Pre Gene Modal
BGIBMGA005449
Annotation
PREDICTED:_DNA_repair_protein_RAD50_[Bombyx_mori]
Full name
DNA repair protein RAD50
Location in the cell
Nuclear Reliability : 2.42
Sequence
CDS
ATGGCGGGAGTGAAATCGCTAGCAATTAGAGGAATAAGAAGTTTTGGACCTGAAGATACCGACGAACAACGCATACTATTTGATTCTCCATTAACGCTGATATTAGGGCAAAATGGATGTGGTAAAACAACAATAATTGAATGCTTAAGATATGCAATCACTGGTCAAATGCCGCCTGGTAGCAGGAACGAATGCTTTGTTCATGATGCAAAAGTGAATAGATCAACAGAAGTACTCGGTCAAGTGAAATTAAAGATTGTCAATGCAAAAGACAAACAGTTGGAGGTGACAAGGTCCATGAAGGTGACTGCCTTAGCCAAGAAAAAGACAAAATTTCAAACCCTGGATTCTTTTCTTTCTACTGTTGATGAAAGTGGCAAAACAAAAGATGTATCTTCAAGATGTGCCGATTTGGACATCCTTATGCATGAGGAACTTGGTAACTTAATTTGA
Protein
MAGVKSLAIRGIRSFGPEDTDEQRILFDSPLTLILGQNGCGKTTIIECLRYAITGQMPPGSRNECFVHDAKVNRSTEVLGQVKLKIVNAKDKQLEVTRSMKVTALAKKKTKFQTLDSFLSTVDESGKTKDVSSRCADLDILMHEELGNLI
Summary
Description
Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair. The complex participates in processes such as DNA recombination, DNA repair, genome stability, telomere integrity and meiosis. The MRN complex may protect telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.
Cofactor
Zn(2+)
Subunit
Homodimer. Probable component of the MRN complex with mre11 (By similarity).
Similarity
Belongs to the SMC family. RAD50 subfamily.
Keywords
ATP-binding
Cell cycle
Chromosome
Coiled coil
Complete proteome
DNA damage
DNA repair
Hydrolase
Meiosis
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Telomere
Zinc
Feature
chain DNA repair protein RAD50
Uniprot
H9J7F7
A0A194PM06
A0A194RCL8
A0A212EI90
A0A0L7L401
A0A2H1WCA4
+ More
A0A2A4J953 A0A067QZL2 A0A2Z5TRB2 A0A1I8P2K6 A0A2G8K5A8 A0A0L0CTW8 W8C472 A0A1A9V356 Q16P37 A0A1S4FUA6 A0A1A9XPD1 A0A1A9ZMN3 A0A1B6G5L2 A0A1B0FGD5 A0A1B0AQ80 A0A034WIL6 A0A1B6F1S1 A0A1I8NB16 A0A182SI89 A0A0A1WNN8 A0A1B6HTP2 A0A1B6KQF5 A0A0K8UNW1 A0A0K8VRS2 W4ZC48 A0A2H9THX1 A0A1A9WRR6 V4B2A7 A0A182G7F0 A0A1Y2AJL4 B0WAP9 K1Q388 A0A182NCI9 G2HJK8 A0A2T7PNK7 A0A1Q3F5U9 B4P7X9 A0A0B4K7L0 B3NNP5 A0A0M4E973 Q9W252 C3YWA5 B4QH58 B4I847 A0A0J9U8E7 D0Z764 A0A182QKZ8 A0A1B0F0N7 A0A0L0T2N0 A0A0L0TEH7 A0A182P3Y5 A0A182RRS7 A0A2C9JC49 A0A1D8NEN8 Q6C910 B4MFQ7 A0A371C8H3 H2ZIL2 A0A182LRK9 D7G250 H2ZIL4 A0A1W4VQG8 H2ZIL3 A0A182YG56 B3RF61 T1JCH0 W5JH02 A0A1S8W2B9 A0A1S8W2B7 A0A139AR39 A0A183AY88 A0A3P9ALK0 L8GZV8 A0A084VEJ8 A0A091PG72 F1NEG1 A0A2T9ZBI4 A0A182KAQ4 A0A2K6QKM9 A0A2I2YPC0 A0A2K6AGU6 A0A2R9A7T5 A0A2I3SC89 E7ESD9 A0A2K6L6A8 A0A2K6CKI5 A0A2K5WF16 A0A096N4P1 A0A182KXV5 A0A2I3GPQ4 G4MSF1 A0A224X5C5 Q7QAJ3
A0A2A4J953 A0A067QZL2 A0A2Z5TRB2 A0A1I8P2K6 A0A2G8K5A8 A0A0L0CTW8 W8C472 A0A1A9V356 Q16P37 A0A1S4FUA6 A0A1A9XPD1 A0A1A9ZMN3 A0A1B6G5L2 A0A1B0FGD5 A0A1B0AQ80 A0A034WIL6 A0A1B6F1S1 A0A1I8NB16 A0A182SI89 A0A0A1WNN8 A0A1B6HTP2 A0A1B6KQF5 A0A0K8UNW1 A0A0K8VRS2 W4ZC48 A0A2H9THX1 A0A1A9WRR6 V4B2A7 A0A182G7F0 A0A1Y2AJL4 B0WAP9 K1Q388 A0A182NCI9 G2HJK8 A0A2T7PNK7 A0A1Q3F5U9 B4P7X9 A0A0B4K7L0 B3NNP5 A0A0M4E973 Q9W252 C3YWA5 B4QH58 B4I847 A0A0J9U8E7 D0Z764 A0A182QKZ8 A0A1B0F0N7 A0A0L0T2N0 A0A0L0TEH7 A0A182P3Y5 A0A182RRS7 A0A2C9JC49 A0A1D8NEN8 Q6C910 B4MFQ7 A0A371C8H3 H2ZIL2 A0A182LRK9 D7G250 H2ZIL4 A0A1W4VQG8 H2ZIL3 A0A182YG56 B3RF61 T1JCH0 W5JH02 A0A1S8W2B9 A0A1S8W2B7 A0A139AR39 A0A183AY88 A0A3P9ALK0 L8GZV8 A0A084VEJ8 A0A091PG72 F1NEG1 A0A2T9ZBI4 A0A182KAQ4 A0A2K6QKM9 A0A2I2YPC0 A0A2K6AGU6 A0A2R9A7T5 A0A2I3SC89 E7ESD9 A0A2K6L6A8 A0A2K6CKI5 A0A2K5WF16 A0A096N4P1 A0A182KXV5 A0A2I3GPQ4 G4MSF1 A0A224X5C5 Q7QAJ3
EC Number
3.6.-.-
Pubmed
19121390
26354079
22118469
26227816
24845553
26760975
+ More
29023486 26108605 24495485 17510324 25348373 25315136 25830018 23254933 26483478 22992520 21484476 17994087 17550304 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 18984573 12537569 15296753 15135728 18563158 22936249 15562597 27603307 15229592 20520714 25244985 20920257 23761445 25977457 25069045 23375108 24438588 15592404 29764946 25362486 22722832 16136131 15372022 21269460 20966253 15846337 12364791 14747013 17210077
29023486 26108605 24495485 17510324 25348373 25315136 25830018 23254933 26483478 22992520 21484476 17994087 17550304 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 18984573 12537569 15296753 15135728 18563158 22936249 15562597 27603307 15229592 20520714 25244985 20920257 23761445 25977457 25069045 23375108 24438588 15592404 29764946 25362486 22722832 16136131 15372022 21269460 20966253 15846337 12364791 14747013 17210077
EMBL
BABH01013770
BABH01013771
BABH01013772
KQ459599
KPI94471.1
KQ460397
+ More
KPJ15214.1 AGBW02014681 OWR41199.1 JTDY01003165 KOB70029.1 ODYU01007696 SOQ50711.1 NWSH01002530 PCG68064.1 KK853069 KDR11819.1 FX985773 BBA93660.1 MRZV01000869 PIK43172.1 JRES01000027 KNC34829.1 GAMC01009761 JAB96794.1 CH477796 EAT36122.1 GECZ01012045 GECZ01006193 JAS57724.1 JAS63576.1 CCAG010008480 JXJN01001729 GAKP01005339 JAC53613.1 GECZ01025672 GECZ01010895 JAS44097.1 JAS58874.1 GBXI01013628 JAD00664.1 GECU01029685 JAS78021.1 GEBQ01026304 GEBQ01016094 JAT13673.1 JAT23883.1 GDHF01024116 JAI28198.1 GDHF01011069 JAI41245.1 AAGJ04116466 AAGJ04116467 AAGJ04116468 AAGJ04116469 AAGJ04116470 AAGJ04116471 AAGJ04116472 MTSL01000178 PJF17348.1 KB200367 ESP01816.1 JXUM01046519 KQ561480 KXJ78447.1 MCOG01000243 ORY22741.1 DS231874 EDS41690.1 JH818466 EKC28378.1 AK306922 BAK63916.1 PZQS01000003 PVD35020.1 GFDL01012100 JAV22945.1 CM000158 EDW92134.2 AE013599 AFH08214.1 CH954179 EDV55602.2 CP012524 ALC41408.1 BT003555 FJ219324 FJ219329 FJ219330 FJ219331 FJ219332 FJ219333 FJ219334 FJ219335 FJ219336 FJ219337 FJ219338 FJ219339 FJ219340 FJ219341 FJ219342 FJ219343 FJ219344 FJ219345 FJ219346 FJ219347 FJ219348 FJ219349 FJ219350 AY052106 GG666560 EEN55434.1 CM000362 EDX08204.1 CH480824 EDW56772.1 CM002911 KMY95790.1 BT100311 ACZ52623.1 AXCN02001185 AJVK01019336 GG745359 KNE69108.1 GG745388 KNE73095.1 CP017556 AOW04096.1 CR382130 CAG81040.1 CH940667 EDW57228.1 KZ858977 RDW26598.1 AXCM01009602 AXCM01009603 FN648669 CBJ33353.1 DP000784 ACE77687.1 JH432064 ADMH02001550 ETN62094.1 LYON01000226 OON08671.1 OON08668.1 KQ965739 KXS19217.1 UZAN01051789 VDP89128.1 KB007974 ELR17626.1 ATLV01012278 KE524778 KFB36392.1 KL387657 KFP90500.1 AC159985 MBFS01000698 PVV01925.1 CABD030040989 AJFE02103193 AJFE02103194 AJFE02103195 AC156804 AC157754 AC004041 AC004042 AC116366 KF457995 KF458010 AQIA01060494 AQIA01060495 AQIA01060496 AQIA01060497 AHZZ02029969 ADFV01188444 ADFV01188445 ADFV01188446 ADFV01188447 ADFV01188448 ADFV01188449 CM001232 EHA53763.1 GFTR01008729 JAW07697.1 AAAB01008888 EAA08790.4
KPJ15214.1 AGBW02014681 OWR41199.1 JTDY01003165 KOB70029.1 ODYU01007696 SOQ50711.1 NWSH01002530 PCG68064.1 KK853069 KDR11819.1 FX985773 BBA93660.1 MRZV01000869 PIK43172.1 JRES01000027 KNC34829.1 GAMC01009761 JAB96794.1 CH477796 EAT36122.1 GECZ01012045 GECZ01006193 JAS57724.1 JAS63576.1 CCAG010008480 JXJN01001729 GAKP01005339 JAC53613.1 GECZ01025672 GECZ01010895 JAS44097.1 JAS58874.1 GBXI01013628 JAD00664.1 GECU01029685 JAS78021.1 GEBQ01026304 GEBQ01016094 JAT13673.1 JAT23883.1 GDHF01024116 JAI28198.1 GDHF01011069 JAI41245.1 AAGJ04116466 AAGJ04116467 AAGJ04116468 AAGJ04116469 AAGJ04116470 AAGJ04116471 AAGJ04116472 MTSL01000178 PJF17348.1 KB200367 ESP01816.1 JXUM01046519 KQ561480 KXJ78447.1 MCOG01000243 ORY22741.1 DS231874 EDS41690.1 JH818466 EKC28378.1 AK306922 BAK63916.1 PZQS01000003 PVD35020.1 GFDL01012100 JAV22945.1 CM000158 EDW92134.2 AE013599 AFH08214.1 CH954179 EDV55602.2 CP012524 ALC41408.1 BT003555 FJ219324 FJ219329 FJ219330 FJ219331 FJ219332 FJ219333 FJ219334 FJ219335 FJ219336 FJ219337 FJ219338 FJ219339 FJ219340 FJ219341 FJ219342 FJ219343 FJ219344 FJ219345 FJ219346 FJ219347 FJ219348 FJ219349 FJ219350 AY052106 GG666560 EEN55434.1 CM000362 EDX08204.1 CH480824 EDW56772.1 CM002911 KMY95790.1 BT100311 ACZ52623.1 AXCN02001185 AJVK01019336 GG745359 KNE69108.1 GG745388 KNE73095.1 CP017556 AOW04096.1 CR382130 CAG81040.1 CH940667 EDW57228.1 KZ858977 RDW26598.1 AXCM01009602 AXCM01009603 FN648669 CBJ33353.1 DP000784 ACE77687.1 JH432064 ADMH02001550 ETN62094.1 LYON01000226 OON08671.1 OON08668.1 KQ965739 KXS19217.1 UZAN01051789 VDP89128.1 KB007974 ELR17626.1 ATLV01012278 KE524778 KFB36392.1 KL387657 KFP90500.1 AC159985 MBFS01000698 PVV01925.1 CABD030040989 AJFE02103193 AJFE02103194 AJFE02103195 AC156804 AC157754 AC004041 AC004042 AC116366 KF457995 KF458010 AQIA01060494 AQIA01060495 AQIA01060496 AQIA01060497 AHZZ02029969 ADFV01188444 ADFV01188445 ADFV01188446 ADFV01188447 ADFV01188448 ADFV01188449 CM001232 EHA53763.1 GFTR01008729 JAW07697.1 AAAB01008888 EAA08790.4
Proteomes
UP000005204
UP000053268
UP000053240
UP000007151
UP000037510
UP000218220
+ More
UP000027135 UP000095300 UP000230750 UP000037069 UP000078200 UP000008820 UP000092443 UP000092445 UP000092444 UP000092460 UP000095301 UP000075901 UP000007110 UP000240830 UP000091820 UP000030746 UP000069940 UP000249989 UP000193920 UP000002320 UP000005408 UP000075884 UP000245119 UP000002282 UP000000803 UP000008711 UP000092553 UP000001554 UP000000304 UP000001292 UP000075886 UP000092462 UP000054350 UP000075885 UP000075900 UP000076420 UP000182444 UP000001300 UP000008792 UP000256601 UP000007875 UP000075883 UP000002630 UP000192221 UP000076408 UP000000673 UP000189906 UP000070544 UP000050740 UP000265140 UP000011083 UP000030765 UP000000539 UP000245609 UP000075881 UP000233200 UP000001519 UP000233140 UP000240080 UP000002277 UP000005640 UP000233180 UP000233120 UP000233100 UP000028761 UP000075882 UP000001073 UP000009058 UP000007062
UP000027135 UP000095300 UP000230750 UP000037069 UP000078200 UP000008820 UP000092443 UP000092445 UP000092444 UP000092460 UP000095301 UP000075901 UP000007110 UP000240830 UP000091820 UP000030746 UP000069940 UP000249989 UP000193920 UP000002320 UP000005408 UP000075884 UP000245119 UP000002282 UP000000803 UP000008711 UP000092553 UP000001554 UP000000304 UP000001292 UP000075886 UP000092462 UP000054350 UP000075885 UP000075900 UP000076420 UP000182444 UP000001300 UP000008792 UP000256601 UP000007875 UP000075883 UP000002630 UP000192221 UP000076408 UP000000673 UP000189906 UP000070544 UP000050740 UP000265140 UP000011083 UP000030765 UP000000539 UP000245609 UP000075881 UP000233200 UP000001519 UP000233140 UP000240080 UP000002277 UP000005640 UP000233180 UP000233120 UP000233100 UP000028761 UP000075882 UP000001073 UP000009058 UP000007062
Interpro
SUPFAM
SSF52540
SSF52540
ProteinModelPortal
H9J7F7
A0A194PM06
A0A194RCL8
A0A212EI90
A0A0L7L401
A0A2H1WCA4
+ More
A0A2A4J953 A0A067QZL2 A0A2Z5TRB2 A0A1I8P2K6 A0A2G8K5A8 A0A0L0CTW8 W8C472 A0A1A9V356 Q16P37 A0A1S4FUA6 A0A1A9XPD1 A0A1A9ZMN3 A0A1B6G5L2 A0A1B0FGD5 A0A1B0AQ80 A0A034WIL6 A0A1B6F1S1 A0A1I8NB16 A0A182SI89 A0A0A1WNN8 A0A1B6HTP2 A0A1B6KQF5 A0A0K8UNW1 A0A0K8VRS2 W4ZC48 A0A2H9THX1 A0A1A9WRR6 V4B2A7 A0A182G7F0 A0A1Y2AJL4 B0WAP9 K1Q388 A0A182NCI9 G2HJK8 A0A2T7PNK7 A0A1Q3F5U9 B4P7X9 A0A0B4K7L0 B3NNP5 A0A0M4E973 Q9W252 C3YWA5 B4QH58 B4I847 A0A0J9U8E7 D0Z764 A0A182QKZ8 A0A1B0F0N7 A0A0L0T2N0 A0A0L0TEH7 A0A182P3Y5 A0A182RRS7 A0A2C9JC49 A0A1D8NEN8 Q6C910 B4MFQ7 A0A371C8H3 H2ZIL2 A0A182LRK9 D7G250 H2ZIL4 A0A1W4VQG8 H2ZIL3 A0A182YG56 B3RF61 T1JCH0 W5JH02 A0A1S8W2B9 A0A1S8W2B7 A0A139AR39 A0A183AY88 A0A3P9ALK0 L8GZV8 A0A084VEJ8 A0A091PG72 F1NEG1 A0A2T9ZBI4 A0A182KAQ4 A0A2K6QKM9 A0A2I2YPC0 A0A2K6AGU6 A0A2R9A7T5 A0A2I3SC89 E7ESD9 A0A2K6L6A8 A0A2K6CKI5 A0A2K5WF16 A0A096N4P1 A0A182KXV5 A0A2I3GPQ4 G4MSF1 A0A224X5C5 Q7QAJ3
A0A2A4J953 A0A067QZL2 A0A2Z5TRB2 A0A1I8P2K6 A0A2G8K5A8 A0A0L0CTW8 W8C472 A0A1A9V356 Q16P37 A0A1S4FUA6 A0A1A9XPD1 A0A1A9ZMN3 A0A1B6G5L2 A0A1B0FGD5 A0A1B0AQ80 A0A034WIL6 A0A1B6F1S1 A0A1I8NB16 A0A182SI89 A0A0A1WNN8 A0A1B6HTP2 A0A1B6KQF5 A0A0K8UNW1 A0A0K8VRS2 W4ZC48 A0A2H9THX1 A0A1A9WRR6 V4B2A7 A0A182G7F0 A0A1Y2AJL4 B0WAP9 K1Q388 A0A182NCI9 G2HJK8 A0A2T7PNK7 A0A1Q3F5U9 B4P7X9 A0A0B4K7L0 B3NNP5 A0A0M4E973 Q9W252 C3YWA5 B4QH58 B4I847 A0A0J9U8E7 D0Z764 A0A182QKZ8 A0A1B0F0N7 A0A0L0T2N0 A0A0L0TEH7 A0A182P3Y5 A0A182RRS7 A0A2C9JC49 A0A1D8NEN8 Q6C910 B4MFQ7 A0A371C8H3 H2ZIL2 A0A182LRK9 D7G250 H2ZIL4 A0A1W4VQG8 H2ZIL3 A0A182YG56 B3RF61 T1JCH0 W5JH02 A0A1S8W2B9 A0A1S8W2B7 A0A139AR39 A0A183AY88 A0A3P9ALK0 L8GZV8 A0A084VEJ8 A0A091PG72 F1NEG1 A0A2T9ZBI4 A0A182KAQ4 A0A2K6QKM9 A0A2I2YPC0 A0A2K6AGU6 A0A2R9A7T5 A0A2I3SC89 E7ESD9 A0A2K6L6A8 A0A2K6CKI5 A0A2K5WF16 A0A096N4P1 A0A182KXV5 A0A2I3GPQ4 G4MSF1 A0A224X5C5 Q7QAJ3
PDB
5DAC
E-value=2.4868e-23,
Score=263
Ontologies
GO
GO:0046872
GO:0030870
GO:0006281
GO:0000723
GO:0016887
GO:0005524
GO:0000784
GO:0007004
GO:0000794
GO:0032508
GO:0070192
GO:0035861
GO:0051880
GO:0043047
GO:0090305
GO:0004017
GO:0003691
GO:0000722
GO:0016233
GO:0000790
GO:0006302
GO:0008104
GO:0000793
GO:0003690
GO:0051321
GO:0000781
GO:0051276
GO:0005634
Topology
Subcellular location
Nucleus
Chromosome
Telomere
Chromosome
Telomere
Length:
150
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00264
Exp number, first 60 AAs:
0.00264
Total prob of N-in:
0.15165
outside
1 - 150
Population Genetic Test Statistics
Pi
191.145268
Theta
204.808087
Tajima's D
-0.199519
CLR
0.043576
CSRT
0.31848407579621
Interpretation
Uncertain
