Gene

KWMTBOMO04471

Pre Gene Modal

BGIBMGA005435

Annotation

PREDICTED:_spindle_assembly_abnormal_protein_6_homolog_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr8(+):7159765-7177608      View in EpiBrowser

Full name

Spindle assembly abnormal protein 6 homolog      

Location in the cell

Nuclear   Reliability : 3.722

CDS

ATGTATCACAAAGGAAAATATTATGTGACCTTTAAACGTGGATGTGAAGAACTTAAGAAAGATATAACATTAATTGTGAATAAAGTTTTTGAAAGTGACAGTTTGAGAATAACTTTATCAGACGATGACGATCCTATGTTTTTATGTGTTCTTATATTAACACGGATTGACTATGATGACTTGAAGAAACAACAAGGCTTACTTGTGGATTTTGATAATTTTCCAGCACAACTTGTTAAACTGTTGCAGCAGTGTGCTATAAATAATATGTTCCTTATAATGCAGCAGACAAATCCTCTACAGTATTATTTAGAAGTAGTAGAGCACAATGAGTTCAAACGTCTTATCCATCTGTCCTTGAAGACTTGTCCAGCGACTGATACAGATATTAAACAACACATGGCTAGTACTATCAAAAATTTGAAAGATTTGTTATCTTCTTTGAAACTTGCTGCTGCAAGTAATGAGTCATCACTAAACACGAAATGTGTTAGTTTAGAAAATAGAATCAAAGAATTGAATCTAACATTAGCAAAAATGCAAGATGATAAAATGAGACAAGAAATAGAAATTCAAAAAACACTAGAACAAGAACGCGATAAAATTACTCAGGAGAGAACAAATCTACAGAAAAATAATGAAATGACAATGAAAGCACATCTGACTTCATACCAAGAAACTATGAACAGAAAAGAGAAAGAACTTGATGAATTAAATATTAGATGCAAACAGTTGAAAGATACTATTTTTGATTTAGAAAAGCAGTTAAGTGAAAGAAATCAAAGATTGAATGTTTTGGAGAAAGAAGTCCAAAAGTCACATATTGAAGTGGCCACACTAAGAGCTAATAATACAGGCTTAGAGAGAGATATTAAAGAGAAAGAGAGGCAGTATACCCATCAAAGTTCTAGATGTACATTTTTGGAAAAGACAGCTAAGGAAAATGCTGATAGTATAAAAGACTTGAAAAACACAATTCAGAACCTTAAAAGGGAAAAAGCATGCTTAGAAGAAAGAGTAGCAGTCAGTGAATCTCATATTAACAAAAACAATGAAATAGTACAATCAACGACGGAGCAACTCATGAAAGCAAATCAAATCATTTCTAAACAAAATGCTGATTTAATAGAATTAAAAGAAAAGCTAATGTGTCGAACGGCTATTGCACTGGAGCAGGAGAAGGTAATCGAGCGTAACTCAAAAGAGATTGACGAACTCAAATCTGAGTTAAACGATAGTAAAAACAACCTAGAGCAGTTGCGCAGAGAACTGAATGATCTCAATCAAAAGTACGAGTCCAGTGAGAAGACTTTAAAAGACAAGGAGGAAACTATAAAAAATAACAATATGGTGATACAGTGGCTACACAAAAAGTTGGAGGGTTGCACGCCAGTAGACCTGCCTCAAAGCTATGATAAGCACGGAACAAAGCCCTCAAGCAGCTCCAGTCCCTATTTCAAAGCTAAAAACAACCGGAACGATTCGCTGCCCTATGTTTCTGATGATTCTATTAATTTTTACGCTACATCCAAATTGTCTGATGTAGAAAAGAGTCCTGAAATTCAAAGTACAACTTCGAAAACAGGATTGGATCCAAAATACTTAAAGCCTGCAAGTAACATCAACCATGCTACGAAAGGTTCGAAAGCTACTTTTGCTGAAACACAAAGAGGTAAAGAAAATACCAACATCAATTTGCCGAAGGTTGATTACAGAGAAAAAAAGTCATCGAGAAGCAATACGTATCGGTCAACACCAGTATCGGCTTATTTTCCATGA

Protein

MYHKGKYYVTFKRGCEELKKDITLIVNKVFESDSLRITLSDDDDPMFLCVLILTRIDYDDLKKQQGLLVDFDNFPAQLVKLLQQCAINNMFLIMQQTNPLQYYLEVVEHNEFKRLIHLSLKTCPATDTDIKQHMASTIKNLKDLLSSLKLAAASNESSLNTKCVSLENRIKELNLTLAKMQDDKMRQEIEIQKTLEQERDKITQERTNLQKNNEMTMKAHLTSYQETMNRKEKELDELNIRCKQLKDTIFDLEKQLSERNQRLNVLEKEVQKSHIEVATLRANNTGLERDIKEKERQYTHQSSRCTFLEKTAKENADSIKDLKNTIQNLKREKACLEERVAVSESHINKNNEIVQSTTEQLMKANQIISKQNADLIELKEKLMCRTAIALEQEKVIERNSKEIDELKSELNDSKNNLEQLRRELNDLNQKYESSEKTLKDKEETIKNNNMVIQWLHKKLEGCTPVDLPQSYDKHGTKPSSSSSPYFKAKNNRNDSLPYVSDDSINFYATSKLSDVEKSPEIQSTTSKTGLDPKYLKPASNINHATKGSKATFAETQRGKENTNINLPKVDYREKKSSRSNTYRSTPVSAYFP

Description

Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:21273447). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).

Subunit

Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.

Keywords

3D-structure   Cell cycle   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Reference proteome  

Feature

chain  Spindle assembly abnormal protein 6 homolog

Uniprot

H9J7E3   A0A2H1WZL4   A0A2A4JZI9   A0A3S2L8P2   A0A194QTV0   A0A194PLX7   + More
K7J292   A0A232FH56   A0A154PTX7   A0A088AGU2   E2ADQ8   A0A2A3E8S0   A0A023EWV8   E2BUT7   A0A195B149   A0A158NR08   A0A195E6G1   A0A195EVD0   A0A310SJQ2   A0A151WME6   A0A0N0BKU5   F4WPG0   E9ISM7   A0A0L7QW73   H0Z4D4   A0A026WNU1   A0A151IEZ1   A0A0J7NJS3   Q1LV44   W5UDD5   A0A091LAZ5   A0A2D0RTN3   M3YL69   G9KMF1   B2GRL0   Q7ZVT3   A0A2Y9P9G2   A0A1S3A386   A0A3L8SPG2   A0A2D0RT26   L5K295   A0A2I0ME20   F1P1V3   A0A2U4A1C0   A0A2U4A1C4   A0A2Y9P3X1   A0A091G852   A0A2U4A1C2   A0A2U4A2B0   A0A2K5LTX6   A0A2K5ZHB8   Q5ZMV2   A0A093I4Y8   A0A091VCH1   A0A096MRG9   A0A2K6BMD1   A0A2K5U4J4   G7NV25   H9EVE5   A0A093H673   F6YWK2   A0A091TS15   A0A091EJH0   A0A2Y9S9T5   A0A2U4A1C3   A0A2K6PXH2   G1N5A5   A0A094L4X6   A0A0D9S6N2   A0A1V4JYU5   A0A1S3GFT2   A0A2K5IYC9   A0A340WRG5   A0A091SK60   A0A099Z2C5   U6CRY5   A0A091UJN8   A0A383Z3Q1   A0A2K6MKI1   Q3UM73   A0A2Y9IXB0   A0A2Y9E277   A0A091QR20   A0A093PT49   A0A341BWK2   A0A2U3XN17   H2N6N4   A0A3B1JZ53   G1RM01   A0A2K5CU70   M3X538   A0A3M0K5N6   A0A3Q0G0E5   G5C723   A0A341BXW2   A0A091L1K4   G1LQV0  

Pubmed

19121390    26354079    20075255    28648823    20798317    25474469    + More
21347285    21719571    21282665    20360741    24508170    30249741    23594743    23127152    23236062    21273447    30282656    23258410    23371554    15592404    15642098    22002653    25319552    17431167    25362486    20838655    10349636    11042159    11076861    11217851    12466851    16141073    25329095    17975172    21993625    20010809   

EMBL

BABH01013675    BABH01013676    ODYU01012305    SOQ58550.1    NWSH01000327    PCG77417.1    + More
RSAL01000088    RVE48219.1    KQ461154    KPJ08425.1    KQ459599    KPI94441.1    AAZX01007799    NNAY01000258    OXU29667.1    KQ435144    KZC14894.1    GL438820    EFN68420.1    KZ288323    PBC28108.1    GBBI01004862    JAC13850.1    GL450746    EFN80560.1    KQ976691    KYM77929.1    ADTU01023720    KQ979608    KYN20462.1    KQ981965    KYN31852.1    KQ761843    OAD56594.1    KQ982944    KYQ49000.1    KQ435692    KOX81088.1    GL888243    EGI64055.1    GL765434    EFZ16306.1    KQ414716    KOC62868.1    ABQF01035311    ABQF01035312    ABQF01035313    ABQF01035314    KK107139    QOIP01000003    EZA57680.1    RLU24642.1    KQ977835    KYM99383.1    LBMM01004165    KMQ92740.1    BX908398    JT406725    AHH37702.1    KK745561    KFP40121.1    AEYP01085897    AEYP01085898    JP017482    AES06080.1    BC165167    AAI65167.1    BC045420    QUSF01000010    RLW05896.1    KB031037    ELK05824.1    AKCR02000018    PKK27929.1    AADN05000647    KL447874    KFO78128.1    AJ719282    KL206922    KFV86885.1    KL410872    KFR00420.1    AHZZ02016461    AQIA01003239    CM001276    EHH50101.1    JU322598    JU471674    AFE66354.1    AFH28478.1    KL217220    KFV74542.1    JSUE03002010    KK462397    KFQ79929.1    KK718445    KFO56534.1    KL359625    KFZ64527.1    AQIB01085936    LSYS01005497    OPJ77265.1    KK476013    KFQ59007.1    KL889294    KGL76619.1    HAAF01001569    CCP73395.1    KK436646    KFQ90392.1    AK145076    BAE26225.1    KK801470    KFQ29061.1    KL670581    KFW79586.1    ABGA01284946    ABGA01284947    ABGA01284948    NDHI03003423    PNJ55265.1    ADFV01190031    ADFV01190032    ADFV01190033    AANG04003279    QRBI01000117    RMC08448.1    JH173665    EHB17334.1    KL291676    KFP49667.1    ACTA01138777    ACTA01146776   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000002358    + More
UP000215335    UP000076502    UP000005203    UP000000311    UP000242457    UP000008237    UP000078540    UP000005205    UP000078492    UP000078541    UP000075809    UP000053105    UP000007755    UP000053825    UP000007754    UP000053097    UP000279307    UP000078542    UP000036403    UP000000437    UP000221080    UP000000715    UP000248483    UP000079721    UP000276834    UP000010552    UP000053872    UP000000539    UP000245320    UP000053760    UP000233060    UP000233140    UP000053584    UP000053283    UP000028761    UP000233120    UP000233100    UP000009130    UP000053875    UP000006718    UP000052976    UP000248484    UP000233200    UP000001645    UP000029965    UP000190648    UP000081671    UP000233080    UP000265300    UP000053641    UP000261681    UP000233180    UP000248482    UP000248480    UP000053258    UP000252040    UP000245341    UP000001595    UP000018467    UP000001073    UP000233020    UP000011712    UP000269221    UP000189705    UP000006813    UP000008912   

PRIDE

H9J7E3   

Pfam

PF16531   SAS-6_N        + More
PF08784   RPA_C
PF01336   tRNA_anti-codon
PF18594   Sas6_CC

Interpro

IPR032396   SAS-6_N        + More
IPR038558   SAS-6_N_sf       
IPR014892   RPA_C       
IPR012340   NA-bd_OB-fold       
IPR036390   WH_DNA-bd_sf       
IPR004365   NA-bd_OB_tRNA       
IPR036388   WH-like_DNA-bd_sf       
IPR041513   SAS6_CC       

SUPFAM

SSF50249   SSF50249        + More
SSF46785   SSF46785       

Gene 3D

2.170.210.20     1.10.10.10    

ProteinModelPortal

H9J7E3   A0A2H1WZL4   A0A2A4JZI9   A0A3S2L8P2   A0A194QTV0   A0A194PLX7   + More
K7J292   A0A232FH56   A0A154PTX7   A0A088AGU2   E2ADQ8   A0A2A3E8S0   A0A023EWV8   E2BUT7   A0A195B149   A0A158NR08   A0A195E6G1   A0A195EVD0   A0A310SJQ2   A0A151WME6   A0A0N0BKU5   F4WPG0   E9ISM7   A0A0L7QW73   H0Z4D4   A0A026WNU1   A0A151IEZ1   A0A0J7NJS3   Q1LV44   W5UDD5   A0A091LAZ5   A0A2D0RTN3   M3YL69   G9KMF1   B2GRL0   Q7ZVT3   A0A2Y9P9G2   A0A1S3A386   A0A3L8SPG2   A0A2D0RT26   L5K295   A0A2I0ME20   F1P1V3   A0A2U4A1C0   A0A2U4A1C4   A0A2Y9P3X1   A0A091G852   A0A2U4A1C2   A0A2U4A2B0   A0A2K5LTX6   A0A2K5ZHB8   Q5ZMV2   A0A093I4Y8   A0A091VCH1   A0A096MRG9   A0A2K6BMD1   A0A2K5U4J4   G7NV25   H9EVE5   A0A093H673   F6YWK2   A0A091TS15   A0A091EJH0   A0A2Y9S9T5   A0A2U4A1C3   A0A2K6PXH2   G1N5A5   A0A094L4X6   A0A0D9S6N2   A0A1V4JYU5   A0A1S3GFT2   A0A2K5IYC9   A0A340WRG5   A0A091SK60   A0A099Z2C5   U6CRY5   A0A091UJN8   A0A383Z3Q1   A0A2K6MKI1   Q3UM73   A0A2Y9IXB0   A0A2Y9E277   A0A091QR20   A0A093PT49   A0A341BWK2   A0A2U3XN17   H2N6N4   A0A3B1JZ53   G1RM01   A0A2K5CU70   M3X538   A0A3M0K5N6   A0A3Q0G0E5   G5C723   A0A341BXW2   A0A091L1K4   G1LQV0  

PDB

2Y3V     E-value=8.27418e-14,     Score=189

KEGG

101745923    K16487 spindle assembly abnormal protein 6 | (RefSeq) spindle assembly abnormal protein 6 homolog

GO

GO:0003676   GO:0005814   GO:0005829   GO:0098536   GO:0005813   GO:0007099   GO:0000280   GO:0007283   GO:0040016   GO:0051298   GO:0007052  

Subcellular location

   Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles.   With evidence from 3 publications.

Length:

592

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00299

Exp number, first 60 AAs:

8e-05

Total prob of N-in:

0.00378

outside

1  -  592

 

 

Pi

141.427939

Theta

111.750315

Tajima's D

0.051086

CLR

0.308654

CSRT

0.387980600969952

Interpretation

Uncertain