Gene

KWMTBOMO04537

Pre Gene Modal

BGIBMGA005463

Annotation

PREDICTED:_enteropeptidase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr8(+):9381897-9389418      View in EpiBrowser

Full name

Enteropeptidase      

Alternative Name

Enterokinase
Serine protease 7
Transmembrane protease serine 15

Location in the cell

Extracellular   Reliability : 3.299

CDS

ATGTCGATACAGTCAGGCACCTTATCAAAAAACGTATCAGATAACGCCGATCGTAATAATTTTATAATGTATAAATTTTATGGTGCAAGTGTTAAAACTAGCGTAGTGCTGATTGTATTGTTTACTAAGTTGTGTGGTTTGACAGAATGTCGACGGGTTAAGAGAGTTGTTAACGGAAATGAAGTTCGATGCGGTACCGAACCTCGTGTGGGCTCCTTACATAGGAGAGACACACAGGAACATCTTTGTGGGGCAGTGGTTCTTTCTCGGAATTTCGCCATAACAGCAGCGCATTGTGTACATCTATCTGAAGACAATTATGTTCTCCAGCTTAATAATTACTGTATCAGAGATGGTGAAACTAGGCCAATAGCTAAAATTACGCAAATTATAACAAATGATCTGTATGATAGGGCATCAAAAGCGCACGACATTGCTTTGTTGAGAATTACACTAGATTTGAATGACGCGAACTCTGAATGGCTTAATGAATCAGTGCTGCCGAGCTCCTCATTTGGTGTGTCAGGTGAATGTACTATTTACGGCTACGGTTACAAGGATGTTAACACAATGAAGACATCGGATGTGTTGTCATCCGGTGAAGTTATAATAATTTCGCTGGACGAATGTACACAAAAATTGGGACCGTTCGTAGCGCCACAACCAGACAGCGGAATGATGTGCGCTATTGGTTATGGAGTAGATGCTTGTCAGGGTGATTCGGGTAGTCCCTTGATATGCGAAGGTTTAATACAAGGCATCAGTAGCTACGGAATGAGCTGCGGTGTATCGAATCTTCCCGGAATATACACCAGCATAGGTGCTCACCTGGACTTCATACAAAACGCAATTCAAACACAGAACCAAATAAAAACCAATGCTTCTGCGAATATTGAATAA

Protein

MSIQSGTLSKNVSDNADRNNFIMYKFYGASVKTSVVLIVLFTKLCGLTECRRVKRVVNGNEVRCGTEPRVGSLHRRDTQEHLCGAVVLSRNFAITAAHCVHLSEDNYVLQLNNYCIRDGETRPIAKITQIITNDLYDRASKAHDIALLRITLDLNDANSEWLNESVLPSSSFGVSGECTIYGYGYKDVNTMKTSDVLSSGEVIIISLDECTQKLGPFVAPQPDSGMMCAIGYGVDACQGDSGSPLICEGLIQGISSYGMSCGVSNLPGIYTSIGAHLDFIQNAIQTQNQIKTNASANIE

Description

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity).

Catalytic Activity

Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.

Subunit

Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.

Similarity

Belongs to the peptidase S1 family.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Membrane   Protease   Reference proteome   Repeat   Serine protease   Signal-anchor   Transmembrane   Transmembrane helix   Zymogen  

Feature

chain  Enteropeptidase non-catalytic heavy chain

Uniprot

A0A2W1BZT5   A0A2A4IX92   A0A2H1V1D1   A0A194QTZ4   A0A194PM44   E9GB32   + More
A0A0P5F3R6   A0A0P4XVX6   A0A0P6I447   A0A3B3C1C2   A0A0P6CUK1   A0A0P6GIJ8   A0A0P5DIE6   A0A146UZ51   A0A3B3C1X5   A0A3B4AC48   A0A0N8DHB8   E9Q6Y6   P97435   H3DEU3   A0A146UXL9   A0A1L8FLU3   A0A146UXA2   A0A3Q2Q818   A0A146UXJ5   A0A2M3ZE40   A0A3B5LVW8   A0A146UXG2   A0A1A8AXS9   A0A3Q1FHB2   A0A3B4AC44   A0A1A8S8U1   A0A3Q3X1C1   A0A1W4ZC14   M4A4V5   Q8CAN9   H3D589   A0A182FII0   A0A3B4AAH6   A0A2M4BVE0   A0A3Q3M963   A0A2M3Z7J6   R0JV69   A0A3S2P3L8   A0A3P9P1R4   A0A3S2MRB3   A0A3B5LQZ5   A0A3Q1CVP0   A0A3B3BF20   A0A3P8SG71   A0A3Q3MTZ1   A0A2M4BV71   U5EQV5   A0A3B3BG67   A0A3B3IM09   A0A3P9JRW9   A4UWM5   A0A3P9JR68   A4UWM6   A0A3P9KGZ9   A0A3B4UG61   A0A3P9HXI9   A0A1U8BJU8   A0A3B4WG00   I3JYM8   A0A3B5BL60   A0A3Q3CW68   A0A3B3XES2   A0A3Q0RDT6   A0A2U9B4D3   A0A3P9M9M9   A0A0P5ZIR4   A0A3P9KWP6   A0A3Q0SR17   A0A099ZE42   R4QR01   W5JKI4   A0A3B4BRU8   A0A3B3TT46   A0A3B4WN70   E6Y432   A0A3P9AGM1   Q6B4R4   W5Q241   A0A2U9B712   A0A146Y9Y3   A0A3Q3IQH3   A0A147AUU9   A0A1S3KCW5   G3NFA1   A0A3B4GGL4   A0A3Q2ZWF1   A0A060XBB7   A0A3P9BHV1   A0A3Q4N5U5   A0A146YBK3   A0A1S3NSU4  

EC Number

3.4.21.9

Pubmed

28756777    26354079    21292972    29451363    25463417    19468303    + More
9486188    15489334    15496914    27762356    23542700    10349636    11042159    11076861    11217851    12466851    16141073    17554307    17438297    24481630    25186727    24679250    20920257    23761445    25069045    17703946    20809919    24755649   

EMBL

KZ149904    PZC78370.1    NWSH01005209    PCG64351.1    ODYU01000234    SOQ34660.1    + More
KQ461154    KPJ08465.1    KQ459599    KPI94397.1    GL732537    EFX83438.1    GDIP01151859    JAJ71543.1    GDIP01237251    JAI86150.1    GDIQ01026413    JAN68324.1    GDIP01078763    GDIQ01090111    JAM24952.1    JAN04626.1    GDIQ01034232    JAN60505.1    GDIP01156858    JAJ66544.1    GCES01076476    JAR09847.1    GDIP01033703    JAM70012.1    AC112257    AC161815    U73378    BC117917    BC117918    GCES01076472    JAR09851.1    CM004478    OCT72566.1    GCES01076473    JAR09850.1    GCES01076470    JAR09853.1    GGFM01006055    MBW26806.1    GCES01076471    JAR09852.1    HADY01021497    SBP59982.1    HAEH01022436    SBS13959.1    AK038356    BAC29973.1    GGFJ01007842    MBW56983.1    GGFM01003733    MBW24484.1    KB743121    EOB01127.1    CM012450    RVE63431.1    CM012449    RVE64986.1    GGFJ01007826    MBW56967.1    GANO01004076    JAB55795.1    AB272104    BAF57203.1    AB272105    BAF57204.1    AERX01036422    CP026245    AWO98823.1    GDIP01042976    JAM60739.1    KL893329    KGL80679.1    KC756844    AGL73301.1    ADMH02001179    ETN63823.1    EU375507    ACB10253.1    AY682203    AAT84164.1    AMGL01006515    AMGL01006516    AMGL01006517    AMGL01006518    AMGL01006519    AMGL01006520    AMGL01006521    AMGL01006522    CP026246    AWO99724.1    GCES01035362    JAR50961.1    GCES01004398    JAR81925.1    FR905186    CDQ76928.1    GCES01035358    JAR50965.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000000305    UP000261560    UP000261520    + More
UP000000589    UP000007303    UP000186698    UP000265000    UP000261380    UP000257200    UP000261620    UP000192224    UP000002852    UP000069272    UP000261640    UP000242638    UP000257160    UP000265080    UP000001038    UP000265200    UP000265180    UP000261420    UP000189706    UP000261360    UP000005207    UP000261400    UP000264840    UP000261480    UP000261340    UP000246464    UP000053641    UP000000673    UP000261440    UP000261500    UP000265140    UP000002356    UP000261600    UP000085678    UP000007635    UP000261460    UP000264800    UP000193380    UP000265160    UP000261580    UP000087266   

PRIDE

E9Q6Y6    P97435   

Pfam

PF00089   Trypsin        + More
PF15494   SRCR_2
PF01390   SEA
PF00629   MAM
PF00530   SRCR
PF00431   CUB
PF00057   Ldl_recept_a
PF09272   Hepsin-SRCR
PF00651   BTB
PF00096   zf-C2H2

Interpro

IPR033116   TRYPSIN_SER        + More
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR001190   SRCR       
IPR036772   SRCR-like_dom_sf       
IPR017448   SRCR-like_dom       
IPR002172   LDrepeatLR_classA_rpt       
IPR000859   CUB_dom       
IPR035914   Sperma_CUB_dom_sf       
IPR036055   LDL_receptor-like_sf       
IPR013320   ConA-like_dom_sf       
IPR036364   SEA_dom_sf       
IPR000082   SEA_dom       
IPR011163   Pept_S1A_enterop       
IPR000998   MAM_dom       
IPR023415   LDLR_class-A_CS       
IPR012224   Pept_S1A_FX       
IPR015352   Hepsin-SRCR_dom       
IPR017949   Thaumatin_CS       
IPR011333   SKP1/BTB/POZ_sf       
IPR036236   Znf_C2H2_sf       
IPR000210   BTB/POZ_dom       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF50494   SSF50494        + More
SSF56487   SSF56487       
SSF82671   SSF82671       
SSF57424   SSF57424       
SSF49899   SSF49899       
SSF49854   SSF49854       
SSF57667   SSF57667       
SSF54695   SSF54695       

Gene 3D

3.10.250.10     2.60.120.290     3.30.70.960     4.10.400.10    

CDD

cd00190  Tryp_SPc
cd00041  CUB
cd00112  LDLa
cd06263  MAM

ProteinModelPortal

A0A2W1BZT5   A0A2A4IX92   A0A2H1V1D1   A0A194QTZ4   A0A194PM44   E9GB32   + More
A0A0P5F3R6   A0A0P4XVX6   A0A0P6I447   A0A3B3C1C2   A0A0P6CUK1   A0A0P6GIJ8   A0A0P5DIE6   A0A146UZ51   A0A3B3C1X5   A0A3B4AC48   A0A0N8DHB8   E9Q6Y6   P97435   H3DEU3   A0A146UXL9   A0A1L8FLU3   A0A146UXA2   A0A3Q2Q818   A0A146UXJ5   A0A2M3ZE40   A0A3B5LVW8   A0A146UXG2   A0A1A8AXS9   A0A3Q1FHB2   A0A3B4AC44   A0A1A8S8U1   A0A3Q3X1C1   A0A1W4ZC14   M4A4V5   Q8CAN9   H3D589   A0A182FII0   A0A3B4AAH6   A0A2M4BVE0   A0A3Q3M963   A0A2M3Z7J6   R0JV69   A0A3S2P3L8   A0A3P9P1R4   A0A3S2MRB3   A0A3B5LQZ5   A0A3Q1CVP0   A0A3B3BF20   A0A3P8SG71   A0A3Q3MTZ1   A0A2M4BV71   U5EQV5   A0A3B3BG67   A0A3B3IM09   A0A3P9JRW9   A4UWM5   A0A3P9JR68   A4UWM6   A0A3P9KGZ9   A0A3B4UG61   A0A3P9HXI9   A0A1U8BJU8   A0A3B4WG00   I3JYM8   A0A3B5BL60   A0A3Q3CW68   A0A3B3XES2   A0A3Q0RDT6   A0A2U9B4D3   A0A3P9M9M9   A0A0P5ZIR4   A0A3P9KWP6   A0A3Q0SR17   A0A099ZE42   R4QR01   W5JKI4   A0A3B4BRU8   A0A3B3TT46   A0A3B4WN70   E6Y432   A0A3P9AGM1   Q6B4R4   W5Q241   A0A2U9B712   A0A146Y9Y3   A0A3Q3IQH3   A0A147AUU9   A0A1S3KCW5   G3NFA1   A0A3B4GGL4   A0A3Q2ZWF1   A0A060XBB7   A0A3P9BHV1   A0A3Q4N5U5   A0A146YBK3   A0A1S3NSU4  

PDB

3W94     E-value=3.11117e-26,     Score=293

KEGG

101738361    no KO assigned | (RefSeq) enteropeptidase

GO

GO:0004252   GO:0016021   GO:0008236   GO:0005044   GO:0016020   GO:0070008   GO:0007596   GO:0005509   GO:0003676   GO:0016301   GO:0006508   GO:0008033   GO:0008175   GO:0032259   GO:0006310   GO:0006418   GO:0009058   GO:0016742   GO:0003824  

Subcellular location

Membrane  

Length:

299

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.99718

Exp number, first 60 AAs:

14.92727

Total prob of N-in:

0.53780

POSSIBLE N-term signal

sequence

outside

1  -  299

 

 

Pi

234.552375

Theta

172.518847

Tajima's D

1.313062

CLR

0.163161

CSRT

0.753212339383031

Interpretation

Uncertain