Gene

KWMTBOMO04488

Pre Gene Modal

BGIBMGA005443

Annotation

UDP-glycosyltransferase_UGT39B1_precursor_[Bombyx_mori]

Location

Bomo_Chr8(+):7614603-7619581      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 3.383

CDS

ATGTTCAACAGTTTCATATTTTTGTTTGTTGTAGTGACGGGCTTATGTGAGTCTGCCAATATTTTGTATGTGATGCCTTTTACTTCTAAATCTCACCATATTATGTTGAAGCCGATTGGATTAGAATTAGCTAGAAGGGGTCACAATGTGACCGTCATCACTGGGTTTCGAGATAAGAATGCTCCTGCAAATTACCGTCAGATACAAGTTGATCAGAAAGAAATATGGGACGTCATAGGAACCAAAAGACCGAACGTTTTCGACATGGTCGGGGTATCAACTGAAGAATTTCACAATATGATTCTCTGGAGAGGGGGACTAGGATTCACAAATCTAACTTTAAATTCAGCTGAAGTGAAGAGTTTTTTAGCTGAAGACAACAAATTCGATTTAGTCATTTGCGAGCAGTTTTTCCAAGAAGCGATGAACATATTAGCACATAAATACAAAGCTCCTTTAGTTCTAGTTACCACATTCGGAAACTGTATGAGACATAACATCATGATAAGAAACCCATTGCAGCTAGCCACTGTGATCAGTGAATTTTTGGAAGTGAGGAACCCGACCAGTTTCTTCGCAAGGTTAAGAAATGTATACTTCACCGTTTACGAATACGTTTGGTGGCGATATTGGTACTTAGAAGAACAAGAGAAATTGGTCAAGAAGTACATTCCAAATTTAGAAGAACCAGTGCCCACTTTGCTTGAGATGCAAAAGAATGCCTCCCTGATACTAATTAACGGACATTTTAGTTTTGATACTCCAGCTGCGTATCTTCCCAATATTATTGAAATTGGCGGAGTGCATCTTTCCAAGAGTGACACTAAGCTGCCCGCGGATTTGCAAAACATTTTAGACGAAGCAAAGCATGGAGTCATTTACATTAACTTTGGATCGAACGTGCGTAGTGCTGAACTACCGTTAGAAAAAAGAAATGTATTTTTGAATGTAATTAAGAAACTGAAGCAGACTGTGGTGTGGAAATGGGAAGATGACAGTCTAGATAAAATGGATAATTTAGTCGTGAGAAAATGGCTACCACAAAAAGAAATATTATCCCACCCAAATATCAAAGTATTCATATCGCATGGTGGATTGATCGGAACACAGGAAGCCATATTCCACGGCGTGCCTATAATTGGAGTTCCTATTTACGCTGACCAATACAATAATTTATTACAAGCAGAAGAAATTGGATTTGGGAAAATACTCGAATTCAAAGATATCAGAGAACAAAACTTAGATAATTACTTGAGAGAGCTTCTTACAAACAATACTTACAGAGACAAAGCTAAAGAGATGTCTATTAGGTTTAAAGATAGACCGACGACTGCTTTAGATACAGCTATGTATTGGATTGAATATATTATAAGGCATAATGGGGCTAGTTTTATGAAAAATCCAGCCAGAAAATTGCACTGGATCCAATACGCAATGCTAGATGTTTATGGTTTTATATTAGCAGTAGTGTTAACTATTTTTTACACTATTTACAAACTAAGCAGTTTCATATTGCATAAATTGAAAGCTCCTGAGAGACTTATTAGAAAAAAGTTTGATTGA

Protein

MFNSFIFLFVVVTGLCESANILYVMPFTSKSHHIMLKPIGLELARRGHNVTVITGFRDKNAPANYRQIQVDQKEIWDVIGTKRPNVFDMVGVSTEEFHNMILWRGGLGFTNLTLNSAEVKSFLAEDNKFDLVICEQFFQEAMNILAHKYKAPLVLVTTFGNCMRHNIMIRNPLQLATVISEFLEVRNPTSFFARLRNVYFTVYEYVWWRYWYLEEQEKLVKKYIPNLEEPVPTLLEMQKNASLILINGHFSFDTPAAYLPNIIEIGGVHLSKSDTKLPADLQNILDEAKHGVIYINFGSNVRSAELPLEKRNVFLNVIKKLKQTVVWKWEDDSLDKMDNLVVRKWLPQKEILSHPNIKVFISHGGLIGTQEAIFHGVPIIGVPIYADQYNNLLQAEEIGFGKILEFKDIREQNLDNYLRELLTNNTYRDKAKEMSIRFKDRPTTALDTAMYWIEYIIRHNGASFMKNPARKLHWIQYAMLDVYGFILAVVLTIFYTIYKLSSFILHKLKAPERLIRKKFD

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.
Belongs to the ubiquitin-conjugating enzyme family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPT8   H9J7F1   A0A2H1W5A1   A0A191T1L9   G9LPP9   A0A3S2N8S7   + More
A0A2A4K0B3   A0A212FL56   A0A2H4WB64   A0A1L8D6G2   A0A194PNY6   A0A212EHV3   G9LPT9   A0A0L7LWH9   A0A194QSA9   D2JLL0   H9J7F0   A0A2H4WB65   A0A2M4BJX2   A0A2M4BJY0   A0A2M4BJY3   A0A182IJQ8   A0A182FDS8   A0A182M8S5   W5JEF5   A0A2M3Z3U6   A0A2M4AGW6   A0A2M4AFV3   A0A2M3Z343   A0A084WK54   A0A182Y289   A0A182WL35   A0A182TC71   A0A2M4AGI4   Q7PTF6   A0A182NJM1   A0A182JUT3   A0A182I6Z1   A0A182R334   A0A182QE42   A0A182L3C8   A0A182WWQ5   A0A182PQN3   A0A182VHN2   A0A182TJ21   A0A1Y9HEP2   A0A1Q3FRS4   A0A1Q3FZT9   B0W9Y5   A0A0M4EDN6   A0A182R101   A0A182JQE6   A0A182XYP3   A0A2J7Q382   B4KPM7   A0A0M3QVA8   Q17GE2   Q17GE3   V5I8H8   U5EXU4   B4LYF5   A0A182WJE5   A0A182M4J5   B4J7P4   A0A2M4CI25   A0A2M3Z5E9   A0A1S4GSA2   A0A2J7Q396   B4KPM8   A0A182NI27   B4MRB3   Q1HRH8   A0A1S4FQK6   A0A2M4BK13   A0A2M3Z5C0   A0A182FDF0   A0A2M4CHZ1   A0A182PQM1   A0A182IIM5   A0A2M4BJZ5   A0A1Y1NF76   A0A023EW79   A0A2M3ZF25   A0A067RFX2   B3MBV3   A0A1A9ZAS7   A0A067R1S8   A0A2J7Q393   A0A2M4AFS8   A0A2J7Q399   A0A1B0DAR4   A0A2M4BKA0   A0A2M4BK77   A0A1Q3FZT2   A0A0K8UF88   A0A1W4UAS2   A0A1I8JUM7   Q7Q5T0   B4GA69   A0A2M4AFT4  

EC Number

2.4.1.17

Pubmed

22155036    19121390    22118469    29027758    26354079    26227816    + More
19954531    20920257    23761445    24438588    25244985    12364791    14747013    17210077    20966253    17994087    17510324    17204158    28004739    24945155    24845553   

EMBL

JQ070245    AEW43161.1    BABH01013714    ODYU01006427    SOQ48259.1    KU680293    + More
ANI21999.1    JQ070206    AEW43122.1    RSAL01000196    RVE44553.1    NWSH01000322    PCG77489.1    AGBW02007908    OWR54430.1    KY202931    AUC64275.1    GEYN01000086    JAV02043.1    KQ459599    KPI94459.1    AGBW02014796    OWR41057.1    JQ070246    AEW43162.1    JTDY01000006    KOB79496.1    KQ461154    KPJ08408.1    GQ915326    ACZ97420.2    KY202935    AUC64279.1    GGFJ01004214    MBW53355.1    GGFJ01004173    MBW53314.1    GGFJ01004216    MBW53357.1    AXCM01005982    ADMH02001746    ETN61209.1    GGFM01002441    MBW23192.1    GGFK01006656    MBW39977.1    GGFK01006354    MBW39675.1    GGFM01002198    MBW22949.1    ATLV01024094    KE525349    KFB50598.1    GGFK01006565    MBW39886.1    AAAB01008807    EAA03993.4    APCN01003712    AXCN02000438    GFDL01004778    JAV30267.1    GFDL01001967    JAV33078.1    DS231867    EDS40643.1    CP012524    ALC42052.1    AXCN02000388    NEVH01019069    PNF23045.1    CH933808    EDW09137.1    ALC42053.1    CH477262    EAT45644.1    EAT45643.1    GALX01004660    JAB63806.1    GANO01000777    JAB59094.1    CH940650    EDW66951.1    AXCM01000608    CH916367    EDW02192.1    GGFL01000775    MBW64953.1    GGFM01002996    MBW23747.1    AAAB01008960    PNF23054.1    EDW09138.2    CH963850    EDW74652.1    DQ440116    ABF18149.1    GGFJ01004254    MBW53395.1    GGFM01002966    MBW23717.1    GGFL01000776    MBW64954.1    APCN01000032    GGFJ01004255    MBW53396.1    GEZM01007277    JAV95265.1    GAPW01000969    JAC12629.1    GGFM01006340    MBW27091.1    KK852488    KDR22771.1    CH902619    EDV36124.2    KK853091    KDR11536.1    PNF23046.1    GGFK01006318    MBW39639.1    PNF23049.1    AJVK01013380    GGFJ01004240    MBW53381.1    GGFJ01004316    MBW53457.1    GFDL01001981    JAV33064.1    GDHF01026977    JAI25337.1    EAA11593.4    CH479181    EDW31821.1    GGFK01006329    MBW39650.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053268    UP000037510    + More
UP000053240    UP000075880    UP000069272    UP000075883    UP000000673    UP000030765    UP000076408    UP000075920    UP000075901    UP000007062    UP000075884    UP000075881    UP000075840    UP000075900    UP000075886    UP000075882    UP000076407    UP000075885    UP000075903    UP000075902    UP000002320    UP000092553    UP000235965    UP000009192    UP000008820    UP000008792    UP000001070    UP000007798    UP000027135    UP000007801    UP000092445    UP000092462    UP000192221    UP000008744   

PRIDE

G9LPT8    H9J7F1    G9LPT9    H9J7F0   

Pfam

PF00201   UDPGT        + More
PF00179   UQ_con

Interpro

IPR035595   UDP_glycos_trans_CS        + More
IPR002213   UDP_glucos_trans       
IPR023313   UBQ-conjugating_AS       
IPR000608   UBQ-conjugat_E2       
IPR016135   UBQ-conjugating_enzyme/RWD       

SUPFAM

SSF54495   SSF54495       

Gene 3D

3.10.110.10    

CDD

cd00195  UBCc

ProteinModelPortal

G9LPT8   H9J7F1   A0A2H1W5A1   A0A191T1L9   G9LPP9   A0A3S2N8S7   + More
A0A2A4K0B3   A0A212FL56   A0A2H4WB64   A0A1L8D6G2   A0A194PNY6   A0A212EHV3   G9LPT9   A0A0L7LWH9   A0A194QSA9   D2JLL0   H9J7F0   A0A2H4WB65   A0A2M4BJX2   A0A2M4BJY0   A0A2M4BJY3   A0A182IJQ8   A0A182FDS8   A0A182M8S5   W5JEF5   A0A2M3Z3U6   A0A2M4AGW6   A0A2M4AFV3   A0A2M3Z343   A0A084WK54   A0A182Y289   A0A182WL35   A0A182TC71   A0A2M4AGI4   Q7PTF6   A0A182NJM1   A0A182JUT3   A0A182I6Z1   A0A182R334   A0A182QE42   A0A182L3C8   A0A182WWQ5   A0A182PQN3   A0A182VHN2   A0A182TJ21   A0A1Y9HEP2   A0A1Q3FRS4   A0A1Q3FZT9   B0W9Y5   A0A0M4EDN6   A0A182R101   A0A182JQE6   A0A182XYP3   A0A2J7Q382   B4KPM7   A0A0M3QVA8   Q17GE2   Q17GE3   V5I8H8   U5EXU4   B4LYF5   A0A182WJE5   A0A182M4J5   B4J7P4   A0A2M4CI25   A0A2M3Z5E9   A0A1S4GSA2   A0A2J7Q396   B4KPM8   A0A182NI27   B4MRB3   Q1HRH8   A0A1S4FQK6   A0A2M4BK13   A0A2M3Z5C0   A0A182FDF0   A0A2M4CHZ1   A0A182PQM1   A0A182IIM5   A0A2M4BJZ5   A0A1Y1NF76   A0A023EW79   A0A2M3ZF25   A0A067RFX2   B3MBV3   A0A1A9ZAS7   A0A067R1S8   A0A2J7Q393   A0A2M4AFS8   A0A2J7Q399   A0A1B0DAR4   A0A2M4BKA0   A0A2M4BK77   A0A1Q3FZT2   A0A0K8UF88   A0A1W4UAS2   A0A1I8JUM7   Q7Q5T0   B4GA69   A0A2M4AFT4  

PDB

2O6L     E-value=1.87879e-22,     Score=263

KEGG

100862830    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT39B1; UDP-glycosyltransferase UGT39B1

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0015020   GO:0016021   GO:0016758   GO:0005524   GO:0043231   GO:0008194   GO:0008152   GO:0046983   GO:0051536   GO:0006310   GO:0003676   GO:0006418   GO:0009058   GO:0016742   GO:0003824  

Subcellular location

Membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.969764

 

 

Length:

520

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

44.66265

Exp number, first 60 AAs:

21.35964

Total prob of N-in:

0.86424

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  481

TMhelix

482  -  504

inside

505  -  520

 

 

Pi

29.980973

Theta

35.513122

Tajima's D

-0.558114

CLR

1.432673

CSRT

0.225988700564972

Interpretation

Uncertain