Gene

KWMTBOMO04330  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014136

Annotation

PREDICTED:_26S_proteasome_non-ATPase_regulatory_subunit_11_[Amyelois_transitella]

Location

Bomo_Chr8(+):3439380-3441005      View in EpiBrowser

Full name

26S proteasome non-ATPase regulatory subunit 11      

Alternative Name

26S proteasome regulatory complex subunit p42B
26S proteasome regulatory subunit Rpn6

Location in the cell

Cytoplasmic   Reliability : 3.204

CDS

ATGGCCGGAGCGATGTTATTTGAAAGATCACGCGTCTCATCATCGACGAACAGAGACGAAGACGTCCGCATGACTGACAAAATGGTCAGCACTGGCGAGCTGCCCGAAGATGATGAAGAAAACATAAGAGCAAAGGAGCAGGGTATCCTTAACCTCGGCGAGAAATACAAAAAGGAAGGGAAGGCTAAGGAGCTGGCAGAACTTATCAAAGCCACCAGACCATTTTTGAGCCTCATAAGTAAAGCTAAAGCTGCGAAACTGGTACGTTCCCTTGTTGACTTCTTCCTAGATTTGGAGGCAGGGATCGGTATAGAAGTACAGTTGTGTAAAGAGTGCATAGAATGGGCCAAGGAAGAACGACGCACCTTTCTTCGGCAGTCTTTGGAAGCAAGACTTATTGCTCTGTATTTCGACACTGGTATGTATACGGAAGCTTTGGACCTTGCTACTGCACTTTTGAAAGAGCTAAAAAAACTTGATGACAAAAACCTATTGGTTGAAGTGCTTCTTTTAGAAAGTAAGACATACCATGCTCTCAGTAACTTACCTAAGGCCCGTGCCTCTTTGACATCAGCAAGAACAACTGCAAATGCTATTTACTGTCCTCCAAAAATGCAAGCAGCCCTCGACCTCCAATCTGGTATACTACATGCAGCTGATGAAAGAGATTTCAAAACTGCTTACTCATACTTTTATGAAGCCTTTGAAGGTTACGATGGAGCTGACAGTCCTAAAGCTCTAACAGCACTGAAATACATGCTTTTATCGAAGATCATGTTGAATCAAGCTGAAGAAGTGGCTACAATATGTGGAAGCAAAGCTGCCCTCAAGTATGCAGGGAAAGAATTAGAAGCGATGCGGGCCGTAGCCACAGCTTCTCATAAAAGATCATTAGCTGACTTCCAAGCAGCCTTAAAAACATACAAACCAGAGCTTGAAGAAGACGCAGTGGTGAGAGCTCATCTTGGTGCTTTGTATGATACTATGTTAGAACAGAACTTGTGCCGAATTGTAGAACCTTACATGAGAGTCCAGGTGGACCATGTAGCTCGCTGTATTCGCTTGCCCGTTGTTCAAGTAGAGAAAAAACTTTCTCAAATGATCTTGGACAAGAAACTGAATGGAATTTTAGATCAAGGAGAAGGAGTGCTGATAGTTTTTGATGAATCCCCCTTAGATAAGACTTATGAAACAGTTTTAGAAACCATCCATCATATGAGCAAGGTTGTTGACACACTTTACCAGAAAGCAAAAAAATTGTCATAG

Protein

MAGAMLFERSRVSSSTNRDEDVRMTDKMVSTGELPEDDEENIRAKEQGILNLGEKYKKEGKAKELAELIKATRPFLSLISKAKAAKLVRSLVDFFLDLEAGIGIEVQLCKECIEWAKEERRTFLRQSLEARLIALYFDTGMYTEALDLATALLKELKKLDDKNLLVEVLLLESKTYHALSNLPKARASLTSARTTANAIYCPPKMQAALDLQSGILHAADERDFKTAYSYFYEAFEGYDGADSPKALTALKYMLLSKIMLNQAEEVATICGSKAALKYAGKELEAMRAVATASHKRSLADFQAALKTYKPELEEDAVVRAHLGALYDTMLEQNLCRIVEPYMRVQVDHVARCIRLPVVQVEKKLSQMILDKKLNGILDQGEGVLIVFDESPLDKTYETVLETIHHMSKVVDTLYQKAKKLS

Description

Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core.

Subunit

Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. Interacts with alien/CSN2. Interacts with Prosalpha2 and Rpt6.

Similarity

Belongs to the proteasome subunit S9 family.

Keywords

3D-structure   Alternative splicing   Complete proteome   Phosphoprotein   Proteasome   Reference proteome  

Feature

chain  26S proteasome non-ATPase regulatory subunit 11
splice variant  In isoform A.

Uniprot

H9JX71   A0A2A4IU11   A0A2H1W556   A0A212EPT1   S4PDZ7   I4DJY3   + More
A0A194RGG1   A0A1E1WSW8   A0A0L7LJY7   A0A067QTZ7   A0A2A3EBE8   A0A088AST3   A0A2J7RBP1   A0A0J7KH65   A0A0M8ZRS1   A0A154PF33   A0A310SFY2   A0A0C9S2N5   E1ZYI0   A0A026W946   A0A151ITK3   A0A195FPH6   A0A151WGR2   F4X2G7   A0A195AXY5   A0A158NFN5   E2BDM3   E9J3G9   A0A0L7R776   A0A232FLE4   A0A195CV19   A0A0K8TRY7   A0A0L0CQG8   A0A1B6BZE6   A0A139WBJ8   A0A1L8DT29   A0A0K8VFZ8   A0A034W6Z5   A0A0K8VC37   A0A0A1WVU6   A0A1W4X0A7   A0A0M4EVT8   A0A1B6FH95   T1PH94   A0A1B6HHR3   W8BVW3   A0A1I8Q9L7   A0A1B6KXL3   B2CKJ1   B4KNN2   B4LM78   R4G8S2   D3TLS6   A0A1W4U5W7   A0A0J9RCV1   B4P7N4   B4HRN7   A0A1A9V2M4   A0A0R1DQQ0   A0A0Q5W049   B3NQT4   A0A1Y1K3D3   A0A1A9YCU5   A0A1B0C5F2   A0A1A9ZFR7   B4J6L2   Q7KLV9-2   A0A0B4K7Z5   Q7KLV9   B3ME32   B4MNS3   A0A1A9WHX5   B5E078   B4GAX9   A0A3B0J2D2   A0A069DU92   A0A0P4VJD6   A0A336KJ15   A0A2R7WGE9   A0A1J1HPW3   A0A1Y9H293   A0A182R0C2   A0A2C9GSP2   A0A1Q3FEA3   U5EVB2   Q16M56   B0X9N8   A0A1Y9HDY5   A0A182GC14   A0A1I8JTD2   A0A182UZT7   A0A182U3B8   Q7PXJ8   T1DTL7   W5J8A7   A0A2M3ZHV8   A0A2M4CFR4   A0A084VTU1   A0A2M4ACW0   A0A2M4CGA2  

Pubmed

19121390    22118469    23622113    22651552    26354079    26227816    + More
24845553    20798317    24508170    30249741    21719571    21347285    21282665    28648823    26369729    26108605    18362917    19820115    25348373    25830018    25315136    24495485    17994087    20353571    22936249    17550304    28004739    10893261    10731132    12537572    12537569    12426099    18327897    22187461    12537568    12537573    12537574    16110336    17569856    17569867    15632085    26334808    27129103    17510324    26483478    12364791    14747013    17210077    20920257    23761445    24438588   

EMBL

BABH01032062    NWSH01007395    PCG62986.1    ODYU01006281    SOQ47982.1    AGBW02013410    + More
OWR43474.1    GAIX01003421    JAA89139.1    AK401601    KQ459302    BAM18223.1    KPJ01838.1    KQ460211    KPJ16534.1    GDQN01000915    JAT90139.1    JTDY01000857    KOB75654.1    KK853018    KDR12438.1    KZ288312    PBC28381.1    NEVH01005891    PNF38242.1    LBMM01007629    KMQ89564.1    KQ435936    KOX68313.1    KQ434890    KZC10455.1    KQ774645    OAD52310.1    GBYB01015166    JAG84933.1    GL435225    EFN73734.1    KK107348    QOIP01000010    EZA52161.1    RLU17836.1    KQ981031    KYN10175.1    KQ981340    KYN42490.1    KQ983159    KYQ46997.1    GL888580    EGI59353.1    KQ976716    KYM76900.1    ADTU01014687    GL447678    EFN86185.1    GL768066    EFZ12578.1    KQ414646    KOC66611.1    NNAY01000061    OXU31403.1    KQ977279    KYN04009.1    GDAI01000494    JAI17109.1    JRES01000049    KNC34615.1    GEDC01030834    JAS06464.1    KQ971372    KYB25309.1    GFDF01004564    JAV09520.1    GDHF01031012    GDHF01014503    JAI21302.1    JAI37811.1    GAKP01007616    JAC51336.1    GDHF01015790    GDHF01000601    JAI36524.1    JAI51713.1    GBXI01011652    JAD02640.1    CP012524    ALC41795.1    GECZ01020198    JAS49571.1    KA647480    AFP62109.1    GECU01033591    JAS74115.1    GAMC01005492    JAC01064.1    GEBQ01031654    GEBQ01023781    GEBQ01022847    JAT08323.1    JAT16196.1    JAT17130.1    EU523050    ACB59075.1    CH933808    EDW10017.2    CH940648    EDW60956.2    ACPB03014260    GAHY01000477    JAA77033.1    CCAG010006864    EZ422378    ADD18654.1    CM002911    KMY93827.1    CM000158    EDW91060.1    CH480816    EDW47901.1    KRJ99594.1    CH954179    KQS62602.1    EDV55994.1    GEZM01094058    JAV55962.1    JXJN01025957    CH916367    EDW00915.1    AF145309    AE013599    AF160939    BT089015    AFH08079.1    CH902619    EDV37577.2    CH963848    EDW73762.2    CM000071    EDY68938.1    CH479181    EDW32081.1    OUUW01000001    SPP75287.1    GBGD01001617    JAC87272.1    GDKW01002306    JAI54289.1    UFQS01000439    UFQT01000439    SSX03952.1    SSX24317.1    KK854787    PTY18723.1    CVRI01000008    CRK88510.1    AXCN02000029    GFDL01009161    JAV25884.1    GANO01001111    JAB58760.1    CH477879    EAT35415.1    EJY57979.1    DS232542    EDS43240.1    JXUM01053532    KQ561780    KXJ77567.1    APCN01000874    AAAB01008987    EAA01750.5    EGK97581.1    GAMD01000874    JAB00717.1    ADMH02001877    ETN60697.1    GGFM01007352    MBW28103.1    GGFL01000004    MBW64182.1    ATLV01016489    KE525092    KFB41385.1    GGFK01005288    MBW38609.1    GGFL01000003    MBW64181.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000027135    UP000242457    UP000005203    UP000235965    UP000036403    UP000053105    UP000076502    UP000000311    UP000053097    UP000279307    UP000078492    UP000078541    UP000075809    UP000007755    UP000078540    UP000005205    UP000008237    UP000053825    UP000215335    UP000078542    UP000037069    UP000007266    UP000192223    UP000092553    UP000095301    UP000095300    UP000009192    UP000008792    UP000015103    UP000092444    UP000192221    UP000002282    UP000001292    UP000078200    UP000008711    UP000092443    UP000092460    UP000092445    UP000001070    UP000000803    UP000007801    UP000007798    UP000091820    UP000001819    UP000008744    UP000268350    UP000183832    UP000075884    UP000075886    UP000075880    UP000008820    UP000002320    UP000075900    UP000069940    UP000249989    UP000075840    UP000075903    UP000075902    UP000007062    UP000000673    UP000030765   

PRIDE

H9JX71    Q7KLV9   

Pfam

PF18503   RPN6_C_helix        + More
PF18055   RPN6_N
PF01399   PCI

Interpro

IPR000717   PCI_dom        + More
IPR035295   PSMD11       
IPR036390   WH_DNA-bd_sf       
IPR040780   Rpn6_C_helix       
IPR040773   Rpn6_N       
IPR011990   TPR-like_helical_dom_sf       

SUPFAM

SSF46785   SSF46785        + More
SSF48452   SSF48452       

ProteinModelPortal

H9JX71   A0A2A4IU11   A0A2H1W556   A0A212EPT1   S4PDZ7   I4DJY3   + More
A0A194RGG1   A0A1E1WSW8   A0A0L7LJY7   A0A067QTZ7   A0A2A3EBE8   A0A088AST3   A0A2J7RBP1   A0A0J7KH65   A0A0M8ZRS1   A0A154PF33   A0A310SFY2   A0A0C9S2N5   E1ZYI0   A0A026W946   A0A151ITK3   A0A195FPH6   A0A151WGR2   F4X2G7   A0A195AXY5   A0A158NFN5   E2BDM3   E9J3G9   A0A0L7R776   A0A232FLE4   A0A195CV19   A0A0K8TRY7   A0A0L0CQG8   A0A1B6BZE6   A0A139WBJ8   A0A1L8DT29   A0A0K8VFZ8   A0A034W6Z5   A0A0K8VC37   A0A0A1WVU6   A0A1W4X0A7   A0A0M4EVT8   A0A1B6FH95   T1PH94   A0A1B6HHR3   W8BVW3   A0A1I8Q9L7   A0A1B6KXL3   B2CKJ1   B4KNN2   B4LM78   R4G8S2   D3TLS6   A0A1W4U5W7   A0A0J9RCV1   B4P7N4   B4HRN7   A0A1A9V2M4   A0A0R1DQQ0   A0A0Q5W049   B3NQT4   A0A1Y1K3D3   A0A1A9YCU5   A0A1B0C5F2   A0A1A9ZFR7   B4J6L2   Q7KLV9-2   A0A0B4K7Z5   Q7KLV9   B3ME32   B4MNS3   A0A1A9WHX5   B5E078   B4GAX9   A0A3B0J2D2   A0A069DU92   A0A0P4VJD6   A0A336KJ15   A0A2R7WGE9   A0A1J1HPW3   A0A1Y9H293   A0A182R0C2   A0A2C9GSP2   A0A1Q3FEA3   U5EVB2   Q16M56   B0X9N8   A0A1Y9HDY5   A0A182GC14   A0A1I8JTD2   A0A182UZT7   A0A182U3B8   Q7PXJ8   T1DTL7   W5J8A7   A0A2M3ZHV8   A0A2M4CFR4   A0A084VTU1   A0A2M4ACW0   A0A2M4CGA2  

PDB

3TXN     E-value=4.91424e-133,     Score=1215

KEGG

101735320    K03036 26S proteasome regulatory subunit N6 | (RefSeq) 26S proteasome non-ATPase regulatory subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0043248   GO:0000502   GO:0008541   GO:0005198   GO:0006511   GO:0007623   GO:0005829   GO:0008063   GO:0005654   GO:0043161   GO:0005838   GO:0005515   GO:0003677   GO:0006351   GO:0008270   GO:0004672   GO:0004674   GO:0009058   GO:0016742   GO:0003824  

PANTHER

PTHR10678:SF6  

Length:

421

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01048

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00347

outside

1  -  421

 

 

Pi

176.906624

Theta

233.669875

Tajima's D

-0.725185

CLR

1.766452

CSRT

0.191140442977851

Interpretation

Uncertain