Gene

KWMTBOMO04376

Pre Gene Modal

BGIBMGA005248

Annotation

Serine_3-dehydrogenase_[Operophtera_brumata]

Location

Bomo_Chr8(-):5069254-5070157      View in EpiBrowser

Full name

Farnesol dehydrogenase      

Alternative Name

NADP+-dependent farnesol dehydrogenase 1

Location in the cell

Cytoplasmic   Reliability : 1.112 PlasmaMembrane   Reliability : 1.314

CDS

ATGGACCATTGGAAAAATAAAGCTGCTATTGTCACAGGCGCAGGGCAGGGCATAGGGGCGCAAATAACAGAAGACCTAATAAAAGCCGGGATGACTGTTATCGGCTTTGAACCAACACAAGCGAAACTCACACCACTATTTAACTTAGCCGATAAATACTCAGAATTGAACAATCAATTGATTCCATGTAAGTGTGACATTTCAAATGACAATGATTTAAAAAATGCTTTCGAGGGAATAGTTAAGCTGTACGGTGGCGTGGATTTGCTGGTGAATAATGCAGCGATAGGAAAAGCCGGTATGATATCTACTGGGAACTTAGAAGATCTCAATAATGTGATCGACGTCAATATTTACGGATTAATAGCTTGTAGTCGACACGCGATCGACTCAATGAAGAACAAAGGAAAAGGACACATTGTTAATGTAAATAGTATTTGTGGACACTATATGCCTTCATTTTCAGAGCCAGTAATGAACGTGTATATTGCGTCTAAACGAAGCATGACTGTTTTTACGAAAACCTTACGAGAAGAATTGAAAATGATTAATTCTAAAATCAAAATAACGAGCGTGTCTCCAGGAATAGTGAAAACGGGAATATTCAAATCTGCTGGCGTCGGATTTATCGACGATGCTTTCTTCTGTGATAATTCACATTTAACCGTGAAAGATGTTTCTGAAGTAATTCTAATGATTTTGTCGTCACCAAGAACTGTAAATATAACTGAGATTATTTTCCGCGGTTTACACTCAAGCTTCTGA

Protein

MDHWKNKAAIVTGAGQGIGAQITEDLIKAGMTVIGFEPTQAKLTPLFNLADKYSELNNQLIPCKCDISNDNDLKNAFEGIVKLYGGVDLLVNNAAIGKAGMISTGNLEDLNNVIDVNIYGLIACSRHAIDSMKNKGKGHIVNVNSICGHYMPSFSEPVMNVYIASKRSMTVFTKTLREELKMINSKIKITSVSPGIVKTGIFKSAGVGFIDDAFFCDNSHLTVKDVSEVILMILSSPRTVNITEIIFRGLHSSF

Description

Mediates oxidation of farnesol into farnesal, a precursor of juvenile hormone in the corpora allata (CA), the glands that synthesize juvenile hormone. Able to oxidize C(10) to C(15) isoprenoid and aliphatic alcohols.

Catalytic Activity

(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH

Biophysicochemical Properties

91 uM for (E,E) farnesol
97 uM for (Z,Z) farnesol
184 uM for 2-decanol
208 uM for geraniol (E)
109 uM for nerol (Z)
133 uM for citronellol
195 uM for octanol

Subunit

Homodimer.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Complete proteome   NAD   NADP   Oxidoreductase   Reference proteome  

Feature

chain  Farnesol dehydrogenase

Uniprot

H9J6V6   A0A2A4J7T1   A0A0L7LD56   A0A2H1WZW0   Q171F3   A0A182HF88   + More
A0A1S3CVJ6   A0A067R7J2   A0A067QVP7   A0A023EKY6   A0A1W7R8Z8   D2WKE1   D2WKE0   A0A182RF95   A0A182WQQ7   A0A1S4G5Z6   A0A1S4G628   A0A182Q801   A0A182K244   A0A067QZX5   A0A182LJK3   A0A182JMS0   A0A3F2YSU5   A0A067QP16   D2WKD9   A0A182U549   A0A2P8ZAU0   B0XBQ6   A0A2K7P6E4   A0A182MNA0   A0A182UZL4   A0A182HF87   A0A2M4BXZ0   W5JT61   B0XBQ5   A0A2J7RI42   A0A182TGU9   Q7Q752   B0WCC9   A0A084WK67   A0A182Y0X1   A0A1Q3FR56   A0A182H2F8   A0A1I8NRZ9   A0A182PHM3   A0A182WII2   B0WCD1   A0A182MQY1   A0A2M4BYU7   A0A182VHH0   A0A182LJ42   Q7Q6V7   A0A182HWS6   A0A182KB61   A0A067QY13   A0A0K8TT77   A0A2M4BXV1   A0A023EL01   A0A182XMX0   A0A182J4V4   A0A182U708   W8AUX2   A0A1B6EKL6   A0A182SKY5   A0A1B6FNP9   A0A1B6EEU8   A0A1Y1MM39   A0A2M4BXX5   D2A464   A0A2J7RI57   A0A1B6EKC2   A0A2M4CZ68   B0XLE8   A0A182H2F7   A0A1S4FRH3   A0A2P8YIU3   A0A182FF11   A0A1B6HEK4   A0A1S4EYV0   A0A1Q3FRN8   W5JII6   A0A1B6J719   Q17L62   A0A2M4CZ18   A0A084W2Y5   A0A2P8Z4F3   B0WER9   A0A2M4BY83   A0A1Y1LDR2   W5JEC7   E0VGI8   B0XBQ7   A0A084WK66   Q16S89   A0A1I8NRH8   A0A0L0BLT4   B0WES0   A0A1B6IR61   T1D4L4   A0A1B6KB28  

EC Number

1.1.1.216

Pubmed

19121390    26227816    17510324    26483478    24845553    24945155    + More
19940247    20966253    29403074    20920257    23761445    12364791    14747013    17210077    24438588    25244985    26369729    24495485    28004739    18362917    19820115    20566863    26108605    24330624   

EMBL

BABH01028435    NWSH01002579    PCG67929.1    JTDY01001623    KOB73320.1    ODYU01012363    + More
SOQ58640.1    CH477457    EAT40616.1    JXUM01133703    KQ568016    KXJ69194.1    KK852890    KDR14275.1    KDR14277.1    GAPW01003735    JAC09863.1    GEHC01000038    JAV47607.1    GQ344799    CH477512    ADB03641.1    EJY57753.1    GQ344798    ADB03640.1    EJY57754.1    AXCN02000361    KK852809    KDR16000.1    APCN01004328    KK853182    KDR10164.1    GQ344797    ADB03639.1    EJY57755.1    PYGN01000121    PSN53617.1    DS232648    EDS44405.1    AXCM01001467    KXJ69193.1    GGFJ01008805    MBW57946.1    ADMH02000550    ETN65914.1    EDS44404.1    NEVH01003505    PNF40507.1    AAAB01008960    EAA11736.1    DS231886    EDS43374.1    ATLV01024096    KE525349    KFB50611.1    GFDL01004976    JAV30069.1    JXUM01105273    KQ564952    KXJ71516.1    EDS43376.1    AXCM01015925    GGFJ01008767    MBW57908.1    EAA11743.4    APCN01001535    KDR14274.1    GDAI01000041    JAI17562.1    GGFJ01008766    MBW57907.1    GAPW01003736    JAC09862.1    GAMC01013876    GAMC01013875    JAB92680.1    GECZ01031281    GECZ01006786    JAS38488.1    JAS62983.1    GECZ01017934    JAS51835.1    GEDC01000853    JAS36445.1    GEZM01031296    JAV84946.1    GGFJ01008768    MBW57909.1    KQ971348    EFA04837.1    PNF40506.1    GECZ01031389    JAS38380.1    GGFL01006445    MBW70623.1    DS234433    EDS33998.1    JXUM01105272    KXJ71515.1    PYGN01000564    PSN44167.1    GECU01034549    JAS73157.1    GFDL01004952    JAV30093.1    ADMH02001376    ETN62710.1    GECU01012743    JAS94963.1    CH477218    EAT47433.1    GGFL01006395    MBW70573.1    ATLV01019729    KE525278    KFB44579.1    PYGN01000200    PSN51373.1    DS231911    EDS45832.1    GGFJ01008906    MBW58047.1    GEZM01062035    JAV70105.1    ETN62712.1    DS235145    EEB12494.1    EDS44406.1    KFB50610.1    CH477680    EAT37326.1    JRES01001683    KNC20987.1    EDS45833.1    GECU01018290    JAS89416.1    GALA01000908    JAA93944.1    GEBQ01031593    GEBQ01028120    JAT08384.1    JAT11857.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000008820    UP000069940    UP000249989    + More
UP000079169    UP000027135    UP000075900    UP000075920    UP000075886    UP000075881    UP000075882    UP000075880    UP000075840    UP000075902    UP000245037    UP000002320    UP000075883    UP000075903    UP000000673    UP000235965    UP000007062    UP000030765    UP000076408    UP000095300    UP000075885    UP000076407    UP000075901    UP000007266    UP000069272    UP000009046    UP000037069   

PRIDE

H9J6V6   

Pfam

PF00106   adh_short

Interpro

IPR002347   SDR_fam        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR020904   Sc_DH/Rdtase_CS       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

H9J6V6   A0A2A4J7T1   A0A0L7LD56   A0A2H1WZW0   Q171F3   A0A182HF88   + More
A0A1S3CVJ6   A0A067R7J2   A0A067QVP7   A0A023EKY6   A0A1W7R8Z8   D2WKE1   D2WKE0   A0A182RF95   A0A182WQQ7   A0A1S4G5Z6   A0A1S4G628   A0A182Q801   A0A182K244   A0A067QZX5   A0A182LJK3   A0A182JMS0   A0A3F2YSU5   A0A067QP16   D2WKD9   A0A182U549   A0A2P8ZAU0   B0XBQ6   A0A2K7P6E4   A0A182MNA0   A0A182UZL4   A0A182HF87   A0A2M4BXZ0   W5JT61   B0XBQ5   A0A2J7RI42   A0A182TGU9   Q7Q752   B0WCC9   A0A084WK67   A0A182Y0X1   A0A1Q3FR56   A0A182H2F8   A0A1I8NRZ9   A0A182PHM3   A0A182WII2   B0WCD1   A0A182MQY1   A0A2M4BYU7   A0A182VHH0   A0A182LJ42   Q7Q6V7   A0A182HWS6   A0A182KB61   A0A067QY13   A0A0K8TT77   A0A2M4BXV1   A0A023EL01   A0A182XMX0   A0A182J4V4   A0A182U708   W8AUX2   A0A1B6EKL6   A0A182SKY5   A0A1B6FNP9   A0A1B6EEU8   A0A1Y1MM39   A0A2M4BXX5   D2A464   A0A2J7RI57   A0A1B6EKC2   A0A2M4CZ68   B0XLE8   A0A182H2F7   A0A1S4FRH3   A0A2P8YIU3   A0A182FF11   A0A1B6HEK4   A0A1S4EYV0   A0A1Q3FRN8   W5JII6   A0A1B6J719   Q17L62   A0A2M4CZ18   A0A084W2Y5   A0A2P8Z4F3   B0WER9   A0A2M4BY83   A0A1Y1LDR2   W5JEC7   E0VGI8   B0XBQ7   A0A084WK66   Q16S89   A0A1I8NRH8   A0A0L0BLT4   B0WES0   A0A1B6IR61   T1D4L4   A0A1B6KB28  

PDB

1XG5     E-value=3.37668e-34,     Score=360

KEGG

101735830    K15890 NADP+-dependent farnesol dehydrogenase [EC:1.1.1.216] | (RefSeq) farnesol dehydrogenase-like

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)
00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0047886   GO:0006718   GO:0102132   GO:0102131   GO:0004316  

Length:

254

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.2429

Exp number, first 60 AAs:

0.01077

Total prob of N-in:

0.18280

outside

1  -  254

 

 

Pi

63.836353

Theta

73.11909

Tajima's D

-0.396905

CLR

0.722156

CSRT

0.267236638168092

Interpretation

Uncertain