Gene

KWMTBOMO04386  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005279

Annotation

PREDICTED:_putative_polypeptide_N-acetylgalactosaminyltransferase_9_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr8(+):5424658-5433562      View in EpiBrowser

Full name

Polypeptide N-acetylgalactosaminyltransferase       + More
Putative polypeptide N-acetylgalactosaminyltransferase 9      

Alternative Name

Protein-UDP acetylgalactosaminyltransferase
Protein-UDP acetylgalactosaminyltransferase 9
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9

Location in the cell

Cytoplasmic   Reliability : 1.069 Mitochondrial   Reliability : 1.08

CDS

ATGAAATACTACAGCATGTTCTTCTTGAGGAGGCGAACCCTGATACTGAAAGCTGTTCTCATACTGACAGCTTTATGGTTTATGATAGCCCTGTTAACTACAAATGGCGGTTCACGGAACGCTATTGGCGCTCAGCCAGTTGAATACGAGGATGCTGAAGCGAAACCGTTGAAAATGGCCAAACCTACGTCGACAAGAAGGAAGAGTGAATCGTATGGCAACAATCTCTCGGACGGTCTAGGCGTGTTAGCTGCGCCCGGTTCGGACAATGCTCCCGGTGAACTTGGCAAACCAGTCGTACTGCCAAAGAACTTAACCGAAGAAACAAAACAGGCTGTCGCCGAGGGCTGGAAAAAGAACGCATTCAATCAATATGTGAGCGATCTTATATCGATCAGGAGGAAATTACCGGATCCTAGAGATGAGTGGTGCAAGCAACCTGGAAGGTATTTGGAAGATTTACCACAGACCTCGGTCGTAATATGCTTCCACAATGAAGCGTGGTCAGTGTTGTTGAGAACTGTGCATTCGGTTTTGGACCGATCACCAGCGCATCTGATCAAAGAAATCATACTTGTTGATGATTTTTCTGATATGCCACACTTGATGCAGCAACTGGACGATTATATGTCGTCACTCCCCAAGGTTAGAATAGTAAGAGCAACACGCCGTGAAGGCTTAATCAGGGCCAGATTGATCGGCGCCCGATACGTGACCGCCCCTATTCTAACCTATCTCGACAGTCATTGCGAATGTACTGAAGGTTGGCTGGAGCCCCTTCTTGATAGGATCGCGCGTAACAAAACGACCGTCGTCTGTCCTGTCATTGATGTAATTGATGACAATACTCTGGAGTATCACTATAGGGATTCTTCATCTGTCAACGTTGGTGGTTTCGACTGGAATTTACAGTTTAATTGGCATCCGGTACCATCGAAGGAACGCGCCAAGCATCAGAATACAGCAGAACCGGTTTGGTCTCCGACTATGGCCGGTGGCCTCTTTGCGATTGATAAGGAGTTCTTCGAAAAACTTGGAACCTACGATAACGGATTCGATATTTGGGGCGGTGAAAATTTGGAATTATCTTTTAAGACGTGGATGTGTGGAGGAACTCTTGAAATTGTGCCGTGCTCTCACGTTGGACATATTTTTAGAAAACGATCTCCATACAAGTGGCGAACAGGAGTTAATGTTTTAAAAAAGAATTCCGTGAGACTGGCAGAGGTTTGGCTCGATGATTACGCCAAATATTATTATCAACGTGTAGGTAACGATAAAGGGGACTACGGTGATGTCAGCAGCCGCAAAACACTGAGAAAAAATCTCGGCTGCAAATCTTTCGAATGGTACTTGAAAAACATCTATCCGGAATTGTTTATCCCTGGAGAATCGGTTGCTCATGGAGAGATACGCAATATTGGCTTCCAAAAGATTTGTCTGGACTCTCCAACCCGCAAGTCAGATCACCATAAGCCAGTCGGACTTTACCCGTGCCACCGACAGGGAGGAAATCAGTACTGGATGTATTCGAAAAACGGAGAGATACGTCGCGATGAAACTTGCTTGGACTATTCCGGGCACGATGTTGTATTGTACCCTTGTCACGGTGCTAAGGGAAATCAATTATGGTTGTACGATCCTAATACAAAGCTACTAAAACATGGCTCAAGCGAGAAATGCATGGCTATTTCTCGTAATAAGGACAAGATCACCATGGAAACGTGCAAAGAATCAGAAGACAGGCAGAAATGGACAATGGAGAATTTCAATGCTGAGCGCCTCAGTCCAGAACTTATAGCTGAGATCCAGTAG

Protein

MKYYSMFFLRRRTLILKAVLILTALWFMIALLTTNGGSRNAIGAQPVEYEDAEAKPLKMAKPTSTRRKSESYGNNLSDGLGVLAAPGSDNAPGELGKPVVLPKNLTEETKQAVAEGWKKNAFNQYVSDLISIRRKLPDPRDEWCKQPGRYLEDLPQTSVVICFHNEAWSVLLRTVHSVLDRSPAHLIKEIILVDDFSDMPHLMQQLDDYMSSLPKVRIVRATRREGLIRARLIGARYVTAPILTYLDSHCECTEGWLEPLLDRIARNKTTVVCPVIDVIDDNTLEYHYRDSSSVNVGGFDWNLQFNWHPVPSKERAKHQNTAEPVWSPTMAGGLFAIDKEFFEKLGTYDNGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRTGVNVLKKNSVRLAEVWLDDYAKYYYQRVGNDKGDYGDVSSRKTLRKNLGCKSFEWYLKNIYPELFIPGESVAHGEIRNIGFQKICLDSPTRKSDHHKPVGLYPCHRQGGNQYWMYSKNGEIRRDETCLDYSGHDVVLYPCHGAKGNQLWLYDPNTKLLKHGSSEKCMAISRNKDKITMETCKESEDRQKWTMENFNAERLSPELIAEIQ

Description

May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Catalytic Activity

L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP

Cofactor

Mn(2+)

Similarity

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Keywords

3D-structure   Alternative splicing   Complete proteome   Disulfide bond   Glycoprotein   Glycosyltransferase   Golgi apparatus   Lectin   Manganese   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Putative polypeptide N-acetylgalactosaminyltransferase 9
splice variant  In isoform E.

Uniprot

A0A3S2TPK5   A0A2A4K279   A0A2H1WZ65   A0A194Q2R8   A0A0N1PIE7   H9J6Y7   + More
A0A212F578   A0A1Y1JSS5   A0A139WCV3   U5EVC4   A0A1Q3G2R0   A0A1Q3G2S0   A0A1Q3G2H7   A0A0K8VWG7   A0A034VQH2   Q17M64   A0A1B6CXC6   A0A182GTH0   A0A023EUU3   A0A2H8TZ85   A0A1I8MII7   A0A1L8E1X9   W8AHD0   A0A1L8E1J6   A0A0P4VZX2   A0A2A3EKC2   A0A158NFL3   A0A1B6D6D2   A0A034VRC2   A0A0C9QHK0   A0A2M4CQV6   A0A088AEG6   A0A0P4W672   D6WY29   A0A2M3Z2J8   E0VG07   K7IWI9   A0A2M4CPY5   A0A182FUE1   A0A2J7QSW7   A0A067RJ22   J9K3C1   A0A2M3YZD5   A0A2M4BG78   A0A3L8DCQ0   A0A1B6E8D1   A0A182K0L1   B4KSN8   A0A2M4A019   A0A182UF65   B4LP94   A0A2M4A0M0   A0A182VEZ2   A0A182KSS0   A0A182HQ00   A0A182XD90   A0A182R5G9   A0A146LKK0   B4QIE5   B4P5X0   B4MIT5   B4HT77   A0A1W4UXH9   W5JMP6   B3NP82   A0A182PBP0   B3MDJ4   A0A0A9WQI9   A0A1B6D832   Q8MRC9   A0A182QCF3   A0A182W988   A0A0Q9XJ23   A0A2R7WZE6   B4H754   A0A2I9LPG6   B5DZF4   A0A3B0IXZ9   A0A0P5KTU2   A0A0P6B1L1   A0A0A9WSG8   A0A0Q9W3D9   A0A151X532   A0A0P5ITQ0   A0A0P5DY35   A0A0Q9WYK2   A0A0R1DSH5   A0A0J9RE15   A0A1W4UKJ2   A0A0Q5VL32   A0A0K8WEC4   Q8MRC9-2   A0A1Z5KV28   A0A2L2Y6F0   B4JWN6   A0A1B0CSE3   A0A0N8P0D7   A0A3B0J1R1   A0A2R5LF21   A0A0R3NXN7  

EC Number

2.4.1.-
2.4.1.41

Pubmed

26354079    19121390    22118469    28004739    18362917    19820115    + More
25348373    17510324    26483478    24945155    25315136    24495485    21347285    20566863    20075255    24845553    30249741    17994087    18057021    20966253    26823975    22936249    17550304    20920257    23761445    25401762    10731132    12537572    12537569    16251381    29248469    15632085    23185243    28528879    26561354   

EMBL

RSAL01000030    RVE51691.1    NWSH01000233    PCG78159.1    ODYU01012201    SOQ58380.1    + More
KQ459580    KPI99294.1    KQ459761    KPJ20143.1    BABH01028458    AGBW02010253    OWR48859.1    GEZM01101764    GEZM01101763    GEZM01101762    GEZM01101761    GEZM01101759    GEZM01101758    JAV52322.1    KQ971362    KYB25760.1    GANO01003468    JAB56403.1    GFDL01001016    JAV34029.1    GFDL01001006    JAV34039.1    GFDL01001043    JAV34002.1    GDHF01009399    JAI42915.1    GAKP01014590    JAC44362.1    CH477208    EAT47781.1    GEDC01020658    GEDC01019191    GEDC01010305    JAS16640.1    JAS18107.1    JAS26993.1    JXUM01002040    KQ560132    KXJ84270.1    GAPW01000852    JAC12746.1    GFXV01007779    MBW19584.1    GFDF01001569    JAV12515.1    GAMC01021513    GAMC01021510    JAB85042.1    GFDF01001568    JAV12516.1    GDRN01083665    JAI61639.1    KZ288230    PBC31629.1    ADTU01014616    ADTU01014617    ADTU01014618    ADTU01014619    ADTU01014620    ADTU01014621    ADTU01014622    GEDC01016173    GEDC01004329    GEDC01001082    JAS21125.1    JAS32969.1    JAS36216.1    GAKP01014592    JAC44360.1    GBYB01003004    JAG72771.1    GGFL01003100    MBW67278.1    GDRN01083666    JAI61638.1    EFA07904.2    GGFM01001917    MBW22668.1    DS235129    EEB12313.1    GGFL01003073    MBW67251.1    NEVH01011211    PNF31680.1    KK852439    KDR23871.1    ABLF02041136    ABLF02041160    GGFM01000881    MBW21632.1    GGFJ01002886    MBW52027.1    QOIP01000009    RLU18255.1    GEDC01025537    GEDC01006763    GEDC01003108    JAS11761.1    JAS30535.1    JAS34190.1    CH933808    EDW10537.1    GGFK01000843    MBW34164.1    CH940648    EDW60203.2    KRF79303.1    GGFK01001033    MBW34354.1    APCN01003286    GDHC01010015    JAQ08614.1    CM000362    CM002911    EDX07392.1    KMY94322.1    CM000158    EDW91886.2    CH963719    EDW72024.1    CH480816    EDW48178.1    ADMH02000607    ETN65652.1    CH954179    EDV55721.2    CH902619    EDV37457.2    GBHO01032877    GBHO01032876    JAG10727.1    JAG10728.1    GEDC01015957    GEDC01015451    GEDC01000234    JAS21341.1    JAS21847.1    JAS37064.1    AE013599    AY121661    BT029588    BT029630    AXCN02001829    KRG05300.1    KK856105    PTY24892.1    CH479216    EDW33587.1    GFWZ01000290    MBW20280.1    CM000071    EDY69575.1    KRT03239.1    OUUW01000001    SPP72784.1    GDIQ01205154    JAK46571.1    GDIP01021717    JAM81998.1    GBHO01032875    GBHO01032874    GBRD01015740    GBRD01015738    JAG10729.1    JAG10730.1    JAG50086.1    KRF79302.1    KQ982536    KYQ55434.1    GDIQ01209208    JAK42517.1    GDIP01155548    JAJ67854.1    KRF97468.1    KRK00182.1    KMY94323.1    KQS62429.1    GDHF01002925    JAI49389.1    GFJQ02008226    JAV98743.1    IAAA01004297    IAAA01004298    IAAA01004299    IAAA01004300    IAAA01004301    LAA02725.1    CH916375    EDV98374.1    AJWK01025919    KPU76836.1    SPP72783.1    GGLE01003995    MBY08121.1    KRT03238.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000053240    UP000005204    UP000007151    + More
UP000007266    UP000008820    UP000069940    UP000249989    UP000095301    UP000242457    UP000005205    UP000005203    UP000009046    UP000002358    UP000069272    UP000235965    UP000027135    UP000007819    UP000279307    UP000075881    UP000009192    UP000075902    UP000008792    UP000075903    UP000075882    UP000075840    UP000076407    UP000075900    UP000000304    UP000002282    UP000007798    UP000001292    UP000192221    UP000000673    UP000008711    UP000075885    UP000007801    UP000000803    UP000075886    UP000075920    UP000008744    UP000001819    UP000268350    UP000075809    UP000001070    UP000092461   

PRIDE

H9J6Y7    Q8MRC9   

Pfam

PF00535   Glycos_transf_2        + More
PF00652   Ricin_B_lectin

Interpro

IPR035992   Ricin_B-like_lectins        + More
IPR000772   Ricin_B_lectin       
IPR001173   Glyco_trans_2-like       
IPR029044   Nucleotide-diphossugar_trans       

SUPFAM

SSF53448   SSF53448        + More
SSF50370   SSF50370       

Gene 3D

3.90.550.10    

CDD

cd00161  RICIN

ProteinModelPortal

A0A3S2TPK5   A0A2A4K279   A0A2H1WZ65   A0A194Q2R8   A0A0N1PIE7   H9J6Y7   + More
A0A212F578   A0A1Y1JSS5   A0A139WCV3   U5EVC4   A0A1Q3G2R0   A0A1Q3G2S0   A0A1Q3G2H7   A0A0K8VWG7   A0A034VQH2   Q17M64   A0A1B6CXC6   A0A182GTH0   A0A023EUU3   A0A2H8TZ85   A0A1I8MII7   A0A1L8E1X9   W8AHD0   A0A1L8E1J6   A0A0P4VZX2   A0A2A3EKC2   A0A158NFL3   A0A1B6D6D2   A0A034VRC2   A0A0C9QHK0   A0A2M4CQV6   A0A088AEG6   A0A0P4W672   D6WY29   A0A2M3Z2J8   E0VG07   K7IWI9   A0A2M4CPY5   A0A182FUE1   A0A2J7QSW7   A0A067RJ22   J9K3C1   A0A2M3YZD5   A0A2M4BG78   A0A3L8DCQ0   A0A1B6E8D1   A0A182K0L1   B4KSN8   A0A2M4A019   A0A182UF65   B4LP94   A0A2M4A0M0   A0A182VEZ2   A0A182KSS0   A0A182HQ00   A0A182XD90   A0A182R5G9   A0A146LKK0   B4QIE5   B4P5X0   B4MIT5   B4HT77   A0A1W4UXH9   W5JMP6   B3NP82   A0A182PBP0   B3MDJ4   A0A0A9WQI9   A0A1B6D832   Q8MRC9   A0A182QCF3   A0A182W988   A0A0Q9XJ23   A0A2R7WZE6   B4H754   A0A2I9LPG6   B5DZF4   A0A3B0IXZ9   A0A0P5KTU2   A0A0P6B1L1   A0A0A9WSG8   A0A0Q9W3D9   A0A151X532   A0A0P5ITQ0   A0A0P5DY35   A0A0Q9WYK2   A0A0R1DSH5   A0A0J9RE15   A0A1W4UKJ2   A0A0Q5VL32   A0A0K8WEC4   Q8MRC9-2   A0A1Z5KV28   A0A2L2Y6F0   B4JWN6   A0A1B0CSE3   A0A0N8P0D7   A0A3B0J1R1   A0A2R5LF21   A0A0R3NXN7  

PDB

6E4Q     E-value=0,     Score=2145

KEGG

101736088    K00710 polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41] | (RefSeq) putative polypeptide N

PATHWAY

00512    Mucin type O-glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0000139   GO:0016021   GO:0030246   GO:0016757   GO:0006486   GO:0005794   GO:0032504   GO:0006493   GO:0031985   GO:0004653   GO:0005829   GO:0046872  

Subcellular location

Golgi apparatus membrane  

Length:

604

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.00064

Exp number, first 60 AAs:

20.99793

Total prob of N-in:

0.99885

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  35

outside

36  -  604

 

 

Pi

229.321017

Theta

192.551715

Tajima's D

0.535067

CLR

0.006417

CSRT

0.51872406379681

Interpretation

Uncertain