Gene

KWMTBOMO04411

Pre Gene Modal

BGIBMGA005396

Annotation

cuticular_protein_hypothetical_5_[Danaus_plexippus]

Location

Bomo_Chr8(-):6345537-6347003      View in EpiBrowser

Full name

Dynein regulatory complex subunit 2      

Alternative Name

Coiled-coil domain-containing protein 65
Testis development protein NYD-SP28

Location in the cell

Nuclear   Reliability : 3.219

CDS

ATGGCACCAAGTAAAGCAGAGAAAAGGGCTAAGAAAGAAGCGAAGAGATTACAAAAATTAAAAGCTGAGGCTGAGGCACGAAAAAAAATAAAACGTGAGGAATTACAACGAGAAATGGCAGCACAGGCGATGAAGAAAGGCGAAATAGACAAAACTTGGAAGGAAATGATGCTAAAGATTAAAGAGCCAGTATTTAAACAAGATATTGAAATCATGTGGCATACATTTGAACGGGCTTATGATAAAAAAGATCACCTCATAAAGTACATTATTAAGTTGATGAACATAGCGGATGATCAATTTCAAAGAACTGTTGCTAGTTTTTGTGACACAATTGATACCATGATTATTAAGTTTCTTGCCGATTTGGACGGGATGTCAATGGAGAACAATAGTAGAACTGGTGCACTTTTAAAATCTGGAGAAGTCGATGCAGCAAAAATTTCAACAGACCATGATTGTGCAGAATCAAATCTTCAGTTGTTACTATATCATGCTCACACTACTTCCGATGCGCTTGCTTGGTCTACCAGAGGAGAAAATTTAGTAAAAGAAGATGAGGACAGAAACAACTATGCTAGTGAACGCGAAAACTTACGGGCCCTATTAGAAAATAATTATAGTAACATGTGGGACGATTACAAAGCAGTGCTTAAGCAATACGTCATAGAAACAGCTGATAATCAAAAGCAGGTACGTACACTTCGTGTTAAAGAAAACTTAATGGCCGACATTATTGCATCTCAGGCAAAGAAAATTGCAAATAGTGATGGAATGCTCAAGCGCCTTCGCACAGAACTTTCAGCTTACGAATCCGGGACCAAGCAAGCAGTTTTTAGGGATCGTAGAAATAGACATAGAGCTGCTTGTCATCGTCTTAAGAAAAATCTGTACGATGGAGTCGCAATCGATATGAGACAATTGGCAAAATTGGTGCGAGATTCTGATGATGCAGTAGAATGGCTGGAATCAGCTCATAAAAAAGTTGAAAAAATACTTCGTCTTGCTGCTTTATGCCGTAAATTTGAAACACAACGCGAAAAAGTGTTGCCTTTTGGTATTAATGACCCATACTCACCAACACAGTCACAGATTAATGTTCGGAAACAACAATCAGACGATTCGCTAGTCGTTAATGCTATGGCCACTACTTGTGGTTTAACTCGATTGTGGCAGAAGATATCGAAAGTAGAGCTATCCAAAAGAGCACTTATGCGAGAGAAAATCTTGTTAGAACACGAAAACGCGATCATAAGATCGAGAATTACTGAATATAACGAAAACAAATTTGCACCAGAAACACAAAATGTTTGTTTATGTACAAAATCTATTCATGGGTCAAACGAACGACCCGTTGCAATTGAAGGTGCTTTAGAAAAGCGGAAATTTGTTTGA

Protein

MAPSKAEKRAKKEAKRLQKLKAEAEARKKIKREELQREMAAQAMKKGEIDKTWKEMMLKIKEPVFKQDIEIMWHTFERAYDKKDHLIKYIIKLMNIADDQFQRTVASFCDTIDTMIIKFLADLDGMSMENNSRTGALLKSGEVDAAKISTDHDCAESNLQLLLYHAHTTSDALAWSTRGENLVKEDEDRNNYASERENLRALLENNYSNMWDDYKAVLKQYVIETADNQKQVRTLRVKENLMADIIASQAKKIANSDGMLKRLRTELSAYESGTKQAVFRDRRNRHRAACHRLKKNLYDGVAIDMRQLAKLVRDSDDAVEWLESAHKKVEKILRLAALCRKFETQREKVLPFGINDPYSPTQSQINVRKQQSDDSLVVNAMATTCGLTRLWQKISKVELSKRALMREKILLEHENAIIRSRITEYNENKFAPETQNVCLCTKSIHGSNERPVAIEGALEKRKFV

Description

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744).

Subunit

Component of the nexin-dynein regulatory complex (N-DRC).

Similarity

Belongs to the DRC2 family.

Keywords

Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Flagellum   Alternative splicing   Ciliopathy   Kartagener syndrome   Polymorphism   Primary ciliary dyskinesia   Reference proteome  

Feature

chain  Dynein regulatory complex subunit 2
splice variant  In isoform 2.
sequence variant  In dbSNP:rs10747556.

Uniprot

H9J7A4   A0A212EHZ4   A0A0L7LIE0   A0A194PY53   A0A2H1W4J0   A0A194RBQ0   + More
A0A1W4WW79   H2Y2X7   A0A1W2WI43   H2YV41   A0A2J7RRB3   M7B077   A0A210Q1Q8   A0A183AKV5   K7F4J7   A0A2Y9E887   D2A534   A0A1I8G2S8   A0A267FBB8   W5MM06   H0V0D0   A0A267FBA7   F6X3T1   A0A1U7SRH4   A0A0P7U305   A0A3S1HRS7   A0A3Q0FLY2   R7UDN7   A0A2K6FM76   A0A1U7SGG4   A0A1S3P4V4   F1SPN2   A0A1L8H9I0   A0A1W4XNB9   A0A2G8JR33   A0A337SLJ8   D2HWS8   M3VU27   A0A060X5J6   A0A2C9JJE0   G8F596   V8PIA0   A0A2K5X8W7   F7DVE6   A0A2K5X8W9   F7DVF7   Q4R7G7   L5KAP6   A9UXB8   G3VMZ5   A0A096MQF6   A0A2K5MDW2   G1S860   G1LKJ8   A0A383ZWN2   A0A2K6E2V3   A0A2J8LQ57   G1KHL0   V9KTF1   A0A2K6E2U9   A0A2K5MDZ4   G1S861   M1EHS3   A0A3B4BX71   G3STT4   A0A1U7UT88   A0A2K5ZPZ2   A0A1S3A337   A0A2K6KW11   A0A1U8BGZ5   A0A2Y9IDW1   A0A2R9CJ03   G2HJW2   A0A2R9CIW7   A0A2U3XCY9   A0A2I3SQH7   A0A2K6KW16   M3YTG6   A0A3Q7PXJ7   A0A2K6NZ85   A0A2K5D1B1   A0A2K6NZA6   A0A2Y9KVR6   A0A2K6SYT3   A0A2J8SYT1   A0A2J8SYS4   K1PK98   A0A2K6SYS9   H2NH56   A0A2U3VZF1   Q8IXS2-2   Q8VHI7   H0WUB2   Q8IXS2   A0A3R7JHE1   A0A3P4M861   A0A3Q7X5A0   A0A384D7K0  

Pubmed

19121390    22118469    26227816    26354079    12481130    15114417    + More
23624526    28812685    17381049    18362917    19820115    26392545    21993624    20431018    23254933    27762356    29023486    17975172    20010809    24755649    15562597    22002653    24297900    17431167    12498619    23258410    18273011    21709235    24402279    23236062    28071753    22722832    16136131    21484476    25362486    22992520    17089017    14702039    16541075    15489334    24094744    16141072    21183079    24813606   

EMBL

BABH01013596    AGBW02014758    OWR41097.1    JTDY01000983    KOB75202.1    KQ459589    + More
KPI97679.1    ODYU01006288    SOQ48001.1    KQ460397    KPJ15263.1    EAAA01000807    EAAA01000808    NEVH01000610    PNF43373.1    KB546351    EMP31236.1    NEDP02005239    OWF42683.1    UZAN01044816    VDP81522.1    AGCU01140503    AGCU01140504    KQ971361    EFA05141.1    NIVC01001245    PAA70369.1    AHAT01032550    AHAT01032551    AHAT01032552    AHAT01032553    AHAT01032554    AHAT01032555    AAKN02015071    NIVC01001246    NIVC01000419    PAA70359.1    PAA83441.1    AAMC01041754    JARO02004438    KPP68532.1    RQTK01000192    RUS84822.1    AMQN01001451    KB302615    ELU04099.1    AEMK02000027    CM004469    OCT92759.1    MRZV01001392    PIK38183.1    AANG04001751    GL193569    EFB19306.1    FR904994    CDQ74711.1    JH331416    EHH62460.1    AZIM01000009    ETE74060.1    AQIA01010852    AQIA01010853    AQIA01010854    AQIA01010855    AQIA01010856    JSUE03006698    JSUE03006699    CM001263    EHH20686.1    AB168851    AB070057    KB030893    ELK08407.1    CH991548    EDQ90361.1    AEFK01205099    AEFK01205100    AEFK01205101    AHZZ02002117    AHZZ02002118    ADFV01003265    ADFV01003266    ADFV01003267    ADFV01003268    ADFV01003269    ACTA01016529    NBAG03000280    PNI49400.1    JW869243    AFP01761.1    JP007079    AER95676.1    AJFE02090795    AJFE02090796    AJFE02090797    AJFE02090798    AJFE02090799    AJFE02090800    AJFE02090801    AACZ04012891    AK307026    BAK64020.1    PNI49398.1    PNI49397.1    AEYP01095599    NDHI03003535    PNJ25927.1    PNJ25928.1    JH815887    EKC22038.1    ABGA01141160    ABGA01141161    AF382188    AK093051    AK098529    AK314623    AC073610    CH471111    BC039317    AF454432    AK077174    BC048073    BC056947    BC060155    AAQR03104316    AAQR03104317    AAQR03104318    NIRI01002614    RJW60459.1    CYRY02008499    VCW77187.1   

Proteomes

UP000005204    UP000007151    UP000037510    UP000053268    UP000053240    UP000192223    + More
UP000008144    UP000007875    UP000235965    UP000031443    UP000242188    UP000050740    UP000007267    UP000248480    UP000007266    UP000095280    UP000215902    UP000018468    UP000005447    UP000008143    UP000189705    UP000034805    UP000271974    UP000014760    UP000233160    UP000087266    UP000008227    UP000186698    UP000192224    UP000230750    UP000011712    UP000193380    UP000076420    UP000009130    UP000233100    UP000006718    UP000010552    UP000001357    UP000007648    UP000028761    UP000233060    UP000001073    UP000008912    UP000261681    UP000233120    UP000001646    UP000261440    UP000007646    UP000189704    UP000233140    UP000079721    UP000233180    UP000189706    UP000248481    UP000240080    UP000002277    UP000245341    UP000000715    UP000286641    UP000233200    UP000233020    UP000248482    UP000233220    UP000005408    UP000001595    UP000245340    UP000005640    UP000000589    UP000005225    UP000286642    UP000261680    UP000291021   

PRIDE

H9J7A4    F1SPN2    Q4R7G7    Q8IXS2    Q8VHI7   

Pfam

PF14772   NYD-SP28        + More
PF00379   Chitin_bind_4
PF14775   NYD-SP28_assoc

Interpro

IPR039750   DRC1/DRC2        + More
IPR039505   DRC1/2_N       
IPR000618   Insect_cuticle       
IPR029440   DRC1_C       

ProteinModelPortal

H9J7A4   A0A212EHZ4   A0A0L7LIE0   A0A194PY53   A0A2H1W4J0   A0A194RBQ0   + More
A0A1W4WW79   H2Y2X7   A0A1W2WI43   H2YV41   A0A2J7RRB3   M7B077   A0A210Q1Q8   A0A183AKV5   K7F4J7   A0A2Y9E887   D2A534   A0A1I8G2S8   A0A267FBB8   W5MM06   H0V0D0   A0A267FBA7   F6X3T1   A0A1U7SRH4   A0A0P7U305   A0A3S1HRS7   A0A3Q0FLY2   R7UDN7   A0A2K6FM76   A0A1U7SGG4   A0A1S3P4V4   F1SPN2   A0A1L8H9I0   A0A1W4XNB9   A0A2G8JR33   A0A337SLJ8   D2HWS8   M3VU27   A0A060X5J6   A0A2C9JJE0   G8F596   V8PIA0   A0A2K5X8W7   F7DVE6   A0A2K5X8W9   F7DVF7   Q4R7G7   L5KAP6   A9UXB8   G3VMZ5   A0A096MQF6   A0A2K5MDW2   G1S860   G1LKJ8   A0A383ZWN2   A0A2K6E2V3   A0A2J8LQ57   G1KHL0   V9KTF1   A0A2K6E2U9   A0A2K5MDZ4   G1S861   M1EHS3   A0A3B4BX71   G3STT4   A0A1U7UT88   A0A2K5ZPZ2   A0A1S3A337   A0A2K6KW11   A0A1U8BGZ5   A0A2Y9IDW1   A0A2R9CJ03   G2HJW2   A0A2R9CIW7   A0A2U3XCY9   A0A2I3SQH7   A0A2K6KW16   M3YTG6   A0A3Q7PXJ7   A0A2K6NZ85   A0A2K5D1B1   A0A2K6NZA6   A0A2Y9KVR6   A0A2K6SYT3   A0A2J8SYT1   A0A2J8SYS4   K1PK98   A0A2K6SYS9   H2NH56   A0A2U3VZF1   Q8IXS2-2   Q8VHI7   H0WUB2   Q8IXS2   A0A3R7JHE1   A0A3P4M861   A0A3Q7X5A0   A0A384D7K0  

KEGG

101740944    no KO assigned | (RefSeq) coiled-coil domain-containing protein 65-like

GO

GO:0070286   GO:0005858   GO:0042302   GO:0005930   GO:0060285   GO:0003352   GO:0031514   GO:0060271  

PANTHER

PTHR21625  

Subcellular location

Cytoplasm  
Cytoskeleton  
Flagellum basal body  
Cell projection  
Cilium  
Flagellum  
Flagellum axoneme  

Length:

464

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00534

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01212

outside

1  -  464

 

 

Pi

306.299363

Theta

213.787445

Tajima's D

1.471357

CLR

0

CSRT

0.780560971951402

Interpretation

Uncertain