Gene

KWMTBOMO04315

Pre Gene Modal

BGIBMGA014130

Annotation

PREDICTED:_glycoprotein-N-acetylgalactosamine_3-beta-galactosyltransferase_1_isoform_X2_[Papilio_polytes]

Location

Bomo_Chr8(+):2966546-2987769      View in EpiBrowser

Full name

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1      

Alternative Name

Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1

Location in the cell

Nuclear   Reliability : 0.957

CDS

ATGGGTCGTCGATTTGTGCTAACCCTGGTGATCGGCATATCGGCCGGATTTAGTTTTGCGTACATATTATTAACATCCACGGCAGGCTCAAGGGATGTGGCTTGGCCAGCGTACAGAGAGTCCCTACGTGACCTCGACAGACATCCAATAGTGAATATAGTTGATCACGGAAGCGACGAACCGGCCCACAAGGATGAGGACCGATCGATTGCCGACGAACTGTCCAAACGCGTCAGAGTGTTGTGCTGGGTGATGACGCAGCCGAGCAACCATGAGAAAAAGGCCAAACACGTGAAGGCCACGTGGGGGAAACGGTGCAATAAACTACTCTTCATGAGCAGCGTTGAAGACAGCAACCTGCCATCGGTAAAGCTTCCCGTGCAAGAAGGTCGAGATTACTTGTGGGCGAAGACGAAAGCCGCCTTCAGATACGTGTACGAACATCACCGGAGGGAGGCCGACTGGTTCCTGAAAGCCGACGACGATACTTATGTTGTCGTCGAAAATCTGAGGTACATGTTGGCTGACTACAGTAGCAACGATCCTGTGTACTTCGGATGCAGGTTCAAGCCGTTTACGCCCCAGGGGTACATGAGCGGCGGCGCGGGCTACGTGCTCAGCCGGGAGGCGCTGGACCAGTTCGTGAACAAGGCGCTGCCCTCCCCGCATCTGTGCAAGGCCAGCGACCACGGCGCAGAGGACGCGGAGATCGGCAAATGTCTCCACAACATCGGGGTGAGGGCGATGGACTCCCGCGACTCGATGAGGCGGGGCCGGTTCTTCCCGTTCGTCCCGCAGGACCACCTGTTCCCCAACAAGGACAAGGGCTTCTGGTACTGGAGCTACATCTACTACCCCAGCGACGAGGGCCTGGATTGTTGCTCCGACCACGCCGTGACGTTCCACTACGTCAACCCGCAACAGATGTACGTGTTCGACTATCTCATATACCACCTTCGGCCTTACGGCATCACGTTCGGAGCTGGCGAGCTGCCCAAGATACTCAGGAACGATACCAAGTAG

Protein

MGRRFVLTLVIGISAGFSFAYILLTSTAGSRDVAWPAYRESLRDLDRHPIVNIVDHGSDEPAHKDEDRSIADELSKRVRVLCWVMTQPSNHEKKAKHVKATWGKRCNKLLFMSSVEDSNLPSVKLPVQEGRDYLWAKTKAAFRYVYEHHRREADWFLKADDDTYVVVENLRYMLADYSSNDPVYFGCRFKPFTPQGYMSGGAGYVLSREALDQFVNKALPSPHLCKASDHGAEDAEIGKCLHNIGVRAMDSRDSMRRGRFFPFVPQDHLFPNKDKGFWYWSYIYYPSDEGLDCCSDHAVTFHYVNPQQMYVFDYLIYHLRPYGITFGAGELPKILRNDTK

Description

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.

Catalytic Activity

an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP

Cofactor

Mg(2+)

Subunit

Homodimer; disulfide-linked.

Similarity

Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Glycosyltransferase   Magnesium   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Uniprot

H9JX65   A0A194PZA1   A0A3S2P8U9   A0A212EHL0   A0A2A4J603   A0A194RKQ1   + More
A0A2H1W6E7   A0A1B6M2T5   A0A067QWL0   A0A2J7PME5   A0A1B6C985   A0A310SD70   A0A088A4W7   A0A023F3Q5   A0A0L7QJU9   A0A2A3EL53   A0A224XR10   A0A232EZJ6   A0A3L8DQW4   T1HZZ2   A0A0K8TSZ5   A0A195CHA7   A0A0T6BAN3   A0A158NFW4   A0A195E6P8   A0A154P0D6   A0A195B2L8   A0A1Y1LBB1   B4KFA1   F4X6V2   E2BDC3   T1PHG0   A0A0H5ASN0   K7IV37   A0A195F123   E2QCQ7   Q7K237   B4NXJ7   B4JZE4   B4HYS8   B4Q7B3   A0A1B6DQC5   A0A151XC16   B3N7V0   Q29JS8   B4GJ75   A0A1W4VZN4   B0W718   A0A182J4C7   A0A146LDU9   D6WWB8   A0A146M0W3   A0A0C9PXN7   A0A1B0CVU0   A0A3B0KC85   A0A1Q3F579   A0A1L8E259   A0A026WPX2   U4ULY6   A0A1Q3F576   A0A226EHW1   B3MNY7   B4LUY2   A0A1W4W4C7   B4JZE7   E9J664   A0A1B6LGY8   B4MUK1   A0A1I8NQ52   A0A182NP33   A0A0K8VZM6   A0A0A1WJD9   A0A1B0D6K6   W8BDZ4   A0A0A1WUB1   A0A1B6GBC1   A0A3B0KL56   A0A3S3RV15   A0A2R7W172   A0A1S4FGV4   B4KFA0   A0A1B0BP47   A0A1A9XWR0   A0A034W3N1   A0A034W040   A0A293LSI2   A0A182J5S4   B4MUK0   A0A1B0GEW9   A0A0M4E6N1   T1JUS0   A0A2M4BQX1   Q171Q2   A0A0Q9XDM3   A0A1D2NB06   A0A182F180   A0A1A9UIV5   A0A131XW28   A0A1A9ZHQ5   A0A182PJL2  

EC Number

2.4.1.122

Pubmed

19121390    26354079    22118469    24845553    25474469    28648823    + More
30249741    26369729    21347285    28004739    17994087    18057021    21719571    20798317    25315136    20075255    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    18985719    17550304    22936249    15632085    26823975    18362917    19820115    24508170    23537049    21282665    25830018    24495485    25348373    17510324    27289101    29652888   

EMBL

BABH01032024    BABH01032025    BABH01032026    KQ459583    KPI98651.1    RSAL01000190    + More
RVE44702.1    AGBW02014869    OWR40967.1    NWSH01002802    PCG67505.1    KQ460211    KPJ16551.1    ODYU01006646    SOQ48675.1    GEBQ01010373    GEBQ01009744    GEBQ01007762    GEBQ01001377    JAT29604.1    JAT30233.1    JAT32215.1    JAT38600.1    KK853163    KDR10418.1    NEVH01024022    PNF17501.1    GEDC01027304    JAS09994.1    KQ763450    OAD55047.1    GBBI01002706    JAC16006.1    KQ415041    KOC58907.1    KZ288219    PBC32224.1    GFTR01005546    JAW10880.1    NNAY01001470    OXU23854.1    QOIP01000006    RLU22188.1    ACPB03016096    GDAI01000114    JAI17489.1    KQ977754    KYN00110.1    LJIG01002548    KRT84392.1    ADTU01014819    KQ979568    KYN20870.1    KQ434782    KZC04610.1    KQ976662    KYM78537.1    GEZM01062525    JAV69630.1    CH933807    EDW12001.1    KRG03030.1    GL888818    EGI57884.1    GL447585    EFN86351.1    KA648206    AFP62835.1    LC017708    BAR92729.1    AAZX01005821    KQ981864    KYN34265.1    AE014134    AAF52723.1    AY061283    CM000157    EDW88588.1    KRJ97924.1    CH916379    EDV94066.1    CH480818    EDW52208.1    CM000361    CM002910    EDX04307.1    KMY89180.1    GEDC01009430    JAS27868.1    KQ982314    KYQ57921.1    CH954177    EDV58311.1    KQS70357.1    CH379062    EAL32883.2    CH479184    EDW37389.1    DS231851    EDS37292.1    GDHC01013397    JAQ05232.1    KQ971361    EFA09301.2    GDHC01005171    JAQ13458.1    GBYB01006253    JAG76020.1    AJWK01031240    AJWK01031241    AJWK01031242    AJWK01031243    OUUW01000010    SPP85820.1    GFDL01012324    JAV22721.1    GFDF01001489    JAV12595.1    KK107135    EZA58028.1    KB632267    ERL91015.1    GFDL01012325    JAV22720.1    LNIX01000003    OXA56930.1    CH902620    EDV32174.1    KPU73829.1    CH940649    EDW63231.1    KRF80977.1    KRF80978.1    EDV94069.1    GL768221    EFZ11692.1    GEBQ01017005    JAT22972.1    CH963857    EDW76196.1    KRF98399.1    GDHF01010519    GDHF01007951    JAI41795.1    JAI44363.1    GBXI01015330    JAC98961.1    AJVK01003695    AJVK01003696    GAMC01018567    GAMC01018566    JAB87989.1    GBXI01012081    GBXI01010767    GBXI01010142    JAD02211.1    JAD03525.1    JAD04150.1    GECZ01010034    JAS59735.1    SPP85821.1    NCKU01004134    NCKU01004111    RWS06399.1    RWS06434.1    KK854232    PTY13477.1    EDW12000.2    JXJN01017809    GAKP01010020    JAC48932.1    GAKP01010021    GAKP01010019    JAC48931.1    GFWV01006744    MAA31474.1    EDW76195.2    CCAG010012610    CCAG010012611    CP012523    ALC40034.1    CAEY01000783    GGFJ01006180    MBW55321.1    CH477448    EAT40729.1    KRG03028.1    LJIJ01000112    ODN02438.1    GEFM01004557    GEGO01002139    JAP71239.1    JAR93265.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000007151    UP000218220    UP000053240    + More
UP000027135    UP000235965    UP000005203    UP000053825    UP000242457    UP000215335    UP000279307    UP000015103    UP000078542    UP000005205    UP000078492    UP000076502    UP000078540    UP000009192    UP000007755    UP000008237    UP000095301    UP000002358    UP000078541    UP000000803    UP000002282    UP000001070    UP000001292    UP000000304    UP000075809    UP000008711    UP000001819    UP000008744    UP000192221    UP000002320    UP000075880    UP000007266    UP000092461    UP000268350    UP000053097    UP000030742    UP000198287    UP000007801    UP000008792    UP000192223    UP000007798    UP000095300    UP000075884    UP000092462    UP000285301    UP000092460    UP000092443    UP000092444    UP000092553    UP000015104    UP000008820    UP000094527    UP000069272    UP000078200    UP000092445    UP000075885   

PRIDE

H9JX65    E2QCQ7    Q7K237   

Pfam

PF02434   Fringe

Interpro

IPR003378   Fringe-like        + More
IPR026842   C1GALT1       
IPR029044   Nucleotide-diphossugar_trans       

SUPFAM

SSF53448   SSF53448       

ProteinModelPortal

H9JX65   A0A194PZA1   A0A3S2P8U9   A0A212EHL0   A0A2A4J603   A0A194RKQ1   + More
A0A2H1W6E7   A0A1B6M2T5   A0A067QWL0   A0A2J7PME5   A0A1B6C985   A0A310SD70   A0A088A4W7   A0A023F3Q5   A0A0L7QJU9   A0A2A3EL53   A0A224XR10   A0A232EZJ6   A0A3L8DQW4   T1HZZ2   A0A0K8TSZ5   A0A195CHA7   A0A0T6BAN3   A0A158NFW4   A0A195E6P8   A0A154P0D6   A0A195B2L8   A0A1Y1LBB1   B4KFA1   F4X6V2   E2BDC3   T1PHG0   A0A0H5ASN0   K7IV37   A0A195F123   E2QCQ7   Q7K237   B4NXJ7   B4JZE4   B4HYS8   B4Q7B3   A0A1B6DQC5   A0A151XC16   B3N7V0   Q29JS8   B4GJ75   A0A1W4VZN4   B0W718   A0A182J4C7   A0A146LDU9   D6WWB8   A0A146M0W3   A0A0C9PXN7   A0A1B0CVU0   A0A3B0KC85   A0A1Q3F579   A0A1L8E259   A0A026WPX2   U4ULY6   A0A1Q3F576   A0A226EHW1   B3MNY7   B4LUY2   A0A1W4W4C7   B4JZE7   E9J664   A0A1B6LGY8   B4MUK1   A0A1I8NQ52   A0A182NP33   A0A0K8VZM6   A0A0A1WJD9   A0A1B0D6K6   W8BDZ4   A0A0A1WUB1   A0A1B6GBC1   A0A3B0KL56   A0A3S3RV15   A0A2R7W172   A0A1S4FGV4   B4KFA0   A0A1B0BP47   A0A1A9XWR0   A0A034W3N1   A0A034W040   A0A293LSI2   A0A182J5S4   B4MUK0   A0A1B0GEW9   A0A0M4E6N1   T1JUS0   A0A2M4BQX1   Q171Q2   A0A0Q9XDM3   A0A1D2NB06   A0A182F180   A0A1A9UIV5   A0A131XW28   A0A1A9ZHQ5   A0A182PJL2  

KEGG

101746328    K00731 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122] | (RefSeq) gly

PATHWAY

00512    Mucin type O-glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016263   GO:0016020   GO:0016266   GO:0016021   GO:0055001   GO:0009247   GO:0021551   GO:0007528   GO:0016267   GO:0046872   GO:1902037   GO:0006486   GO:0051489   GO:0048531   GO:0016757   GO:0006508   GO:0005622   GO:0009113   GO:0005524   GO:0009058   GO:0016742   GO:0003824  

PANTHER

PTHR23033:SF13  

Subcellular location

Membrane  

Length:

340

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.62242

Exp number, first 60 AAs:

21.58034

Total prob of N-in:

0.97166

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  340

 

 

Pi

239.291711

Theta

172.460702

Tajima's D

0.417787

CLR

0.601353

CSRT

0.494025298735063

Interpretation

Uncertain