Gene

KWMTBOMO04474

Pre Gene Modal

BGIBMGA005370

Annotation

cell_cycle_checkpoint_kinase_2_[Bombyx_mori]

Location

Bomo_Chr8(-):7221224-7228134      View in EpiBrowser

Full name

Ovarian-specific serine/threonine-protein kinase Lok      

Alternative Name

Protein loki
dMNK

Location in the cell

Nuclear   Reliability : 2.832

CDS

ATGGGGGACGATCCAATACACGATAGCGAAAACACTCAAACACAAACCCAAAACTCACAAGTAGATTGGAGTCAGCAAAATACACCAGCCACAATTCCAAATATTTGGGGAAGATTGTATTCTACAAAGGTATCAATTAATGGTAAATATTGTTGGAAACAAGAATATCAACCTGAATATATCGATCTTATACAACCCGAATTCAGCTTGGGAAGATCATTCAACTGCACTTTCATAATGAGAAAAGACAATATAAAAGAGAGTATTATAAGGAATGTGAGCAAGCTACACTTTGTTATTAAGAGAAATCTATCTGAACTTCTAAGCCCTGCTATAATAACAGACCTGTCACACAATGGTACCTTTGTGAATGGCGAAGACATAGGTAAAGGAAACAGTAGAGTTCTAGATGACAATGATGTAATATCAGTTACTCATCGTATTGTTAAAATTTTTATATTTAAAGACTTATTGAAAAACGAACAAGACCAAGTACCTAAAGAAATTTCACAAAAGTATTATATCTCAAGGGTTTTAGGGCAGGGGGCTTGCGGCCTTGTTAAATTAGTTTATGACAAGATAAAATGCACCAAGCATGCCATGAAAATTATAAAAAAAAGTAGACTTACAAATGGTCAAATTAATCACATAAATAAGCCCGCTAAAATTATGAACGAGATCAATATAATGAAAGCACTCAGACATCCATGCATTATTTCAATAGAAGAAGTATTTGACTCTCGCGATGCTGTGTATATTATTTTAGAACTCATGGAAGGCGGTGAACTGTTTGATAGGATAACAAAATTTAGTCACTTGACAGAACCATTAACACGGTTTATTTTCCGACAAATGGTACTTGCAGTCAAGTACTTGCACTCTCAGGGTATAACTCATCGGGATTTGAAGCCTGAGAATGTCCTGTTGGAAGGTGACGAAGACGAAACATTAGTGAAAATTACTGACTTTGGACTGAGTAAGTTTGTAGGAGAGGACAGCTTTATGAAGACAATGTGTGGGACACCATTGTATCTGGCTCCAGAAGTGCTCAGAGCTAATGGACAAAATACTTATGGACCAGAGGTTGATGTTTGGAGTCTAGGAGTCATATTCTTTGTATGCCTTGTGGGTTATTTACCCTTCTCGCACGACTACAAAGAGATGTCACTCAAGAACCAGATATTAAATGGACAATACAAGTTCTCACAGGCTCACTGGAAGAATATAAGCTTGCAGGCCAAGCTGCTTATGAAAAGAATGCTCACAGTGCAAGTCAGCAGGAGGATAACCCTTGATCAGATACTGAATCATGCTTGGATGCAGGACGTTGATACGATCATAAGGGTTGAGAAACTTCTATCACACATCCGCTCTAAGGGCATGAAACAGGCGACAAATAGCACCACCGGTGACGGCGACGACAATGTCCGTAACAGCACGGTGGCCATAATACAAGTGGTAGCCGCGGGTAAGCGAGCCCTCAGCGACACGTTCTGCGCCACCGAACCGAACGCAAAAAAAATTAAAATAGCCTTGACCAATGACGACGAAACTAGTTCCACAAACAGTTATTGCTCAAATGCTTAA

Protein

MGDDPIHDSENTQTQTQNSQVDWSQQNTPATIPNIWGRLYSTKVSINGKYCWKQEYQPEYIDLIQPEFSLGRSFNCTFIMRKDNIKESIIRNVSKLHFVIKRNLSELLSPAIITDLSHNGTFVNGEDIGKGNSRVLDDNDVISVTHRIVKIFIFKDLLKNEQDQVPKEISQKYYISRVLGQGACGLVKLVYDKIKCTKHAMKIIKKSRLTNGQINHINKPAKIMNEINIMKALRHPCIISIEEVFDSRDAVYIILELMEGGELFDRITKFSHLTEPLTRFIFRQMVLAVKYLHSQGITHRDLKPENVLLEGDEDETLVKITDFGLSKFVGEDSFMKTMCGTPLYLAPEVLRANGQNTYGPEVDVWSLGVIFFVCLVGYLPFSHDYKEMSLKNQILNGQYKFSQAHWKNISLQAKLLMKRMLTVQVSRRITLDQILNHAWMQDVDTIIRVEKLLSHIRSKGMKQATNSTTGDGDDNVRNSTVAIIQVVAAGKRALSDTFCATEPNAKKIKIALTNDDETSSTNSYCSNA

Description

May have a role in germline establishment.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CDS1 subfamily.
Belongs to the ubiquitin-conjugating enzyme family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Kinase   Nucleotide-binding   Nucleus   Reference proteome   Transferase  

Feature

chain  Ovarian-specific serine/threonine-protein kinase Lok
splice variant  In isoform Short.

Uniprot

H9J778   Q5R1T9   A0A2A4K0W4   A0A2H1X294   A0A212FBW0   A0A3S2M0C9   + More
A0A194QTU5   A0A194PLY2   A0A2A4K186   A0A1I8MT58   A0A034WRB7   A0A0L0C9G7   A0A0K8UI60   A0A1I8P361   A0A1I8P303   A0A0A1X8Z4   W8BDL4   A0A067QEX6   A0A0Q5VK69   B3NL10   O61267   O61267-2   A4V0X0   A0A0R1DPJ5   A0A1W4VYG8   A0A0J9R4V2   A0A0Q9XBV4   B4JQ87   A0A1W4VK90   B4PBH1   A0A0Q9X4P6   B4N7N9   B4KEP1   B3ML32   A0A0P8ZFI1   B4M9L4   V4C6S6   A0A1S3HKX9   A0A1A9W2P4   B4I626   A0A2T7PDM7   A0A0M9AAQ0   A0A2J7RJL5   A0A3B0JV41   A0A0M3QU81   A0A0B6XZ20   Q29KK4   B4GT76   A0A0R3NUJ5   A0A087ZR28   Q171S5   A0A2Z5U631   K1R1E4   A0A2A3E930   A0A1Q3F563   A0A210R6F6   A0A1Q3F527   A0A1Q3F521   A0A154PFN3   A0A1Q3F582   B0WQ25   A0A1B0GDY8   A0A1A9VM20   A0A2C9JI89   A0A232EYX4   K7ISU1   A0A0L8G8I3   A0A1A9Y7G5   A0A1A9UNG1   A0A1B0BTC4   A0A1B0BKJ7   T1IRU8   A0A1B0A5M9   A0A1Q3F5F1   A0A2G8K946   A0A1B0FRF0   A0A3L8SBJ6   A7RVB0   A0A0J7NZB3   G7Y516   A0A0R3VXU3   H0ZC01   W5JFI3   A0A091N9K7   A0A1B0AHF7   A0A093QGW9   A0A3M7TA35   A0A093HKE0   A0A091ENI5   Q98TW0   A0A091HHU0   A0A2M4CYM9   Q9I8V3   A0A093PI42   A0A182WGM0   A0A182MQ34   A0A091GBF5   A0A2M4CYG6   A0A182HRU3  

EC Number

2.7.11.1

Pubmed

19121390    22118469    26354079    25315136    25348373    26108605    + More
25830018    24495485    24845553    17994087    9507063    10731132    12537572    12537569    12537568    12537573    12537574    16110336    17569856    17569867    17550304    22936249    23254933    26383154    15632085    17510324    26760975    22992520    28812685    15562597    28648823    20075255    29023486    30282656    17615350    22023798    20360741    20920257    23761445    30375419    10793133   

EMBL

BABH01013683    BABH01013684    AB194683    BAD74191.1    NWSH01000327    PCG77403.1    + More
ODYU01012852    SOQ59358.1    AGBW02009268    OWR51215.1    RSAL01000088    RVE48215.1    KQ461154    KPJ08420.1    KQ459599    KPI94446.1    PCG77402.1    GAKP01000821    JAC58131.1    JRES01000736    KNC28882.1    GDHF01031755    GDHF01025940    GDHF01002665    GDHF01002632    JAI20559.1    JAI26374.1    JAI49649.1    JAI49682.1    GBXI01006946    GBXI01006052    JAD07346.1    JAD08240.1    GAMC01007160    JAB99395.1    KK853689    KDQ97283.1    CH954179    KQS61847.1    EDV54588.1    AB007821    AB007822    U87984    AE014134    AY070549    AAN11063.1    CM000158    KRJ99215.1    CM002910    KMY91118.1    CH933807    KRG02970.1    CH916372    EDV99067.1    EDW90485.1    CH964214    KRF99271.1    EDW80378.1    EDW11920.1    CH902620    EDV31650.1    KPU73526.1    CH940654    EDW57890.1    KB201305    ESO97334.1    CH480822    EDW55832.1    PZQS01000004    PVD31511.1    KQ435709    KOX79956.1    NEVH01002992    PNF41023.1    OUUW01000010    SPP85965.1    CP012523    ALC40203.1    HACG01002243    CEK49108.1    CH379061    EAL33170.2    CH479189    EDW25585.1    KRT04792.1    CH477447    EAT40742.1    FX985821    BBA93708.1    JH818716    EKC37339.1    KZ288344    PBC27699.1    GFDL01012376    JAV22669.1    NEDP02000123    OWF56643.1    GFDL01012378    JAV22667.1    GFDL01012383    JAV22662.1    KQ434893    KZC10673.1    GFDL01012382    JAV22663.1    DS232032    EDS32669.1    CCAG010012075    NNAY01001525    OXU23686.1    AAZX01006436    KQ423210    KOF73346.1    JXJN01020073    JXJN01015972    JH431388    GFDL01012250    JAV22795.1    MRZV01000774    PIK44483.1    CCAG010004927    QUSF01000030    RLV99732.1    DS469543    EDO44613.1    LBMM01000692    KMQ97735.1    DF142866    GAA48052.1    UYRS01001261    VDK24633.1    ABQF01029141    ADMH02001647    ETN61569.1    KK843751    KFP85712.1    KL671659    KFW83347.1    REGN01000043    RNA44946.1    KL206193    KFV79870.1    KK718897    KFO59498.1    AF326574    BC166130    AAG59884.1    AAI66130.1    KL217497    KFO95853.1    GGFL01006197    MBW70375.1    AF174295    AAF75829.1    KL225417    KFW71867.1    AXCM01002017    KL447264    KFO71512.1    GGFL01006196    MBW70374.1    APCN01001747   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    + More
UP000095301    UP000037069    UP000095300    UP000027135    UP000008711    UP000000803    UP000002282    UP000192221    UP000009192    UP000001070    UP000007798    UP000007801    UP000008792    UP000030746    UP000085678    UP000091820    UP000001292    UP000245119    UP000053105    UP000235965    UP000268350    UP000092553    UP000001819    UP000008744    UP000005203    UP000008820    UP000005408    UP000242457    UP000242188    UP000076502    UP000002320    UP000092444    UP000078200    UP000076420    UP000215335    UP000002358    UP000053454    UP000092443    UP000092460    UP000092445    UP000230750    UP000276834    UP000001593    UP000036403    UP000046400    UP000282613    UP000007754    UP000000673    UP000053258    UP000276133    UP000053584    UP000052976    UP000054308    UP000054081    UP000075920    UP000075883    UP000053760    UP000075840   

PRIDE

H9J778    Q5R1T9    O61267   

Pfam

PF00069   Pkinase        + More
PF00498   FHA
PF00179   UQ_con

Interpro

IPR008271   Ser/Thr_kinase_AS        + More
IPR011009   Kinase-like_dom_sf       
IPR008984   SMAD_FHA_dom_sf       
IPR000253   FHA_dom       
IPR000719   Prot_kinase_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR000608   UBQ-conjugat_E2       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR023313   UBQ-conjugating_AS       

SUPFAM

SSF56112   SSF56112        + More
SSF49879   SSF49879       
SSF54495   SSF54495       

Gene 3D

3.10.110.10    

CDD

cd00060  FHA
cd00195  UBCc

ProteinModelPortal

H9J778   Q5R1T9   A0A2A4K0W4   A0A2H1X294   A0A212FBW0   A0A3S2M0C9   + More
A0A194QTU5   A0A194PLY2   A0A2A4K186   A0A1I8MT58   A0A034WRB7   A0A0L0C9G7   A0A0K8UI60   A0A1I8P361   A0A1I8P303   A0A0A1X8Z4   W8BDL4   A0A067QEX6   A0A0Q5VK69   B3NL10   O61267   O61267-2   A4V0X0   A0A0R1DPJ5   A0A1W4VYG8   A0A0J9R4V2   A0A0Q9XBV4   B4JQ87   A0A1W4VK90   B4PBH1   A0A0Q9X4P6   B4N7N9   B4KEP1   B3ML32   A0A0P8ZFI1   B4M9L4   V4C6S6   A0A1S3HKX9   A0A1A9W2P4   B4I626   A0A2T7PDM7   A0A0M9AAQ0   A0A2J7RJL5   A0A3B0JV41   A0A0M3QU81   A0A0B6XZ20   Q29KK4   B4GT76   A0A0R3NUJ5   A0A087ZR28   Q171S5   A0A2Z5U631   K1R1E4   A0A2A3E930   A0A1Q3F563   A0A210R6F6   A0A1Q3F527   A0A1Q3F521   A0A154PFN3   A0A1Q3F582   B0WQ25   A0A1B0GDY8   A0A1A9VM20   A0A2C9JI89   A0A232EYX4   K7ISU1   A0A0L8G8I3   A0A1A9Y7G5   A0A1A9UNG1   A0A1B0BTC4   A0A1B0BKJ7   T1IRU8   A0A1B0A5M9   A0A1Q3F5F1   A0A2G8K946   A0A1B0FRF0   A0A3L8SBJ6   A7RVB0   A0A0J7NZB3   G7Y516   A0A0R3VXU3   H0ZC01   W5JFI3   A0A091N9K7   A0A1B0AHF7   A0A093QGW9   A0A3M7TA35   A0A093HKE0   A0A091ENI5   Q98TW0   A0A091HHU0   A0A2M4CYM9   Q9I8V3   A0A093PI42   A0A182WGM0   A0A182MQ34   A0A091GBF5   A0A2M4CYG6   A0A182HRU3  

PDB

3I6U     E-value=7.19117e-93,     Score=870

KEGG

692482    K06641 serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] | (RefSeq) Chk2, BmChk2; cell cycle check

GO

GO:0004672   GO:0005524   GO:0006282   GO:0005634   GO:0050321   GO:0044773   GO:0006919   GO:0051091   GO:0072332   GO:0035234   GO:0071480   GO:0030717   GO:0071481   GO:0004674   GO:0008630   GO:0045944   GO:0006974   GO:0006915   GO:0000077   GO:0016607   GO:0007281   GO:0006468   GO:0016021   GO:0005516   GO:0005737   GO:0018105   GO:0035556   GO:0046777   GO:0004683   GO:0009931   GO:0050821   GO:0001302   GO:0006978   GO:0006975   GO:0042803   GO:0042771   GO:0006302   GO:0019901   GO:0016605   GO:0044257   GO:0090307   GO:0042176   GO:0072428   GO:0000086   GO:0045893   GO:0000781   GO:0005794   GO:0031625   GO:0005515   GO:0006310   GO:0003676   GO:0006418   GO:0009058   GO:0016742   GO:0003824  

Subcellular location

Nucleus speckle  

Length:

528

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

6.83066999999999

Exp number, first 60 AAs:

0.00015

Total prob of N-in:

0.01517

outside

1  -  528

 

 

Pi

203.436426

Theta

180.164304

Tajima's D

0.509973

CLR

0.014541

CSRT

0.516674166291685

Interpretation

Uncertain