Silkworm Genome Informatics Database

Gene

KWMTBOMO04567

Pre Gene Modal

BGIBMGA005333

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_G_protein-coupled_receptor_kinase_1_[Bombyx_mori]

Location

Bomo_Chr8(-):9952491-9994981 View in EpiBrowser

Full name

G protein-coupled receptor kinase + More
G protein-coupled receptor kinase 1

Location in the cell

Cytoplasmic Reliability : 3.458

CDS

ATGGCGGACCTCGAGGCTGTGCTGGCAGACGTGAGCTACTTGATGGCTATGGAGAAATCGAAATGCACTCCTGCAGCACGAGCTAGCAAAAAAATCGTTCTTCCAGATCCAAGTGTTCGGAGTGTAATGCACAAATACATGGAAAAGAAAAACGAAGTGAACTTTGACAAAATATTCAATCAAGTATTAGGTTATTTATTATTTAAGGAATTCTGTGAACAGACGTCAGACGAACCAGTGCCACAATTAAAATTTTACGAAGAGATAAAACTGTTCGAGAAACAAGAATGCGTGGAAGAAAGGCAACGAATCGCGAGGGATATTTACGATAATTTTATAATGAAGGAATTACTATCACATGCGCATGATTATTCTAAAGAATGCGTAGCTCATGTACAGAAGTATTTATTGAAGCATGAAGTACCACCAAATCTATTTGAGCCATATATAGAGGAAATATTCCAACATCTTCGTGGAGAGCCATTCAAAAATTTCTTAGAAAGTGATAAGTACACGAGGTTTTGTCAATGGAAGAATCTAGAACTAAACATCCAGCTAACTATGAACGATTTTAGCGTACATCGTATTATCGGCAGGGGAGGTTTCGGAGAGGTATACGGATGTCGGAAGGCGGACACAGGAAAAATGTACGCAATGAAATGTCTCGATAAGAAACGAATAAAGATGAAGCAAGGAGAGACGCTTGCCTTGAACGAGAGGATTATGCTCTCGCTAGTCAGTACCGGGGTCGACTGTCCGTTTATCGTATGTATGACGTACGCGTTTCACACTCCCGATAAGCTGTGCTTCATCCTGGACCTGATGAATGGAGGCGACCTCCACTATCATCTCTCCCAGCATGGAGTATTTAATGAAGCCGAAATGAAGTTCTACGCTGCCGAAGTAATATTAGGTTTGGAGCACATGCACAAACGTCACATAGTTTATAGAGATTTGAAGCCTGCGAACATACTCCTCGACGAGCATGGACACGTTAGAATATCAGATCTAGGCCTCGCCTGTGACTTCTCCAAAAAGAAACCTCACGCTAGTGTCGGCACTCACGGCTACATGGCCCCCGAGGTTCTCTCGAAGGGGACAGGCTACGATTCGTCCGCGGATTGGTTCAGTTTCGGCTGCATGCTCTACAAGCTGCTCAAGGGACATTCCCCGTTCCGCCAGCACAAAACCAAAGACAAGCACGAGATCGACAAGATGACCCTGACAATGAACGTGGAGCTACCGGAGTCGTTCAGTCCTAGTCTGAAGAGTCTTCTCGAAGGTCTGCTCCAAAGGGATATCAACAAACGTCTCGGCTGCAAAGGAAGAGGCGCCGACGAAGTGAAGGAGCACGTTTTCTTCGCTGGCATCGATTGGCAGCAGGTTTACCACCAGAAGTACACTCCGCCACTGATACCGCCGCGCGGGGAGGTCAACGCCGCCGATGCCTTCGACATTGGAAGCTTCGACGAAGAAGACACCAAAGGAATTAAGTTAACAGAAACGGATCAGATGCAATACAAGGACTTCCCTTTGGTGATATCGGAACGTTGGCAGGCCGAAGTCGCTGAGACCGTATTCGATACGGTCAACCTGGAAGCCGACAAGCTCGAACAGAAGAGGAAGGCTAAACAGAAGCAGAAGTTCGACGCTGACGAGAAGGAATCGGATTGTATACTCCACGGTTACATTAAGAAGTTGGGCGGCCCCTTCGCTAGTGCGTGGCAAACTCGTTACGCCAAACTGTACCCGAACCGGCTCGAGCTGCACCTCGAGAACAGCGCCAAGCCCGAAATGATTCTGCTGGACACTGTCGAGGAGGTTTCCTCCGACTTCGTTTCCATCAAGGGAGAGCAGTGCATCGTGCTGCGAACCCGAAACGACACCAAGGTCGTGCTCACGAATACGGACGAGATCGGCCTGAAGGAGTGGGCCCTGTCGCTGCGTTCGGCTCACAAATGTTCCCAAGAACTCCTTGCCTCGATGGCGAAGAAAGCCGGCAAGATCTACGGGACGGACGGCGCCAAAGAAGGAGCGCCCCCCGCGCGGCCCCTTCCCGCCGCCCCCGCCCCTCCGCGGCCCTCTAATGGCACCAACTAG

Protein

MADLEAVLADVSYLMAMEKSKCTPAARASKKIVLPDPSVRSVMHKYMEKKNEVNFDKIFNQVLGYLLFKEFCEQTSDEPVPQLKFYEEIKLFEKQECVEERQRIARDIYDNFIMKELLSHAHDYSKECVAHVQKYLLKHEVPPNLFEPYIEEIFQHLRGEPFKNFLESDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMNVELPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKESDCILHGYIKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSSDFVSIKGEQCIVLRTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGKIYGTDGAKEGAPPARPLPAAPAPPRPSNGTN

Description

Specifically phosphorylates the activated forms of G protein-coupled receptors.

Catalytic Activity

[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Keywords

ATP-binding Complete proteome Kinase Nucleotide-binding Reference proteome Transferase

Feature

chain G protein-coupled receptor kinase 1

Uniprot

A0A1L2FNL7 A0A194QT43 A0A3S2NV68 A0A3L8DLV4 A0A2M4ADE1 A0A0C9QY06 + More
A0A2M3ZHL9 A0A1S4H885 A0A2M4CUS6 A0A1B6DKB9 A0A2A3E6W6 V9IDF8 A0A2M4ADH9 A0A2M4BFB7 A0A1B6DI59 A0A087ZIR1 E0V9K7 A0A1Q3FU11 A0A0L7R0Z2 A0A1L8DL34 K7IV58 A0A2M4CUC8 A0A2M4BFB3 A0A2H4WAM5 A0A067RH83 A0A0A9X434 A0A0A9X1Y6 A0A224XJ79 A0A0P4VUE1 T1HQV9 A0A069DZG4 A0A0K8TRW7 A0A023F5P5 A0A1Y1KHT3 U5EYZ3 A0A0P4W427 E9G660 A0A0N8EIU4 Q9U756 A0A151XC10 W8B2H4 A0A0P8XKM2 A0A0A1WXZ3 A0A195E6Z4 A0A0K8V1T3 A0A195B2L3 A0A158NFW2 A0A0L0CKW0 A0A034WAR7 E1ZYY1 E1JGX2 P32865 A0A0R1EEC7 A0A195CHA2 A0A2H8TS30 X1X0Z1 A0A2S2P8S0 E2BDB8 A0A088AJN4 A0A1Z5KW37 A0A2S2PZZ8 A0A139WD85 A0A293LUM8 A0A0M4EWV6 T1JT63 B4MCJ4 A0A131YVJ4 A0A1A9YGA3 A0A1B0B9X5 A0A3B0K6C1 T1PGH8 A0A1B6GPF5 A0A232F5I1 A0A1I8PJX8 A0A1I8PJV2 A0A336K7K6 B4KLY3 A0A1B6K3P4 A0A0C9Q3K1 A0A2R5LI07 L7M0Y0 A0A0J7L2T5 A0A1A9WF34 L7LX23 A0A195F128 A0A1D2N7S2 A0A087T686 F4X6U8 A0A2L2YKS8 A0A1V9X4D5 A0A1D1W359 A0A1A9ZV38 A0A182QXX9 Q7PZQ1 A0A1J1J725 B7PZR9 A0A1J1JAX7 A0A0K8V481 A0A0N0BBB2 F1KWC8

EC Number

2.7.11.-
2.7.11.16

Pubmed

26354079 30249741 12364791 20920257 20566863 20075255 + More
29182505 24845553 25401762 26823975 27129103 26334808 26369729 25474469 28004739 21292972 24495485 17994087 18057021 25830018 21347285 26108605 25348373 20798317 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 1662381 17550304 28528879 18362917 19820115 26830274 25315136 28648823 25576852 27289101 21719571 26561354 28327890 27649274 21685128

EMBL

KT364485 ANZ22924.1 KQ461154 KPJ08489.1 RSAL01000163 RVE45358.1 + More
QOIP01000006 RLU21414.1 GGFK01005480 MBW38801.1 GBYB01008661 GBYB01008662 GBYB01008664 GBYB01008666 JAG78428.1 JAG78429.1 JAG78431.1 JAG78433.1 GGFM01007250 MBW28001.1 AAAB01008986 GGFL01004892 MBW69070.1 GEDC01011238 JAS26060.1 KZ288349 PBC27455.1 JR039413 AEY58682.1 GGFK01005524 MBW38845.1 GGFJ01002604 MBW51745.1 GEDC01011929 JAS25369.1 AAZO01000176 AAZO01000177 AAZO01000178 AAZO01000179 DS234994 EEB10063.1 GFDL01004079 JAV30966.1 KQ414668 KOC64519.1 GFDF01007009 JAV07075.1 AAZX01007189 AAZX01007308 AAZX01008580 AAZX01008824 AAZX01010596 AAZX01012511 GGFL01004776 MBW68954.1 GGFJ01002566 MBW51707.1 MG020527 AUC64083.1 KK852473 KDR23117.1 GBHO01028865 JAG14739.1 GBHO01042631 GBHO01042630 GBHO01028867 GBHO01028866 GBHO01028863 GBRD01008853 GDHC01017922 GDHC01008493 GDHC01002614 JAG00973.1 JAG00974.1 JAG14737.1 JAG14738.1 JAG14741.1 JAG56968.1 JAQ00707.1 JAQ10136.1 JAQ16015.1 GFTR01007784 JAW08642.1 GDKW01000440 JAI56155.1 ACPB03000493 ACPB03000494 GBGD01000685 JAC88204.1 GDAI01000705 JAI16898.1 GBBI01002224 JAC16488.1 GEZM01083779 JAV61013.1 GANO01001717 JAB58154.1 GDRN01093628 JAI59852.1 GL732533 EFX84879.1 GDIQ01022516 JAN72221.1 AF157046 AAF05109.1 KQ982314 KYQ57926.1 GAMC01011220 GAMC01011219 JAB95335.1 CH902628 KPU75351.1 GBXI01010358 GBXI01002421 JAD03934.1 JAD11871.1 KQ979568 KYN20866.1 GDHF01019422 JAI32892.1 KQ976662 KYM78532.1 ADTU01014814 ADTU01014815 ADTU01014816 JRES01000340 KNC32114.1 GAKP01008054 JAC50898.1 GL435242 EFN73671.1 AE013599 ACZ94331.1 M80493 BT022770 BT022801 BT044475 CH891640 KRK05079.1 KQ977754 KYN00105.1 GFXV01004597 MBW16402.1 ABLF02022439 ABLF02022440 GGMR01013201 MBY25820.1 GL447585 EFN86346.1 GFJQ02007648 GFJQ02000637 JAV99321.1 GGMS01001884 MBY71087.1 KQ971361 KYB25938.1 GFWV01006748 MAA31478.1 CP012524 ALC42662.1 CAEY01000473 CH940659 EDW71382.2 GEDV01006047 JAP82510.1 JXJN01010630 OUUW01000029 SPP89777.1 KA647881 AFP62510.1 GECZ01005479 JAS64290.1 NNAY01000956 OXU25738.1 UFQS01000095 UFQT01000095 SSW99355.1 SSX19735.1 CH933808 EDW09793.2 GECU01004879 GECU01001636 JAT02828.1 JAT06071.1 GBYB01008663 JAG78430.1 GGLE01004952 MBY09078.1 GACK01007339 JAA57695.1 LBMM01001065 KMQ96988.1 GACK01009630 JAA55404.1 KQ981864 KYN34270.1 LJIJ01000163 ODN01281.1 KK113633 KFM60625.1 GL888818 EGI57880.1 IAAA01029774 IAAA01029775 LAA08716.1 MNPL01025528 OQR68266.1 BDGG01000012 GAV05814.1 AXCN02001675 EAA00439.4 CVRI01000074 CRL08192.1 ABJB010008870 ABJB010250407 ABJB010400182 ABJB010518260 ABJB010700802 ABJB010726179 ABJB010808601 ABJB011016109 ABJB011052208 DS827347 EEC12091.1 CRL08193.1 GDHF01018929 JAI33385.1 KQ436242 KOX67318.1 JI166981 ADY42182.1

Proteomes

UP000053240 UP000283053 UP000279307 UP000242457 UP000009046 UP000053825 + More
UP000002358 UP000027135 UP000015103 UP000000305 UP000075809 UP000007801 UP000078492 UP000078540 UP000005205 UP000037069 UP000000311 UP000000803 UP000002282 UP000078542 UP000007819 UP000008237 UP000005203 UP000007266 UP000092553 UP000015104 UP000008792 UP000092443 UP000092460 UP000268350 UP000095301 UP000215335 UP000095300 UP000009192 UP000036403 UP000091820 UP000078541 UP000094527 UP000054359 UP000007755 UP000192247 UP000186922 UP000092445 UP000075886 UP000007062 UP000183832 UP000001555 UP000053105

PRIDE

E1JGX2 P32865

Pfam

PF00615   RGS        + More
PF00069   Pkinase
PF00169   PH
PF00780   CNH
PF15796   KELK
PF00130   C1_1
PF02878   PGM_PMM_I
PF02880   PGM_PMM_III
PF02879   PGM_PMM_II
PF00408   PGM_PMM_IV
PF07535   zf-DBF

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR011993   PH-like_dom_sf
IPR008271   Ser/Thr_kinase_AS
IPR001849   PH_domain
IPR011009   Kinase-like_dom_sf
IPR016137   RGS
IPR036305   RGS_sf
IPR000961   AGC-kinase_C
IPR000719   Prot_kinase_dom
IPR000239   GPCR_kinase
IPR014930   Myotonic_dystrophy_kinase_coil
IPR001180   CNH_dom
IPR000095   CRIB_dom
IPR002219   PE/DAG-bd
IPR031597   KELK
IPR005841   Alpha-D-phosphohexomutase_SF
IPR005843   A-D-PHexomutase_C
IPR005846   A-D-PHexomutase_a/b/a-III
IPR005844   A-D-PHexomutase_a/b/a-I
IPR036900   A-D-PHexomutase_C_sf
IPR016055   A-D-PHexomutase_a/b/a-I/II/III
IPR016066   A-D-PHexomutase_CS
IPR005845   A-D-PHexomutase_a/b/a-II
IPR036788   T_IF-3_C_sf
IPR038545   Znf_DBF_sf
IPR006572   Znf_DBF

SUPFAM

SSF56112   SSF56112        + More
SSF48097   SSF48097
SSF53738   SSF53738
SSF55957   SSF55957

Gene 3D

2.30.29.30 3.30.110.10 3.30.160.680

CDD

cd00132 CRIB
cd00029 C1

ProteinModelPortal

A0A1L2FNL7 A0A194QT43 A0A3S2NV68 A0A3L8DLV4 A0A2M4ADE1 A0A0C9QY06 + More
A0A2M3ZHL9 A0A1S4H885 A0A2M4CUS6 A0A1B6DKB9 A0A2A3E6W6 V9IDF8 A0A2M4ADH9 A0A2M4BFB7 A0A1B6DI59 A0A087ZIR1 E0V9K7 A0A1Q3FU11 A0A0L7R0Z2 A0A1L8DL34 K7IV58 A0A2M4CUC8 A0A2M4BFB3 A0A2H4WAM5 A0A067RH83 A0A0A9X434 A0A0A9X1Y6 A0A224XJ79 A0A0P4VUE1 T1HQV9 A0A069DZG4 A0A0K8TRW7 A0A023F5P5 A0A1Y1KHT3 U5EYZ3 A0A0P4W427 E9G660 A0A0N8EIU4 Q9U756 A0A151XC10 W8B2H4 A0A0P8XKM2 A0A0A1WXZ3 A0A195E6Z4 A0A0K8V1T3 A0A195B2L3 A0A158NFW2 A0A0L0CKW0 A0A034WAR7 E1ZYY1 E1JGX2 P32865 A0A0R1EEC7 A0A195CHA2 A0A2H8TS30 X1X0Z1 A0A2S2P8S0 E2BDB8 A0A088AJN4 A0A1Z5KW37 A0A2S2PZZ8 A0A139WD85 A0A293LUM8 A0A0M4EWV6 T1JT63 B4MCJ4 A0A131YVJ4 A0A1A9YGA3 A0A1B0B9X5 A0A3B0K6C1 T1PGH8 A0A1B6GPF5 A0A232F5I1 A0A1I8PJX8 A0A1I8PJV2 A0A336K7K6 B4KLY3 A0A1B6K3P4 A0A0C9Q3K1 A0A2R5LI07 L7M0Y0 A0A0J7L2T5 A0A1A9WF34 L7LX23 A0A195F128 A0A1D2N7S2 A0A087T686 F4X6U8 A0A2L2YKS8 A0A1V9X4D5 A0A1D1W359 A0A1A9ZV38 A0A182QXX9 Q7PZQ1 A0A1J1J725 B7PZR9 A0A1J1JAX7 A0A0K8V481 A0A0N0BBB2 F1KWC8

PDB

5UKM E-value=0, Score=2530

KEGG

101741546 K00910 beta-adrenergic-receptor kinase [EC:2.7.11.15] | (RefSeq) G protein-coupled receptor kinase 1

PATHWAY

04144 Endocytosis - Bombyx mori (domestic silkworm)
04745 Phototransduction - fly - Bombyx mori (domestic silkworm)

GO

GO:0004703 GO:0007165 GO:0005524 GO:0004674 GO:0035556 GO:0030036 GO:0046872 GO:0005886 GO:0001664 GO:0035091 GO:0005737 GO:0007603 GO:0006468 GO:0016060 GO:0050254 GO:0045880 GO:0005975 GO:0000287 GO:0016868 GO:0008270 GO:0006413 GO:0003676 GO:0004672 GO:0015031 GO:0016020 GO:0016742 GO:0003824

Length:

699

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.14717

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00654

outside

1 - 699

Pi

232.086848

Theta

182.199356

Tajima's D

0.968109

CLR

0.003225

CSRT

0.652517374131293

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics