW02069693    AAGW02069694    AY029528    AK011324    AK154709    BC058090    AEYP01082328    LSYS01001700    OPJ87658.1   

Proteomes

UP000283053    UP000053240    UP000027135    UP000235965    UP000085678    UP000001555    + More
UP000030746    UP000192223    UP000014760    UP000261620    UP000257160    UP000265080    UP000265180    UP000008672    UP000261400    UP000265120    UP000001593    UP000261600    UP000001554    UP000261660    UP000265040    UP000265140    UP000242188    UP000002494    UP000261500    UP000252040    UP000245320    UP000248483    UP000261460    UP000007648    UP000002280    UP000008227    UP000248484    UP000001073    UP000261480    UP000001074    UP000248480    UP000233120    UP000233100    UP000233140    UP000028761    UP000233060    UP000006718    UP000008225    UP000005640    UP000007646    UP000240080    UP000002277    UP000001519    UP000002356    UP000261681    UP000233020    UP000265160    UP000265100    UP000002281    UP000009136    UP000261360    UP000005225    UP000286640    UP000002254    UP000081671    UP000005215    UP000233160    UP000006813    UP000011712    UP000233220    UP000001811    UP000079721    UP000000589    UP000248482    UP000000715    UP000190648    UP000233180   

PRIDE

V5HJN4    B7Q989    F1RFG5    Q96QU8    B7ZM10    Q924Z6    + More

Pfam

PF08389   Xpo1        + More
PF03810   IBN_N

Interpro

IPR001494   Importin-beta_N        + More
IPR013598   Exportin-1/Importin-b-like       
IPR016024   ARM-type_fold       
IPR040016   XPO6       
IPR011989   ARM-like       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

ProteinModelPortal

A0A3S2NH06   A0A2H1VLE0   A0A194QT65   V5HJN4   A0A067R0K4   A0A131XZF0   + More
A0A147BCU1   A0A2J7Q0D7   A0A1S3GYH4   B7Q989   A0A1S3ITZ6   V3YVJ7   A0A1W4X8A3   R7U8G1   A0A3Q4BB91   A0A3Q1BZZ2   A0A3P8TIE2   A0A3P9M9Z9   H3BET1   A0A3B4ZUM0   A0A3P8WA05   A7S0X1   A0A3Q3K7P5   C3Z7U1   A0A3Q3GG94   A0A3Q1HEM0   A0A3P8XV62   A0A210Q338   G3V858   A0A3B3UCB3   A0A093BBZ1   A0A341BCS7   A0A341BB52   A0A2U4A8M7   A0A2Y9PN22   A0A3B4FKQ4   A0A2Y9PFT7   G3WLI9   F6VYP1   F1RFG5   A0A2Y9ERI3   G1RLJ3   A0A3B3YX66   G1PLR1   A0A2Y9E596   A0A2K6BA70   A0A2K5VRV6   A0A2K5Y6A4   A0A096NHJ9   A0A2K5M6N0   H9FRV4   U3DFH2   G3WLI8   F7HX34   A0A2J8TJT7   Q96QU8   G3UKR7   A0A2R9AZ27   H2QAT9   G3QS71   B7ZM10   W5NS68   G3T8H8   A0A384AGD8   A0A2K5E3W3   A0A3P9BW10   L8IQ84   A0A3P8P010   F6Y1V2   F1MI29   A0A3B4X6W1   S7PHR5   H0X7V2   A0A3Q7STZ1   F1PV75   A0A286ZTA7   A0A1S3ESV0   A0A287D026   A0A2K6FF59   G5AJV1   I3MIP4   A0A3Q2L596   M3WD24   A0A2K6TSD7   A0A2K6TS26   G1SI70   A0A1S3A1T8   Q924Z6   A0A3Q7TNE9   A0A2Y9L8B6   M3YNB4   A0A1V4KTA2   A0A2K6KV57  

PDB

4HAV     E-value=2.63118e-05,     Score=116

KEGG

101735669    no KO assigned | (RefSeq) exportin-6

GO

GO:0005634   GO:0008565   GO:0008536   GO:0006611   GO:0005049   GO:0005886   GO:0005730   GO:0032991   GO:0005829   GO:0005737   GO:0005488   GO:0006886   GO:0020037   GO:0016491   GO:0007165   GO:0015031   GO:0016020   GO:0016742   GO:0003824  

PANTHER

PTHR21452  

Subcellular location

Nucleus  
Cytoplasm   Shuttles between the nucleus and the cytoplasm.   With evidence from 8 publications.

Length:

667

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10944

Exp number, first 60 AAs:

0.00707

Total prob of N-in:

0.00216

outside

1  -  667

 

 

Pi

202.307608

Theta

169.813063

Tajima's D

0.677909

CLR

0.136408

CSRT

0.568171591420429

Interpretation

Uncertain