Gene

KWMTBOMO04311

Pre Gene Modal

BGIBMGA014128

Annotation

PREDICTED:_5-hydroxytryptamine_receptor_[Amyelois_transitella]

Location

Bomo_Chr8(+):2798805-2828226      View in EpiBrowser

Full name

5-hydroxytryptamine receptor      

Alternative Name

Serotonin receptor

Location in the cell

PlasmaMembrane   Reliability : 4.821

CDS

ATGAATGCGTCTCAACTATCAAGCGAGTTGAACACTACTAACAATGACGTCGCATATCCGACCTCTGAGTGGTTCGACGCGAACTGCTCCTGGGTGGAAGTGGTATCGTGGGGCTGCAACACTACGGTCAACAGCACAGCAAGCAACTCCACGAGCAGTGACGTCACGTCGCTCGTCCTTATGGCTGTCACCTCTGTAGTTCTCGCTCTCATCATCTTAGCTACTATCGTTGGCAATGTTTTCGTGATAGCCGCTATTATTATCGAGAGGAATCTTCAGAATGTAGCTAATTATCTGGTCGCGTCGCTAGCGGTCGCTGACCTCATGGTCGCGTGCTTGGTGATGCCCTTGGGCGCTGTATATGAAGTTAGTCAAGGTTGGATCCTGGGTCCCGAGCTCTGCGACATGTGGACCTCAAGCGACGTACTCTGCAGTTCCGCATCGATATTGCACCTGGTCGCTATCGCCACTGACAGGTATTGGGCCGTGACCGATGTTGACTACATCCATATACGTAACGAGAAACGGATCTTCACCATGATTGTCCTGGTGTGGGGTGCTGCTCTCGTCGTCTCTCTGGCACCGCAGCTGGGCTGGAAGGACCCTGACTACCTGGCCAGGATCACGCAACAGCAAAAGTGCCTTGTTAGTCAAGACTTGGCATATCAGATCTTCGCCACTTGCTCCACATTCTATGTACCTCTTGCTGTAATTCTGATTCTCTACTGGAAGATATTTCAAACTGCAAGACGACGTATAAGGAGAAGACGCGAACCTCCTCCCCCTCGACCCACTTCAGCTGACGGTGCTCCACCATCAGGACGCCCAATCCAGTCGGCGCGAGACCGGCGGTTCGTTAAGAAAAGATTCCTGAACTTGAAGAAATGCAATCAGCGCACTCGTGTCGAAACTTTAGCAGCTGCGTTATTACTGACCGAGGGTCAAAGCACTTCGACGGTTGATACACTAGATGAAGAGCCAAGGACCACTGCGTTTACCGTAAACGAGAAAATGCAATCTGTTTCCCCAGAAAAGTCTTCCTCGACGGTCACAAATGGCTCGAAACCAGAAAAGGCGATCGTTTCAGCTCCGACTCATCGTGAAAAGAAGGAGTCTCTCGAAGCGAAGAGGGAGAGGAAAGCAGCGAAGACCCTTGCAATCATAACGGGAGCGTTTGTGTTCTGCTGGCTTCCGTTCTTCATCATGGCGCTGGTGATGCCAATCTGCCAAACGTGCGTGATCAGCGATTACTTGGCCAGTTTCTTCTTGTGGCTCGGCTATTTCAACTCGACCCTGAACCCGGTTATATACACGATATTCAGTCCGGATTTCCGTCAAGCCTTCGCTCGAATCCTTTTCGGAACTCACAGGAGGGGACGCAACAAAAAATTCTAA

Protein

MNASQLSSELNTTNNDVAYPTSEWFDANCSWVEVVSWGCNTTVNSTASNSTSSDVTSLVLMAVTSVVLALIILATIVGNVFVIAAIIIERNLQNVANYLVASLAVADLMVACLVMPLGAVYEVSQGWILGPELCDMWTSSDVLCSSASILHLVAIATDRYWAVTDVDYIHIRNEKRIFTMIVLVWGAALVVSLAPQLGWKDPDYLARITQQQKCLVSQDLAYQIFATCSTFYVPLAVILILYWKIFQTARRRIRRRREPPPPRPTSADGAPPSGRPIQSARDRRFVKKRFLNLKKCNQRTRVETLAAALLLTEGQSTSTVDTLDEEPRTTAFTVNEKMQSVSPEKSSSTVTNGSKPEKAIVSAPTHREKKESLEAKRERKAAKTLAIITGAFVFCWLPFFIMALVMPICQTCVISDYLASFFLWLGYFNSTLNPVIYTIFSPDFRQAFARILFGTHRRGRNKKF

Description

This is a receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  5-hydroxytryptamine receptor

Uniprot

A0A0A7LX89   Q0GMY2   Q25190   B9TXV9   Q5TLF3   A0A142F416   + More
H9JX63   A0A212F8E5   A0A194RGV4   A0A2H1WE62   A0A0L7L9D4   A0A1Y1K5Z8   A0A1Y1K2R9   A0A2J7PF77   A0A1B6MHQ9   A0A1W4XU12   A0A1W4XIV5   R9ULB8   D6X301   N1NVF0   A0A067QXY2   A0A1S4EC22   A0A336LXD8   A0A1B6C7L4   B0F4P9   A0A2H8TKQ3   A0A164WNM4   A0A0P5LHA0   Q6QR16   A0A0P6A6W3   A0A0P4Y4T9   A0A0P5VSJ8   B8Q6C0   E9FYY2   A0A0A9WDL6   A0A0P5DFZ2   A0A0P5AL81   A0A0A9WBR5   Q32Z81   A0A1Y1KIA8   A0A1I8NV00   A0A1A9UF97   A0A1B6CLU4   A0A1A9XTX1   A0A1I8NUZ6   A0A1B0AGY9   A0A0P5CSV0   E1JGM2   A0A1A9WA30   K7IZ04   A0A158P484   A0A0P6IFU1   A0A1B0GFJ9   E0W0M7   A0A139WC03   A0A139WBY7   A0A0C9Q4T7   A0A067RBN2   A0A3L8E366   A0A154PG55   A0A0L7R6Q2   D2U6U8   T1HY03   A0A2J7PF57   A0A195CTZ6   A0A0P5GIS6   A0A1B0B6F5   D6X0M4   T1I3R2   A0A142F417   B7Q8G2   A0A1B3P5Y1   A0A164WNP0   A0A194RGE6   A0A194Q8S6   A0A212EYW7   A0A0P5AEP6   A0A1I8NUZ8   A0A1I8NA04   A0A0P5R111   A0A0P5SNH1   A0A151WLZ1   A0A0P5LW97   A0A0P5TGN0   A0A2W1BU56   A0A2A4JW03   A0A0P5T634   A0A0N8E0H8   Q0GMY1   A0A2H1WHH4   A0A0P6BWY1   A0A0P6D0Q1   A0A0P5ZCK7   A0A0P6H333   Q6VWJ2   E2B4E0   A0A0P5JVM6   A0A0P5IY22   A0A151IWP2   A0A0P4Z017  

Pubmed

16935223    9014328    15544938    26354079    26974346    19121390    + More
22118469    26227816    28004739    23741451    18362917    19820115    18054377    18025266    18316733    20068045    21843505    23604020    24845553    18083737    15116388    19184976    21292972    25401762    26823975    16949686    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    20075255    21347285    20566863    30249741    25315136    28756777    14728666    20798317   

EMBL

KM236100    AIZ66399.1    DQ840515    ABI33826.1    X95605    EU402612    + More
ABY85410.1    AB182632    KQ459583    BAD72868.1    KPI98646.1    KT946786    AMQ67545.1    BABH01032009    BABH01032010    AGBW02009755    OWR49993.1    KQ460211    KPJ16555.1    ODYU01007735    SOQ50774.1    JTDY01002149    KOB71995.1    GEZM01096579    GEZM01096576    GEZM01096561    GEZM01096545    JAV54816.1    GEZM01096584    GEZM01096583    GEZM01096580    GEZM01096573    GEZM01096570    GEZM01096568    GEZM01096565    GEZM01096562    GEZM01096556    GEZM01096553    GEZM01096552    GEZM01096546    JAV54798.1    NEVH01026085    PNF14990.1    GEBQ01004523    JAT35454.1    KC196076    AGN56420.1    KQ971372    EFA10707.2    BK005865    DAA64502.1    KK852843    KDR15155.1    UFQT01000035    SSX18308.1    GEDC01027826    JAS09472.1    EU131667    ABX10973.1    GFXV01002911    MBW14716.1    LRGB01001151    KZS13433.1    GDIQ01169576    JAK82149.1    AY528822    AAS18607.1    GDIP01038499    JAM65216.1    GDIP01232575    JAI90826.1    GDIP01096176    JAM07539.1    EU363466    ACB38667.1    GL732527    EFX87693.1    GBHO01037715    GDHC01002643    JAG05889.1    JAQ15986.1    GDIP01156939    JAJ66463.1    GDIP01202381    JAJ21021.1    GBHO01037717    JAG05887.1    AY661549    AAV48573.1    GEZM01085676    JAV59950.1    GEDC01022878    JAS14420.1    GDIP01182085    JAJ41317.1    AE013599    ACZ94473.2    ADTU01008704    ADTU01008705    GDIQ01005118    JAN89619.1    CCAG010014112    CCAG010014113    DS235861    EEB19183.1    KQ971371    KYB25477.1    KYB25478.1    GBYB01009093    JAG78860.1    KK852571    KDR21127.1    QOIP01000001    RLU26893.1    KQ434890    KZC10424.1    KQ414646    KOC66555.1    FN645449    CBI75449.1    ACPB03016262    PNF14957.1    KQ977279    KYN04125.1    GDIQ01239936    JAK11789.1    JXJN01009087    BK005866    DAA64503.1    ACPB03003452    ACPB03003453    ACPB03003454    KT946787    AMQ67546.1    ABJB010142903    DS883764    EEC15134.1    KU712069    AOG12999.1    KZS13434.1    KQ460398    KPJ15006.1    KQ459302    KPJ01804.1    AGBW02011422    OWR46685.1    GDIP01199875    JAJ23527.1    GDIQ01109428    JAL42298.1    GDIP01137534    JAL66180.1    KQ982959    KYQ48715.1    GDIQ01164270    JAK87455.1    GDIP01126494    JAL77220.1    KZ149900    PZC78578.1    NWSH01000528    PCG75868.1    GDIP01132232    JAL71482.1    GDIQ01073844    JAN20893.1    DQ840516    ABI33827.1    ODYU01008709    SOQ52521.1    GDIP01008371    JAM95344.1    GDIQ01086947    JAN07790.1    GDIP01047797    JAM55918.1    GDIQ01025961    JAN68776.1    AY323235    AAQ89933.1    GL445552    EFN89434.1    GDIQ01192905    JAK58820.1    GDIQ01232345    JAK19380.1    KQ980846    KYN12249.1    GDIP01221090    JAJ02312.1   

Proteomes

UP000053268    UP000005204    UP000007151    UP000053240    UP000037510    UP000235965    + More
UP000192223    UP000007266    UP000027135    UP000079169    UP000076858    UP000000305    UP000095300    UP000078200    UP000092443    UP000092445    UP000000803    UP000091820    UP000002358    UP000005205    UP000092444    UP000009046    UP000279307    UP000076502    UP000053825    UP000005203    UP000015103    UP000078542    UP000092460    UP000001555    UP000095301    UP000075809    UP000218220    UP000008237    UP000078492   

PRIDE

Q25190    H9JX63    E1JGM2   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR002233   ADR_fam       

ProteinModelPortal

A0A0A7LX89   Q0GMY2   Q25190   B9TXV9   Q5TLF3   A0A142F416   + More
H9JX63   A0A212F8E5   A0A194RGV4   A0A2H1WE62   A0A0L7L9D4   A0A1Y1K5Z8   A0A1Y1K2R9   A0A2J7PF77   A0A1B6MHQ9   A0A1W4XU12   A0A1W4XIV5   R9ULB8   D6X301   N1NVF0   A0A067QXY2   A0A1S4EC22   A0A336LXD8   A0A1B6C7L4   B0F4P9   A0A2H8TKQ3   A0A164WNM4   A0A0P5LHA0   Q6QR16   A0A0P6A6W3   A0A0P4Y4T9   A0A0P5VSJ8   B8Q6C0   E9FYY2   A0A0A9WDL6   A0A0P5DFZ2   A0A0P5AL81   A0A0A9WBR5   Q32Z81   A0A1Y1KIA8   A0A1I8NV00   A0A1A9UF97   A0A1B6CLU4   A0A1A9XTX1   A0A1I8NUZ6   A0A1B0AGY9   A0A0P5CSV0   E1JGM2   A0A1A9WA30   K7IZ04   A0A158P484   A0A0P6IFU1   A0A1B0GFJ9   E0W0M7   A0A139WC03   A0A139WBY7   A0A0C9Q4T7   A0A067RBN2   A0A3L8E366   A0A154PG55   A0A0L7R6Q2   D2U6U8   T1HY03   A0A2J7PF57   A0A195CTZ6   A0A0P5GIS6   A0A1B0B6F5   D6X0M4   T1I3R2   A0A142F417   B7Q8G2   A0A1B3P5Y1   A0A164WNP0   A0A194RGE6   A0A194Q8S6   A0A212EYW7   A0A0P5AEP6   A0A1I8NUZ8   A0A1I8NA04   A0A0P5R111   A0A0P5SNH1   A0A151WLZ1   A0A0P5LW97   A0A0P5TGN0   A0A2W1BU56   A0A2A4JW03   A0A0P5T634   A0A0N8E0H8   Q0GMY1   A0A2H1WHH4   A0A0P6BWY1   A0A0P6D0Q1   A0A0P5ZCK7   A0A0P6H333   Q6VWJ2   E2B4E0   A0A0P5JVM6   A0A0P5IY22   A0A151IWP2   A0A0P4Z017  

PDB

6G79     E-value=1.79023e-58,     Score=573

KEGG

101746040    K04153 5-hydroxytryptamine receptor 1 | (RefSeq) 5-hydroxytryptamine receptor

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004930   GO:0016021   GO:0005886   GO:0004993   GO:0030594   GO:0005887   GO:0030425   GO:0007187   GO:0007268   GO:0004935   GO:0004715   GO:0007186   GO:0005622   GO:0009113   GO:0005524   GO:0046872   GO:0009058   GO:0016742   GO:0003824  

Subcellular location

Cell membrane  

Length:

464

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

155.7489

Exp number, first 60 AAs:

0.77596

Total prob of N-in:

0.05359

outside

1  -  65

TMhelix

66  -  88

inside

89  -  94

TMhelix

95  -  117

outside

118  -  136

TMhelix

137  -  156

inside

157  -  176

TMhelix

177  -  199

outside

200  -  223

TMhelix

224  -  246

inside

247  -  385

TMhelix

386  -  408

outside

409  -  417

TMhelix

418  -  440

inside

441  -  464

 

 

Pi

23.553808

Theta

20.2732

Tajima's D

0.931538

CLR

0.609836

CSRT

0.649167541622919

Interpretation

Uncertain