Gene

KWMTBOMO04543  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005466

Annotation

PREDICTED:_AP-2_complex_subunit_alpha_[Papilio_xuthus]

Location

Bomo_Chr8(+):9442087-9445141      View in EpiBrowser

Full name

AP-2 complex subunit alpha      

Alternative Name

Alpha-adaptin

Location in the cell

Cytoplasmic   Reliability : 1.232 Golgi   Reliability : 1.838

CDS

ATGCCTGCCGTCAGAGGAGATGGTATGCGAGGGCTCGCTGTCTTTATCTCAGACATAAGAAACTGTAAGAGTAAAGAAGCAGAAATAAAGAGAATCAACAAGGAGCTTGCAAATATAAGAAGTAAGTTTAAGGGTGATAAAACTCTAGATGGATATCAAAAGAAGAAGTATGTGTGTAAACTTCTGTTTATATTTCTGCTCGGACATGATATCGACTTCGGGCACATGGAAGCAGTAAACTTACTTTCATCCAATAAATACTCCGAAAAACAGATTGGATACCTTTTCATATCTGTCCTAGTCAATACCAACAGTGACCTCATTAAACTTATCATTCAGAGCATTAAAAACGACTTGCAGTCTCGCAATCCTATTCATGTAAACTTAGCTCTTCAATGTATTGCCAACATTGGTAGCAAAGATATGGCTGAAGCTTTTGGTACTGAAATACCCAAACTTCTTGTCTCTGGTGATACCATGGATGTAGTGAAACAATCTGCTGCACTTTGCCTCCTTCGCTTATTTCGCAAATCTCCTGAGATAATACCTGGAGGAGAGTGGACTTCTCGCATAATTCATCTTTTGAATGACCCCCATATGGGTGTAGTAACTGCAGCGACATCTTTGATTGATGCTCTTGTAAAGAAGAATCCTGATGAGTATAAGGGTTGTGTAACATTGGCTGTAGCTCGACTTAGCAGAATTGTTACTGCCAGTTACACAGATTTACAAGATTATACATATTACTTTGTACCTGCTCCTTGGTTGTCTGTCAAACTGTTACGCCTCTTACAAAACTACACCCCTCCATCTGAAGAACCTGGAGTTCGAGGACGTCTTTCAGAATGCCTAGAAACAATATTCAACAAAGCTCAAGAACCACCAAAATCTAAAAAAGTGCAACATTCCAATGCCAAGAATGCTGTTCTTTTTGAAGCAATAAGTCTTATTATACACAACGACAGTGAACCTAACTTATTAGTTCGTGCTTGCAATCAGCTGGGACAATTTCTTAGTAATCGTGAAACTAACTTGCGCTATTTAGCTCTTGAATCAATGTGTCATTTAGCTACATCAGAATTTTCTCATGAAGCAGTAAAAAAGCATCAAGAAATAGTAATCCTCTCAATGAAAATGGAAAAAGATGTTTCTGTCAGGCAGCAGGCTGTAGATCTTCTGTATGCAATGTGTGATAAGACTAATGCAGAAGAAATTGTACAAGAAATGTTAGCTTATTTAGAAACTGCTGATTATTCAATCAGAGAAGAAATGGTGTTAAAAGTTGCTATATTAGCAGAAAAGTATGCTACAGATTTCACTTGGTATGTGGATGTAATTCTTAATCTTATAAGAATTGCTGGTGATTATGTCTCAGAAGAAGTTTGGTACAGAGTAATTCAAATAGTAATAAATAGAGATGAAGTTCAAGCATATGCTGCTAAAACTGTATTTGAAGCATTACAAGCCCCAACATGCCATGAGAATATGGTTAAAGTTGGAGGATACATTCTGGGAGAGTTTGGTAACTTGATAGCTGGAGATACAAGATCATCACCACAAGTTCAGTTTGAACTTCTACATTCCAAATACCATTTGTGTTCTGTTGCAACAAGAGCCCTATTGTTATCAACGTATATAAAGTTGGTTAATCTTTTCCCAGAAATAAAAAATAGAGTTCAAGAAGTATTTAAGGCAGATTCTAATTTACGTTCAGCTGATGTTGAGTTGCAACAAAGGGCATCAGAATACTTGCAACTTAGTATTGTAGCCAGTACAGATGTTTTAGCCACAGTATTAGAAGAAATGCCTGCTTTCCCTGAAAGAGAATCTTCTATCTTAGCAGTATTGAAAAAGAAGAAGCCAGGTCGTATTCCAGATGATGTTAGAGAATCAAAGAGCCCTCTGCCCACTGTTGCTCCCACTGCTATACTAAATTCTACTAACAATACTAATAGCTCCAGTGCTGATCTCCTAGGACTGTCTACACCACCTGGTTCTGCAGCCCCTACTACAGGGAATGGCTTATTGGATGTACTTGGAGATTTGTACACATCAACAAAAATAAGCCCCAGTACTGTACAGCAAAATAACATCAAAAAGTTTTTGTTTAAAAACAATGGGGTGCTTTTTGAAAATGAATTGATCCAAATTGGTGTTAAAAGTGAGTTCAGACAAAATCTTGGCAGAATTGGCCTATTTTATGGCAACAAAACCCAATTTCCAATCCAGAATGTCCATCCTGAGTTACATTGGACTGACTTGCATAAGTTGAATGTACAAATGAAACCAATGGAACCTATATTGGAAGCAGGTGCTCAAATCCAACAAATGTTGACAGCTGAATGTATAGAAGATTTTACTGATGTACCAAGCATGTCAGTCTCATTTATATATAACAATGTACCACAGAAAATAACAATGAAACTCCCACTCACCCTTAACAAATTCTTTGAACCAACTGAAATGAATGGTGAATCATTCTTTGCACGGTGGAAAAATTTGGGAGGCGAACAACAGAGAGCCCAAAAGATTTTCAAAGCTCAGGGACCGATTGATTTGACTGGCACAAGAACAAAATTGGCTGGATTTGGCATGCAATTATTAGATGGTATCGATCCTAATCCAGATAACTTTGTATGTGCCGGCATTGTCCATACAAAGATGCAACAAGTTGGATGTTTAATGAGACTGGAACCTAACAAACAAGCTCAAATGTACAGACTAACCATACGATCTAGTAAGGAGTCAGTTTCTCAAGAAATCTGCAACTTACTTGCTGACCAGTTTTGA

Protein

MPAVRGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIKLIIQSIKNDLQSRNPIHVNLALQCIANIGSKDMAEAFGTEIPKLLVSGDTMDVVKQSAALCLLRLFRKSPEIIPGGEWTSRIIHLLNDPHMGVVTAATSLIDALVKKNPDEYKGCVTLAVARLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYTPPSEEPGVRGRLSECLETIFNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHNDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEAVKKHQEIVILSMKMEKDVSVRQQAVDLLYAMCDKTNAEEIVQEMLAYLETADYSIREEMVLKVAILAEKYATDFTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINRDEVQAYAAKTVFEALQAPTCHENMVKVGGYILGEFGNLIAGDTRSSPQVQFELLHSKYHLCSVATRALLLSTYIKLVNLFPEIKNRVQEVFKADSNLRSADVELQQRASEYLQLSIVASTDVLATVLEEMPAFPERESSILAVLKKKKPGRIPDDVRESKSPLPTVAPTAILNSTNNTNSSSADLLGLSTPPGSAAPTTGNGLLDVLGDLYTSTKISPSTVQQNNIKKFLFKNNGVLFENELIQIGVKSEFRQNLGRIGLFYGNKTQFPIQNVHPELHWTDLHKLNVQMKPMEPILEAGAQIQQMLTAECIEDFTDVPSMSVSFIYNNVPQKITMKLPLTLNKFFEPTEMNGESFFARWKNLGGEQQRAQKIFKAQGPIDLTGTRTKLAGFGMQLLDGIDPNPDNFVCAGIVHTKMQQVGCLMRLEPNKQAQMYRLTIRSSKESVSQEICNLLADQF

Description

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adapter (By similarity).
Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP-2alpha is a subunit of the plasma membrane adapter.
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.

Subunit

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit AP17).

Similarity

Belongs to the adaptor complexes large subunit family.
Belongs to the adapter complexes large subunit family.

Keywords

Cell membrane   Coated pit   Complete proteome   Endocytosis   Membrane   Protein transport   Reference proteome   Transport   Alternative splicing   Phosphoprotein   RNA editing  

Feature

chain  AP-2 complex subunit alpha
splice variant  In isoform B.

Uniprot

H9J7H4   A0A2W1BXL5   A0A1E1WGS0   A0A2H1V2Z5   A0A194QTZ9   A0A194PM39   + More
A0A212EQQ2   A0A0L7LFU1   A0A1Y1KZK6   V5IA26   A0A034VTV9   N6TXW3   A0A1W4WTG7   W8BAQ1   A0A0K8VJ03   D6W7L4   A0A0A1XAN1   A0A0C9RDP5   A0A336KC15   A0A336M3M0   A0A1B6F6F6   A0A1I8QF67   A0A1A9YSF6   A0A1I8MJ14   A0A0L0CCN8   U5EX15   A0A182GJ46   A0A1B0FD53   A0A1A9V0X6   A0A1A9ZQQ7   Q17CP2   A0A151IK21   A0A3L8E6I8   A0A151I5J6   A0A158NWA4   F4WLP8   A0A195EC81   A0A2M4BCJ2   E2A8U3   A0A151JTU0   A0A232FFM4   B4G8A5   Q29N38   A0A182F4E2   W5J6P4   A0A182NE80   A0A2M4ACF8   A0A1A9WUR4   A0A1W4UQ49   A0A3B0K163   A0A0J7KSA5   A0A0M4E743   A0A182Y5R8   B4N0V9   A0A182RGH4   A0A182VV19   A0A182Q353   B4LTK9   A0A1Q3FAY3   A0A1Q3FAR8   B4ICW5   A0A1L8DVR8   A0A182MDW3   Q7QG73   A0A1B6DVE5   B3N7P9   B4Q635   P91926   A0A182JGX0   B3MUI1   B4P2D9   B0XEL0   A0A182JYE8   A0A1J1J1F9   B4KFJ2   A0A182P954   A0A088APJ2   B4JDP0   A0A0A9YVV3   A0A069DXV4   A0A0K8V223   A0A2A3EMD2   A0A0V0G7Q7   A0A023F5Q8   A0A182UBX7   A0A151X1G5   A0A0M9A3D5   A0A182VNP6   P91926-2   E8NH12   A0A084VPB0   A0A310SAK0   A0A182IE13   A0A2H8TLI9   A0A2S2PGU7   X1XNU7   A0A182T5A2   A0A0P4WDI2   T1IZY9   A0A0P5MQY6  

Pubmed

19121390    28756777    26354079    22118469    26227816    28004739    + More
25348373    23537049    24495485    18362917    19820115    25830018    25315136    26108605    26483478    17510324    30249741    21347285    21719571    20798317    28648823    17994087    15632085    20920257    23761445    25244985    18057021    12364791    22936249    9118220    9285813    10731132    12537572    17018572    18327897    17550304    25401762    26334808    25474469    24438588   

EMBL

BABH01013842    KZ149904    PZC78395.1    GDQN01004875    JAT86179.1    ODYU01000234    + More
SOQ34654.1    KQ461154    KPJ08470.1    KQ459599    KPI94392.1    AGBW02013261    OWR43805.1    JTDY01001362    KOB74076.1    GEZM01075037    GEZM01075036    JAV64327.1    GALX01001920    JAB66546.1    GAKP01013405    GAKP01013404    GAKP01013403    JAC45547.1    APGK01047112    KB741077    KB632384    ENN74140.1    ERL94271.1    GAMC01012452    GAMC01012451    GAMC01012450    JAB94103.1    GDHF01016326    GDHF01013774    JAI35988.1    JAI38540.1    KQ971307    EFA11263.1    GBXI01015587    GBXI01006554    GBXI01005354    JAC98704.1    JAD07738.1    JAD08938.1    GBYB01005101    JAG74868.1    UFQS01000285    UFQT01000285    SSX02434.1    SSX22809.1    UFQS01000393    UFQT01000393    SSX03566.1    SSX23931.1    GECZ01024098    JAS45671.1    JRES01000561    KNC30198.1    GANO01001170    JAB58701.1    JXUM01054903    JXUM01054904    JXUM01067295    JXUM01067296    JXUM01067297    KQ562443    KQ561842    KXJ75904.1    KXJ77374.1    CCAG010003896    CH477305    EAT44154.1    KQ977282    KYN03973.1    QOIP01000001    RLU27589.1    KQ976434    KYM87176.1    ADTU01002959    GL888212    EGI64876.1    KQ979074    KYN22830.1    GGFJ01001624    MBW50765.1    GL437663    EFN70172.1    KQ981972    KYN31649.1    NNAY01000274    OXU29566.1    CH479180    EDW28585.1    CH379060    EAL33505.1    ADMH02002133    ETN58439.1    GGFK01005119    MBW38440.1    OUUW01000004    SPP79699.1    LBMM01003688    KMQ93233.1    CP012523    ALC38515.1    CH963920    EDW77722.1    AXCN02000868    CH940649    EDW64982.1    KRF81968.1    GFDL01010373    JAV24672.1    GFDL01010426    JAV24619.1    CH480829    EDW45391.1    GFDF01003557    JAV10527.1    AXCM01000251    AAAB01008839    GEDC01020541    GEDC01014060    GEDC01012641    GEDC01007658    JAS16757.1    JAS23238.1    JAS24657.1    JAS29640.1    CH954177    EDV57225.1    CM000361    CM002910    EDX03219.1    KMY87307.1    Y11104    Y13092    AE014134    BT032839    BT003458    CH902624    EDV33510.1    CM000157    EDW87135.1    DS232843    EDS26071.1    CVRI01000065    CRL05770.1    CH933807    EDW13107.1    KRG03580.1    CH916368    EDW03410.1    GBHO01009919    JAG33685.1    GBGD01000347    JAC88542.1    GDHF01019674    JAI32640.1    KZ288219    PBC32319.1    GECL01002791    JAP03333.1    GBBI01002203    JAC16509.1    KQ982600    KYQ54033.1    KQ435750    KOX76387.1    BT125866    ADU79254.1    ATLV01014994    KE524999    KFB39804.1    KQ762237    OAD56004.1    APCN01004553    GFXV01003212    MBW15017.1    GGMR01016044    MBY28663.1    ABLF02023931    ABLF02023933    ABLF02023934    GDRN01066780    JAI64473.1    JH431728    GDIQ01175394    JAK76331.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000037510    UP000019118    + More
UP000030742    UP000192223    UP000007266    UP000095300    UP000092443    UP000095301    UP000037069    UP000069940    UP000249989    UP000092444    UP000078200    UP000092445    UP000008820    UP000078542    UP000279307    UP000078540    UP000005205    UP000007755    UP000078492    UP000000311    UP000078541    UP000215335    UP000008744    UP000001819    UP000069272    UP000000673    UP000075884    UP000091820    UP000192221    UP000268350    UP000036403    UP000092553    UP000076408    UP000007798    UP000075900    UP000075920    UP000075886    UP000008792    UP000001292    UP000075883    UP000007062    UP000008711    UP000000304    UP000000803    UP000075880    UP000007801    UP000002282    UP000002320    UP000075881    UP000183832    UP000009192    UP000075885    UP000005203    UP000001070    UP000242457    UP000075902    UP000075809    UP000053105    UP000075903    UP000030765    UP000075840    UP000007819    UP000075901   

PRIDE

H9J7H4    Q7QG73    P91926    E8NH12   

Pfam

PF02883   Alpha_adaptinC2        + More
PF02296   Alpha_adaptin_C
PF01602   Adaptin_N
PF00034   Cytochrom_C

Interpro

IPR009028   Coatomer/calthrin_app_sub_C        + More
IPR008152   Clathrin_a/b/g-adaptin_app_Ig       
IPR011989   ARM-like       
IPR017104   AP2_complex_asu       
IPR013041   Clathrin_app_Ig-like_sf       
IPR002553   Clathrin/coatomer_adapt-like_N       
IPR003164   Clathrin_a-adaptin_app_sub_C       
IPR016024   ARM-type_fold       
IPR012295   TBP_dom_sf       
IPR002327   Cyt_c_1A/1B       
IPR036909   Cyt_c-like_dom_sf       
IPR009056   Cyt_c-like_dom       

SUPFAM

SSF49348   SSF49348        + More
SSF48371   SSF48371       
SSF55711   SSF55711       
SSF46626   SSF46626       

Gene 3D

1.25.10.10     3.30.310.10     1.10.760.10    

ProteinModelPortal

H9J7H4   A0A2W1BXL5   A0A1E1WGS0   A0A2H1V2Z5   A0A194QTZ9   A0A194PM39   + More
A0A212EQQ2   A0A0L7LFU1   A0A1Y1KZK6   V5IA26   A0A034VTV9   N6TXW3   A0A1W4WTG7   W8BAQ1   A0A0K8VJ03   D6W7L4   A0A0A1XAN1   A0A0C9RDP5   A0A336KC15   A0A336M3M0   A0A1B6F6F6   A0A1I8QF67   A0A1A9YSF6   A0A1I8MJ14   A0A0L0CCN8   U5EX15   A0A182GJ46   A0A1B0FD53   A0A1A9V0X6   A0A1A9ZQQ7   Q17CP2   A0A151IK21   A0A3L8E6I8   A0A151I5J6   A0A158NWA4   F4WLP8   A0A195EC81   A0A2M4BCJ2   E2A8U3   A0A151JTU0   A0A232FFM4   B4G8A5   Q29N38   A0A182F4E2   W5J6P4   A0A182NE80   A0A2M4ACF8   A0A1A9WUR4   A0A1W4UQ49   A0A3B0K163   A0A0J7KSA5   A0A0M4E743   A0A182Y5R8   B4N0V9   A0A182RGH4   A0A182VV19   A0A182Q353   B4LTK9   A0A1Q3FAY3   A0A1Q3FAR8   B4ICW5   A0A1L8DVR8   A0A182MDW3   Q7QG73   A0A1B6DVE5   B3N7P9   B4Q635   P91926   A0A182JGX0   B3MUI1   B4P2D9   B0XEL0   A0A182JYE8   A0A1J1J1F9   B4KFJ2   A0A182P954   A0A088APJ2   B4JDP0   A0A0A9YVV3   A0A069DXV4   A0A0K8V223   A0A2A3EMD2   A0A0V0G7Q7   A0A023F5Q8   A0A182UBX7   A0A151X1G5   A0A0M9A3D5   A0A182VNP6   P91926-2   E8NH12   A0A084VPB0   A0A310SAK0   A0A182IE13   A0A2H8TLI9   A0A2S2PGU7   X1XNU7   A0A182T5A2   A0A0P4WDI2   T1IZY9   A0A0P5MQY6  

PDB

2XA7     E-value=0,     Score=2707

KEGG

101739513    K11824 AP-2 complex subunit alpha | (RefSeq) AP-2 complex subunit alpha

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0072583   GO:0006886   GO:0035615   GO:0030122   GO:0006897   GO:0005905   GO:0005737   GO:0048488   GO:0005886   GO:0015031   GO:0098793   GO:0008356   GO:0030100   GO:0045807   GO:0008104   GO:0010508   GO:1990386   GO:0008565   GO:0030707   GO:0048489   GO:0009055   GO:0046872   GO:0020037   GO:0016192   GO:0030131   GO:0030117   GO:0005488   GO:0016020   GO:0016742   GO:0003824  

Subcellular location

Cytoplasm  
Membrane  
Coated pit  
Cell membrane   Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.   With evidence from 2 publications.

Length:

929

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.35419

Exp number, first 60 AAs:

0.04975

Total prob of N-in:

0.01762

outside

1  -  929

 

 

Pi

5.349285

Theta

18.649393

Tajima's D

-2.04379

CLR

1462.922816

CSRT

0.0121993900304985

Interpretation

Uncertain