Gene

KWMTBOMO04302

Pre Gene Modal

BGIBMGA014123

Annotation

PREDICTED:_UDP-xylose_and_UDP-N-acetylglucosamine_transporter_[Papilio_machaon]

Location

Bomo_Chr8(+):2222945-2224429      View in EpiBrowser

Full name

UDP-xylose and UDP-N-acetylglucosamine transporter      

Alternative Name

ER GDP-fucose transporter
Solute carrier family 35 member B4 homolog

Location in the cell

PlasmaMembrane   Reliability : 4.977

CDS

ATGAATTTAAAGGCAGCGCTCGCCATTACTATGGTGTTTGTTGGATGTTGTTCCAACGTAGTTTTTTTGGAGTTTGTCGTCAAAGAGGACCCCGGAGCCGGTAACCTAGCGACCTTCCTGCAGTTTGTATTCATAGCTACGATTGGGTTCTGTACCGTCGGCAAATTCGGTATGGCCAAACGAAATATACCGTTTAGGCAGTATCTACTCCTGGTTGGGTTCTTTTGGACGAGCAGCGTCGCCAACAACTACGCCTTCGACTTTAACATCGCGATGCCGCTGCACATGATCTTCCGAGCTGGTTCTCTAATGGCCAACATGGCCATGGGCGTTTGGATCCTCAAGAAGCGGTACCCACCGCTGAAATACCTGGCCGTGTTTATGATTTCTGCCGGCATAGCCATTTGCACCATTCAGTCTAGCGGAGACGTGAAGGCGCCTCGCAAAACCCACGAGGACGCTGCCGAAGAGGAGAAACTGAAGTTCATCGACTGGCTGTGGTGGTGTTTGGGTATTGCCATACTGACCTTCGCCTTATTCGTCTCGGCTCGGATGGGAATCTTTCAAGAGTCGCTTTATTCGAAGTACGGAAAACACCCGTGGGAGGCATTATACTACACGCATCTTTTGCCATTGATGTTCTGGTTGCCGACCGCTTCGAATCTGATCGGACACGTCGAAATCGCGACAGAAACCCCTGCCGTCGAGTTCTTAGGGTTCATTTTGCCACGACAAGTTCTGTGGCTGTTGCTGTACGTTTCGACTCAGGGTCTGTGTATTAGCGCGGTCTACGTTTTGACAACCGAATGTGCGTCGCTGACAGTGACGTTAGCTGTCACTTTGAGAAAGTTCGTGTCGCTTCTGTTCTCTATAATGTACTTCAGGAATCCCTTCACTTTAGGGCACTGGATAGGGACATTGCTAGTGTTCGTCGGTACGTTGATATTCACGGAGATATTGCAGAAATGCTTGGCCGTGTTTACTACAGACGATAAGAAGAAAAAATAA

Protein

MNLKAALAITMVFVGCCSNVVFLEFVVKEDPGAGNLATFLQFVFIATIGFCTVGKFGMAKRNIPFRQYLLLVGFFWTSSVANNYAFDFNIAMPLHMIFRAGSLMANMAMGVWILKKRYPPLKYLAVFMISAGIAICTIQSSGDVKAPRKTHEDAAEEEKLKFIDWLWWCLGIAILTFALFVSARMGIFQESLYSKYGKHPWEALYYTHLLPLMFWLPTASNLIGHVEIATETPAVEFLGFILPRQVLWLLLYVSTQGLCISAVYVLTTECASLTVTLAVTLRKFVSLLFSIMYFRNPFTLGHWIGTLLVFVGTLIFTEILQKCLAVFTTDDKKKK

Description

Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk.

Similarity

Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.

Keywords

Complete proteome   Endoplasmic reticulum   Membrane   Reference proteome   Sugar transport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  UDP-xylose and UDP-N-acetylglucosamine transporter

Uniprot

H9JX58   A0A194RFF5   A0A194Q204   A0A2H1VJI7   A0A1Z2RRJ7   A0A1E1W6N0   + More
S4NNN6   A0A212EP67   A0A0L7L6J9   A0A0K8TQS5   A0A182XC69   A0A182LPE1   A0A2C9GQT5   Q7Q357   A0A182LTW9   A0A182VGY5   A0A336K9S9   A0A2M4BT84   B4NPD8   A0A2M3Z9R0   A0A2M3ZE64   T1DNH9   A0A2M4BT00   Q174K4   W5JJP8   A0A182QE09   A0A2M4AQ20   A0A084WB95   J9KAW4   B0WBU7   A0A2J7QCY3   A0A067R3Y0   A0A182JXG0   A0A154PF24   A0A182J086   C4WUT8   A0A1Q3FHN4   A0A182PVC9   B3MQ47   A0A1Q3FHT1   A0A1B0CTY7   A0A0L7QU21   E1ZV25   A0A1Q3FHF1   A0A182FU17   B4M864   B4L6J2   E2B348   A0A182YJZ8   A4V408   Q9W429   B4MH52   A0A3B0JW76   B4R5D8   A0A0R1E9Q2   B4PYP7   B3NXP4   B4HB97   Q29GG2   A0A182MY20   A0A026X0H2   A0A0C9Q2C5   B4L6J3   A0A3L8DS66   A0A0K8U8G2   B4JNK7   A0A1B6MFC4   T1P969   A0A1L8DEL9   A0A1B6C7M0   A0A0T6BCG0   A0A195AVF8   A0A158P260   A0A151IQU3   A0A1W4VSE8   W8CA71   A0A1I8MZC4   A0A0M9A234   A0A1L8DEW4   A0A195FJ21   A0A2A3E4K2   A0A0L0CKV5   A0A195DMA6   U5EU57   B4MBW8   A0A1I8PE78   A0A1I8PEG5   B4JNK8   A0A3B3RQX3   E9FSD0   D7EIK0   K7IR88   A0A0M4EUI7   A0A315VYV1   I3JPR9   A0A3Q3BJK3   A0A3B5ATC2   A0A3B3VZD6  

Pubmed

19121390    26354079    28605547    23622113    22118469    26227816    + More
26369729    20966253    12364791    14747013    17210077    17994087    17510324    20920257    23761445    24438588    24845553    18057021    20798317    25244985    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    19948734    17550304    15632085    23185243    24508170    30249741    21347285    24495485    25315136    26108605    29240929    21292972    18362917    19820115    20075255    29703783    25186727   

EMBL

BABH01031954    KQ460211    KPJ16558.1    KQ459580    KPI99363.1    ODYU01002910    + More
SOQ40995.1    KY938828    ASA46469.1    GDQN01008416    JAT82638.1    GAIX01013856    JAA78704.1    AGBW02013518    OWR43274.1    JTDY01002683    KOB70936.1    GDAI01000894    JAI16709.1    APCN01001930    AAAB01008966    EAA13009.4    AXCM01000360    UFQS01000100    UFQT01000100    SSW99523.1    SSX19903.1    GGFJ01007073    MBW56214.1    CH964291    EDW86378.1    GGFM01004525    MBW25276.1    GGFM01006085    MBW26836.1    GAMD01002860    JAA98730.1    GGFJ01007075    MBW56216.1    CH477409    EAT41500.1    EAT41501.1    ADMH02001328    ETN62994.1    AXCN02001640    GGFK01009538    MBW42859.1    ATLV01022327    KE525331    KFB47489.1    ABLF02031956    DS231882    EDS42877.1    NEVH01015855    PNF26435.1    KK852715    KDR17872.1    KQ434885    KZC10044.1    AK341218    BAH71658.1    GFDL01007978    JAV27067.1    CH902621    EDV44473.1    KPU81612.1    GFDL01007919    JAV27126.1    AJWK01028174    KQ414740    KOC62054.1    GL434395    EFN74954.1    GFDL01008112    JAV26933.1    CH940653    EDW62340.1    CH933812    EDW05988.1    KRG07109.1    GL445285    EFN89897.1    AE014298    AAN09162.1    BT021217    CH941246    EDW71473.1    OUUW01000011    SPP86335.1    CM000366    EDX17234.1    CM000162    KRK05861.1    KRK05862.1    KRK05863.1    EDX00983.2    CH954180    EDV47345.1    CH479248    EDW37909.1    CH379064    EAL32147.1    KRT06996.1    KRT06997.1    KK107054    EZA61573.1    GBYB01008153    JAG77920.1    EDW05989.1    QOIP01000004    RLU23285.1    GDHF01029446    GDHF01016511    JAI22868.1    JAI35803.1    CH916371    EDV92300.1    GEBQ01005385    JAT34592.1    KA645249    AFP59878.1    GFDF01009193    JAV04891.1    GEDC01027884    JAS09414.1    LJIG01002143    KRT84797.1    KQ976731    KYM76218.1    ADTU01006992    KQ976755    KYN08577.1    GAMC01001541    GAMC01001540    GAMC01001539    JAC05017.1    KQ435778    KOX74846.1    GFDF01009194    JAV04890.1    KQ981523    KYN40366.1    KZ288387    PBC26414.1    JRES01000340    KNC32109.1    KQ980724    KYN14035.1    GANO01002473    JAB57398.1    CH940656    EDW58589.1    EDV92301.1    GL732524    EFX89856.1    KQ971307    EFA12028.1    CP012528    ALC48760.1    NHOQ01000831    PWA28500.1    AERX01010942   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000037510    UP000076407    + More
UP000075882    UP000075840    UP000007062    UP000075883    UP000075903    UP000007798    UP000008820    UP000000673    UP000075886    UP000030765    UP000007819    UP000002320    UP000235965    UP000027135    UP000075881    UP000076502    UP000075880    UP000075885    UP000007801    UP000092461    UP000053825    UP000000311    UP000069272    UP000008792    UP000009192    UP000008237    UP000076408    UP000000803    UP000268350    UP000000304    UP000002282    UP000008711    UP000008744    UP000001819    UP000075884    UP000053097    UP000279307    UP000001070    UP000078540    UP000005205    UP000078542    UP000192221    UP000095301    UP000053105    UP000078541    UP000242457    UP000037069    UP000078492    UP000095300    UP000261540    UP000000305    UP000007266    UP000002358    UP000092553    UP000005207    UP000264840    UP000261400    UP000261500   

PRIDE

H9JX58    A4V408    Q9W429   

Pfam

PF08449   UAA        + More
PF02213   GYF
PF12796   Ank_2
PF03020   LEM

Interpro

IPR013657   UAA        + More
IPR035445   GYF-like_dom_sf       
IPR003169   GYF       
IPR003887   LEM_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR011015   LEM/LEM-like_dom_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR002110   Ankyrin_rpt       
IPR034998   ANKLE1       

SUPFAM

SSF55277   SSF55277        + More
SSF63451   SSF63451       
SSF48403   SSF48403       

Gene 3D

3.30.1490.40     1.10.720.40     1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9JX58   A0A194RFF5   A0A194Q204   A0A2H1VJI7   A0A1Z2RRJ7   A0A1E1W6N0   + More
S4NNN6   A0A212EP67   A0A0L7L6J9   A0A0K8TQS5   A0A182XC69   A0A182LPE1   A0A2C9GQT5   Q7Q357   A0A182LTW9   A0A182VGY5   A0A336K9S9   A0A2M4BT84   B4NPD8   A0A2M3Z9R0   A0A2M3ZE64   T1DNH9   A0A2M4BT00   Q174K4   W5JJP8   A0A182QE09   A0A2M4AQ20   A0A084WB95   J9KAW4   B0WBU7   A0A2J7QCY3   A0A067R3Y0   A0A182JXG0   A0A154PF24   A0A182J086   C4WUT8   A0A1Q3FHN4   A0A182PVC9   B3MQ47   A0A1Q3FHT1   A0A1B0CTY7   A0A0L7QU21   E1ZV25   A0A1Q3FHF1   A0A182FU17   B4M864   B4L6J2   E2B348   A0A182YJZ8   A4V408   Q9W429   B4MH52   A0A3B0JW76   B4R5D8   A0A0R1E9Q2   B4PYP7   B3NXP4   B4HB97   Q29GG2   A0A182MY20   A0A026X0H2   A0A0C9Q2C5   B4L6J3   A0A3L8DS66   A0A0K8U8G2   B4JNK7   A0A1B6MFC4   T1P969   A0A1L8DEL9   A0A1B6C7M0   A0A0T6BCG0   A0A195AVF8   A0A158P260   A0A151IQU3   A0A1W4VSE8   W8CA71   A0A1I8MZC4   A0A0M9A234   A0A1L8DEW4   A0A195FJ21   A0A2A3E4K2   A0A0L0CKV5   A0A195DMA6   U5EU57   B4MBW8   A0A1I8PE78   A0A1I8PEG5   B4JNK8   A0A3B3RQX3   E9FSD0   D7EIK0   K7IR88   A0A0M4EUI7   A0A315VYV1   I3JPR9   A0A3Q3BJK3   A0A3B5ATC2   A0A3B3VZD6  

KEGG

101745518    K15278 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 | (RefSe

GO

GO:0016021   GO:0055085   GO:0030173   GO:0005464   GO:0022857   GO:0030176   GO:0005462   GO:0015012   GO:0005783   GO:0005457   GO:0036066   GO:0005789   GO:0015790   GO:0005794   GO:1990570   GO:0015786   GO:0015782   GO:0008643   GO:0015787   GO:0015783   GO:0036084   GO:1990569  

PANTHER

PTHR46427  

Subcellular location

Endoplasmic reticulum membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.543140

 

 

Length:

335

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

204.58497

Exp number, first 60 AAs:

43.99553

Total prob of N-in:

0.99173

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  36

TMhelix

37  -  59

inside

60  -  67

TMhelix

68  -  86

outside

87  -  95

TMhelix

96  -  114

inside

115  -  165

TMhelix

166  -  188

outside

189  -  202

TMhelix

203  -  225

inside

226  -  245

TMhelix

246  -  268

outside

269  -  297

TMhelix

298  -  320

inside

321  -  335

 

 

Pi

230.963706

Theta

213.205857

Tajima's D

0.23076

CLR

0

CSRT

0.428328583570821

Interpretation

Uncertain