Silkworm Genome Informatics Database

Gene

KWMTBOMO04321 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014132

Annotation

conventional_protein_kinase_C_[Bombyx_mori]

Location

Bomo_Chr8(+):3193496-3216917 View in EpiBrowser

Full name

Protein kinase C       + More
Non-specific serine/threonine protein kinase
Protein kinase C, brain isozyme

Alternative Name

dPKC53E(BR)

Location in the cell

Cytoplasmic Reliability : 2.21

CDS

ATGGTTAGTTCGAAGGGCTTTGGAAAACAAGGATTCCAGTGCCAAGTGTGCAGTTTCGTGGTGCACAAGCGATGCCACGAGTATGTTACCTTCACGTGTCCCGGCGCCGACAAGGGGGCGGATTCCGACGACACACGCACGAGACACAACTTTCGCGTTTACACGTATTCTTCTCCAACGTTCTGCGATCACTGTGGCTCTCTGCTGTACGGGCTCATCCACCAGGGCCTGAAATGTCAAGCATGCGACATGAACGTTCACAAACGCTGCGAGGAGTCAGTGCCCAACCTCTGCGGATGCGACCACACGGAGCGACGCGGGAGAATCCAACTAATCGTCTCTTGCCAAGGATACAAGCTTACCGTTGAAGTCAAGCAGGGTCGCAACTTGATCCCCATGGACCCGAACGGGCTGTCGGACCCTTACGTCAAGATGAAGCTGATCCCTGACTCTGATAACGTCAAGAAAAAAACCAAGACCATCCGTAGCACCTTGAACCCCGTCTGGAATGAGGTCCTCTCGTTCGACCTCAAAGCTGAGGATAAAGATCGGCGGCTTCTTATTGAGGTTTGGGACTGGGATAGAACTTCCCGCAATGATTTCATGGGCTCGCTATCCTTCGGAATATCCGAAGTGATGAAAGCACCGGCCGAGGGATGGTTCAAACTCCTGACTCAAGAAGAAGGAGAGTTCTATAACGTGCCGGTGCCGGAGGAGGGCGCCGACTTGGTCCAGCTCAAGAACCAGATGAGGGCTACAACGGTGGGGGCTCGCCGACCTCCGCCCCCGCCAGACCGCGAGGTGCCTCACAACGTGGCCGCCGCTGATGTTATCCGAGCTACCGACTTCAATTTCATTATGGTGCTCGGGAAAGGTTCCTTTGGGAAGGTAATGTTGGCCGAACGTCGCGGCACAGACGAACTGTACGCCATCAAGATCCTGAAGAAGGACATCATCATTCAGGACGATGACGTTGAGTGCACCATGGTCGAGAAGCGAGTGCTGGCTCTGAGCAACAAACCACCGTTTTTAGTGCAATTACATTCCTGCTTCCAGACTATGGATCGTCTGTACTTTGTGATGGAATACGTGAACGGAGGTGATCTGATGTTCCAAATACAGCAGTGCGGGAAATTCAAGGAACCCGTAGCCGTGTTTTATTCAGCGGAAATCGCGATCGGCCTGTTTTTCCTTCACTCGCGCGGCATCGTGTATCGCGACTTGAAACTAGACAACGTTCTCCTCGACCAAGACGGCCATATTAAGATCGCGGATTTCGGCATGTGCAAGGAAGGGATCACGGGCGACAAAACCACGAAGACCTTTTGCGGAACACCCGACTACATAGCCCCGGAGATCATCTTATACCAGCCCTATGGTAAATCCGTGGACTGGTGGGCTTATGGTGTGCTGCTGTACGAAATGCTGGTGGGTCAGCCGCCGTTCGACGGAGAAGATGAGGAGGAATTATTCGCCGCCATCACCGATAACAGTGTGTCTTATCCGAAGACTTTAAGCAAGGAGGCAAAGGACGCGTGCAAGTCGTTCCTGAGCAAGAACCCTCAGAAGCGGCTGGGGTGCGGCGCGCGGGGGGAGGAGGACGTCCGCACGCACGCATTCTTCCGCCGCATCGACTGGGCCAGGGTCGAGGCTAGGGACGTCCAGCCGCCCTTCAAGCCTAAGATCAAACACCGTAAGGACGTGTCGAACTTCGACAAGCAGTTCACTCAGGAGAAGACCGAGCTGACTCCAACGGACAAACTGTTCATGATGAACCTTGACCAGACAGAATTCATGGGCTTCTCGTTCCTCAATCCTGAGTTCGTGCAGCACGTCTGA

Protein

MVSSKGFGKQGFQCQVCSFVVHKRCHEYVTFTCPGADKGADSDDTRTRHNFRVYTYSSPTFCDHCGSLLYGLIHQGLKCQACDMNVHKRCEESVPNLCGCDHTERRGRIQLIVSCQGYKLTVEVKQGRNLIPMDPNGLSDPYVKMKLIPDSDNVKKKTKTIRSTLNPVWNEVLSFDLKAEDKDRRLLIEVWDWDRTSRNDFMGSLSFGISEVMKAPAEGWFKLLTQEEGEFYNVPVPEEGADLVQLKNQMRATTVGARRPPPPPDREVPHNVAAADVIRATDFNFIMVLGKGSFGKVMLAERRGTDELYAIKILKKDIIIQDDDVECTMVEKRVLALSNKPPFLVQLHSCFQTMDRLYFVMEYVNGGDLMFQIQQCGKFKEPVAVFYSAEIAIGLFFLHSRGIVYRDLKLDNVLLDQDGHIKIADFGMCKEGITGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDNSVSYPKTLSKEAKDACKSFLSKNPQKRLGCGARGEEDVRTHAFFRRIDWARVEARDVQPPFKPKIKHRKDVSNFDKQFTQEKTELTPTDKLFMMNLDQTEFMGFSFLNPEFVQHV

Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Miscellaneous

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.
The sequence shown is that of Oregon-R.

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Keywords

Alternative splicing ATP-binding Calcium Complete proteome Kinase Metal-binding Nucleotide-binding Reference proteome Repeat Transferase Zinc Zinc-finger

Feature

chain Protein kinase C, brain isozyme
splice variant In isoform Short.

Uniprot

Q4AED6 A0A3S2LE20 A0A2H1V9Q0 B7SJR4 U5EVB0 A0A1B6I5I2 + More
A0A2M4CFS2 A0A2M4CG08 A0A1B6GZN3 A0A2M3Z0G5 A0A2M4A5H1 T1DR46 A0A195D314 A0A1Q3FVK6 A0A151I099 A0A158P293 Q17M58 A0A026WE33 A0A195E424 A0A2C9GQF4 A0A084WUJ0 A0A0C9PVL2 A0A0A9X7J5 E7E8G5 A0A146MGA7 A0A1Y1KPZ7 A0A154PTC7 A0A1B6MUM2 A0A2A3EMS7 K7IYS5 A0A0C9RES7 A0A1B6E075 A0A069DWB7 A0A336M1V8 A0A1B6KG43 A0A023F5U6 A0A2A4IXU0 E0VZ80 V9I8Q4 A0A2H8TUR3 A0A195FJY9 A0A0M9A898 X1WIJ1 A0A212FCL7 H9JX67 A0A0P4WF51 A0A151X2L9 A0A3S5HJG3 A0A067QT55 A0A2S2QQT9 A0A3S3PBV5 A0A2R5L950 A0A0F7VKG4 W5JP71 A0A0P4XL39 A0A0P5D8U5 A0A0P5DL28 Q7Q042 E9H7K4 A0A0L7QVB3 U5Q0I7 E2AUA9 A0A336M7E0 E2C036 A0A2H4WAM9 A0A0P5S9D6 A0A0L0CM72 A0A2J7QBG0 A0A0K2ULE4 A0A087ZWI0 A0A293MRD6 A0A1I8NB64 B3NP50 P05130 A0A1W4VCQ2 P05130-2 A0A3Q8S2G7 A0A0B4KFT3 A0A0Q5VMW0 A0A0J9REQ3 A0A1W4VE13 B4P8K3 A0A0J9REJ1 A0A0R1DTJ1 B4HTB4 B4MR97 A0A1D2M9Z3 B4LP68 A0A0Q9WAN6 A0A3B0JQ90 A0A1I8PHG2 A0A0K2UKB2 A0A0A9WKY4 A0A1I8PHL8 A0A232FBI1 A0A0Q9XJ37 B4KSR1 A0A1E1XQS4 A0A034V8S4 A0A182R5H4

EC Number

2.7.11.13
2.7.11.1

Pubmed

18790718 21347285 17510324 24508170 30249741 24438588 + More
25401762 26823975 28004739 20075255 26334808 25474469 20566863 22118469 19121390 24845553 20920257 23761445 12364791 21292972 24146884 20798317 29182505 26108605 25315136 17994087 3107983 10731132 12537572 25639794 12537568 12537573 12537574 16110336 17569856 17569867 22936249 17550304 27289101 28648823 18057021 29209593 25348373

EMBL

AB184961 BAE17022.1 RSAL01000190 RVE44699.1 ODYU01001403 SOQ37531.1 + More
EU307653 ABZ88709.1 GANO01001957 JAB57914.1 GECU01025518 JAS82188.1 GGFL01000012 MBW64190.1 GGFL01000011 MBW64189.1 GECZ01001897 JAS67872.1 GGFM01001235 MBW21986.1 GGFK01002736 MBW36057.1 GAMD01000815 JAB00776.1 KQ976885 KYN07287.1 GFDL01003467 JAV31578.1 KQ976632 KYM78894.1 ADTU01007033 ADTU01007034 ADTU01007035 ADTU01007036 ADTU01007037 ADTU01007038 ADTU01007039 ADTU01007040 CH477208 EAT47787.1 KK107250 QOIP01000002 EZA54327.1 RLU25527.1 KQ979657 KYN19935.1 APCN01003284 APCN01003285 ATLV01027092 ATLV01027093 KE525423 KFB53884.1 GBYB01005493 JAG75260.1 GBHO01036455 GBHO01026922 JAG07149.1 JAG16682.1 HQ620620 ADU04569.1 GDHC01013556 GDHC01000364 JAQ05073.1 JAQ18265.1 GEZM01077226 JAV63364.1 KQ435078 KZC14430.1 GEBQ01007770 GEBQ01000378 JAT32207.1 JAT39599.1 KZ288215 PBC32459.1 GBYB01005490 GBYB01005491 JAG75257.1 JAG75258.1 GEDC01005970 JAS31328.1 GBGD01000753 JAC88136.1 UFQT01000437 SSX24296.1 GEBQ01029592 JAT10385.1 GBBI01002159 JAC16553.1 NWSH01005314 PCG64296.1 AAZO01006409 AAZO01006410 DS235850 EEB18686.1 JR035813 JR035814 AEY56698.1 AEY56699.1 GFXV01006208 MBW18013.1 KQ981523 KYN40319.1 KQ435713 KOX79275.1 ABLF02038174 ABLF02038185 ABLF02038189 ABLF02038192 ABLF02064969 AGBW02009166 OWR51484.1 BABH01032043 BABH01032044 GDRN01094414 JAI59725.1 KQ982580 KYQ54490.1 MH169597 AZK16019.1 KK852965 KDR13146.1 GGMS01010871 MBY80074.1 NCKU01001434 NCKU01001421 NCKU01001393 RWS12113.1 RWS12140.1 RWS12214.1 GGLE01001905 MBY06031.1 LN830673 CFW94182.1 ADMH02000553 ETN65896.1 GDIP01239824 JAI83577.1 GDIP01161222 JAJ62180.1 GDIP01155587 GDIP01063383 JAJ67815.1 AAAB01008986 EAA00266.4 GL732601 EFX72294.1 KQ414727 KOC62570.1 KC896830 AGY49601.1 GL442815 EFN62966.1 SSX24297.1 GL451712 EFN78732.1 MG020532 AUC64088.1 GDIP01142837 JAL60877.1 JRES01000195 KNC33448.1 NEVH01016298 PNF25923.1 HACA01021140 CDW38501.1 GFWV01017901 MAA42629.1 CH954179 EDV55689.1 X05076 X05279 X05280 X05281 X05282 X05283 AE013599 AY095003 MH169598 AZK16020.1 AGB93567.1 KQS62404.1 CM002911 KMY94401.1 CM000158 EDW92220.1 KMY94397.1 KRK00405.1 CH480816 EDW48215.1 CH963849 EDW74636.1 LJIJ01002347 ODM89806.1 CH940648 EDW60177.1 KRF79287.1 OUUW01000001 SPP74821.1 HACA01021139 CDW38500.1 GBHO01036457 GBHO01036456 JAG07147.1 JAG07148.1 NNAY01000499 OXU27982.1 CH933808 KRG05316.1 EDW10560.1 GFAA01001841 JAU01594.1 GAKP01020994 JAC37958.1

Proteomes

UP000283053 UP000078542 UP000078540 UP000005205 UP000008820 UP000053097 + More
UP000279307 UP000078492 UP000075840 UP000030765 UP000076502 UP000242457 UP000002358 UP000218220 UP000009046 UP000078541 UP000053105 UP000007819 UP000007151 UP000005204 UP000075809 UP000027135 UP000285301 UP000000673 UP000007062 UP000000305 UP000053825 UP000000311 UP000008237 UP000037069 UP000235965 UP000005203 UP000095301 UP000008711 UP000000803 UP000192221 UP000002282 UP000001292 UP000007798 UP000094527 UP000008792 UP000268350 UP000095300 UP000215335 UP000009192 UP000075900

PRIDE

Q4AED6 H9JX67 P05130

Pfam

PF00433   Pkinase_C        + More
PF00130   C1_1
PF00168   C2
PF00069   Pkinase

Interpro

IPR035892   C2_domain_sf        + More
IPR000961   AGC-kinase_C
IPR020454   DAG/PE-bd
IPR014375   Protein_kinase_C_a/b/g
IPR017892   Pkinase_C
IPR000719   Prot_kinase_dom
IPR008271   Ser/Thr_kinase_AS
IPR011009   Kinase-like_dom_sf
IPR000008   C2_dom
IPR017441   Protein_kinase_ATP_BS
IPR002219   PE/DAG-bd

SUPFAM

SSF56112 SSF56112

Gene 3D

2.60.40.150

CDD

cd00029 C1

ProteinModelPortal

Q4AED6 A0A3S2LE20 A0A2H1V9Q0 B7SJR4 U5EVB0 A0A1B6I5I2 + More
A0A2M4CFS2 A0A2M4CG08 A0A1B6GZN3 A0A2M3Z0G5 A0A2M4A5H1 T1DR46 A0A195D314 A0A1Q3FVK6 A0A151I099 A0A158P293 Q17M58 A0A026WE33 A0A195E424 A0A2C9GQF4 A0A084WUJ0 A0A0C9PVL2 A0A0A9X7J5 E7E8G5 A0A146MGA7 A0A1Y1KPZ7 A0A154PTC7 A0A1B6MUM2 A0A2A3EMS7 K7IYS5 A0A0C9RES7 A0A1B6E075 A0A069DWB7 A0A336M1V8 A0A1B6KG43 A0A023F5U6 A0A2A4IXU0 E0VZ80 V9I8Q4 A0A2H8TUR3 A0A195FJY9 A0A0M9A898 X1WIJ1 A0A212FCL7 H9JX67 A0A0P4WF51 A0A151X2L9 A0A3S5HJG3 A0A067QT55 A0A2S2QQT9 A0A3S3PBV5 A0A2R5L950 A0A0F7VKG4 W5JP71 A0A0P4XL39 A0A0P5D8U5 A0A0P5DL28 Q7Q042 E9H7K4 A0A0L7QVB3 U5Q0I7 E2AUA9 A0A336M7E0 E2C036 A0A2H4WAM9 A0A0P5S9D6 A0A0L0CM72 A0A2J7QBG0 A0A0K2ULE4 A0A087ZWI0 A0A293MRD6 A0A1I8NB64 B3NP50 P05130 A0A1W4VCQ2 P05130-2 A0A3Q8S2G7 A0A0B4KFT3 A0A0Q5VMW0 A0A0J9REQ3 A0A1W4VE13 B4P8K3 A0A0J9REJ1 A0A0R1DTJ1 B4HTB4 B4MR97 A0A1D2M9Z3 B4LP68 A0A0Q9WAN6 A0A3B0JQ90 A0A1I8PHG2 A0A0K2UKB2 A0A0A9WKY4 A0A1I8PHL8 A0A232FBI1 A0A0Q9XJ37 B4KSR1 A0A1E1XQS4 A0A034V8S4 A0A182R5H4

PDB

3PFQ E-value=0, Score=2217

KEGG

692526 K02677 classical protein kinase C alpha type [EC:2.7.11.13] | (RefSeq) Cpkc; conventional protein ki

PATHWAY

04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04745    Phototransduction - fly - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0008270 GO:0005524 GO:0004697 GO:0035556 GO:0046872 GO:0018105 GO:0004674 GO:0035206 GO:2000370 GO:0004712 GO:0006468 GO:0005886 GO:0004672 GO:0005515 GO:0009058 GO:0016742 GO:0003824

Length:

612

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.835739999999999

Exp number, first 60 AAs:

0.00914

Total prob of N-in:

0.01146

outside

1 - 612

Pi

265.600755

Theta

188.059537

Tajima's D

1.970838

CLR

0.417326

CSRT

0.87595620218989

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics