SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO04576
Pre Gene Modal
BGIBMGA005478
Annotation
Dual_oxidase_[Papilio_machaon]
Full name
Dual oxidase      
Location in the cell
PlasmaMembrane   Reliability : 3.515
 

Sequence

CDS
ATGATGGCGTTCAAATGTTTAACGCCATTACATCGACTGTTATCAATAACAATCATCGCCGCCGTTCTCTCTTCGTGCTACTGCGACCCAGAGGTTTACTACGAGAAACAGCGGTACGATGGATGGTTTAATAACAGAGCGTATCCAGATTGGGGATCGGTTGGCAGTCGATTGAATCGTAAAACTCCAGCGTCATACGCTGACGGCGTTTATATGATGGCCGGTCCTGAGAGACCTGGTGCCAGGACCCTTTCGAAGATCTTCATGAGGGGTCAGGATGGACTGCCCTCACTAACGAATAGAACAGCGCTACTTGCATTCTTCGGGCAAGTGGTGACGGGCGAGATTGTAATGGCCTCAGAGTCCGGATGTCCTATCGAGCATCATCGTATACCGGTCGATAAATGCGATCATATGTACGACTCGGAATGTCAAGGTGCCAAGTATATGCCCTTTTTGCGAGCTGCGTACGACCGCAATACTGGACAGAGTCCCAACAGCCCCCGGGAACAAATAAATCAGATGACTTCGTGGATTGACGGGAGCTTCGTGTACAGCACGAGTGAGGCATGGGTGAATGCAATGAGGTCATTTCAGAACGGAAGTTTCGCCAGCGACGGAGGGATGCCACTACGGAACACAAAGAGGGTACCGCTTTTCAACAACCCCGTGCCGCATTACATGAGGATGCTTAGCCCAGAAAGGCTATTTTTACTAGGAGATCCACGTACCAATCAAAATCCAGCAATGGTGAGCTTCGGCATACTGCTGTTCCGCTGGCACAACGTCGTCGCAGCCCGAGTACACAAACAGCATCCGGACTGGAGCGACGAACAACTGTTCCAGAGAGCGCGGAGGATTGTCATAGCCAGTTTGCAAAACATCATTTTGTATGAATACGTGCCAGCGTTCCTCGGAGCAGCGCTTCCGCCTTACGAAGGTTACAAGCCGGAAGTAGCTCCGGGAGTGACCCACGAGTTCGCCGTAGCAGCATTTAGATTCGGCCATACATTAGTGCCACCAGCTATTCTACTTAGAAATAGGAAATGCGGTTACGGCAGAGCGCCGGGAGGACATGACGCTATTAGATTGTGTCAGACATGGTGGGACGGAAATGACGTTATGTCTCAAGTTCCACTAGAAGAAGTTTTGATGGGGATGGCCTCACAACTATCCGAGAGAGAGGACGCTCTACTGTGTTCCGATGTACGAGATAATTTGTTCGGTCCCATGGAATTTTCTAGACGAGACCTTGGCGCTTTGAATATAATGAGAGGAAGGGACAATGGTGTTCCAGATTATAATACAGTTAGGGAATACTTCGGCCTACGAAAAATAAAGACATTCAACGAAATAAATCCTGATCTGTTCGAGAAAAATCCTGATCTATTACAAAAATTTATCCAAATTTACAACGGAGACGTCGATAATATAGATGTGTATATCGGTGGGATGCTGGAGTCTAATGGACATCCGGGTGAATTGTTTAGAGCCATTATAATAGATCAATTTACAAGAATACGAGATTCTGATCGATTTTGGTTCGAAAATGACAAGAACGGTATATTCACTCCTCGAGATATAGAAGAGCTTCGTCGTATAACTCTGTGGGATATAATAGTGAACAGTACAACAATAGGTGCCAAAGATATACAAAGGGACGTGTTCCATTGGCGAGCGGGTGATCCGTGTCCACAACCATACCAACTGAACGCTTCCAAGCTTCCACCCTGCAAATATTTGAAGGGCTACGATTATTTTGAGGGAAACGAATTCGCCTACATCTACATCTGTTTGATATTAGTGTTCGTTCCCATATTATGCGCCGGAGCTGGTTACGGGGTTGTGAAGCTACAGAACAGTCGCAGACGGCGTTTGAAGATTCAGCAAGAACACCTTAAAAATGCTCAATGTAAAGGTTCAGTCGATAAAATGGTCTGTCGAGAATGGGTCCACGCGTCACACAAGAGACTTGTAAAGCTACGGCTTGGTCCAGAATCAGCCTTGCACGTGACAGATCGTAAGGGAGAAAAACTACGGACGCTGCCGTTGGATCACACTGATCAACTTACCGTAGTTGAAAGTCAGGAAGGTCGGAACAACAAACGTCCCCTCGTCCTCGTACGAGTCCCTCGGGAACATGACTTAGTGCTTGAAATGGACTCCATCGCATCTCGGCGCAAGTTTTTAGTCAAACTCGACACTTTCCTGGCGCAGCACAAGAAAGCGTTGAATCTTACTCAGGGACCGCGTGAACAAATTTTGGCTACAGCTGAAACAAGGGAGCGTCGACAACGCAAGTTAGAACATTTCTTCAGAGAAGCCTACGCTATAACATTCGGCCTCGCGCCTGGAGAGAAGCGGAGGAGGTCTGAAGATGCCGATCCTGAGTCAATAGTTATGAGAACGTCACTATCGAAAAGTGAATTTGCTAGTGCACTTGGTATGAAAGGAGACGCAGTCTTCGTCAAAAAAATGTTCAATATCGTCGACAAAGATGGCGACGGCAGGATTTCTTTTCAGGAGTTCCTTGATACTGTAGTTCTATTCTCTCGAGGAGCTACTGAGGATAAGCTTCGTATAATATTTGATATGTGCGACAACGATAGAAACGGTGTTATCGATAAAGGCGAACTGAGCGAGATGCTGAGGTCGCTCGTGGAAATAGCAAGAACTACCTCACTGAGAGATGAACATGTCACTGAGCTGATTGACGGAATGTTTTCTGATGCCGGACTTCAACACAAAGACCATTTGACCTACTCCGATTTCAAGCTGATGATGAAAGAATACAAAGGAGAGTTCGTGGCCATAGGTCTGGATTGTAAAGGCGCTAAGCAAAATTTCCTCGACACATCAACGAACGTTGCAAGAATGACCAGCTTCCATATTGAGCCTTCGATGGAACAGACCAGGCACTGGCTACTATTAAAATGGGATACCTTAACAACATTCTTGGAAGAAAACAGGCAAAATATATTTTATCTTTTCATTTTCTACGTTGTGACCATAGGCCTGTTTGTAGAAAGGTTCGCCCACTATTCGTTTATGTCGGAACATCTAGACTTGCGTCATATTATGGGAGTCGGTATCGCCATCACCAGAGGATCGGCCGCCTCGCTATCTTTCTGCTATAGTCTACTGTTATTGACGATGTCCAGGAATCTTTTAACGAAATTGAAGGAATTCAGTATCCAACAATACATACCTCTGGACTCGAGCATCCAGTTTCACAAGATCGTGGCCTGTACGGCTCTATTCTTTTCCTTGCTGCACACCGCCGGTCATATGGTCAACTTCTACCACGTGTCCACACAGCCCGTCGAGAACCTTCGATGTTTGACCAAAGAAGTACATTTCACATCCGACTTCAGGCCCGGCATTACCTACTGGGTATTCCAGACTGTTACTGGTGTAAGTGGGGTGCTGTTATTCGTGATCATGTGTATAATATTCGTATTTGCACATCCCGTGATCCGTAAACGCGCGTATCCATGGTTTTGGCGCGCTCACTCGCTGCACGTCGCGCTCTACGCGCTGTGCTTAGTCCACGGACTCGCTCGCCTTACCGGAGCCCCTAGGTTCTGGATATTCTTCCTTGGACCGGCTATCATATACACTCTGGATAAGGTGGTGTCCTTGAGAACGGAGTACCTTGCTTTAGACGTTTTAGAAACGGAGATGTTACCATCAGACGTTATAAAGATTAAGTTCTACCGACCCCCTAACCTAAAATATCTATCAGGTCAATGGGTTCGTTTGTCGTGTACAGCGTTTAAGAAGGAGGAGTTCCATTCGTTTACACTCACATCAGCACCGCACGAGAACTTCCTCTCGTGTCACATCAAAGCACAAGGACCGTGGACTTGGAAACTAAGAAACTACTTCGACCCTTGCAATTATAATACAGACGATCATCCTAAAATCAGAATACAAGGTCCGTTCGGTGGCGGGAACCAGGACTGGTACAAGTTCGAGGTGGCCGTGATGGTGGGCGGAGGCATCGGCGTCACTCCCTACGCCTCCATACTTAACGACCTCGTATTCGGAACATCCACGAACAGATATTCTGGGGTTGCTTGTAAAAAGGTATATTTTCTATGGATATGTCCATCGCACAAACACTTCGAATGGTTCATAGACGTTCTCCGCGACGTCGAGCGGAAAGACGTGACTAACGTACTGGAAATCCACATCTTCATAACGCAATTCTTCCACAAGTTCGATCTGAGGACGACCATGCTGTACATATGCGAGAATCATTTCCAACGTCTGTCTCGGACGTCGATGTTCACGGGACTGAAGGCGGTCAACCACTTCGGCCGACCAGACATGTCCTCCTTCCTCAAGTTCGTACAGAAGAAACATAGTTACGTGTCAAAGATCGGTGTGTTTTCGTGTGGGCCCCGACCACTCACCAAGTCGGTGATGTCAGCTTGCGAAGAAGTAAACAGGACCAGGCGTCTGCCTTACTTCATACATCACTTTGAAAACTTTGGATAA
Protein
MMAFKCLTPLHRLLSITIIAAVLSSCYCDPEVYYEKQRYDGWFNNRAYPDWGSVGSRLNRKTPASYADGVYMMAGPERPGARTLSKIFMRGQDGLPSLTNRTALLAFFGQVVTGEIVMASESGCPIEHHRIPVDKCDHMYDSECQGAKYMPFLRAAYDRNTGQSPNSPREQINQMTSWIDGSFVYSTSEAWVNAMRSFQNGSFASDGGMPLRNTKRVPLFNNPVPHYMRMLSPERLFLLGDPRTNQNPAMVSFGILLFRWHNVVAARVHKQHPDWSDEQLFQRARRIVIASLQNIILYEYVPAFLGAALPPYEGYKPEVAPGVTHEFAVAAFRFGHTLVPPAILLRNRKCGYGRAPGGHDAIRLCQTWWDGNDVMSQVPLEEVLMGMASQLSEREDALLCSDVRDNLFGPMEFSRRDLGALNIMRGRDNGVPDYNTVREYFGLRKIKTFNEINPDLFEKNPDLLQKFIQIYNGDVDNIDVYIGGMLESNGHPGELFRAIIIDQFTRIRDSDRFWFENDKNGIFTPRDIEELRRITLWDIIVNSTTIGAKDIQRDVFHWRAGDPCPQPYQLNASKLPPCKYLKGYDYFEGNEFAYIYICLILVFVPILCAGAGYGVVKLQNSRRRRLKIQQEHLKNAQCKGSVDKMVCREWVHASHKRLVKLRLGPESALHVTDRKGEKLRTLPLDHTDQLTVVESQEGRNNKRPLVLVRVPREHDLVLEMDSIASRRKFLVKLDTFLAQHKKALNLTQGPREQILATAETRERRQRKLEHFFREAYAITFGLAPGEKRRRSEDADPESIVMRTSLSKSEFASALGMKGDAVFVKKMFNIVDKDGDGRISFQEFLDTVVLFSRGATEDKLRIIFDMCDNDRNGVIDKGELSEMLRSLVEIARTTSLRDEHVTELIDGMFSDAGLQHKDHLTYSDFKLMMKEYKGEFVAIGLDCKGAKQNFLDTSTNVARMTSFHIEPSMEQTRHWLLLKWDTLTTFLEENRQNIFYLFIFYVVTIGLFVERFAHYSFMSEHLDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLLTKLKEFSIQQYIPLDSSIQFHKIVACTALFFSLLHTAGHMVNFYHVSTQPVENLRCLTKEVHFTSDFRPGITYWVFQTVTGVSGVLLFVIMCIIFVFAHPVIRKRAYPWFWRAHSLHVALYALCLVHGLARLTGAPRFWIFFLGPAIIYTLDKVVSLRTEYLALDVLETEMLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFKKEEFHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNTDDHPKIRIQGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVERKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSRTSMFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACEEVNRTRRLPYFIHHFENFG

Summary

Description
Plays a role in innate immunity limiting microbial proliferation in the gut (PubMed:16272120, PubMed:25639794). Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). May generate antimicrobial oxidative burst through its peroxidase-like domain (PubMed:16272120).
Catalytic Activity
H(+) + NADH + O2 = H2O2 + NAD(+)
H(+) + NADPH + O2 = H2O2 + NADP(+)
Similarity
In the N-terminal section; belongs to the peroxidase family.
Keywords
Calcium   Complete proteome   FAD   Flavoprotein   Glycoprotein   Hydrogen peroxide   Membrane   Metal-binding   NADP   Oxidoreductase   Peroxidase   Phosphoprotein   Reference proteome   Repeat   Transmembrane   Transmembrane helix  
Feature
chain  Dual oxidase
EMBL
JQ768349    AFV61649.1    BABH01013910    BABH01013911    BABH01013912    BABH01013913    + More
BABH01013914    KQ461154    KPJ08497.1    RSAL01000163    RVE45365.1    KQ459599    KPI94366.1    AGBW02012896    OWR44265.1    ODYU01000617    SOQ35716.1    GGFL01004263    MBW68441.1    AAAB01008980    APCN01001661    APCN01001662    AXCM01001826    NEVH01005891    PNF38268.1    EAA13921.4    ATLV01016141    KE525057    KFB41042.1    AXCN02001965    KY386660    ARU79623.1    AXCP01008099    GANO01002274    JAB57597.1    DS231851    EDS37293.1    GFDL01015736    JAV19309.1    AE014134    AGB92505.1    BT015247    CM002910    KMY87751.1    KQ971330    EFA01258.2    CH477448    EAT40728.2    CH379061    EAL33223.2    KRT04822.1    BT100299    ACZ06885.1    CH954177    EDV57530.2    CH963920    EDW77948.1    GAKP01021421    GAKP01021420    JAC37532.1    CH916379    EDV94075.1    CM000157    EDW87445.2    CP012523    ALC39816.1    CH940649    EDW63224.2    KRF80974.1    GDHF01012548    JAI39766.1    KP824741    AKS43593.1    GBXI01014165    GBXI01009467    GBXI01002107    JAD00127.1    JAD04825.1    JAD12185.1    ADMH02002110    ETN58940.1    OUUW01000006    SPP82413.1    GAMC01021098    GAMC01021097    GAMC01021096    GAMC01021095    JAB85457.1    SPP82412.1    AJVK01003690    AJVK01003691    AJVK01003692    CH933807    EDW11994.2    JRES01000175    KNC33589.1    GEDC01019500    JAS17798.1    UFQT01000040    SSX18662.1    JXJN01017817    CM000361    EDX03528.1    GEBQ01001336    JAT38641.1    CH479272    EDW39992.1    QOIP01000001    RLU26860.1    CH902620    EDV30689.2    KK107154    EZA56872.1    KQ435922    KOX68568.1    CVRI01000038    CRK94094.1    KQ976885    KYN07485.1    ADTU01023460    BR000285    FAA00352.1    GL888066    EGI68387.1    GL435030    EFN74201.1    LNIX01000003    OXA58721.1    KQ982335    KYQ57577.1    KQ980824    KYN12552.1    KQ981280    KYN43473.1    KQ976511    KYM82538.1    ACPB03010969    ACPB03010970    ACPB03010971    ACPB03010972    KZ288405    PBC26142.1    GDHC01019283    JAP99345.1    GBHO01043131    JAG00473.1    GGMS01005077    MBY74280.1    JQ266749    AFK29281.1    DS235793    EEB17126.1    GDIP01089476    LRGB01000086    JAM14239.1    KZS20913.1    GL732637    EFX69361.1    GBHO01043128    JAG00476.1    ABLF02030921    GDIQ01007363    JAN87374.1   
Pfam
PF08022   FAD_binding_8        + More
PF00036   EF-hand_1
PF03098   An_peroxidase
PF01794   Ferric_reduct
PF08030   NAD_binding_6
PF13499   EF-hand_7
PF13833   EF-hand_8
PF13405   EF-hand_6
Interpro
IPR037120   Haem_peroxidase_sf_animal        + More
IPR019791   Haem_peroxidase_animal       
IPR002048   EF_hand_dom       
IPR011992   EF-hand-dom_pair       
IPR039261   FNR_nucleotide-bd       
IPR013130   Fe3_Rdtase_TM_dom       
IPR034821   DUOX_peroxidase       
IPR017927   FAD-bd_FR_type       
IPR013112   FAD-bd_8       
IPR017938   Riboflavin_synthase-like_b-brl       
IPR013121   Fe_red_NAD-bd_6       
IPR010255   Haem_peroxidase_sf       
IPR018247   EF_Hand_1_Ca_BS       
IPR029595   DUOX1/Duox       
SUPFAM
SSF48113   SSF48113        + More
SSF47473   SSF47473       
SSF52343   SSF52343       
SSF63380   SSF63380       
Gene 3D
PDB
6ERC     E-value=3.42581e-54,     Score=541

Ontologies

Topology

Subcellular location
Membrane  
SignalP
Position:   1 - 28,         Likelihood:  0.972961
 
 
Length:
1500
Number of predicted TMHs:
6
Exp number of AAs in TMHs:
136.75384
Exp number, first 60 AAs:
0.67935
Total prob of N-in:
0.03132
outside
1  -  592
TMhelix
593  -  615
inside
616  -  992
TMhelix
993  -  1012
outside
1013  -  1026
TMhelix
1027  -  1049
inside
1050  -  1079
TMhelix
1080  -  1102
outside
1103  -  1131
TMhelix
1132  -  1154
inside
1155  -  1174
TMhelix
1175  -  1197
outside
1198  -  1500
 
 

Population Genetic Test Statistics

Pi
282.630374
Theta
198.438871
Tajima's D
1.010968
CLR
0.330731
CSRT
0.661566921653917
Interpretation
Uncertain
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