Gene

KWMTBOMO04347

Annotation

PREDICTED:_4-hydroxyphenylpyruvate_dioxygenase-like_[Amyelois_transitella]

Location

Bomo_Chr8(-):4027061-4028089      View in EpiBrowser

Full name

4-hydroxyphenylpyruvate dioxygenase      

Alternative Name

4-hydroxyphenylpyruvic acid oxidase

Location in the cell

Cytoplasmic   Reliability : 1.6

CDS

ATGCCTATAACCATAATATTCGAGTCACCCACAAAACCGGACAGTGAAATCGCGAGCAGCTTAAACACTCACGGAGACTTCGTGAAGGATGTGGCATTTGAAGTTCACAATCTCGACGAGCTGGTTCGGAGGGCCATAGAAGGGCGAGCCGAGATAATTAAAACAACAACACAAATTGAAGACAACGATGGTGTCTTGAAATACGCCATTTTGAAAACGTATGGAGAGAACACACATACGTTAATTGATCGGAGCAGATATAACGGTATCTTGTTGCCTGGATTCGTAGCCGTTGAAGATGATCCACTGACAGCGATGTTGTGA

Protein

MPITIIFESPTKPDSEIASSLNTHGDFVKDVAFEVHNLDELVRRAIEGRAEIIKTTTQIEDNDGVLKYAILKTYGENTHTLIDRSRYNGILLPGFVAVEDDPLTAML

Description

Key enzyme in the degradation of tyrosine.

Catalytic Activity

3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate

Cofactor

Fe cation

Similarity

Belongs to the 4HPPD family.

Keywords

Complete proteome   Dioxygenase   Iron   Metal-binding   Oxidoreductase   Phenylalanine catabolism   Reference proteome   Repeat   Tyrosine catabolism  

Feature

chain  4-hydroxyphenylpyruvate dioxygenase

Uniprot

A0A2A4IY11   A0A2A4IUV6   A0A194Q7D9   A0A194QLP7   A0A0L7KYG5   A0A212EXC3   + More
A0A212EYA1   A0A194QMV1   A0A2A4ISS0   I4DJI5   A0A194Q189   A0A2A4IS65   A0A195FM03   A0A3L8DEL4   H9J6X0   A0A140DKW1   A0A1I8IJD7   F4WEM2   E2BIZ1   A0A210PRQ4   A0A195C642   E9IWI6   A0A2H1W9R5   A0A0K8TWD3   A0A1S3JV90   A0A026WR60   A0A158NF97   A0A2A3EPS1   A0A0C9RMG1   A0A195AVG6   A0A088ACK9   A0A0N0U440   A0A0N4XB01   A0A267E053   A0A267H602   A0A1W4WLA9   A0A232F978   A0A1I8IMR3   F1L6R5   A0A2H2IKY3   A0A2B7Y825   A0A1D1VAW0   A0A165JYY0   A0A2C9JS97   D6WZP4   A0A0P6ENL0   A0A0B1TK92   A0A0P6DRR7   A0A0P5VJ77   A0A0U2N329   A0A0P6DF79   A0A0P5F559   K7J3E2   A0A0P5VD00   W6NC52   A0A0P5AQJ9   A0A0P5BJ32   A0A0P5NZL2   A0A0P5N2X2   A0A0P5ATU2   A0A0P5XAL6   Q22633   A0A0N8A5M5   A0A0P5BLJ0   A0A0P5MUW4   A0A0P5Q3X8   A0A0P4ZGJ1   A0A0P5QA72   A0A3B5A4L3   A0A151WHV6   W8B5L7   W8AU74   T1FNN4   R7V6N7   A0A3Q1J7S4   E2AE27   A0A3P8Z521   A0A3S3NZJ3   A0A3B3QJX6   A0A1I7TMB3   A0A0P5GQT2   A0A2G9TNT5   A0A2P8XHR9   A0A0P5SQ41   A0A2P4VGT7   A0A261BV92   E3LZD7   A0A3P8Z5R8   A0A0P6B140   A0A395GUJ1   V4A0B7   A0A3N0YSI0   A0A3P8Z6J3   A0A2G9UN36   Q6AZV8   F1Q986   A0A1B6M4D0   A0A060WF31   A0A0L7QZ05   A0A1S3PI18  

EC Number

1.13.11.27

Pubmed

26354079    26227816    22118469    22651552    30249741    19121390    + More
26392545    21719571    20798317    28812685    21282665    24508170    21347285    28648823    21685128    27649274    26693682    15562597    18362917    19820115    20075255    9851916    24495485    23254933    25069045    29240929    29403074    26114425    26394399    23594743    24755649   

EMBL

NWSH01005678    PCG64062.1    NWSH01007556    PCG62913.1    KQ459580    KPI99320.1    + More
KQ461196    KPJ06289.1    JTDY01004486    KOB68089.1    AGBW02011783    OWR46152.1    AGBW02011602    OWR46441.1    KPJ06290.1    NWSH01007858    PCG62781.1    AK401453    BAM18075.1    KPI99321.1    NWSH01008285    PCG62625.1    KQ981490    KYN41356.1    QOIP01000009    RLU18348.1    BABH01028340    BABH01028341    KT748795    AMK48576.1    GL888103    EGI67385.1    GL448543    EFN84336.1    NEDP02005541    OWF39134.1    KQ978287    KYM95641.1    GL766526    EFZ15088.1    ODYU01007234    SOQ49835.1    GDHF01033929    JAI18385.1    KK107119    EZA58527.1    ADTU01013709    KZ288204    PBC33226.1    GBYB01014597    JAG84364.1    KQ976736    KYM76052.1    KQ435840    KOX71401.1    UZAF01023597    VDO90544.1    NIVC01002946    PAA54239.1    NIVC01000022    PAA93731.1    NNAY01000645    OXU27215.1    JI172563    ADY45819.1    PDNA01000065    PGH17385.1    BDGG01000005    GAU98781.1    KV407454    KZF26804.1    KQ971372    EFA10456.1    GDIQ01060920    JAN33817.1    KN549647    KHJ96521.1    GDIQ01077658    JAN17079.1    GDIP01099251    JAM04464.1    KR181950    ALJ76674.1    GDIQ01079712    JAN15025.1    GDIQ01267568    JAJ84156.1    GDIP01116891    JAL86823.1    CAVP010058440    CDL94656.1    GDIP01200342    JAJ23060.1    GDIP01198880    JAJ24522.1    GDIQ01142393    JAL09333.1    GDIQ01159286    JAK92439.1    GDIP01198879    JAJ24523.1    GDIP01076462    GDIQ01068717    LRGB01001361    JAM27253.1    JAN26020.1    KZS12608.1    Z50016    GDIP01180137    JAJ43265.1    GDIP01183491    JAJ39911.1    GDIQ01162285    JAK89440.1    GDIQ01140597    JAL11129.1    GDIP01217134    JAJ06268.1    GDIQ01123049    JAL28677.1    KQ983106    KYQ47412.1    GAMC01014147    JAB92408.1    GAMC01014145    JAB92410.1    AMQM01007398    KB097605    ESN93556.1    AMQN01004913    KB294684    ELU14199.1    GL438827    EFN68260.1    NCKU01005195    RWS04895.1    GDIQ01239002    JAK12723.1    KZ357420    PIO59597.1    PYGN01002085    PSN31547.1    GDIQ01092552    JAL59174.1    LFJK02000579    POM36507.1    NIPN01000070    OZG14229.1    DS268419    EFO86670.1    GDIP01021619    JAM82096.1    KZ824460    RAK97773.1    KB201305    ESO97258.1    RJVU01027559    ROL49134.1    KZ345871    PIO71709.1    BC077167    BC165880    AAH77167.1    AAI65880.1    CABZ01049825    CABZ01049826    GEBQ01009219    JAT30758.1    FR904513    CDQ65631.1    KQ414685    KOC63806.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000037510    UP000007151    UP000078541    + More
UP000279307    UP000005204    UP000095280    UP000007755    UP000008237    UP000242188    UP000078542    UP000085678    UP000053097    UP000005205    UP000242457    UP000078540    UP000005203    UP000053105    UP000038042    UP000268014    UP000215902    UP000192223    UP000215335    UP000005237    UP000224634    UP000186922    UP000076632    UP000076420    UP000007266    UP000002358    UP000025227    UP000076858    UP000001940    UP000261400    UP000075809    UP000015101    UP000014760    UP000265040    UP000000311    UP000265140    UP000285301    UP000261540    UP000095282    UP000245037    UP000237256    UP000216463    UP000008281    UP000249402    UP000030746    UP000000437    UP000193380    UP000053825    UP000087266   

PRIDE

H9J6X0    A0A088ACK9    Q22633   

Pfam

PF00903   Glyoxalase

Interpro

IPR005956   4OHPhenylPyrv_dOase        + More
IPR041736   4OHPhenylPyrv_dOase_N       
IPR037523   VOC       
IPR029068   Glyas_Bleomycin-R_OHBP_Dase       
IPR004360   Glyas_Fos-R_dOase_dom       
IPR041735   4OHPhenylPyrv_dOase_C       
IPR018146   Glyoxalase_1_CS       

SUPFAM

SSF54593   SSF54593       

Gene 3D

3.10.180.10    

CDD

cd08342  HPPD_N_like
cd07250  HPPD_C_like

ProteinModelPortal

A0A2A4IY11   A0A2A4IUV6   A0A194Q7D9   A0A194QLP7   A0A0L7KYG5   A0A212EXC3   + More
A0A212EYA1   A0A194QMV1   A0A2A4ISS0   I4DJI5   A0A194Q189   A0A2A4IS65   A0A195FM03   A0A3L8DEL4   H9J6X0   A0A140DKW1   A0A1I8IJD7   F4WEM2   E2BIZ1   A0A210PRQ4   A0A195C642   E9IWI6   A0A2H1W9R5   A0A0K8TWD3   A0A1S3JV90   A0A026WR60   A0A158NF97   A0A2A3EPS1   A0A0C9RMG1   A0A195AVG6   A0A088ACK9   A0A0N0U440   A0A0N4XB01   A0A267E053   A0A267H602   A0A1W4WLA9   A0A232F978   A0A1I8IMR3   F1L6R5   A0A2H2IKY3   A0A2B7Y825   A0A1D1VAW0   A0A165JYY0   A0A2C9JS97   D6WZP4   A0A0P6ENL0   A0A0B1TK92   A0A0P6DRR7   A0A0P5VJ77   A0A0U2N329   A0A0P6DF79   A0A0P5F559   K7J3E2   A0A0P5VD00   W6NC52   A0A0P5AQJ9   A0A0P5BJ32   A0A0P5NZL2   A0A0P5N2X2   A0A0P5ATU2   A0A0P5XAL6   Q22633   A0A0N8A5M5   A0A0P5BLJ0   A0A0P5MUW4   A0A0P5Q3X8   A0A0P4ZGJ1   A0A0P5QA72   A0A3B5A4L3   A0A151WHV6   W8B5L7   W8AU74   T1FNN4   R7V6N7   A0A3Q1J7S4   E2AE27   A0A3P8Z521   A0A3S3NZJ3   A0A3B3QJX6   A0A1I7TMB3   A0A0P5GQT2   A0A2G9TNT5   A0A2P8XHR9   A0A0P5SQ41   A0A2P4VGT7   A0A261BV92   E3LZD7   A0A3P8Z5R8   A0A0P6B140   A0A395GUJ1   V4A0B7   A0A3N0YSI0   A0A3P8Z6J3   A0A2G9UN36   Q6AZV8   F1Q986   A0A1B6M4D0   A0A060WF31   A0A0L7QZ05   A0A1S3PI18  

PDB

1SQI     E-value=4.02559e-15,     Score=191

KEGG

101737290    K00457 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27] | (RefSeq) 4-hydroxyphenylpyruvate dioxyg

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
00360    Phenylalanine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0003868   GO:0009072   GO:0046872   GO:0004462   GO:0000139   GO:0005789   GO:0006572   GO:0006559   GO:0051213  

PANTHER

PTHR11959  

Length:

107

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00132

Exp number, first 60 AAs:

0

Total prob of N-in:

0.05263

outside

1  -  107

 

 

Pi

137.449887

Theta

71.406709

Tajima's D

1.479351

CLR

0

CSRT

0.780260986950652

Interpretation

Uncertain