Gene
KWMTBOMO04299 Validated by peptides from experiments
Pre Gene Modal
BGIBMGA014116
Annotation
beta-N-acetylglucosaminidase_2_precursor_[Bombyx_mori]
Full name
Beta-hexosaminidase
Location in the cell
Cytoplasmic Reliability : 1.353 Lysosomal Reliability : 1.041
Sequence
CDS
ATGCAATCGATAGAAATTCCTTACTACAAATTTGATAGTGATGTACTTGAAATTAAGGTAATCGAACATGATTGTCCTATTCTGTCGAATGCCGTCCAACGGAGTCTGGCGGTATTGAGAGATATGCTCCGAATCGCGAGTCCGTATGTAAACCGCAATGCGCCACAACAGGTCTTAGATGATGATACATACGACGGACCACTGAAGAGTCTAAGCATTTACTTGACATCACCCTGTGAAGAATATCCGCATTTCGGCATGATCGAGAGCTACAATCTGACGATCGCCGCTGACAGCACACTCAGAAGTTCATCGATATGGGGAATACTGAGAGGCTTGGAAAGTTGGACGCACCTGTTTCATCTCTCAGATAATCGTGATCAATTGCACATTAACAAAGGTGAAGTTCACGACTTTCCCCGTTACCCTCACAGAGGACTGCTCGTTGACACATCACGTCATTACATCTCAATGTCTAATATCCTACTCATTTTGGACGCTATGGCCATGAACAAGATGAACGTATTTCACTGGCACATTGTTGACGACCAGAGTTTCCCATATCAGAGCGAAAGGTTTCCCGATTTGAGTCGTCTGGGAGCCTATCACGAGACCTTGATTTACACCAAGAAAGACATTCAGACGGTTATCGACTACGCAAGGAACAGGGGGATCAGAGTTATTCCTGAATTCGATGTACCCGGTCACACAAGGTCCTGGGGTGTAGCCAAACCCGAACTCCTGACACATTGCTACAACGAATACGCTGTCGACATGGGTCTCGGTCCGATGAACCCAATCAAGGACAGCACATACACCTTCCTGCGGGAACTGTTTCATGAGGTCCAGGCCTTGTTTCCGGATAGATACATTCACATCGGAGGTGATGAAGTCGATCTAGATTGCTGGGAGTCGAATCCAGAATTCCAGAGATACATACAAGAGCACAACCTGACTTCGGTAGCTGATTTTCACGCTCTATTCATGCGCAACACGATTCCTCTGCTCAGCGAAAACTCGAGACCGATTGTGTGGCAGGAAGTTTTCGATGAAGGCGTGCCCCTTCCGAAGGACACTATCGTGCAAGTGTGGAAGGGAAACGAAGTTTACGAAATGTTGAATATCCTAAGAGCAAGTCACCAGTTAATCTATTCCTCTGGCTGGTACCTTGACCATCTGAAAACTGGAGGCGATTGGACGGAATTTTTCAACAAGGACCCTCGGGATATGGTCAGCGGCCTCAGCAAAGACATCAATGTTGACAACATTGTAGGTGGCGAAGCTTGCATGTGGACAGAAGTTGTTAACGACATGAACATTATGAGCAGAGTATGGCCACGAGCTAGTGCTGTAGCTGAAAGACTGTGGGGCCACGAATCACAGGCAGCATATCAAGTATACTCTCGCTTAGAGGAGCACACATGCAGAATGAACGCGCGCGGCATACGCGCCCAGCCACCCAGTGGCCCTGGCTTCTGCCTAGGCGCTTAG
Protein
MQSIEIPYYKFDSDVLEIKVIEHDCPILSNAVQRSLAVLRDMLRIASPYVNRNAPQQVLDDDTYDGPLKSLSIYLTSPCEEYPHFGMIESYNLTIAADSTLRSSSIWGILRGLESWTHLFHLSDNRDQLHINKGEVHDFPRYPHRGLLVDTSRHYISMSNILLILDAMAMNKMNVFHWHIVDDQSFPYQSERFPDLSRLGAYHETLIYTKKDIQTVIDYARNRGIRVIPEFDVPGHTRSWGVAKPELLTHCYNEYAVDMGLGPMNPIKDSTYTFLRELFHEVQALFPDRYIHIGGDEVDLDCWESNPEFQRYIQEHNLTSVADFHALFMRNTIPLLSENSRPIVWQEVFDEGVPLPKDTIVQVWKGNEVYEMLNILRASHQLIYSSGWYLDHLKTGGDWTEFFNKDPRDMVSGLSKDINVDNIVGGEACMWTEVVNDMNIMSRVWPRASAVAERLWGHESQAAYQVYSRLEEHTCRMNARGIRAQPPSGPGFCLGA
Summary
Catalytic Activity
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Similarity
Belongs to the glycosyl hydrolase 20 family.
Feature
chain Beta-hexosaminidase
Uniprot
H9JX51
A4PHN7
Q3L6N4
Q3L6N3
H9JX50
A4LAF9
+ More
Q2Q1D3 A0A212F3V9 A0A194QY72 A0A194QY01 Q3LS76 Q2Q1D2 Q3LS75 A0A194PM72 H9J3V5 A0A2H1WXN3 B6CI24 A0A2H1V9E6 A0A194PMI9 A0A2A4JYB6 A0A1L8DQZ7 E2ARG4 A0A1W6EW10 A0A0J7KWU3 B0XBN5 Q17BL1 J9HI66 K7J7D5 A0A154PNT4 E2BEQ0 K7J7D4 B0XBN6 A0A087ZUU5 A0A182KFH4 E0VQW8 A0A336ML82 A0A182HR23 A0A232EL87 Q7Q0Z2 A0A1B0CZC5 A0A0M8ZZH8 A0A182VFS0 A0A182PTQ9 A0A026WT31 A0A182UFT6 A0A182L7V3 A0A182XHA2 A0A182QVJ5 A0A151JLX5 A0A182W8J9 A0A0L7KE68 A0A182JLR9 A0A151K0V1 A0A3G5BIJ3 A0A182Y637 A0A2J7PCV4 W5JJY2 A0A182NNT6 A0A182GID0 A0A2J7PCU7 D6WRR7 U5ETX4 A0A2P8Y3J8 A0A1J1HQF6 A0A1B6CMM3 E9J970 A0A182R1R5 U4U517 A0A0C5CE39 A0A2A4JZ13 A0A084W3Y6 F4X5M9 A0A1Y1LY98 A0A151IJ64 D6WRR9 A0A1W4XBS7 A0A182LTR5 A0A151WXQ3 A0A0C9RX26 A0A310SF93 A0A067R5X1 A0A1B6EVU7 U4TU30 D6WRR8 N6T5A7 A0A147B289 A0A1S3HI83 A0A1B6KR81 A0A182FN54 A0A1B6KBG0 A0A1S3HJI4 A0A1S3HGE0 V3ZMB9 A0A1B6EJM4 V5HIZ5 A0A093PRV1 V5ICC8 A0A1D2MNV3 A0A1V4L1F7 A0A146Z1P6
Q2Q1D3 A0A212F3V9 A0A194QY72 A0A194QY01 Q3LS76 Q2Q1D2 Q3LS75 A0A194PM72 H9J3V5 A0A2H1WXN3 B6CI24 A0A2H1V9E6 A0A194PMI9 A0A2A4JYB6 A0A1L8DQZ7 E2ARG4 A0A1W6EW10 A0A0J7KWU3 B0XBN5 Q17BL1 J9HI66 K7J7D5 A0A154PNT4 E2BEQ0 K7J7D4 B0XBN6 A0A087ZUU5 A0A182KFH4 E0VQW8 A0A336ML82 A0A182HR23 A0A232EL87 Q7Q0Z2 A0A1B0CZC5 A0A0M8ZZH8 A0A182VFS0 A0A182PTQ9 A0A026WT31 A0A182UFT6 A0A182L7V3 A0A182XHA2 A0A182QVJ5 A0A151JLX5 A0A182W8J9 A0A0L7KE68 A0A182JLR9 A0A151K0V1 A0A3G5BIJ3 A0A182Y637 A0A2J7PCV4 W5JJY2 A0A182NNT6 A0A182GID0 A0A2J7PCU7 D6WRR7 U5ETX4 A0A2P8Y3J8 A0A1J1HQF6 A0A1B6CMM3 E9J970 A0A182R1R5 U4U517 A0A0C5CE39 A0A2A4JZ13 A0A084W3Y6 F4X5M9 A0A1Y1LY98 A0A151IJ64 D6WRR9 A0A1W4XBS7 A0A182LTR5 A0A151WXQ3 A0A0C9RX26 A0A310SF93 A0A067R5X1 A0A1B6EVU7 U4TU30 D6WRR8 N6T5A7 A0A147B289 A0A1S3HI83 A0A1B6KR81 A0A182FN54 A0A1B6KBG0 A0A1S3HJI4 A0A1S3HGE0 V3ZMB9 A0A1B6EJM4 V5HIZ5 A0A093PRV1 V5ICC8 A0A1D2MNV3 A0A1V4L1F7 A0A146Z1P6
EC Number
3.2.1.52
Pubmed
19121390
17617724
16427309
22118469
26354079
16684772
+ More
20798317 17510324 20075255 20566863 28648823 12364791 24508170 30249741 20966253 26227816 30400621 25244985 20920257 23761445 26483478 18362917 19820115 29403074 21282665 23537049 25224926 24438588 21719571 28004739 24845553 23254933 25765539 27289101
20798317 17510324 20075255 20566863 28648823 12364791 24508170 30249741 20966253 26227816 30400621 25244985 20920257 23761445 26483478 18362917 19820115 29403074 21282665 23537049 25224926 24438588 21719571 28004739 24845553 23254933 25765539 27289101
EMBL
BABH01031930
BABH01031931
BABH01031932
AB286958
BAF52532.1
AY601817
+ More
AAT99455.1 AY601818 AAT99456.1 BABH01031937 BABH01031938 EF469203 ABO65045.1 DQ249307 ABB76924.1 AGBW02010485 OWR48417.1 KQ460949 KPJ10417.1 KPJ10418.1 DQ183186 DQ249309 ABA27426.1 ABB76926.1 DQ249308 ABB76925.1 DQ183187 ABA27427.1 KQ459598 KPI94536.1 BABH01028856 BABH01028857 ODYU01011852 SOQ57833.1 EU180214 ABY57947.1 ODYU01001373 SOQ37455.1 KPI94537.1 NWSH01000359 PCG77015.1 GFDF01005290 JAV08794.1 GL442063 EFN63973.1 KY563514 ARK19923.1 LBMM01002481 KMQ94768.1 DS232645 EDS44384.1 CH477320 EAT43655.1 EJY57559.1 AAZX01003868 KQ435007 KZC13512.1 GL447845 EFN85825.1 AAZX01003866 EDS44385.1 DS235442 EEB15774.1 UFQT01001452 SSX30615.1 APCN01001633 NNAY01003607 OXU19117.1 AAAB01008980 EAA14547.4 AJVK01009523 AJVK01009524 KQ435792 KOX74285.1 KK107128 QOIP01000006 EZA58264.1 RLU21577.1 AXCN02001981 KQ978966 KYN26909.1 JTDY01010100 KOB61159.1 KQ981225 KYN44362.1 MK075207 AYV99610.1 NEVH01026403 PNF14160.1 ADMH02001300 ETN63089.1 JXUM01066149 KQ562383 KXJ76018.1 PNF14159.1 KQ971354 EFA05960.2 GANO01002584 JAB57287.1 PYGN01000972 PSN38811.1 CVRI01000008 CRK88449.1 GEDC01022680 JAS14618.1 GL769168 EFZ10621.1 KB631654 ERL85065.1 KM217121 AJO25046.1 PCG77016.1 ATLV01020229 ATLV01020230 KE525296 KFB44930.1 GL888730 EGI58234.1 GEZM01046313 JAV77340.1 KQ977412 KYN02892.1 EFA07069.1 AXCM01006623 KQ982665 KYQ52596.1 GBYB01012436 JAG82203.1 KQ765174 OAD54088.1 KK852722 KDR17734.1 GECZ01027707 JAS42062.1 ERL85064.1 EFA05959.1 APGK01052022 APGK01052023 KB741208 ENN72853.1 GCES01001496 JAR84827.1 GEBQ01026015 JAT13962.1 GEBQ01031184 JAT08793.1 KB202050 ESO92513.1 GECZ01031630 JAS38139.1 GANP01000808 JAB83660.1 KL670487 KFW79126.1 GANP01013912 JAB70556.1 LJIJ01000794 ODM94535.1 LSYS01000242 OPJ90466.1 GCES01026591 JAR59732.1
AAT99455.1 AY601818 AAT99456.1 BABH01031937 BABH01031938 EF469203 ABO65045.1 DQ249307 ABB76924.1 AGBW02010485 OWR48417.1 KQ460949 KPJ10417.1 KPJ10418.1 DQ183186 DQ249309 ABA27426.1 ABB76926.1 DQ249308 ABB76925.1 DQ183187 ABA27427.1 KQ459598 KPI94536.1 BABH01028856 BABH01028857 ODYU01011852 SOQ57833.1 EU180214 ABY57947.1 ODYU01001373 SOQ37455.1 KPI94537.1 NWSH01000359 PCG77015.1 GFDF01005290 JAV08794.1 GL442063 EFN63973.1 KY563514 ARK19923.1 LBMM01002481 KMQ94768.1 DS232645 EDS44384.1 CH477320 EAT43655.1 EJY57559.1 AAZX01003868 KQ435007 KZC13512.1 GL447845 EFN85825.1 AAZX01003866 EDS44385.1 DS235442 EEB15774.1 UFQT01001452 SSX30615.1 APCN01001633 NNAY01003607 OXU19117.1 AAAB01008980 EAA14547.4 AJVK01009523 AJVK01009524 KQ435792 KOX74285.1 KK107128 QOIP01000006 EZA58264.1 RLU21577.1 AXCN02001981 KQ978966 KYN26909.1 JTDY01010100 KOB61159.1 KQ981225 KYN44362.1 MK075207 AYV99610.1 NEVH01026403 PNF14160.1 ADMH02001300 ETN63089.1 JXUM01066149 KQ562383 KXJ76018.1 PNF14159.1 KQ971354 EFA05960.2 GANO01002584 JAB57287.1 PYGN01000972 PSN38811.1 CVRI01000008 CRK88449.1 GEDC01022680 JAS14618.1 GL769168 EFZ10621.1 KB631654 ERL85065.1 KM217121 AJO25046.1 PCG77016.1 ATLV01020229 ATLV01020230 KE525296 KFB44930.1 GL888730 EGI58234.1 GEZM01046313 JAV77340.1 KQ977412 KYN02892.1 EFA07069.1 AXCM01006623 KQ982665 KYQ52596.1 GBYB01012436 JAG82203.1 KQ765174 OAD54088.1 KK852722 KDR17734.1 GECZ01027707 JAS42062.1 ERL85064.1 EFA05959.1 APGK01052022 APGK01052023 KB741208 ENN72853.1 GCES01001496 JAR84827.1 GEBQ01026015 JAT13962.1 GEBQ01031184 JAT08793.1 KB202050 ESO92513.1 GECZ01031630 JAS38139.1 GANP01000808 JAB83660.1 KL670487 KFW79126.1 GANP01013912 JAB70556.1 LJIJ01000794 ODM94535.1 LSYS01000242 OPJ90466.1 GCES01026591 JAR59732.1
Proteomes
UP000005204
UP000007151
UP000053240
UP000053268
UP000218220
UP000000311
+ More
UP000036403 UP000002320 UP000008820 UP000002358 UP000076502 UP000008237 UP000005203 UP000075881 UP000009046 UP000075840 UP000215335 UP000007062 UP000092462 UP000053105 UP000075903 UP000075885 UP000053097 UP000279307 UP000075902 UP000075882 UP000076407 UP000075886 UP000078492 UP000075920 UP000037510 UP000075880 UP000078541 UP000076408 UP000235965 UP000000673 UP000075884 UP000069940 UP000249989 UP000007266 UP000245037 UP000183832 UP000075900 UP000030742 UP000030765 UP000007755 UP000078542 UP000192223 UP000075883 UP000075809 UP000027135 UP000019118 UP000085678 UP000069272 UP000030746 UP000053258 UP000094527 UP000190648
UP000036403 UP000002320 UP000008820 UP000002358 UP000076502 UP000008237 UP000005203 UP000075881 UP000009046 UP000075840 UP000215335 UP000007062 UP000092462 UP000053105 UP000075903 UP000075885 UP000053097 UP000279307 UP000075902 UP000075882 UP000076407 UP000075886 UP000078492 UP000075920 UP000037510 UP000075880 UP000078541 UP000076408 UP000235965 UP000000673 UP000075884 UP000069940 UP000249989 UP000007266 UP000245037 UP000183832 UP000075900 UP000030742 UP000030765 UP000007755 UP000078542 UP000192223 UP000075883 UP000075809 UP000027135 UP000019118 UP000085678 UP000069272 UP000030746 UP000053258 UP000094527 UP000190648
Pfam
Interpro
IPR029019
HEX_eukaryotic_N
+ More
IPR015883 Glyco_hydro_20_cat
IPR029018 Hex-like_dom2
IPR017853 Glycoside_hydrolase_SF
IPR025705 Beta_hexosaminidase_sua/sub
IPR036412 HAD-like_sf
IPR004274 FCP1_dom
IPR036734 Neur_chan_lig-bd_sf
IPR006202 Neur_chan_lig-bd
IPR004625 PyrdxlKinase
IPR013749 PM/HMP-P_kinase-1
IPR029056 Ribokinase-like
IPR015883 Glyco_hydro_20_cat
IPR029018 Hex-like_dom2
IPR017853 Glycoside_hydrolase_SF
IPR025705 Beta_hexosaminidase_sua/sub
IPR036412 HAD-like_sf
IPR004274 FCP1_dom
IPR036734 Neur_chan_lig-bd_sf
IPR006202 Neur_chan_lig-bd
IPR004625 PyrdxlKinase
IPR013749 PM/HMP-P_kinase-1
IPR029056 Ribokinase-like
SUPFAM
Gene 3D
ProteinModelPortal
H9JX51
A4PHN7
Q3L6N4
Q3L6N3
H9JX50
A4LAF9
+ More
Q2Q1D3 A0A212F3V9 A0A194QY72 A0A194QY01 Q3LS76 Q2Q1D2 Q3LS75 A0A194PM72 H9J3V5 A0A2H1WXN3 B6CI24 A0A2H1V9E6 A0A194PMI9 A0A2A4JYB6 A0A1L8DQZ7 E2ARG4 A0A1W6EW10 A0A0J7KWU3 B0XBN5 Q17BL1 J9HI66 K7J7D5 A0A154PNT4 E2BEQ0 K7J7D4 B0XBN6 A0A087ZUU5 A0A182KFH4 E0VQW8 A0A336ML82 A0A182HR23 A0A232EL87 Q7Q0Z2 A0A1B0CZC5 A0A0M8ZZH8 A0A182VFS0 A0A182PTQ9 A0A026WT31 A0A182UFT6 A0A182L7V3 A0A182XHA2 A0A182QVJ5 A0A151JLX5 A0A182W8J9 A0A0L7KE68 A0A182JLR9 A0A151K0V1 A0A3G5BIJ3 A0A182Y637 A0A2J7PCV4 W5JJY2 A0A182NNT6 A0A182GID0 A0A2J7PCU7 D6WRR7 U5ETX4 A0A2P8Y3J8 A0A1J1HQF6 A0A1B6CMM3 E9J970 A0A182R1R5 U4U517 A0A0C5CE39 A0A2A4JZ13 A0A084W3Y6 F4X5M9 A0A1Y1LY98 A0A151IJ64 D6WRR9 A0A1W4XBS7 A0A182LTR5 A0A151WXQ3 A0A0C9RX26 A0A310SF93 A0A067R5X1 A0A1B6EVU7 U4TU30 D6WRR8 N6T5A7 A0A147B289 A0A1S3HI83 A0A1B6KR81 A0A182FN54 A0A1B6KBG0 A0A1S3HJI4 A0A1S3HGE0 V3ZMB9 A0A1B6EJM4 V5HIZ5 A0A093PRV1 V5ICC8 A0A1D2MNV3 A0A1V4L1F7 A0A146Z1P6
Q2Q1D3 A0A212F3V9 A0A194QY72 A0A194QY01 Q3LS76 Q2Q1D2 Q3LS75 A0A194PM72 H9J3V5 A0A2H1WXN3 B6CI24 A0A2H1V9E6 A0A194PMI9 A0A2A4JYB6 A0A1L8DQZ7 E2ARG4 A0A1W6EW10 A0A0J7KWU3 B0XBN5 Q17BL1 J9HI66 K7J7D5 A0A154PNT4 E2BEQ0 K7J7D4 B0XBN6 A0A087ZUU5 A0A182KFH4 E0VQW8 A0A336ML82 A0A182HR23 A0A232EL87 Q7Q0Z2 A0A1B0CZC5 A0A0M8ZZH8 A0A182VFS0 A0A182PTQ9 A0A026WT31 A0A182UFT6 A0A182L7V3 A0A182XHA2 A0A182QVJ5 A0A151JLX5 A0A182W8J9 A0A0L7KE68 A0A182JLR9 A0A151K0V1 A0A3G5BIJ3 A0A182Y637 A0A2J7PCV4 W5JJY2 A0A182NNT6 A0A182GID0 A0A2J7PCU7 D6WRR7 U5ETX4 A0A2P8Y3J8 A0A1J1HQF6 A0A1B6CMM3 E9J970 A0A182R1R5 U4U517 A0A0C5CE39 A0A2A4JZ13 A0A084W3Y6 F4X5M9 A0A1Y1LY98 A0A151IJ64 D6WRR9 A0A1W4XBS7 A0A182LTR5 A0A151WXQ3 A0A0C9RX26 A0A310SF93 A0A067R5X1 A0A1B6EVU7 U4TU30 D6WRR8 N6T5A7 A0A147B289 A0A1S3HI83 A0A1B6KR81 A0A182FN54 A0A1B6KBG0 A0A1S3HJI4 A0A1S3HGE0 V3ZMB9 A0A1B6EJM4 V5HIZ5 A0A093PRV1 V5ICC8 A0A1D2MNV3 A0A1V4L1F7 A0A146Z1P6
PDB
3LMY
E-value=1.04774e-105,
Score=981
Ontologies
PATHWAY
00511
Other glycan degradation - Bombyx mori (domestic silkworm)
00520 Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
00531 Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00603 Glycosphingolipid biosynthesis - globo and isoglobo series - Bombyx mori (domestic silkworm)
00604 Glycosphingolipid biosynthesis - ganglio series - Bombyx mori (domestic silkworm)
01100 Metabolic pathways - Bombyx mori (domestic silkworm)
04142 Lysosome - Bombyx mori (domestic silkworm)
00520 Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
00531 Glycosaminoglycan degradation - Bombyx mori (domestic silkworm)
00603 Glycosphingolipid biosynthesis - globo and isoglobo series - Bombyx mori (domestic silkworm)
00604 Glycosphingolipid biosynthesis - ganglio series - Bombyx mori (domestic silkworm)
01100 Metabolic pathways - Bombyx mori (domestic silkworm)
04142 Lysosome - Bombyx mori (domestic silkworm)
GO
Topology
Length:
496
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.05452
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00575
outside
1 - 496
Population Genetic Test Statistics
Pi
146.291593
Theta
143.02573
Tajima's D
-0.830656
CLR
1.312984
CSRT
0.168291585420729
Interpretation
Uncertain
