Gene

KWMTBOMO04538  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005344

Annotation

PREDICTED:_cytoplasmic_phosphatidylinositol_transfer_protein_1_[Papilio_machaon]

Location

Bomo_Chr8(-):9394714-9398116      View in EpiBrowser

Full name

Cytoplasmic phosphatidylinositol transfer protein 1      

Alternative Name

Retinal degeneration B homolog beta
Mammalian rdgB homolog beta

Location in the cell

Cytoplasmic   Reliability : 2.029

CDS

ATGGTATTAACAAGAGAATACAGAATATGCATGCCTATGACTGTAGAAGAGTACCGTATTGGTCAATTATACATGATAGCAAGACACAGTTTTGAGCAATCTAGTAATGGTGAAGGTGTGGAGGTGATAGCAAATGAACAGGTGAATGATGAAAAAAATGGTATAGGACAGTTCACTGAGAAGAGAATCCATTTATCTAGTCATTTGCCTTATTGGGTCCAATCTATGATACCAAAAATATTTTATGTTACGGAAAAGGCATGGAATTTTTACCCATACACAATAACCGAATACACATGCTCATTCATACCGAAATTTTCCATCTCTATTCAAACAAGGTATGAAGATAATAATGGGACCACTGAAAATTGCCTTGGTTTCACCTCTGAAGAGTTAGAACAGCGAGAAGTAGACTTTATAGACATTGCATATGATGATATCAAATCACACCATTATAAAGAAGCTGAAGACCCTAAGTTTTTCAAATCAGAGAAAACCGGCCGCGGACCTCTAATTGAAGGGTGGAGGGACACATTCAAACCCATAATGTGTTGTTACAAAGCTGTTTCTATTAAGTTTGAAGTATGGGGCTTGCAAACCAGAGTTGAAGAGTATGTGCAGGGAGCAATTCGCGAAATTTTATTATTGGGACATCGTCAGGCATTTGCCTGGATGGATGACTGGTATAACATGAGTATAGAAGACGTAAGAGAATATGAACGCGAAATGCAAGCCAAGACGAATATAAAGTTGAAAACGACTTCTGAGAATGGTGAAGGGAAATCTGACGAGAGTGACGAGACGAAATCGAATTCTTCGAAACCACAGACTCCGAGAACTCCGAAATCGCCAAAGAGTCCAAGCAGTACTCCGACAGCAGAGGGACGAAGTTGGTTCAATTGGTCGTAA

Protein

MVLTREYRICMPMTVEEYRIGQLYMIARHSFEQSSNGEGVEVIANEQVNDEKNGIGQFTEKRIHLSSHLPYWVQSMIPKIFYVTEKAWNFYPYTITEYTCSFIPKFSISIQTRYEDNNGTTENCLGFTSEELEQREVDFIDIAYDDIKSHHYKEAEDPKFFKSEKTGRGPLIEGWRDTFKPIMCCYKAVSIKFEVWGLQTRVEEYVQGAIREILLLGHRQAFAWMDDWYNMSIEDVREYEREMQAKTNIKLKTTSENGEGKSDESDETKSNSSKPQTPRTPKSPKSPSSTPTAEGRSWFNWS

Description

Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity.
Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Isoform 2 specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development.

Similarity

Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.

Keywords

Complete proteome   Lipid transport   Lipid-binding   Reference proteome   Transport   Alternative splicing   Cytoplasm   Nucleus   Phosphoprotein  

Feature

chain  Cytoplasmic phosphatidylinositol transfer protein 1
splice variant  In isoform 4.

Uniprot

A0A2W1BZV5   A0A2A4IYV1   A0A2H1V1D9   A0A194QY14   A0A3S2M504   A0A212EQQ6   + More
H9J752   A0A1E1VY14   A0A0C9QHL5   E9I8B4   V9IFY7   A0A0J7NV44   A0A087ZP11   A0A026VXE8   E2BF69   A0A195BJ38   A0A195DV06   A0A195F4N3   A0A158NJU3   D6WY44   A0A3L8DNS6   A0A0L0BNY7   J3JWK5   A0A1B0D981   U4U0X8   A0A1S3D367   A0A310SMK7   A0A1Y1L4M8   A0A336LZK0   A0A151XE44   A0A067RMZ4   B3NML8   B4J8L5   A0A1B6KBC2   A0A195CL38   A0A2J7RDC4   B4MPN9   A0A1B6ISQ8   B4KMX4   J9JMS4   B4LNC4   A0A1W4XBN7   A0A0M4EDS6   A0A0F7VK74   A0A1B6GT25   A0A0M8ZXX1   A0A154NY03   A0A0J9RFI1   A0A336LXC2   D3TP06   B4HMZ1   A0A224XHE9   A0A1L8DYT7   Q28Z48   A0A0V0GBI8   A0A1B6C760   B4GIA4   A0A023F4V1   A0A2M3ZC66   A0A2M4AXX7   A0A0K8UW46   A0A069DQW1   A0A1W4VCL4   B4P554   B3MIE3   W5JDA8   Q16R16   T1PGZ5   Q9U9P7   A0A182NSG3   A0A1S4FS70   A0A182PTC3   A0A182XFC5   A0A226DBQ2   A0A3B0JQ37   A0A0A1X9P8   A0A023ELS9   A0A1I8PZW0   A0A182JTZ5   A0A0A9YYI6   A0A1Q3FDX7   L8BSU6   Q5TSY2   A0A0P6JH43   A0A1S2ZTG3   K9IVU7   A0A1S3PJB2   I3N7H0   A0A286XCN4   A0A1B0FHV0   A0A2Y9DH67   Q8K4R4-2   K9IX44   A0A3B3RWG1   G1QL61   A0A2J8V029   A0A3Q7RY60   M3VY39   A0A2Y9KR92   M3YTB3  

Pubmed

28756777    26354079    22118469    19121390    21282665    24508170    + More
20798317    21347285    18362917    19820115    30249741    26108605    22516182    23537049    28004739    24845553    17994087    22936249    20353571    15632085    25474469    26334808    17550304    20920257    23761445    17510324    25315136    10731132    12537572    10731138    25830018    24945155    25401762    12364791    14747013    17210077    21993624    12562526    16141072    19468303    15489334    15345747    21183079    29240929    17975172   

EMBL

KZ149904    PZC78390.1    NWSH01005209    PCG64350.1    ODYU01000234    SOQ34658.1    + More
KQ461154    KPJ08466.1    RSAL01000032    RVE51541.1    AGBW02013261    OWR43809.1    BABH01013837    GDQN01011475    GDQN01004953    JAT79579.1    JAT86101.1    GBYB01003019    JAG72786.1    GL761538    EFZ23142.1    JR045483    AEY59990.1    LBMM01001467    KMQ96265.1    KK107681    EZA48101.1    GL447952    EFN85655.1    KQ976465    KYM84349.1    KQ980304    KYN16745.1    KQ981820    KYN35346.1    ADTU01018383    KQ971362    EFA07896.1    QOIP01000006    RLU22100.1    JRES01001589    KNC21688.1    APGK01035766    BT127623    KB740928    AEE62585.1    ENN77950.1    AJVK01004273    AJVK01004274    KB631763    ERL85933.1    KQ762329    OAD55966.1    GEZM01064783    JAV68642.1    UFQT01000257    SSX22451.1    KQ982254    KYQ58590.1    KK852528    KDR21990.1    CH954179    EDV54957.1    CH916367    EDW01282.1    GEBQ01031237    JAT08740.1    KQ977634    KYN01172.1    NEVH01005291    PNF38837.1    CH963849    EDW74078.1    GECU01017769    JAS89937.1    CH933808    EDW09896.1    ABLF02034549    ABLF02034555    ABLF02034557    ABLF02045036    CH940648    EDW61076.1    CP012524    ALC41188.1    LN830736    CFW94245.1    GECZ01004266    JAS65503.1    KQ435798    KOX73370.1    KQ434781    KZC04497.1    CM002911    KMY94656.1    SSX22450.1    EZ423158    ADD19434.1    CH480816    EDW48341.1    GFTR01004511    JAW11915.1    GFDF01002488    JAV11596.1    CM000071    EAL25767.2    GECL01000782    JAP05342.1    GEDC01027996    GEDC01022797    JAS09302.1    JAS14501.1    CH479183    EDW36224.1    GBBI01002698    JAC16014.1    GGFM01005340    MBW26091.1    GGFK01012274    MBW45595.1    GDHF01021405    JAI30909.1    GBGD01002441    JAC86448.1    CM000158    EDW91755.1    CH902619    EDV36991.1    ADMH02001863    ETN60799.1    CH477726    EAT36858.1    KA648077    AFP62706.1    AE013599    AF160934    LNIX01000025    OXA42603.1    OUUW01000001    SPP73268.1    GBXI01006909    JAD07383.1    GAPW01003375    JAC10223.1    GBHO01032889    GBHO01032883    GBHO01005527    GBHO01005524    GBRD01017016    JAG10715.1    JAG10721.1    JAG38077.1    JAG38080.1    JAG48811.1    GFDL01009282    JAV25763.1    HF549287    CCO62048.1    AAAB01008898    EAL40545.4    GEBF01000357    JAO03276.1    GACC01000052    JAA53755.1    AGTP01052648    AGTP01052649    AGTP01052650    AGTP01052651    AGTP01052652    AGTP01052653    AGTP01052654    AGTP01052655    AGTP01052656    AGTP01052657    AAKN02045239    AAKN02045240    AAKN02045241    CCAG010015795    AB077281    AB077282    AK153625    AK171340    AL596116    AL645687    AL645905    BC108351    GABZ01007299    JAA46226.1    ADFV01091842    ADFV01091843    ADFV01091844    ADFV01091845    ADFV01091846    ADFV01091847    ADFV01091848    ADFV01091849    ADFV01091850    ADFV01091851    NDHI03003438    PNJ50874.1    AANG04004184    AEYP01025685    AEYP01025686    AEYP01025687    AEYP01025688    AEYP01025689    AEYP01025690    AEYP01025691    AEYP01025692    AEYP01025693    AEYP01025694   

Proteomes

UP000218220    UP000053240    UP000283053    UP000007151    UP000005204    UP000036403    + More
UP000005203    UP000053097    UP000008237    UP000078540    UP000078492    UP000078541    UP000005205    UP000007266    UP000279307    UP000037069    UP000019118    UP000092462    UP000030742    UP000079169    UP000075809    UP000027135    UP000008711    UP000001070    UP000078542    UP000235965    UP000007798    UP000009192    UP000007819    UP000008792    UP000192223    UP000092553    UP000053105    UP000076502    UP000001292    UP000001819    UP000008744    UP000192221    UP000002282    UP000007801    UP000000673    UP000008820    UP000095301    UP000000803    UP000075884    UP000075885    UP000076407    UP000198287    UP000268350    UP000095300    UP000075881    UP000007062    UP000079721    UP000087266    UP000005215    UP000005447    UP000092444    UP000248480    UP000000589    UP000261540    UP000001073    UP000286641    UP000011712    UP000248482    UP000000715   

PRIDE

H9J752    Q9U9P7    Q8K4R4   

Pfam

PF02121   IP_trans

Interpro

IPR001666   PI_transfer        + More
IPR023393   START-like_dom_sf       

Gene 3D

3.30.530.20    

ProteinModelPortal

A0A2W1BZV5   A0A2A4IYV1   A0A2H1V1D9   A0A194QY14   A0A3S2M504   A0A212EQQ6   + More
H9J752   A0A1E1VY14   A0A0C9QHL5   E9I8B4   V9IFY7   A0A0J7NV44   A0A087ZP11   A0A026VXE8   E2BF69   A0A195BJ38   A0A195DV06   A0A195F4N3   A0A158NJU3   D6WY44   A0A3L8DNS6   A0A0L0BNY7   J3JWK5   A0A1B0D981   U4U0X8   A0A1S3D367   A0A310SMK7   A0A1Y1L4M8   A0A336LZK0   A0A151XE44   A0A067RMZ4   B3NML8   B4J8L5   A0A1B6KBC2   A0A195CL38   A0A2J7RDC4   B4MPN9   A0A1B6ISQ8   B4KMX4   J9JMS4   B4LNC4   A0A1W4XBN7   A0A0M4EDS6   A0A0F7VK74   A0A1B6GT25   A0A0M8ZXX1   A0A154NY03   A0A0J9RFI1   A0A336LXC2   D3TP06   B4HMZ1   A0A224XHE9   A0A1L8DYT7   Q28Z48   A0A0V0GBI8   A0A1B6C760   B4GIA4   A0A023F4V1   A0A2M3ZC66   A0A2M4AXX7   A0A0K8UW46   A0A069DQW1   A0A1W4VCL4   B4P554   B3MIE3   W5JDA8   Q16R16   T1PGZ5   Q9U9P7   A0A182NSG3   A0A1S4FS70   A0A182PTC3   A0A182XFC5   A0A226DBQ2   A0A3B0JQ37   A0A0A1X9P8   A0A023ELS9   A0A1I8PZW0   A0A182JTZ5   A0A0A9YYI6   A0A1Q3FDX7   L8BSU6   Q5TSY2   A0A0P6JH43   A0A1S2ZTG3   K9IVU7   A0A1S3PJB2   I3N7H0   A0A286XCN4   A0A1B0FHV0   A0A2Y9DH67   Q8K4R4-2   K9IX44   A0A3B3RWG1   G1QL61   A0A2J8V029   A0A3Q7RY60   M3VY39   A0A2Y9KR92   M3YTB3  

PDB

1T27     E-value=2.63757e-45,     Score=457

KEGG

101738951    no KO assigned | (RefSeq) cytoplasmic phosphatidylinositol transfer protein 1

GO

GO:0005548   GO:0035091   GO:0005737   GO:0008526   GO:0016740   GO:0008289   GO:0007165   GO:0046488   GO:0005634   GO:0005622   GO:0006810   GO:0008033   GO:0008175   GO:0032259   GO:0006310   GO:0006418   GO:0009058   GO:0016742   GO:0003824   GO:0015914  

PANTHER

PTHR10658  

Subcellular location

Cytoplasm  
Nucleus  

Length:

302

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01998

Exp number, first 60 AAs:

0.00035

Total prob of N-in:

0.07297

outside

1  -  302

 

 

Pi

174.282872

Theta

189.187245

Tajima's D

-0.449118

CLR

23.980173

CSRT

0.253437328133593

Interpretation

Uncertain