Gene

KWMTBOMO04508  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005451

Annotation

BET1-like_protein_[Bombyx_mori]

Location

Bomo_Chr8(+):8326408-8327072      View in EpiBrowser

Full name

Adenylate kinase      

Alternative Name

ATP-AMP transphosphorylase
ATP:AMP phosphotransferase
Adenylate kinase cytosolic and mitochondrial
Adenylate monophosphate kinase

Location in the cell

Cytoplasmic   Reliability : 1.532

CDS

ATGAGGCGAGCCCGCGAAGGCTACCACTATCAGCCAGTGCCCAGAGTAGCTACGGAAGATACTATCGAAAATGAAAATGAACGAATGGCTGAAGAACTCAGTGGCAAGATATCTTCACTTAAATACATTTCCATTGAGTTAGGCAATGAAGTAAGGGACCAAGAAAAACTTTTGCGTGGATTAGATGATGATGTTGACAGAAGCTCAGGTTTCCTTGGAAAAACCATGGGAAGAGTTTTAAGGCTTGGCAAAGGGAACCACAACTATTATATTTTCTATCTATTCCTCTTCTCCATTTTTGTGTTCTTTTTGTTGTATATTATTTTAAAATTTAGATGA

Protein

MRRAREGYHYQPVPRVATEDTIENENERMAEELSGKISSLKYISIELGNEVRDQEKLLRGLDDDVDRSSGFLGKTMGRVLRLGKGNHNYYIFYLFLFSIFVFFLLYIILKFR

Description

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.

Catalytic Activity

AMP + ATP = 2 ADP

Subunit

Monomer.

Similarity

Belongs to the adenylate kinase family. AK2 subfamily.

Uniprot

Q1HQ33   I4DJS2   A0A2H1VQR1   A0A0L7LUA2   A0A194RC87   A0A212EI83   + More
D6X1L1   A0A1Y1N2J4   A0A2P8Z095   A0A0K8TNP3   E2BC20   A0A026VXK5   A0A151IQI7   A0A1Q3FDN7   A0A088ALI2   A0A2A3EA78   A0A154P2U4   A0A151ILZ6   A0A1B6KK99   A0A1B6GGZ1   A0A1B6HZV2   A0A1B6KR69   A0A1B6FH72   B0WTL9   E9JAW9   A0A0L7QMK1   A0A1I8NT41   A0A1B6JPK0   E2ALV2   U4U0L8   J3JWV7   A0A1Q3FD71   A0A2J7QFJ2   A0A0J7KR19   A0A0P4VUN7   R4G501   A0A151J7Q5   A0A158N934   A0A151X4Z9   F4WHG8   A0A2R7WYH8   W8CD23   A0A1B6CVQ8   A0A195FVN2   A0A1B6EFK4   T1GGW8   A0A067QNJ5   A0A195BTV2   K7J8L2   E0W482   A0A0C9QCI1   U5EW94   A0A182PBQ0   A0A182Y1U5   A0A182S8U1   A0A182VIJ9   A0A182UCI7   A0A182KSQ2   A0A182XD81   Q7Q060   A0A182HQ13   A0A1S3DT01   W5JNI7   A0A2L2Y9M6   A0A232ESH4   A0A084WHY3   A0A182JCK2   A0A1J1IT26   E2AEK4   A0A182M098   A0A182W977   A0A1L8DA37   A0A182QCC7   A0A182JNZ0   A0A182R5F7   A0A182MYI4   A0A1D2M4R4   A0A182FU43   A0A2M4C3T8   A0A336MV24   T1E7B0   A0A2M3ZAQ1   A0A1W4UQW1   A0A0M8ZYK6   A0A2L2Y960   A0A1L8E8Q1   T1IH28   A0A1L8ED46   A0A226DKQ0   A0A1A9Y0X2   B4ITM7   B4IG08   B4QQE0   B3NDY6   A0A087TV38   A0A0A9X851   A0A1I8ML06  

EC Number

2.7.4.3

Pubmed

19121390    22651552    26354079    26227816    22118469    18362917    + More
19820115    28004739    29403074    26369729    20798317    24508170    30249741    21282665    23537049    22516182    27129103    21347285    21719571    24495485    24845553    20075255    20566863    25244985    20966253    12364791    14747013    17210077    20920257    23761445    26561354    28648823    24438588    27289101    17994087    17550304    22936249    25401762    26823975    25315136   

EMBL

BABH01013773    DQ443219    ABF51308.1    AK401540    KQ459599    BAM18162.1    + More
KPI94474.1    ODYU01003876    SOQ43181.1    JTDY01000068    KOB79058.1    KQ460397    KPJ15217.1    AGBW02014681    OWR41196.1    KQ971370    EFA09340.1    GEZM01014307    JAV92143.1    PYGN01000257    PSN49925.1    GDAI01001845    JAI15758.1    GL447247    EFN86745.1    KK107638    QOIP01000004    EZA48405.1    RLU23692.1    KQ976785    KYN08303.1    GFDL01009368    JAV25677.1    KZ288324    PBC28086.1    KQ434807    KZC06152.1    KQ977085    KYN05915.1    GEBQ01028106    JAT11871.1    GECZ01008206    JAS61563.1    GECU01027514    GECU01006052    JAS80192.1    JAT01655.1    GEBQ01026025    JAT13952.1    GECZ01020207    JAS49562.1    DS232089    EDS34472.1    GL770679    EFZ10062.1    KQ414889    KOC59842.1    GECU01006520    JAT01187.1    GL440652    EFN65586.1    KB631843    ERL86632.1    APGK01044296    BT127725    KB741022    AEE62687.1    ENN74998.1    GFDL01009572    JAV25473.1    NEVH01015297    PNF27354.1    LBMM01004075    KMQ92827.1    GDKW01000177    JAI56418.1    ACPB03010353    GAHY01000925    JAA76585.1    KQ979640    KYN20048.1    ADTU01009059    KQ982543    KYQ55359.1    GL888161    EGI66322.1    KK856000    PTY24589.1    GAMC01002696    GAMC01002694    JAC03860.1    GEDC01019669    JAS17629.1    KQ981268    KYN43919.1    GEDC01000628    JAS36670.1    CAQQ02178081    KK853197    KDR09963.1    KQ976405    KYM91864.1    AAZX01007490    DS235886    EEB20438.1    GBYB01001009    JAG70776.1    GANO01000666    JAB59205.1    AAAB01008986    EAA00304.2    APCN01003288    ADMH02001044    ETN64339.1    IAAA01012538    IAAA01012539    LAA04697.1    NNAY01002421    OXU21310.1    ATLV01023896    KE525347    KFB49827.1    AXCP01006759    CVRI01000056    CRL01657.1    GL438870    EFN68127.1    AXCM01002401    GFDF01010900    JAV03184.1    AXCN02001041    LJIJ01004309    ODM87968.1    GGFJ01010794    MBW59935.1    UFQT01001890    SSX32097.1    GAMD01003197    JAA98393.1    GGFM01004820    MBW25571.1    KQ435794    KOX73740.1    IAAA01012537    LAA04688.1    GFDG01003755    JAV15044.1    JH429682    GFDG01002148    JAV16651.1    LNIX01000017    OXA45700.1    CM000159    CH891721    EDW95351.1    EDW99740.1    CH480834    EDW46595.1    CM000363    CM002912    EDX11046.1    KMZ00509.1    CH954178    EDV52340.1    KK116875    KFM68977.1    GBHO01027783    GBRD01000468    GDHC01008544    JAG15821.1    JAG65353.1    JAQ10085.1   

Proteomes

UP000005204    UP000053268    UP000037510    UP000053240    UP000007151    UP000007266    + More
UP000245037    UP000008237    UP000053097    UP000279307    UP000078542    UP000005203    UP000242457    UP000076502    UP000002320    UP000053825    UP000095300    UP000000311    UP000030742    UP000019118    UP000235965    UP000036403    UP000015103    UP000078492    UP000005205    UP000075809    UP000007755    UP000078541    UP000015102    UP000027135    UP000078540    UP000002358    UP000009046    UP000075885    UP000076408    UP000075901    UP000075903    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000079169    UP000000673    UP000215335    UP000030765    UP000075880    UP000183832    UP000075883    UP000075920    UP000075886    UP000075881    UP000075900    UP000075884    UP000094527    UP000069272    UP000192221    UP000053105    UP000198287    UP000092443    UP000002282    UP000001292    UP000000304    UP000008711    UP000054359    UP000095301   

PRIDE

Q1HQ33   

Pfam

PF03908   Sec20        + More
PF05191   ADK_lid
PF12796   Ank_2
PF12075   KN_motif
PF05739   SNARE

Interpro

IPR039897   BET1        + More
IPR039899   BET1_SNARE       
IPR000727   T_SNARE_dom       
IPR005606   Sec20       
IPR027417   P-loop_NTPase       
IPR033690   Adenylat_kinase_CS       
IPR007862   Adenylate_kinase_lid-dom       
IPR000850   Adenylat/UMP-CMP_kin       
IPR006259   Adenyl_kin_sub       
IPR028587   AK2       
IPR020683   Ankyrin_rpt-contain_dom       
IPR021939   KN_motif       
IPR036770   Ankyrin_rpt-contain_sf       
IPR002110   Ankyrin_rpt       

SUPFAM

SSF52540   SSF52540        + More
SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd15853  SNARE_Bet1
cd01428  ADK
cd00204  ANK

ProteinModelPortal

Q1HQ33   I4DJS2   A0A2H1VQR1   A0A0L7LUA2   A0A194RC87   A0A212EI83   + More
D6X1L1   A0A1Y1N2J4   A0A2P8Z095   A0A0K8TNP3   E2BC20   A0A026VXK5   A0A151IQI7   A0A1Q3FDN7   A0A088ALI2   A0A2A3EA78   A0A154P2U4   A0A151ILZ6   A0A1B6KK99   A0A1B6GGZ1   A0A1B6HZV2   A0A1B6KR69   A0A1B6FH72   B0WTL9   E9JAW9   A0A0L7QMK1   A0A1I8NT41   A0A1B6JPK0   E2ALV2   U4U0L8   J3JWV7   A0A1Q3FD71   A0A2J7QFJ2   A0A0J7KR19   A0A0P4VUN7   R4G501   A0A151J7Q5   A0A158N934   A0A151X4Z9   F4WHG8   A0A2R7WYH8   W8CD23   A0A1B6CVQ8   A0A195FVN2   A0A1B6EFK4   T1GGW8   A0A067QNJ5   A0A195BTV2   K7J8L2   E0W482   A0A0C9QCI1   U5EW94   A0A182PBQ0   A0A182Y1U5   A0A182S8U1   A0A182VIJ9   A0A182UCI7   A0A182KSQ2   A0A182XD81   Q7Q060   A0A182HQ13   A0A1S3DT01   W5JNI7   A0A2L2Y9M6   A0A232ESH4   A0A084WHY3   A0A182JCK2   A0A1J1IT26   E2AEK4   A0A182M098   A0A182W977   A0A1L8DA37   A0A182QCC7   A0A182JNZ0   A0A182R5F7   A0A182MYI4   A0A1D2M4R4   A0A182FU43   A0A2M4C3T8   A0A336MV24   T1E7B0   A0A2M3ZAQ1   A0A1W4UQW1   A0A0M8ZYK6   A0A2L2Y960   A0A1L8E8Q1   T1IH28   A0A1L8ED46   A0A226DKQ0   A0A1A9Y0X2   B4ITM7   B4IG08   B4QQE0   B3NDY6   A0A087TV38   A0A0A9X851   A0A1I8ML06  

KEGG

732930    K08504 blocked early in transport 1 | (RefSeq) BET1-like protein

PATHWAY

04130    SNARE interactions in vesicular transport - Bombyx mori (domestic silkworm)

GO

GO:0015031   GO:0030173   GO:0031201   GO:0006888   GO:0005484   GO:0000138   GO:0048280   GO:0016021   GO:0004017   GO:0005829   GO:0005758   GO:0046033   GO:0046034   GO:0006172   GO:0005524   GO:0005515   GO:0046872   GO:0006281   GO:0016887   GO:0030870   GO:0006310   GO:0006418   GO:0009058   GO:0016742   GO:0003824  

PANTHER

PTHR12791   PTHR23359  

Subcellular location

Cytoplasm   Predominantly mitochondrial.   With evidence from 1 publications.
Cytosol   Predominantly mitochondrial.   With evidence from 1 publications.
Mitochondrion intermembrane space   Predominantly mitochondrial.   With evidence from 1 publications.

Length:

112

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.35259

Exp number, first 60 AAs:

0

Total prob of N-in:

0.90587

inside

1  -  86

TMhelix

87  -  109

outside

110  -  112

 

 

Pi

78.060326

Theta

136.118406

Tajima's D

-1.122508

CLR

314.01962

CSRT

0.115144242787861

Interpretation

Uncertain