Gene

KWMTBOMO04568  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005473

Annotation

PREDICTED:_ATP-binding_cassette_transporter_subfamily_B_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr8(+):10000352-10016416      View in EpiBrowser

Full name

Guanylate cyclase      

Location in the cell

PlasmaMembrane   Reliability : 4.769

CDS

ATGGTAGTTGCATTAACAGTTACTCTGGTAGTATTTCCATTGTCGGCCTACTTAGCGATCCTCGAGAGGAGGTTCTTATTACCGTCCGTGCCTCCTAGAGGTCACGGTTTTGTACTCTTGGTTTTTTGGGCTATGATATTCGTATCGGAGAATTTATCATTTTTAAATATCAACAAAGAAGGATGGTGGTGGCACTTGAAAAATCTTCAAGATCGCCTCGAAATGTCATTGTTCGTCGGTCGTTACGTGTCGTGTATGATAATGTTCGTGCTCGGTATGAAGGCGCCGGGCATCATGCACCACTTCGACTACTTAGAGGACGAACACGAAGGCCGAAGGAATATACAGCCACGCGATGACAACAGATCGACGTTCAGAAATGTGTTTACGAAATTGCGCACACTCCTACCGTTCCTGTGGCCGAAGAAGAATTTCATCCTCCAACTCTATGTGCTCATATGTATACTGGCTCTCATTGCTGGAAGAGCTATCAATCTATACGTCCCTATATACAACAGGCTGATATTTAACAGCATATCGGAACCGCCTCTCTCCTTCCGCTGGGATCTGGTATTGATATATGTGTTTTTCAAGTTCCTCCAAGGAGGGGGTACCGGCGGAATGGGTTTATTGAATAATATGCGTTCGTTTTTGTGGATCAAGGTCCAACAATACACCACAAGAGAGTTGGAGCTGGAACTGTTCAAGCATCTCCATGACTTGCCTTTACGCTGGCATTTGTCTCGCAAAACCGGAGAAGTCCTCAGGGTGATGGACCGAGGAACGGATTCTATAAACAATCTCCTCTCGTACATTCTGTTCTCTATCACTCCAACGCTGGTCGATATCTTGGTGGCAGTCATCTATTTTGTCACGGCGTTCAATATTTGGTTCGGACTGATCGTTTTTACTACAATGATCCTGTATATTATCGCAACAATAGCCGTGACGGAATGGCGCACGAAGTTCCAACGTCGCATGAATCTCGCCGACAACGAGCAGAAGGCTCGCTCGGTCGACTCTCTGTTGAACTACGAGACTGTTAAATATTACGGAGCGGAATCTTATGAAGTGATGTCTTATAGAGAAGCCATCCTTAATTATCAGAAAGAAGAGTTTAAATCATTGTTCACATTAAACATTTTGAACACCATTCAAAATATCATCATCTGCAGCGGCTTACTTGCTGGTTCGTTGCTCTGCGTGTCGTTGGTGGTGAAGACGGCTGAATTCACTGTCGGTGACTACGCTTTGTTCGCGTCGTACATAGTGCAGCTTTACGTTCCCTTGAATTGGTTCGGAACATATTACAGAGCTATACAGAAGAATTTCGTGGACATGGAGAACATGTTCGACCTGCTGAGGGTGGATACGGACGTGCGCGACGCGGCCGGGGCGCCCGAGCTGGTGGTGCGGCGCGGCGGAGTCGAGTTCAAGCACGTGTCCTTCGGATACGGCTCCGAGAGGCTCGTCCTTAACAACATCAGTTTTAAAATCGCCCCCGGAAGCACCGTTGCATTGGTCGGGCCCAGCGGCGCGGGAAAATCGACGATAATGCGTCTGTTATTCCGTTTTTACGACGTGAACGAGGGCGCCGTGCTGGTGGACGAGCAGGACGTGCGCACCGTCACGCAGGCCTCGCTGCGCGCCAACATCGGCGTCGTGCCGCAGGACACGGTGCTCTTCAACAACACCGTTAGATACAACATTCAATACGGAAGATTGAACGCGCCCGCCGCTGATATAATATCTGCCGCCAAGAACGCGGACATTCACGACCGAATACTGACGTTTCCCGACGCTTACGACACGCAGGTTGGAGAAAGGGGCCTTAGGCTGAGCGGTGGCGAAAAGCAAAGAATAGCTATTGCACGAACGATCTTAAAAGATCCCGCCATTGTCCTGCTCGATGAAGCTACTTCTGCGCTAGACACGAACACAGAAAGAAATATTCAAGCCGCGTTGGCACGAGTGTGCGCAAACAGAACTACCCTTATAATTGCACACAGGCTCTCAACGATCATTCATGCCGACGAAATACTGGTCCTTAAGGACGGTGAGATTATCGAACGTGGAAACCATGAAGCCCTCCTAGCGCAGGCCGGGTTCTATGCGTCCATGTGGCAACAGCAACTCGAGAATCGAAACAGCAACGGTAACAACGATGATGACGTCAGCGGCGGCGAAGGGAACAACAACCAGAGGAGCCAAATCGTCGCGCCCGTGTTCGGTCACGGCCATGGTCATGGGCATGGTCATTAA

Protein

MVVALTVTLVVFPLSAYLAILERRFLLPSVPPRGHGFVLLVFWAMIFVSENLSFLNINKEGWWWHLKNLQDRLEMSLFVGRYVSCMIMFVLGMKAPGIMHHFDYLEDEHEGRRNIQPRDDNRSTFRNVFTKLRTLLPFLWPKKNFILQLYVLICILALIAGRAINLYVPIYNRLIFNSISEPPLSFRWDLVLIYVFFKFLQGGGTGGMGLLNNMRSFLWIKVQQYTTRELELELFKHLHDLPLRWHLSRKTGEVLRVMDRGTDSINNLLSYILFSITPTLVDILVAVIYFVTAFNIWFGLIVFTTMILYIIATIAVTEWRTKFQRRMNLADNEQKARSVDSLLNYETVKYYGAESYEVMSYREAILNYQKEEFKSLFTLNILNTIQNIIICSGLLAGSLLCVSLVVKTAEFTVGDYALFASYIVQLYVPLNWFGTYYRAIQKNFVDMENMFDLLRVDTDVRDAAGAPELVVRRGGVEFKHVSFGYGSERLVLNNISFKIAPGSTVALVGPSGAGKSTIMRLLFRFYDVNEGAVLVDEQDVRTVTQASLRANIGVVPQDTVLFNNTVRYNIQYGRLNAPAADIISAAKNADIHDRILTFPDAYDTQVGERGLRLSGGEKQRIAIARTILKDPAIVLLDEATSALDTNTERNIQAALARVCANRTTLIIAHRLSTIIHADEILVLKDGEIIERGNHEALLAQAGFYASMWQQQLENRNSNGNNDDDVSGGEGNNNQRSQIVAPVFGHGHGHGHGH

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Feature

chain  Guanylate cyclase

Uniprot

H9J7I1   F2YDQ5   A0A2H1VR01   A0A194QU21   A0A194PN02   A0A2J7RS07   + More
A0A2J7RS02   A0A1Y1K9V1   A0A182J8S9   A0A067QIY2   A0A182XLW2   A0A182LQD1   Q7QKD8   A0A182HS10   A0A088ARD0   A0A182UIB4   A0A182UDT7   A0A182UYY8   A0A1L8DUM0   A0A1L8DUM7   A0A182PEG5   A0A182MX05   V5GJI0   A0A0H5BVD5   K7IWV7   A0A2A3EBS9   A0A232FCS4   A0A182R7N0   Q16ZP7   A0A1S4FIQ7   A0A0U9HU18   A0A182NAA1   A0A2M3Z3S9   A0A2M3Z3H4   A0A182FBM7   A0A2M4AA77   A0A2M4BDR4   A0A182GIV6   A0A2M4BDQ9   A0A2M4BDS1   A0A2M4A9K2   A0A182QA77   A0A1Q3FIS0   E2AI03   A0A1Q3FJ49   A0A1Q3FI81   A0A1Q3FID3   D2A5D4   W5JI45   A0A026VXZ9   N6TZJ9   A0A1J1ITU1   A0A195DFL3   A0A158P2U1   A0A336MLG8   U5EX21   A0A336KJI7   U4UN61   A0A154PIV9   A0A0N0BG58   E2BRY8   A0A1I8QBP0   A0A0C9QIE0   T1EB34   B0XFW9   A0A0P4VKT9   A0A0L0CC45   A0A069DWZ9   A0A224XIP0   A0A0A1WT89   A0A3B0JPZ0   A0A023EUV0   A0A1A9YK51   A0A023F3I3   B4GEV0   B4PRJ6   A0A0A9YUP4   Q9VF20   T1I161   B4HLH1   A0A1A9WJI9   Q296Q1   B3P3W5   A0A146KT46   B3M387   A0A0V0G5P0   W8C2W4   B4LX86   T1PGC8   A0A1I8M0V8   A0A1A9UTM3   B4JT46   A0A1W4VB65   B4NBA7   A0A182W2J8   A0A034VPM6   A0A0K8TYR2   A0A0K8VRN2   A0A0M4EHK7   A0A3L8D578  

EC Number

4.6.1.2

Pubmed

19121390    26354079    28004739    24845553    20966253    12364791    + More
14747013    17210077    25244985    20075255    28648823    17510324    26483478    20798317    18362917    19820115    20920257    23761445    24508170    23537049    21347285    27129103    26108605    26334808    25830018    24945155    25474469    17994087    17550304    25401762    26823975    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    19001374    26109357    26109356    15632085    18057021    24495485    25315136    25348373    29121518    30249741   

EMBL

BABH01013894    BABH01013895    HQ896031    ADZ56943.1    ODYU01003917    SOQ43271.1    + More
KQ461154    KPJ08490.1    KQ459599    KPI94373.1    NEVH01000596    PNF43620.1    PNF43621.1    GEZM01093597    JAV56226.1    KK853292    KDR08849.1    AAAB01008799    EAA03770.5    APCN01000232    GFDF01003957    JAV10127.1    GFDF01003956    JAV10128.1    AXCM01000557    GALX01004212    JAB64254.1    LK392616    CDS25232.1    AAZX01010983    KZ288308    PBC28742.1    NNAY01000459    OXU28249.1    CH477487    EAT40111.1    GARF01000036    JAC88909.1    GGFM01002404    MBW23155.1    GGFM01002316    MBW23067.1    GGFK01004376    MBW37697.1    GGFJ01002043    MBW51184.1    JXUM01066956    JXUM01066957    JXUM01066958    JXUM01066959    JXUM01066960    KQ562425    KXJ75945.1    GGFJ01002049    MBW51190.1    GGFJ01001970    MBW51111.1    GGFK01004165    MBW37486.1    AXCN02002617    GFDL01007545    JAV27500.1    GL439621    EFN66911.1    GFDL01007446    JAV27599.1    GFDL01007788    JAV27257.1    GFDL01007728    JAV27317.1    KQ971345    EFA05094.1    ADMH02001118    ETN64062.1    KK107597    EZA48612.1    APGK01045421    APGK01045422    APGK01045423    KB741036    ENN74715.1    CVRI01000057    CRL01945.1    KQ980903    KYN11632.1    ADTU01007480    UFQS01001404    UFQT01001404    SSX10719.1    SSX30401.1    GANO01001160    JAB58711.1    UFQS01000450    UFQT01000450    SSX04132.1    SSX24497.1    KB632394    ERL94567.1    KQ434931    KZC11789.1    KQ435791    KOX74318.1    GL450107    EFN81504.1    GBYB01003269    GBYB01006338    JAG73036.1    JAG76105.1    GAMD01000393    JAB01198.1    DS232967    EDS27088.1    GDKW01001630    JAI54965.1    JRES01000623    KNC29821.1    GBGD01000484    JAC88405.1    GFTR01008116    JAW08310.1    GBXI01012471    JAD01821.1    OUUW01000008    SPP84274.1    GAPW01000383    JAC13215.1    GBBI01002789    JAC15923.1    CH479182    EDW34135.1    CM000160    EDW97396.1    GBHO01006882    GBHO01006879    GBRD01014300    GDHC01007934    JAG36722.1    JAG36725.1    JAG51526.1    JAQ10695.1    AE014297    AY084209    EU571211    AAF55241.1    AAL89947.1    ACE60575.1    ACPB03016557    ACPB03016558    ACPB03016559    CH480815    EDW41991.1    CM000070    EAL28407.2    CH954181    EDV49071.1    GDHC01018968    JAP99660.1    CH902617    EDV43548.1    KPU80307.1    GECL01003410    JAP02714.1    GAMC01002992    JAC03564.1    CH940650    EDW66738.2    KA647744    AFP62373.1    CH916373    EDV94936.1    CH964232    EDW81071.1    KY849624    GAKP01014523    ATY74508.1    JAC44429.1    GDHF01032712    GDHF01026906    GDHF01005764    JAI19602.1    JAI25408.1    JAI46550.1    GDHF01010765    JAI41549.1    CP012526    ALC45884.1    QOIP01000013    RLU15386.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000235965    UP000075880    UP000027135    + More
UP000076407    UP000075882    UP000007062    UP000075840    UP000005203    UP000075902    UP000075903    UP000075885    UP000075883    UP000076408    UP000002358    UP000242457    UP000215335    UP000075900    UP000008820    UP000075884    UP000069272    UP000069940    UP000249989    UP000075886    UP000000311    UP000007266    UP000000673    UP000053097    UP000019118    UP000183832    UP000078492    UP000005205    UP000030742    UP000076502    UP000053105    UP000008237    UP000095300    UP000002320    UP000037069    UP000268350    UP000092443    UP000008744    UP000002282    UP000000803    UP000015103    UP000001292    UP000091820    UP000001819    UP000008711    UP000007801    UP000008792    UP000095301    UP000078200    UP000001070    UP000192221    UP000007798    UP000075920    UP000092553    UP000279307   

PRIDE

H9J7I1    F2YDQ5    Q9VF20   

Pfam

PF00005   ABC_tran        + More
PF16185   MTABC_N
PF00664   ABC_membrane
PF05207   zf-CSL
PF01094   ANF_receptor
PF07714   Pkinase_Tyr
PF00211   Guanylate_cyc

Interpro

IPR003593   AAA+_ATPase        + More
IPR017871   ABC_transporter_CS       
IPR039421   Type_I_exporter       
IPR032410   MTABC_N       
IPR003439   ABC_transporter-like       
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR036671   Znf_DHP_sf       
IPR007872   Znf_DHP       
IPR000719   Prot_kinase_dom       
IPR029787   Nucleotide_cyclase       
IPR001054   A/G_cyclase       
IPR028082   Peripla_BP_I       
IPR011009   Kinase-like_dom_sf       
IPR001170   ANPR/GUC       
IPR001828   ANF_lig-bd_rcpt       
IPR018297   A/G_cyclase_CS       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       

SUPFAM

SSF52540   SSF52540        + More
SSF90123   SSF90123       
SSF144217   SSF144217       
SSF56112   SSF56112       
SSF55073   SSF55073       
SSF53822   SSF53822       

Gene 3D

1.20.1560.10     3.10.660.10     3.30.70.1230    

ProteinModelPortal

H9J7I1   F2YDQ5   A0A2H1VR01   A0A194QU21   A0A194PN02   A0A2J7RS07   + More
A0A2J7RS02   A0A1Y1K9V1   A0A182J8S9   A0A067QIY2   A0A182XLW2   A0A182LQD1   Q7QKD8   A0A182HS10   A0A088ARD0   A0A182UIB4   A0A182UDT7   A0A182UYY8   A0A1L8DUM0   A0A1L8DUM7   A0A182PEG5   A0A182MX05   V5GJI0   A0A0H5BVD5   K7IWV7   A0A2A3EBS9   A0A232FCS4   A0A182R7N0   Q16ZP7   A0A1S4FIQ7   A0A0U9HU18   A0A182NAA1   A0A2M3Z3S9   A0A2M3Z3H4   A0A182FBM7   A0A2M4AA77   A0A2M4BDR4   A0A182GIV6   A0A2M4BDQ9   A0A2M4BDS1   A0A2M4A9K2   A0A182QA77   A0A1Q3FIS0   E2AI03   A0A1Q3FJ49   A0A1Q3FI81   A0A1Q3FID3   D2A5D4   W5JI45   A0A026VXZ9   N6TZJ9   A0A1J1ITU1   A0A195DFL3   A0A158P2U1   A0A336MLG8   U5EX21   A0A336KJI7   U4UN61   A0A154PIV9   A0A0N0BG58   E2BRY8   A0A1I8QBP0   A0A0C9QIE0   T1EB34   B0XFW9   A0A0P4VKT9   A0A0L0CC45   A0A069DWZ9   A0A224XIP0   A0A0A1WT89   A0A3B0JPZ0   A0A023EUV0   A0A1A9YK51   A0A023F3I3   B4GEV0   B4PRJ6   A0A0A9YUP4   Q9VF20   T1I161   B4HLH1   A0A1A9WJI9   Q296Q1   B3P3W5   A0A146KT46   B3M387   A0A0V0G5P0   W8C2W4   B4LX86   T1PGC8   A0A1I8M0V8   A0A1A9UTM3   B4JT46   A0A1W4VB65   B4NBA7   A0A182W2J8   A0A034VPM6   A0A0K8TYR2   A0A0K8VRN2   A0A0M4EHK7   A0A3L8D578  

PDB

4MRV     E-value=1.55558e-128,     Score=1179

KEGG

100862833    K05661 ATP-binding cassette, subfamily B (MDR/TAP), member 6 | (RefSeq) abcb; ATP-binding cassette t

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0042626   GO:0016021   GO:0005774   GO:0046872   GO:0004383   GO:0004672   GO:0035556   GO:0046686   GO:0015886   GO:0070574   GO:0005743   GO:0015232   GO:0006810   GO:0016887   GO:0007165   GO:0015031   GO:0016020   GO:0016742   GO:0003824   GO:0055085  

PANTHER

PTHR24221  

Length:

753

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

187.955370000001

Exp number, first 60 AAs:

41.73996

Total prob of N-in:

0.98826

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  21

outside

22  -  35

TMhelix

36  -  58

inside

59  -  76

TMhelix

77  -  99

outside

100  -  145

TMhelix

146  -  168

inside

169  -  267

TMhelix

268  -  290

outside

291  -  293

TMhelix

294  -  316

inside

317  -  383

TMhelix

384  -  406

outside

407  -  415

TMhelix

416  -  435

inside

436  -  753

 

 

Pi

200.115252

Theta

155.162529

Tajima's D

1.095289

CLR

0.077233

CSRT

0.691715414229289

Interpretation

Uncertain