Gene

KWMTBOMO04470  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005372

Annotation

PREDICTED:_LDLR_chaperone_boca_[Amyelois_transitella]

Location

Bomo_Chr8(-):7151181-7153694      View in EpiBrowser

Full name

LDLR chaperone boca      

Location in the cell

Cytoplasmic   Reliability : 1.649 Nuclear   Reliability : 1.573

CDS

ATGGTTAAAACTGTGCTAATCGCATTGATTTTATGGATTTCTTTATGTTCTGCGAAAAAGGCTGCACAAAAACCGGATTGGGCTAAAAAAGATATTCGAGACTTTTCTGATGCTGATATGGAAAGGCTTTTAGATCAATGGGAAGAAGATGAAGAGCCTCTTCCTGAAGACGAACTCCCTGAGCACTTAAGAAAACCTCCAGCTTTAGATCTTACAAAGATGGATATGTCGAACCCTGAGGCAGTTTTACAAGCAACTAAAAAAGGCCAGACTCTGATGATGTTTGTGTCTGTAGCCAACAAACCTTCTAGAGCAAGAACAGAAGAAATTACTAAGATATGGCAAACATCACTTTGGAGCAATCATATTCAAGCAGAAAGGTACTTAATAGATGATGACAGAGCCATTTTCATGTTCAAAGATGGATCTCAAGCATGGACTGCTAAAGAATTTCTATTAGAACAGGAGGAGCTTAAAGAAGTTCAATTGGAAAGTCAAACATACCCAGGAAAGAAACCTGATATTAAAAACAAAGCTCTAAGGGATGAGTTATAA

Protein

MVKTVLIALILWISLCSAKKAAQKPDWAKKDIRDFSDADMERLLDQWEEDEEPLPEDELPEHLRKPPALDLTKMDMSNPEAVLQATKKGQTLMMFVSVANKPSRARTEEITKIWQTSLWSNHIQAERYLIDDDRAIFMFKDGSQAWTAKEFLLEQEELKEVQLESQTYPGKKPDIKNKALRDEL

Description

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway.

Subunit

Monomer (By similarity). Interacts with Arrow and Yolkless.

Similarity

Belongs to the ubiquitin-conjugating enzyme family.
Belongs to the MESD family.

Keywords

3D-structure   Chaperone   Complete proteome   Endoplasmic reticulum   Reference proteome   Signal   Wnt signaling pathway  

Feature

chain  LDLR chaperone boca

Uniprot

H9J780   I4DK67   A0A194QSX6   A0A2H1WZX3   A0A1E1W4D7   A0A2A4JZG9   + More
A0A3S2NTL3   S4NTY4   A0A212FBV9   D6WAF9   A0A1I8M8A9   A0A1I8PI30   A0A1Y1KZ66   A0A182QNN3   A0A084WJG4   A0A1L8DU78   A0A2M4ACE1   A0A2M3Z6G7   A0A1J1IU53   A0A1L8DU83   A0A182VGJ2   A0A182RA30   Q16SS0   A0A182PLD3   A0A182J0S9   A0A0L0C1C0   A0A182JW82   T1DF60   A0A182G3T2   N6U025   A0A182X4A4   A0A182HPA8   Q7Q9R4   A0A2R7WB35   W8BQW8   A0A182M7A8   A0A2M4DM52   A0A2M4C111   A0A1A9WMW4   A0A0A1WHE5   A0A182NLZ5   R4FLS3   A0A023EJ90   B4KPQ1   A0A182WB66   A0A2J7PX53   A0A240SWV8   D3TKV3   U5EXW9   A0A1A9Y3Y1   R4V4J6   A0A0T6AUK0   N6T410   B4LJ90   A0A1B0D3G5   A0A0A9Z546   A0A1A9ZYF5   B4J7Y4   A0A182FL80   B0WUH0   A0A1A9VL15   A0A0A9YXM0   A0A0P5YK83   B4MIQ0   A0A0P5XVF5   A0A034WNU2   A0A0C9QVT0   A0A0N8CT48   A0A0P5HE94   A0A0P5FPB2   A0A0P6AVA7   A0A0P5IMI0   A0A0P5HWR3   A0A3B0JSL8   A0A1W4UZN1   B3MHR0   A0A023F7X5   Q28YJ5   A0A0P6JNC0   A0A0M4EHI3   E9G1P3   A0A0K8RGF4   A0A0K8VAR7   A0A1Q3FH12   A0A067RHF9   B4H8J2   B4QEP1   A0A131Y7I3   Q8T9B6   B4HR38   B3N9W9   L7MA02   A0A182U5V7   B4P1R9   A0A224YUM5   A0A336LFK9   A0A293N329   A0A023GML7   G3MNK6  

Pubmed

19121390    22651552    26354079    23622113    22118469    18362917    + More
19820115    25315136    28004739    24438588    17510324    26108605    24330624    26483478    23537049    12364791    14747013    17210077    24495485    25830018    24945155    17994087    20353571    25401762    26823975    25348373    25474469    15632085    21292972    24845553    22936249    10731132    12537572    12581524    25576852    17550304    28797301    22216098   

EMBL

BABH01013673    AK401685    KQ459599    BAM18307.1    KPI94443.1    KQ461154    + More
KPJ08424.1    ODYU01012305    SOQ58552.1    GDQN01009230    JAT81824.1    NWSH01000327    PCG77397.1    RSAL01000088    RVE48217.1    GAIX01012036    JAA80524.1    AGBW02009268    OWR51213.1    KQ971312    EEZ98006.1    GEZM01068899    JAV66709.1    AXCN02000957    ATLV01024026    KE525348    KFB50358.1    GFDF01004086    JAV09998.1    GGFK01005071    MBW38392.1    GGFM01003365    MBW24116.1    CVRI01000059    CRL03719.1    GFDF01004085    JAV09999.1    CH477667    EAT37515.1    JRES01001012    KNC26143.1    GALA01000767    JAA94085.1    JXUM01007035    KQ560229    KXJ83725.1    APGK01044411    APGK01044412    KB741026    ENN74895.1    APCN01002939    AAAB01008900    EAA09378.3    KK854549    PTY16749.1    GAMC01002885    JAC03671.1    AXCM01006669    GGFL01014468    MBW78646.1    GGFJ01009823    MBW58964.1    GBXI01015823    JAC98468.1    ACPB03002152    GAHY01002014    JAA75496.1    GAPW01004709    JAC08889.1    CH933808    EDW09161.1    NEVH01020861    PNF20918.1    CCAG010008041    EZ422040    ADD18463.1    GANO01000730    JAB59141.1    KC740964    AGM32788.1    LJIG01022817    KRT78565.1    KB631924    ENN74894.1    ERL87180.1    CH940648    EDW61526.1    AJVK01023537    GBHO01006664    GBRD01014788    GDHC01002990    JAG36940.1    JAG51038.1    JAQ15639.1    CH916367    EDW02214.1    DS232105    EDS34952.1    GBHO01006660    JAG36944.1    GDIP01056627    JAM47088.1    CH963719    EDW71989.1    GDIQ01118807    GDIP01109364    GDIP01066721    LRGB01000007    JAL32919.1    JAM36994.1    KZS21925.1    GAKP01001756    JAC57196.1    GBYB01004757    JAG74524.1    GDIP01101463    JAM02252.1    GDIQ01251116    JAK00609.1    GDIQ01252465    JAJ99259.1    GDIP01024158    JAM79557.1    GDIQ01219270    JAK32455.1    GDIQ01221818    GDIP01098962    JAK29907.1    JAM04753.1    OUUW01000001    SPP75721.1    CH902619    EDV36897.1    GBBI01001362    JAC17350.1    CM000071    EAL25970.2    GDIQ01013817    JAN80920.1    CP012524    ALC42035.1    GL732529    EFX86776.1    GADI01003667    JAA70141.1    GDHF01016346    JAI35968.1    GFDL01008223    JAV26822.1    KK852470    KDR23217.1    CH479223    EDW35027.1    CM000362    CM002911    EDX06037.1    KMY92019.1    GEFM01001009    JAP74787.1    AE013599    AY069840    BT044294    CH480816    EDW46781.1    CH954177    EDV59665.1    GACK01004347    JAA60687.1    CM000157    EDW89205.1    GFPF01006374    MAA17520.1    UFQS01001286    UFQS01005118    UFQT01001286    UFQT01005118    SSX10120.1    SSX16714.1    SSX29842.1    GFWV01022736    MAA47463.1    GBBM01000336    JAC35082.1    JO843457    AEO35074.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000283053    UP000007151    + More
UP000007266    UP000095301    UP000095300    UP000075886    UP000030765    UP000183832    UP000075903    UP000075900    UP000008820    UP000075885    UP000075880    UP000037069    UP000075881    UP000069940    UP000249989    UP000019118    UP000076407    UP000075840    UP000007062    UP000075883    UP000091820    UP000075884    UP000015103    UP000009192    UP000075920    UP000235965    UP000092444    UP000092443    UP000030742    UP000008792    UP000092462    UP000092445    UP000001070    UP000069272    UP000002320    UP000078200    UP000007798    UP000076858    UP000268350    UP000192221    UP000007801    UP000001819    UP000092553    UP000000305    UP000027135    UP000008744    UP000000304    UP000000803    UP000001292    UP000008711    UP000075902    UP000002282   

PRIDE

H9J780    Q8T9B6   

Pfam

PF10185   Mesd        + More
PF00179   UQ_con

Interpro

IPR019330   MESD        + More
IPR023313   UBQ-conjugating_AS       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR000608   UBQ-conjugat_E2       

SUPFAM

SSF54495   SSF54495       

Gene 3D

3.10.110.10    

CDD

cd00195  UBCc

ProteinModelPortal

H9J780   I4DK67   A0A194QSX6   A0A2H1WZX3   A0A1E1W4D7   A0A2A4JZG9   + More
A0A3S2NTL3   S4NTY4   A0A212FBV9   D6WAF9   A0A1I8M8A9   A0A1I8PI30   A0A1Y1KZ66   A0A182QNN3   A0A084WJG4   A0A1L8DU78   A0A2M4ACE1   A0A2M3Z6G7   A0A1J1IU53   A0A1L8DU83   A0A182VGJ2   A0A182RA30   Q16SS0   A0A182PLD3   A0A182J0S9   A0A0L0C1C0   A0A182JW82   T1DF60   A0A182G3T2   N6U025   A0A182X4A4   A0A182HPA8   Q7Q9R4   A0A2R7WB35   W8BQW8   A0A182M7A8   A0A2M4DM52   A0A2M4C111   A0A1A9WMW4   A0A0A1WHE5   A0A182NLZ5   R4FLS3   A0A023EJ90   B4KPQ1   A0A182WB66   A0A2J7PX53   A0A240SWV8   D3TKV3   U5EXW9   A0A1A9Y3Y1   R4V4J6   A0A0T6AUK0   N6T410   B4LJ90   A0A1B0D3G5   A0A0A9Z546   A0A1A9ZYF5   B4J7Y4   A0A182FL80   B0WUH0   A0A1A9VL15   A0A0A9YXM0   A0A0P5YK83   B4MIQ0   A0A0P5XVF5   A0A034WNU2   A0A0C9QVT0   A0A0N8CT48   A0A0P5HE94   A0A0P5FPB2   A0A0P6AVA7   A0A0P5IMI0   A0A0P5HWR3   A0A3B0JSL8   A0A1W4UZN1   B3MHR0   A0A023F7X5   Q28YJ5   A0A0P6JNC0   A0A0M4EHI3   E9G1P3   A0A0K8RGF4   A0A0K8VAR7   A0A1Q3FH12   A0A067RHF9   B4H8J2   B4QEP1   A0A131Y7I3   Q8T9B6   B4HR38   B3N9W9   L7MA02   A0A182U5V7   B4P1R9   A0A224YUM5   A0A336LFK9   A0A293N329   A0A023GML7   G3MNK6  

PDB

2KGL     E-value=2.82757e-27,     Score=299

KEGG

101745690    no KO assigned | (RefSeq) LDLR chaperone boca

GO

GO:0006457   GO:0019789   GO:0005524   GO:0045177   GO:0005788   GO:0006612   GO:0042802   GO:0006888   GO:0016021   GO:0005783   GO:0012505   GO:0005737   GO:0016055  

PANTHER

PTHR17600  

Subcellular location

Endoplasmic reticulum  

SignalP

Position:   1 - 18,         Likelihood:  0.984663

 

 

Length:

184

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.25355

Exp number, first 60 AAs:

0.25318

Total prob of N-in:

0.06474

outside

1  -  184

 

 

Pi

201.87826

Theta

154.398225

Tajima's D

1.034194

CLR

0

CSRT

0.671566421678916

Interpretation

Uncertain