Gene

KWMTBOMO04541

Pre Gene Modal

BGIBMGA005465

Annotation

putative_Der1-like_domain_family?_member_2_[Danaus_plexippus]

Location

Bomo_Chr8(+):9419197-9423269      View in EpiBrowser

Full name

Derlin      

Location in the cell

PlasmaMembrane   Reliability : 4.792

CDS

ATGGCGTATCAAACCCTTCTCCAAGAGTATATGCTAATACCACCAGTCACCAGGGCTTACACCACAGCTTGTGTTGTCACAACTTTGGCTGTTCAACTTGATTTAGTATCACCTTTTCAACTATACTTCAATCCAAATTTGATACTGAGAAAATATCAACTATGGAGACTGTTAACAACATTCCTGTTCTTTGGAAACCTTGGGTTTAATTTCTTTTTCAATGTGATATTCACATATAGATATTGCAGAATGCTTGAAGAAGGCTCTTTCAGATCGAGAACAGCAGATTTTGTTGTCATGTTCATATTTGGAGGCTTATTAATGATTATATGTGCTTTCTTTGTTAATCTATTGTTTTTAGGGCAAGCGTTTACAATCATGATTGTGTATGTATGGTCACGCAGGAATGTTTTCGTGAGAATGAACTTCTTTGGATTAATGAACTTCCAGGCACCTTACCTCCCCTGGGTTCTGCTTGGTTTCTCAGTTCTGCTCGGCAATGCAATTTCAGTTGATCTAGTTGGAATGGCAATCGGTCACATTTACTTTTTCTTGGAGGATGTTCTACCGAGACAAAGGAATGGAGAAAGACTCTTGAAAACACCCAATTTTTTGAAAAAACTCTTTGATCCACGGCCAGAGGAACCTGAATATGTTCATCTTCCAGAATTGGATAATGTACGCCCAGGAGGCTACGAGTGGCGCCATCCATATCCCCGAGAGGAACAGAATGGTCAAGTGCAATAA

Protein

MAYQTLLQEYMLIPPVTRAYTTACVVTTLAVQLDLVSPFQLYFNPNLILRKYQLWRLLTTFLFFGNLGFNFFFNVIFTYRYCRMLEEGSFRSRTADFVVMFIFGGLLMIICAFFVNLLFLGQAFTIMIVYVWSRRNVFVRMNFFGLMNFQAPYLPWVLLGFSVLLGNAISVDLVGMAIGHIYFFLEDVLPRQRNGERLLKTPNFLKKLFDPRPEEPEYVHLPELDNVRPGGYEWRHPYPREEQNGQVQ

Description

May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.

Similarity

Belongs to the derlin family.

Uniprot

A0A212EQQ0   A0A2H1V1K8   S4PY45   I4DKZ2   A0A2J7PW01   A0A067RH38   + More
A0A0A9Z290   A0A087ZSH6   A0A310SSF7   A0A2A3EF40   A0A0V0G4K9   V9IMT8   A0A224XIT1   E2BF68   A0A3L8DNR0   A0A0P4VJJ3   R4G8D3   A0A026VWJ9   E9I8B3   A0A0L7RA47   A0A069DQL7   K7IS16   A0A158NJU4   A0A195CKD7   A0A195DV71   F4X4F6   A0A154PBH8   A0A1B0CIJ1   A0A151XDZ8   D6WY45   A2I451   A0A1L8DUU3   A0A023FA87   A0A023EQX5   A0A182QF78   Q28F56   J9JP53   J3JUU9   A0A1B6ENZ5   A0A1B6HYM1   V5GVP5   A0A3M6UJK9   U5EW22   A0A1S3DAD9   A0A182XXX3   V4B1D4   C3Z4B6   A0A182RMT9   A0A2H8TZ00   A0A182W5E2   A0A182N1J0   Q7Q4X4   A0A182HMN1   A0A0C9RXF8   A7RM47   A0A2S2PR81   A0A2P8Y910   T1JJJ7   A0A182JGD2   A0A1B6MPE4   A0A0B8RRY9   U3ETK6   A0A1W4XM33   F7GGU1   A0A2G8JC77   A0A2T7PD67   A0A1W7RHY5   A0A098M0N9   J3S490   T1DN97   A0A2D0QES7   A0A3L8S2Y6   A0A091RH09   A0A3B1JJ50   A0A3B4E1F3   A0A1U7U4H0   C1BMC0   G1PQ24   L5LDJ5   S7NN06   A0A218V261   H0Z1A2   A0A099ZMW5   A0A1V4K2S6   V9KNH3   A0A2K6G4L9   A0A3P4MH37   W5S0I3   B9ELQ7   A0A0D9RJX0   A0A3B3CHG2   A0A3S2U8U7   H9GLY8   A0A2K6DCG2   A0A2K5MLS4   H2MB52   A0A3P9JTD5   A0A3P8ZZX3   A0A1S3RK30   W5S1K7  

Pubmed

22118469    23622113    22651552    26354079    24845553    25401762    + More
26823975    20798317    30249741    27129103    24508170    21282665    26334808    20075255    21347285    21719571    18362917    19820115    25474469    24945155    20431018    22516182    23537049    30382153    25244985    23254933    18563158    12364791    14747013    17210077    17615350    29403074    25476704    23915248    17495919    29023486    26358130    23025625    23758969    25727380    30282656    25329095    21993624    20360741    24402279    24755649    24452024    20433749    29451363    21881562    17554307    25069045   

EMBL

AGBW02013261    OWR43807.1    ODYU01000234    SOQ34656.1    GAIX01003928    JAA88632.1    + More
AK401960    KQ459599    BAM18582.1    KPI94394.1    NEVH01020940    PNF20517.1    KK852473    KDR23092.1    GBHO01007674    GBRD01000268    GDHC01018876    JAG35930.1    JAG65553.1    JAP99752.1    KQ760974    OAD58583.1    KZ288280    PBC29631.1    GECL01003145    JAP02979.1    JR053353    AEY61914.1    GFTR01004039    JAW12387.1    GL447952    EFN85654.1    QOIP01000006    RLU21519.1    GDKW01001416    JAI55179.1    ACPB03000489    GAHY01001172    JAA76338.1    KK107681    EZA48102.1    GL761538    EFZ23157.1    KQ414619    KOC67735.1    GBGD01002689    JAC86200.1    ADTU01018383    KQ977634    KYN01173.1    KQ980304    KYN16746.1    GL888644    EGI58666.1    KQ434868    KZC09201.1    AJWK01013389    KQ982254    KYQ58592.1    KQ971362    EFA08946.1    EF070554    ABM55620.1    GFDF01003877    JAV10207.1    GBBI01000793    JAC17919.1    GAPW01002572    JAC11026.1    AXCN02001449    AAMC01010900    BC135880    CR762155    AAI35881.1    CAJ81565.1    ABLF02034680    APGK01036041    BT127014    KB740932    AEE61976.1    ENN77820.1    GECZ01030125    JAS39644.1    GECU01027944    JAS79762.1    GALX01004153    JAB64313.1    RCHS01001413    RMX53714.1    GANO01001628    JAB58243.1    KB199882    ESP04118.1    GG666578    EEN52729.1    GFXV01007699    MBW19504.1    AAAB01008963    EAA12044.3    APCN01004842    GBYB01013800    JAG83567.1    DS469519    EDO47541.1    GGMR01019361    MBY31980.1    PYGN01000803    PSN40624.1    JH431878    GEBQ01002204    JAT37773.1    GBSH01000845    JAG68180.1    GAEP01000453    GBEW01000284    JAB54368.1    JAI10081.1    MRZV01002612    PIK33342.1    PZQS01000004    PVD31363.1    GDAY02000662    JAV50763.1    GBSI01000707    JAC95789.1    JU174351    GBEX01000940    AFJ49877.1    JAI13620.1    GAAZ01000682    GBKC01000974    GBKD01000614    JAA97261.1    JAG45096.1    JAG47004.1    QUSF01000076    RLV95826.1    KK815970    KFQ38239.1    BT075749    ACO10173.1    AAPE02045492    AAPE02045493    KB113082    ELK24070.1    KE164426    EPQ17880.1    MUZQ01000070    OWK59851.1    ABQF01026134    KL896091    KGL83211.1    LSYS01005108    OPJ78762.1    JW867065    AFO99582.1    CYRY02011602    VCW79241.1    KC747865    FR904525    AHG98257.1    CDQ66008.1    BT056582    ACM08454.1    AQIB01138032    CM012448    RVE65566.1    AAWZ02026898    KC747864    FR904640    AHG98256.1    CDQ68747.1   

Proteomes

UP000007151    UP000053268    UP000235965    UP000027135    UP000005203    UP000242457    + More
UP000008237    UP000279307    UP000015103    UP000053097    UP000053825    UP000002358    UP000005205    UP000078542    UP000078492    UP000007755    UP000076502    UP000092461    UP000075809    UP000007266    UP000075886    UP000008143    UP000007819    UP000019118    UP000275408    UP000079169    UP000076408    UP000030746    UP000001554    UP000075900    UP000075920    UP000075884    UP000007062    UP000075840    UP000001593    UP000245037    UP000075880    UP000192223    UP000002280    UP000230750    UP000245119    UP000221080    UP000276834    UP000018467    UP000261440    UP000189704    UP000001074    UP000197619    UP000007754    UP000053641    UP000190648    UP000233160    UP000193380    UP000087266    UP000029965    UP000261560    UP000001646    UP000233120    UP000233060    UP000001038    UP000265180    UP000265200    UP000265140   

Pfam

PF04511   DER1

Interpro

IPR007599   DER1        + More
IPR035952   Rhomboid-like_sf       

Gene 3D

1.20.1540.10    

ProteinModelPortal

A0A212EQQ0   A0A2H1V1K8   S4PY45   I4DKZ2   A0A2J7PW01   A0A067RH38   + More
A0A0A9Z290   A0A087ZSH6   A0A310SSF7   A0A2A3EF40   A0A0V0G4K9   V9IMT8   A0A224XIT1   E2BF68   A0A3L8DNR0   A0A0P4VJJ3   R4G8D3   A0A026VWJ9   E9I8B3   A0A0L7RA47   A0A069DQL7   K7IS16   A0A158NJU4   A0A195CKD7   A0A195DV71   F4X4F6   A0A154PBH8   A0A1B0CIJ1   A0A151XDZ8   D6WY45   A2I451   A0A1L8DUU3   A0A023FA87   A0A023EQX5   A0A182QF78   Q28F56   J9JP53   J3JUU9   A0A1B6ENZ5   A0A1B6HYM1   V5GVP5   A0A3M6UJK9   U5EW22   A0A1S3DAD9   A0A182XXX3   V4B1D4   C3Z4B6   A0A182RMT9   A0A2H8TZ00   A0A182W5E2   A0A182N1J0   Q7Q4X4   A0A182HMN1   A0A0C9RXF8   A7RM47   A0A2S2PR81   A0A2P8Y910   T1JJJ7   A0A182JGD2   A0A1B6MPE4   A0A0B8RRY9   U3ETK6   A0A1W4XM33   F7GGU1   A0A2G8JC77   A0A2T7PD67   A0A1W7RHY5   A0A098M0N9   J3S490   T1DN97   A0A2D0QES7   A0A3L8S2Y6   A0A091RH09   A0A3B1JJ50   A0A3B4E1F3   A0A1U7U4H0   C1BMC0   G1PQ24   L5LDJ5   S7NN06   A0A218V261   H0Z1A2   A0A099ZMW5   A0A1V4K2S6   V9KNH3   A0A2K6G4L9   A0A3P4MH37   W5S0I3   B9ELQ7   A0A0D9RJX0   A0A3B3CHG2   A0A3S2U8U7   H9GLY8   A0A2K6DCG2   A0A2K5MLS4   H2MB52   A0A3P9JTD5   A0A3P8ZZX3   A0A1S3RK30   W5S1K7  

KEGG

101739234    K13989 Derlin-2/3 | (RefSeq) derlin-2

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0005789   GO:0016021   GO:0001967   GO:0030176   GO:0048500   GO:0008284   GO:0030968   GO:0005769   GO:0030970   GO:0005770   GO:0005785   GO:1904153   GO:0030433   GO:0030307  

Subcellular location

Endoplasmic reticulum membrane  

Length:

248

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

95.55198

Exp number, first 60 AAs:

21.18351

Total prob of N-in:

0.81011

POSSIBLE N-term signal

sequence

inside

1  -  56

TMhelix

57  -  79

outside

80  -  98

TMhelix

99  -  132

inside

133  -  152

TMhelix

153  -  175

outside

176  -  248

 

 

Pi

152.353501

Theta

154.597995

Tajima's D

-0.440116

CLR

157.165221

CSRT

0.258387080645968

Interpretation

Uncertain