Gene

KWMTBOMO04473

Pre Gene Modal

BGIBMGA005437

Annotation

PREDICTED:_protein_spinster_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr8(+):7210685-7219946      View in EpiBrowser

Full name

Protein spinster      

Alternative Name

Protein benchwarmer
Protein diphthong

Location in the cell

PlasmaMembrane   Reliability : 4.973

CDS

ATGTCAATACAATATCAAGCAACAATCAGTGTTTTAAATAATGTCAAAACTGAATTCGAAATTGGTGATGGCAAGGCTGGATTTCTACAGACAGTGTTCGTCGTCGCGTACATGTTGTTCGCGCCAATATTTGGCTACTTAGGAGATAGATACTCAAGGCGCGTCATTATGGCCAGTGGCGTTGCGCTCTGGAGTCTAACAACTTTCTTTGGCTCGTTTTTACACGATTACGAGTCGTTTGCATTCTTCCGTGGTCTCGTTGGAATTGGAGAAGCCTCGTACTCCACGATAGCCCCTACCATCATCAGCGATCTCTTCGTGGGGGATGTAAGATCGAAGATGTTAGCATTCTTCTATTTTGCCATCCCAGTCGGAAGTGGTCTCGGATATATAGTAGGGTCAGTTGTGGGTGCAGCGCTAGGCAATTGGCGATACGGTCTACGGGTGACGCCTTTCTTTGGCGCGATTGCCGTCGCGCTCATCATATGGGTCATGGAAGACCCGGAACGAGGCGCCTCCGAAGAGAGTCACATAAAACCCACTTCGTATAAGGACGATCTGCGTGCTCTCATAAAAAATCCATCGTTCATGCTGTCGACGATCGCTTTTACATGCGTAGCGTTCGTGACCGGCGCGCTCACGTGGTGGGGACCGCAAGTTATTTACTTGGGTCTCGGCTTGCAACCTGGCAACGAGTTTTCCTTCGAAAGCGTGTCGTACAAGTTCGGGTTGGTGGGCATGGCGGCGGGCGCGCTGGGCGTGCCGCTGGGCTGCGCGGCGGCGGCGCGCGCGCGGCCCCTCGTGGCCGACGCCGACCCGCTGCTGTGCGGCGCCGCGCTGCTGCTCTCCGCGCCGCTCGTGTTCTGTGCGCTGATCGCCGTGCGTGCCTCCGCCGCGGGGACCTTCGCGCTCATCTTCTTCGGCATGCTCACTCTCAACCTCACCTGGTCCGTAGTCGCCGACATGATCCTGTACGTTGTCATACCACCAAGGCGTTCGACAGCAGAAGCTTTCCAGATATTAATATCGCACATGTTTGGGGATGCTGGAAGTCCGTACTTAGTCGGAGTTATATCAGAAAGTTTGAAGTCCTACTTGATGCCATCACCGGATGATTTGCCAAGTAAAACTGTAGAATTCAGAGCGCTTCAGTATGCGCTGTTCATAACGTGCTTCGTGGAAGTACTCGGAGGAATATTCTTCCTTATAACATCGGCGTACATTGTCAGGGACAAACTAAAAGTGGACAGAGCTATTGCAGAAGCAGAAGCACAGCACACGGAGCCGTCCCACGCTTCAGCACACGAAGACATTGTAGCCGGCGAATAG

Protein

MSIQYQATISVLNNVKTEFEIGDGKAGFLQTVFVVAYMLFAPIFGYLGDRYSRRVIMASGVALWSLTTFFGSFLHDYESFAFFRGLVGIGEASYSTIAPTIISDLFVGDVRSKMLAFFYFAIPVGSGLGYIVGSVVGAALGNWRYGLRVTPFFGAIAVALIIWVMEDPERGASEESHIKPTSYKDDLRALIKNPSFMLSTIAFTCVAFVTGALTWWGPQVIYLGLGLQPGNEFSFESVSYKFGLVGMAAGALGVPLGCAAAARARPLVADADPLLCGAALLLSAPLVFCALIAVRASAAGTFALIFFGMLTLNLTWSVVADMILYVVIPPRRSTAEAFQILISHMFGDAGSPYLVGVISESLKSYLMPSPDDLPSKTVEFRALQYALFITCFVEVLGGIFFLITSAYIVRDKLKVDRAIAEAEAQHTEPSHASAHEDIVAGE

Description

Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage.

Similarity

Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Differentiation   Endosome   Glycoprotein   Lipid transport   Lysosome   Membrane   Oogenesis   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Protein spinster
splice variant  In isoform E.

Uniprot

A0A2A4K150   H9J7E5   A0A2A4K019   A0A2A4JZG3   A0A2A4K0F0   A0A1Y1LAR1   + More
A0A1Y1LAQ8   A0A1Y1LFH6   A0A1Y1LI80   A0A1B6F604   A0A336KI24   D6WWV4   A0A1L8DE93   A0A1B6IY79   A0A1B6JDS6   A0A336KDF3   A0A1B6JMB3   A0A336M1G7   A0A336MS93   A0A2J7RJL4   Q0IEQ4   A0A0K8TM89   A7UU76   A0A1I8JU77   A0A1Q3FWR3   A0A182K9W4   A0A2M3Z527   Q0IEQ3   Q7PIC0   A7UU77   A0A023F3L6   A0A0P9AGM4   A0A1Q3FXA7   A0A154PEF7   J9K505   A0A2M4BHV4   A0A0V0G8J6   A0A0P8XQY7   A0A2M4BH73   A0A0J9U3C6   A0A2S2QQ45   A0A2H8TVW2   N6V997   A0A0R1DST5   A0A2M4CLN4   A0A023EVL5   A0A2M4CLK5   A0A2S2PFH2   R4NR58   Q9GQQ0   A0A067R556   K4M4D5   A0A2M4A6N2   A0A2M4CLP9   A0A1B6JA87   A0A1Q3FX49   A0A0Q5VM11   A0A0Q9W6V7   A0A0J7N4Y2   A0A2Y9D1L0   A0A1B6HEE3   A0A0Q5VM10   A0A0J9RF33   A0A084WKA3   Q9GQQ0-4   W5JS35   A0A195BZK1   B4HSK2   A0A1J1HTU0   A0A158NP22   A0A3B0JL53   A0A1W4W4J4   Q9GQQ0-3   A0A1W4VBU4   B4P6Q9   A0A1J1HZD5   A0A1W4WF20   B3MF45   A0A0Q9WDE1   A0A0R3NQQ6   A0A1W4W4H5   A0A3Q0JGF3   U4U5S7   B4LL62   A0A151XDQ2   E2AXC6   B4H6B2   A0A1B0CTB9   Q28WT0   E9IEC1   A0A146M1V6   A0A3B0J088   B3NPX0   F4WGK1   A0A0L7QYX8   A0A0Q5W0Z4   Q9GQQ0-2   A0A195DXJ9   A0A026VZK9   A0A3B0JS91  

Pubmed

19121390    28004739    18362917    19820115    17510324    26369729    + More
12364791    14747013    17210077    25474469    17994087    22936249    15632085    17550304    24945155    11340170    10731132    12537572    12537569    12408844    15998804    24845553    24438588    20920257    23761445    21347285    23537049    20798317    21282665    26823975    21719571    24508170    30249741   

EMBL

NWSH01000327    PCG77400.1    BABH01013680    BABH01013681    BABH01013682    BABH01013683    + More
PCG77399.1    PCG77401.1    PCG77398.1    GEZM01061156    JAV70723.1    GEZM01061155    JAV70724.1    GEZM01061154    JAV70725.1    GEZM01061153    JAV70727.1    GECZ01024162    JAS45607.1    UFQS01000325    UFQT01000325    SSX02895.1    SSX23262.1    KQ971360    EFA09102.2    GFDF01009305    JAV04779.1    GECU01015815    JAS91891.1    GECU01010364    JAS97342.1    SSX02896.1    SSX23263.1    GECU01007315    JAT00392.1    UFQT01000391    SSX23890.1    UFQT01002419    SSX33414.1    NEVH01002992    PNF41022.1    CH477504    EAT39877.1    GDAI01002340    JAI15263.1    AAAB01008960    EDO63855.1    GFDL01002984    JAV32061.1    GGFM01002869    MBW23620.1    EAT39876.1    EAA44203.4    EDO63854.1    GBBI01002774    JAC15938.1    CH902619    KPU76967.1    GFDL01002963    JAV32082.1    KQ434874    KZC09658.1    ABLF02034683    GGFJ01003247    MBW52388.1    GECL01002338    JAP03786.1    KPU76968.1    GGFJ01003246    MBW52387.1    CM002911    KMY94180.1    GGMS01010648    MBY79851.1    GFXV01005877    MBW17682.1    CM000071    ENO01981.2    CM000158    KRK00232.1    GGFL01002015    MBW66193.1    GAPW01000517    JAC13081.1    GGFL01002016    MBW66194.1    GGMR01015570    MBY28189.1    BT150099    AGL46748.1    AF212366    AF212367    AF212368    AF212369    AF212370    AE013599    BT032842    AY051792    KK852687    KDR18407.1    BT149866    AFV15811.1    GGFK01002967    MBW36288.1    GGFL01002017    MBW66195.1    GECU01011609    JAS96097.1    GFDL01002989    JAV32056.1    CH954179    KQS62471.1    CH940648    KRF80294.1    LBMM01009983    KMQ87745.1    GECU01034660    JAS73046.1    KQS62470.1    KMY94179.1    ATLV01024104    KE525349    KFB50647.1    ADMH02000627    ETN65559.1    KQ976394    KYM93351.1    CH480816    EDW48080.1    CVRI01000021    CRK91488.1    ADTU01022127    ADTU01022128    OUUW01000001    SPP73966.1    EDW91986.2    CRK91489.1    EDV37673.2    KRF80295.1    KRT03196.1    KB631763    ERL85956.1    EDW61869.2    KQ982268    KYQ58504.1    GL443548    EFN61906.1    CH479213    EDW33336.1    AJWK01027427    EAL26587.2    GL762576    EFZ21086.1    GDHC01005220    JAQ13409.1    SPP73967.1    EDV55817.1    GL888137    EGI66666.1    KQ414685    KOC63820.1    KQS62472.1    KQ980167    KYN17339.1    KK107536    QOIP01000008    EZA49187.1    RLU19810.1    SPP73968.1   

Proteomes

UP000218220    UP000005204    UP000007266    UP000235965    UP000008820    UP000007062    + More
UP000075900    UP000075881    UP000007801    UP000076502    UP000007819    UP000001819    UP000002282    UP000000803    UP000027135    UP000008711    UP000008792    UP000036403    UP000075884    UP000030765    UP000000673    UP000078540    UP000001292    UP000183832    UP000005205    UP000268350    UP000192223    UP000192221    UP000079169    UP000030742    UP000075809    UP000000311    UP000008744    UP000092461    UP000007755    UP000053825    UP000078492    UP000053097    UP000279307   

PRIDE

H9J7E5    Q9GQQ0    K4M4D5   

Pfam

PF07690   MFS_1

Interpro

IPR020846   MFS_dom        + More
IPR036259   MFS_trans_sf       
IPR011701   MFS       

SUPFAM

SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

A0A2A4K150   H9J7E5   A0A2A4K019   A0A2A4JZG3   A0A2A4K0F0   A0A1Y1LAR1   + More
A0A1Y1LAQ8   A0A1Y1LFH6   A0A1Y1LI80   A0A1B6F604   A0A336KI24   D6WWV4   A0A1L8DE93   A0A1B6IY79   A0A1B6JDS6   A0A336KDF3   A0A1B6JMB3   A0A336M1G7   A0A336MS93   A0A2J7RJL4   Q0IEQ4   A0A0K8TM89   A7UU76   A0A1I8JU77   A0A1Q3FWR3   A0A182K9W4   A0A2M3Z527   Q0IEQ3   Q7PIC0   A7UU77   A0A023F3L6   A0A0P9AGM4   A0A1Q3FXA7   A0A154PEF7   J9K505   A0A2M4BHV4   A0A0V0G8J6   A0A0P8XQY7   A0A2M4BH73   A0A0J9U3C6   A0A2S2QQ45   A0A2H8TVW2   N6V997   A0A0R1DST5   A0A2M4CLN4   A0A023EVL5   A0A2M4CLK5   A0A2S2PFH2   R4NR58   Q9GQQ0   A0A067R556   K4M4D5   A0A2M4A6N2   A0A2M4CLP9   A0A1B6JA87   A0A1Q3FX49   A0A0Q5VM11   A0A0Q9W6V7   A0A0J7N4Y2   A0A2Y9D1L0   A0A1B6HEE3   A0A0Q5VM10   A0A0J9RF33   A0A084WKA3   Q9GQQ0-4   W5JS35   A0A195BZK1   B4HSK2   A0A1J1HTU0   A0A158NP22   A0A3B0JL53   A0A1W4W4J4   Q9GQQ0-3   A0A1W4VBU4   B4P6Q9   A0A1J1HZD5   A0A1W4WF20   B3MF45   A0A0Q9WDE1   A0A0R3NQQ6   A0A1W4W4H5   A0A3Q0JGF3   U4U5S7   B4LL62   A0A151XDQ2   E2AXC6   B4H6B2   A0A1B0CTB9   Q28WT0   E9IEC1   A0A146M1V6   A0A3B0J088   B3NPX0   F4WGK1   A0A0L7QYX8   A0A0Q5W0Z4   Q9GQQ0-2   A0A195DXJ9   A0A026VZK9   A0A3B0JS91  

PDB

3O65     E-value=0.0277269,     Score=88

KEGG

101746070    no KO assigned | (RefSeq) protein spinster

GO

GO:0016021   GO:0055085   GO:0008643   GO:0090099   GO:0008582   GO:0045476   GO:0031902   GO:0005765   GO:0098793   GO:0048477   GO:0007040   GO:0009267   GO:0035193   GO:0008333   GO:0031982   GO:0045477   GO:0040011   GO:0048488   GO:0012501   GO:0006897   GO:0043067   GO:0006869   GO:0010001   GO:0045924   GO:0008347   GO:0007619   GO:0051124   GO:0005634   GO:0006260   GO:0006281   GO:0006310   GO:0003676   GO:0006418   GO:0009058   GO:0016742   GO:0003824  

Subcellular location

Late endosome membrane  
Lysosome membrane  

Length:

442

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

232.68414

Exp number, first 60 AAs:

28.45139

Total prob of N-in:

0.02179

POSSIBLE N-term signal

sequence

outside

1  -  25

TMhelix

26  -  48

inside

49  -  54

TMhelix

55  -  74

outside

75  -  79

TMhelix

80  -  102

inside

103  -  114

TMhelix

115  -  137

outside

138  -  146

TMhelix

147  -  164

inside

165  -  195

TMhelix

196  -  218

outside

219  -  237

TMhelix

238  -  260

inside

261  -  272

TMhelix

273  -  295

outside

296  -  304

TMhelix

305  -  327

inside

328  -  339

TMhelix

340  -  362

outside

363  -  381

TMhelix

382  -  404

inside

405  -  442

 

 

Pi

373.209725

Theta

205.842541

Tajima's D

0.584506

CLR

0.142706

CSRT

0.537523123843808

Interpretation

Uncertain