Gene

KWMTBOMO04547

Pre Gene Modal

BGIBMGA005342

Annotation

PREDICTED:_ubiquitin_carboxyl-terminal_hydrolase_calypso_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr8(-):9493232-9499086      View in EpiBrowser

Full name

Ubiquitin carboxyl-terminal hydrolase       + More
Ubiquitin carboxyl-terminal hydrolase calypso      
Clustered mitochondria protein homolog      

Alternative Name

BAP1 homolog

Location in the cell

Nuclear   Reliability : 2.939

CDS

ATGCCGGTAGAACTAAACAGTCTTACCGAAGGCTGGCTAGAATTGGAAAGTGATCCTGGTCTTTTTACTTTACTATTAGAAGATTTCGGTGTTAAAGGTGTGCAAGTTGAGGAAATTTATGACCTGCATAAGCCTTTAGAGAGCCCGGTGTACGGATTTATCTTTTTATTTAGATGGATAGAAGAGCGCAGATCAAGGCGAAAATTCGTTGAACAAATTGAAAGCTTTGTACGGGATGAGGAGACCATCAATAATATTTTTTTTGCACAGCAAATGGTACCCAACAGTTGCGCCACTCATGCTTTACTTTCCATTTTACTAAACTGTCCAAATCTTCATTTAGGAGAAACATTAAGTAGGTTAAAACATCATACAGTGGGTATGAATCCTGAAAACAAAGGATGGGCAATAGGAAATACACCTGAGTTGGCTTGTGCCCACAACTCACATGCCATACCACAAGCACGCAAAAAGACAGACAAAAATGCTGGAGTTTCTACTGGCAGATTTACAGGTGAAGCATACCATTTTGTTAGCTTGGTACCAATCAATGGACATTTGTTTGAACTAGATGGTCTTAAACCATATCCTATGGATCATGGTCCGTGGGCAGCTGATGAGGATTGGACAGATAAATTTAGAAGGGTAATGGCAGAAAGACTTGGTAGAGATGCAGGAGAACAAGTTCATGATATTAGATTCAACCTAATGGCAGTTGTACCAGACAGAAGGTTAGCATTAACACAAAAGCTTGGGGCACTTGAAATAAATCAGAAGAGAGTCAAAGAAGCTATTTCAAAAATAGGGAAACATCTACGGCATTTGTTGGGGAAAGGCAGAGAATACAACGGTCAGAGCGAGCTCATAACTAGCAATGATATTGATACATCTCTTAATGATAGCATGGTCCACATTAGTGAAGAGACAATATTAACAGCATTGCAATCATCACAACTACGCACATATGACATAGATTACACACTACCAATTACAATTGAGATTGGTGCTATGGACAGACCTCATCAGGATAGCAGTATTTTATTAGTGGATCCTGTGGAACAAGGAGCTGTTGTGAAATTCGTTACAGCAAATAAAGATAGTCAAATCATTGGTGATATCTATCCAACATCAACAACCGCCCTAGTGAGAAGTAATGAATCACCAGTTCTATTGTGCTCCGAAATAGCTCCGGAACAGCCCTATAAGTTGAGGAAATTGCTCCTTTCTCATTCGGAACTTAATGCGCTAATGAGCTGCATTGTCGGTGAAGTGCAATCGTGTCAGCAGGCTCTAAACGATGAGAACGATAAAAGAGATATGTATAAAGTAGACGATTGTCGACGTACGCACAACTACGACGAGTTCATCTGCACTTTCCTATCGATGTTGACGGAACGTGGAGCTCTGGCCGAACTGGTCGCCGCGCAGTTAGAACGAGGCCGGTCTCCGAGAGTGAGACGACGACGTCCTAGACCCAGACCCCGAGCGCGACCTAGACCAAGGCCACGTGGAAGAAAATAA

Protein

MPVELNSLTEGWLELESDPGLFTLLLEDFGVKGVQVEEIYDLHKPLESPVYGFIFLFRWIEERRSRRKFVEQIESFVRDEETINNIFFAQQMVPNSCATHALLSILLNCPNLHLGETLSRLKHHTVGMNPENKGWAIGNTPELACAHNSHAIPQARKKTDKNAGVSTGRFTGEAYHFVSLVPINGHLFELDGLKPYPMDHGPWAADEDWTDKFRRVMAERLGRDAGEQVHDIRFNLMAVVPDRRLALTQKLGALEINQKRVKEAISKIGKHLRHLLGKGREYNGQSELITSNDIDTSLNDSMVHISEETILTALQSSQLRTYDIDYTLPITIEIGAMDRPHQDSSILLVDPVEQGAVVKFVTANKDSQIIGDIYPTSTTALVRSNESPVLLCSEIAPEQPYKLRKLLLSHSELNALMSCIVGEVQSCQQALNDENDKRDMYKVDDCRRTHNYDEFICTFLSMLTERGALAELVAAQLERGRSPRVRRRRPRPRPRARPRPRPRGRK

Description

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1) (By similarity).
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit

Component of the PR-DUB complex.

Similarity

Belongs to the peptidase C12 family.
Belongs to the peptidase C12 family. BAP1 subfamily.
Belongs to the CLU family.

Keywords

Chromatin regulator   Complete proteome   Hydrolase   Nucleus   Protease   Reference proteome   Thiol protease   Ubl conjugation pathway  

Feature

chain  Ubiquitin carboxyl-terminal hydrolase calypso

Uniprot

A0A2W1BTK7   A0A3S2TP17   A0A2H1X2U2   A0A194QSH3   A0A194PN17   A0A212EQN4   + More
A0A1Y1M336   A0A0C9R2C2   A0A182G692   Q17N72   A0A2K7P683   A0A182QRG7   A0A182UJZ4   A0A2M4CQE1   W5JU35   A0A182VMZ7   A0A084WIS1   A0A182L4Z4   A0A0E4G8E3   A0A182HHG5   D6WQP0   A0A1Q3F3L7   N6URG2   J3JVQ4   U4U5U8   A0A2M4BM15   A0A2H8TMW7   A0A2S2PDP5   J9KA29   A0A2M4BK63   A0A023F4R4   A0A2S2QUH2   A0A2R7VWY5   B0W2R4   A0A0T6AVZ7   A0A347ZJG0   A0A182XGU6   A0A182JQA8   A0A1D2N4H0   A0A2J7RGI3   A0A224XQI9   A0A131XEL9   A0A162PPH8   A0A0P6G6Y0   A0A0P5KZR3   A0A0P5NYZ3   A0A0P6HQ92   A0A0N8CS94   A0A0P6B3F3   A0A0P5QZC6   A0A0P5UZU2  

EC Number

3.4.19.12

Pubmed

28756777    26354079    22118469    28004739    26483478    17510324    + More
20920257    23761445    24438588    20966253    12364791    18362917    19820115    23537049    22516182    25474469    27289101    28049606   

EMBL

KZ149904    PZC78398.1    RSAL01000036    RVE51304.1    ODYU01013022    SOQ59635.1    + More
KQ461154    KPJ08473.1    KQ459599    KPI94388.1    AGBW02013261    OWR43802.1    GEZM01042006    JAV80073.1    GBYB01001021    JAG70788.1    JXUM01147457    KQ570372    KXJ68377.1    CH477201    AXCN02001095    GGFL01003376    MBW67554.1    ADMH02000368    ETN66808.1    ATLV01023945    KE525347    KFB50115.1    AAAB01008986    HACL01000148    CFW94442.1    APCN01002408    KQ971354    EFA06996.2    GFDL01012926    JAV22119.1    APGK01019580    KB740112    ENN81342.1    BT127322    AEE62284.1    KB631985    ERL87718.1    GGFJ01004954    MBW54095.1    GFXV01002823    MBW14628.1    GGMR01014958    MBY27577.1    ABLF02034500    GGFJ01004325    MBW53466.1    GBBI01002719    JAC15993.1    GGMS01012203    MBY81406.1    KK854141    PTY12016.1    DS231828    LJIG01022674    KRT79315.1    FX985728    BBA84466.1    LJIJ01000243    ODM99954.1    NEVH01003779    PNF39946.1    GFTR01006187    JAW10239.1    GEFH01003524    JAP65057.1    LRGB01000452    KZS19032.1    GDIQ01048122    JAN46615.1    GDIQ01177102    JAK74623.1    GDIQ01135836    GDIP01060950    JAL15890.1    JAM42765.1    GDIQ01016613    JAN78124.1    GDIP01103895    JAL99819.1    GDIP01022678    JAM81037.1    GDIQ01108090    JAL43636.1    GDIP01106491    JAL97223.1   

Proteomes

UP000283053    UP000053240    UP000053268    UP000007151    UP000069940    UP000249989    + More
UP000008820    UP000075886    UP000075902    UP000000673    UP000075903    UP000030765    UP000075882    UP000075840    UP000007266    UP000019118    UP000030742    UP000007819    UP000002320    UP000076407    UP000075881    UP000094527    UP000235965    UP000076858   

Pfam

PF01088   Peptidase_C12        + More
PF18031   UCH_C
PF12807   eIF3_p135
PF13236   CLU
PF15044   CLU_N
PF05303   DUF727

Interpro

IPR038765   Papain-like_cys_pep_sf        + More
IPR041507   UCH_C       
IPR001578   Peptidase_C12_UCH       
IPR036959   Peptidase_C12_UCH_sf       
IPR025697   CLU_dom       
IPR027523   CLU       
IPR011990   TPR-like_helical_dom_sf       
IPR028275   CLU_N       
IPR033646   CLU-central       
IPR007967   GSKIP_dom       

SUPFAM

SSF54001   SSF54001        + More
SSF48452   SSF48452       

Gene 3D

3.40.532.10     1.25.40.10    

CDD

cd15466  CLU-central

ProteinModelPortal

A0A2W1BTK7   A0A3S2TP17   A0A2H1X2U2   A0A194QSH3   A0A194PN17   A0A212EQN4   + More
A0A1Y1M336   A0A0C9R2C2   A0A182G692   Q17N72   A0A2K7P683   A0A182QRG7   A0A182UJZ4   A0A2M4CQE1   W5JU35   A0A182VMZ7   A0A084WIS1   A0A182L4Z4   A0A0E4G8E3   A0A182HHG5   D6WQP0   A0A1Q3F3L7   N6URG2   J3JVQ4   U4U5U8   A0A2M4BM15   A0A2H8TMW7   A0A2S2PDP5   J9KA29   A0A2M4BK63   A0A023F4R4   A0A2S2QUH2   A0A2R7VWY5   B0W2R4   A0A0T6AVZ7   A0A347ZJG0   A0A182XGU6   A0A182JQA8   A0A1D2N4H0   A0A2J7RGI3   A0A224XQI9   A0A131XEL9   A0A162PPH8   A0A0P6G6Y0   A0A0P5KZR3   A0A0P5NYZ3   A0A0P6HQ92   A0A0N8CS94   A0A0P6B3F3   A0A0P5QZC6   A0A0P5UZU2  

PDB

6HGC     E-value=1.20444e-111,     Score=1032

KEGG

101739798    K08588 ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12] | (RefSeq) ubiquitin carboxyl-termi

GO

GO:0004843   GO:0006511   GO:0036459   GO:0000790   GO:0035522   GO:0006342   GO:0035517   GO:0003682   GO:0016579   GO:0005737   GO:0003723   GO:0048312   GO:0005622   GO:0030117   GO:0005488   GO:0008565   GO:0015031   GO:0016020   GO:0016742   GO:0003824  

PANTHER

PTHR10589  

Subcellular location

Nucleus   Localizes to PcG response elements (PREs).   With evidence from 1 publications.
Cytoplasm  

Length:

506

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00870999999999999

Exp number, first 60 AAs:

0.00158

Total prob of N-in:

0.00119

outside

1  -  506

 

 

Pi

338.063412

Theta

198.52108

Tajima's D

2.034491

CLR

0

CSRT

0.884405779711014

Interpretation

Uncertain