Gene

KWMTBOMO04300  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014116

Annotation

beta-N-acetylglucosaminidase_3_precursor_[Bombyx_mori]

Location

Bomo_Chr8(-):2098477-2116999      View in EpiBrowser

Full name

Beta-hexosaminidase      

Location in the cell

Cytoplasmic   Reliability : 2.041

CDS

ATGGAAATAAGCGATATTTTAGGCGCTTTTTTAGTGACCGGTTTGCATATCGTGGAACCGGGACCCGAATATCCAGCATCGAAAGGTGCAATTTGGCCAAGACCGCAAATGCAATCGATAGAAATTCCTTATTACAAATTTGATAGTGATATACTCGAAATTAAGGTAGTCGATCACGATTGCCCTATTCTGTCGAATGCCGTCCAACGGAGTCTGGCGGTACTGAGAGAGATGCTCCGAATCGCGAGTCCGTATGTAAACCGCAATGCGCCACAACAGGTCTTAGATGATGATACATACGACGGACCACTGAAGAGTCTAAGCATTTACTTGACATCACCCTGTGAAGAGTATCCGCATTTCGGCATGATCGAGAGCTACAATCTGACGATCGCCGCTGACAGCACACTCAGGAGCTCATCGATATGGGGAATACTGAGAGGCTTGGAAAGTTGGACGCACCTGTTTCATCTCTCAGATAATCGTGATCAATTGCACATTAACAAAGGTGAAGTTCACGACTTTCCCCGTTACGCTCACAGAGGACTGCTCGTTGACACATCACGTCATTACATCTCAATGTCTAATATCCTACTCATTTTGGACGCTATGGCCATGAACAAGATGAACGTTTTTCACTGGCACATTGTTGACGACCAGAGCTTCCCATATCAGAGCGAAAGGTTTCCGGATTTAAGACAGTCTATAAGAATCGTTGGTCTAGGTCACACAAGGTCCTGGGGTGTAGCCAAACCCGACCTCCTGACACATTGCTACGACCAAGACGGTGACTACGTGGGTCTCGGTCCGATGAACCCAATCAAGGACAGCACATACACCTTCCTGCAGGAACTGTTTCATGAGGTCCAGGCCTTGTTTCCGGATAGATACATTCACATCGGAGGTGATGAAGTCGATCTAGATTGCTGGGAGTCGAATCCAGAATTCCAGAGATACATACAAGAGCACAACCTGACTTCGGTAGCTGATTTTCACGCTCTATTCATGCGCAACACGATTCCTCTGCTCAGCGAAAACTCGAGACCGATAGTGTGGCAGGAAGTTTTCGATGAAGGCGTGCCCCTTCCGAAGGACACTATCGTGCAAGTGTGGAAGGAAAACGAAGCTCCTGAAATGTTGAATATCCTAAGAGCAAGTCACCAGTTAATCTATTCCACTGGCTGGTACCTTGATCATCTGAACACTGGAGGCGACTGGACGGAATTTTTCAACAAGGACCCTCGGGACCTGGTCAACGGCCTCAGCAAAGACATCAATGTTGACAACATTGTAGGTGGCGAAGCTTGCATGTGGGCAGAAGTTGTTAACGACATGAACATTATGAGCAGAGTATGGCCACGAGCTAGTGCTGTAGCTGAAAGACTGTGGGGCCACGAATCACAGGCAACATATCAAGTACACTGTCGCTTAGAGGAGCACACGTGCAGAATGAACGCGCGCGGCATACATGCCCAGCCACCCAGCGGCCCTGGCTTCTGCCTAGGCGTTTAG

Protein

MEISDILGAFLVTGLHIVEPGPEYPASKGAIWPRPQMQSIEIPYYKFDSDILEIKVVDHDCPILSNAVQRSLAVLREMLRIASPYVNRNAPQQVLDDDTYDGPLKSLSIYLTSPCEEYPHFGMIESYNLTIAADSTLRSSSIWGILRGLESWTHLFHLSDNRDQLHINKGEVHDFPRYAHRGLLVDTSRHYISMSNILLILDAMAMNKMNVFHWHIVDDQSFPYQSERFPDLRQSIRIVGLGHTRSWGVAKPDLLTHCYDQDGDYVGLGPMNPIKDSTYTFLQELFHEVQALFPDRYIHIGGDEVDLDCWESNPEFQRYIQEHNLTSVADFHALFMRNTIPLLSENSRPIVWQEVFDEGVPLPKDTIVQVWKENEAPEMLNILRASHQLIYSTGWYLDHLNTGGDWTEFFNKDPRDLVNGLSKDINVDNIVGGEACMWAEVVNDMNIMSRVWPRASAVAERLWGHESQATYQVHCRLEEHTCRMNARGIHAQPPSGPGFCLGV

Catalytic Activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Similarity

Belongs to the glycosyl hydrolase 20 family.

Feature

chain  Beta-hexosaminidase

Uniprot

Q3L6N4   H9JX51   A4PHN7   Q3L6N3   H9JX50   A4LAF9   + More
Q2Q1D3   Q3LS76   Q2Q1D2   Q3LS75   A0A194QY72   A0A212F3V9   A0A194QY01   A0A194PM72   A0A2H1V9E6   B6CI24   B0XBN5   J9HI66   Q17BL1   A0A182KFH4   A0A182QVJ5   A0A182VFS0   A0A182HR23   A0A182W8J9   A0A182L7V3   A0A1L8DQZ7   A0A0L7KE68   B0XBN6   A0A182Y637   A0A182JLR9   A0A026WT31   E0VQW8   Q7Q0Z2   U5ETX4   A0A3G5BIJ3   W5JJY2   A0A1W6EW10   A0A1B0CZC5   A0A182R1R5   D6WRR7   A0A1Y1LY98   A0A1J1HQF6   A0A087ZUU5   A0A084W3Y6   A0A0M8ZZH8   A0A2J7PCV4   A0A0L7QS85   A0A1B6CMM3   A0A2P8Y3J8   D6WRR9   A0A182PTQ9   A0A182UFT6   A0A182XHA2   D6WRR8   A0A182NNT6   A0A182GID0   U4TU30   N6T5A7   A0A2J7PCU7   A0A182FN54   A0A067R5X1   A0A1W4XBS7   V5H217   A0A182LTR5   A0A147B289   A0A1B6KR81   A0A146Z1P6   A0A3Q2QBK9   A0A1B6KBG0   A0A0C9RX26   A0A1S3HJI4   B7PE53   A0A3Q1IDG1   A0A1D2MNV3   A0A0K2SW92   A0A131YVJ8   A0A1S3HGE0   A0A1B6EVU7   A0A3Q1EKY7   A0A1S3HI83   V3ZMB9   Q7YTB2   L7MG67   A0A224YPI0   A0A3B1J6J9   A0A3P8XAC0   A0A131XKM5   A0A1S3HGG6   A0A3Q3G324   A0A3B3Q349   A0A2D0QB43   A0A3M7R7F3   A0A3B1J888   A0A3Q1CKD5   A0A3Q1H4L2   A0A2R5LAG8   A0A0A1WSN4   A0A131XIX2   A0A3Q1I5U8   A0A3B1K7J4  

EC Number

3.2.1.52

Pubmed

19121390    17617724    16427309    16684772    26354079    22118469    + More
17510324    20966253    26227816    25244985    24508170    30249741    20566863    12364791    30400621    20920257    23761445    18362917    19820115    28004739    24438588    29403074    26483478    23537049    24845553    25765539    27289101    26830274    23254933    12828682    25576852    28797301    25329095    25069045    28049606    29240929    30375419    25830018   

EMBL

AY601817    AAT99455.1    BABH01031930    BABH01031931    BABH01031932    AB286958    + More
BAF52532.1    AY601818    AAT99456.1    BABH01031937    BABH01031938    EF469203    ABO65045.1    DQ249307    ABB76924.1    DQ183186    DQ249309    ABA27426.1    ABB76926.1    DQ249308    ABB76925.1    DQ183187    ABA27427.1    KQ460949    KPJ10417.1    AGBW02010485    OWR48417.1    KPJ10418.1    KQ459598    KPI94536.1    ODYU01001373    SOQ37455.1    EU180214    ABY57947.1    DS232645    EDS44384.1    CH477320    EJY57559.1    EAT43655.1    AXCN02001981    APCN01001633    GFDF01005290    JAV08794.1    JTDY01010100    KOB61159.1    EDS44385.1    KK107128    QOIP01000006    EZA58264.1    RLU21577.1    DS235442    EEB15774.1    AAAB01008980    EAA14547.4    GANO01002584    JAB57287.1    MK075207    AYV99610.1    ADMH02001300    ETN63089.1    KY563514    ARK19923.1    AJVK01009523    AJVK01009524    KQ971354    EFA05960.2    GEZM01046313    JAV77340.1    CVRI01000008    CRK88449.1    ATLV01020229    ATLV01020230    KE525296    KFB44930.1    KQ435792    KOX74285.1    NEVH01026403    PNF14160.1    KQ414768    KOC61341.1    GEDC01022680    JAS14618.1    PYGN01000972    PSN38811.1    EFA07069.1    EFA05959.1    JXUM01066149    KQ562383    KXJ76018.1    KB631654    ERL85064.1    APGK01052022    APGK01052023    KB741208    ENN72853.1    PNF14159.1    KK852722    KDR17734.1    GANP01013509    JAB70959.1    AXCM01006623    GCES01001496    JAR84827.1    GEBQ01026015    JAT13962.1    GCES01026591    JAR59732.1    GEBQ01031184    JAT08793.1    GBYB01012436    JAG82203.1    ABJB010025437    ABJB010031690    ABJB010274095    ABJB010318523    ABJB010440044    ABJB010990743    ABJB011081853    ABJB011094047    ABJB011106130    ABJB011126424    DS693693    EEC04875.1    LJIJ01000794    ODM94535.1    HACA01000653    CDW18014.1    GEDV01005318    JAP83239.1    GECZ01027707    JAS42062.1    KB202050    ESO92513.1    AJ518021    CAD57204.1    GACK01002776    JAA62258.1    GFPF01008361    MAA19507.1    GEFH01001454    JAP67127.1    REGN01004092    RNA19155.1    GGLE01002319    MBY06445.1    GBXI01012203    JAD02089.1    GEFH01002269    JAP66312.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000002320    UP000008820    + More
UP000075881    UP000075886    UP000075903    UP000075840    UP000075920    UP000075882    UP000037510    UP000076408    UP000075880    UP000053097    UP000279307    UP000009046    UP000007062    UP000000673    UP000092462    UP000075900    UP000007266    UP000183832    UP000005203    UP000030765    UP000053105    UP000235965    UP000053825    UP000245037    UP000075885    UP000075902    UP000076407    UP000075884    UP000069940    UP000249989    UP000030742    UP000019118    UP000069272    UP000027135    UP000192223    UP000075883    UP000265000    UP000085678    UP000001555    UP000265040    UP000094527    UP000257200    UP000030746    UP000018467    UP000265140    UP000261660    UP000261540    UP000221080    UP000276133    UP000257160   

PRIDE

Q3L6N4    H9JX51    A4PHN7    Q3L6N3    H9JX50   

Pfam

PF14845   Glycohydro_20b2        + More
PF00728   Glyco_hydro_20
PF03031   NIF
PF02931   Neur_chan_LBD
PF08543   Phos_pyr_kin

Interpro

IPR017853   Glycoside_hydrolase_SF        + More
IPR025705   Beta_hexosaminidase_sua/sub       
IPR029018   Hex-like_dom2       
IPR015883   Glyco_hydro_20_cat       
IPR029019   HEX_eukaryotic_N       
IPR036412   HAD-like_sf       
IPR004274   FCP1_dom       
IPR036734   Neur_chan_lig-bd_sf       
IPR006202   Neur_chan_lig-bd       
IPR004625   PyrdxlKinase       
IPR013749   PM/HMP-P_kinase-1       
IPR029056   Ribokinase-like       

SUPFAM

SSF51445   SSF51445        + More
SSF55545   SSF55545       
SSF56784   SSF56784       
SSF63712   SSF63712       
SSF53613   SSF53613       

Gene 3D

3.30.379.10     2.70.170.10     3.40.1190.20    

CDD

cd01173  pyridoxal_pyridoxamine_kinase

ProteinModelPortal

Q3L6N4   H9JX51   A4PHN7   Q3L6N3   H9JX50   A4LAF9   + More
Q2Q1D3   Q3LS76   Q2Q1D2   Q3LS75   A0A194QY72   A0A212F3V9   A0A194QY01   A0A194PM72   A0A2H1V9E6   B6CI24   B0XBN5   J9HI66   Q17BL1   A0A182KFH4   A0A182QVJ5   A0A182VFS0   A0A182HR23   A0A182W8J9   A0A182L7V3   A0A1L8DQZ7   A0A0L7KE68   B0XBN6   A0A182Y637   A0A182JLR9   A0A026WT31   E0VQW8   Q7Q0Z2   U5ETX4   A0A3G5BIJ3   W5JJY2   A0A1W6EW10   A0A1B0CZC5   A0A182R1R5   D6WRR7   A0A1Y1LY98   A0A1J1HQF6   A0A087ZUU5   A0A084W3Y6   A0A0M8ZZH8   A0A2J7PCV4   A0A0L7QS85   A0A1B6CMM3   A0A2P8Y3J8   D6WRR9   A0A182PTQ9   A0A182UFT6   A0A182XHA2   D6WRR8   A0A182NNT6   A0A182GID0   U4TU30   N6T5A7   A0A2J7PCU7   A0A182FN54   A0A067R5X1   A0A1W4XBS7   V5H217   A0A182LTR5   A0A147B289   A0A1B6KR81   A0A146Z1P6   A0A3Q2QBK9   A0A1B6KBG0   A0A0C9RX26   A0A1S3HJI4   B7PE53   A0A3Q1IDG1   A0A1D2MNV3   A0A0K2SW92   A0A131YVJ8   A0A1S3HGE0   A0A1B6EVU7   A0A3Q1EKY7   A0A1S3HI83   V3ZMB9   Q7YTB2   L7MG67   A0A224YPI0   A0A3B1J6J9   A0A3P8XAC0   A0A131XKM5   A0A1S3HGG6   A0A3Q3G324   A0A3B3Q349   A0A2D0QB43   A0A3M7R7F3   A0A3B1J888   A0A3Q1CKD5   A0A3Q1H4L2   A0A2R5LAG8   A0A0A1WSN4   A0A131XIX2   A0A3Q1I5U8   A0A3B1K7J4  

PDB

3LMY     E-value=6.07724e-90,     Score=845

KEGG

692647    K12373 hexosaminidase [EC:3.2.1.52] | (RefSeq) GlcNAcase3; beta-N-acetylglucosaminidase 3

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
00531    Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00603    Glycosphingolipid biosynthesis - globo and isoglobo series - Bombyx mori (domestic silkworm)
00604    Glycosphingolipid biosynthesis - ganglio series - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0102148   GO:0004563   GO:0005975   GO:0016021   GO:0005230   GO:0008152   GO:0009443   GO:0008478   GO:0001525   GO:0004553   GO:0004637   GO:0009113   GO:0005524   GO:0046872   GO:0009058   GO:0016742   GO:0003824  

Length:

503

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01208

Exp number, first 60 AAs:

0.00516

Total prob of N-in:

0.00092

outside

1  -  503

 

 

Pi

167.45173

Theta

153.98996

Tajima's D

0.452305

CLR

0.361197

CSRT

0.495125243737813

Interpretation

Uncertain