Gene

KWMTBOMO04298

Pre Gene Modal

BGIBMGA014117

Annotation

PREDICTED:_dullard-like_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr8(-):2050211-2058199      View in EpiBrowser

Full name

CTD nuclear envelope phosphatase 1 homolog      

Alternative Name

Serine/threonine-protein phosphatase dullard homolog

Location in the cell

Mitochondrial   Reliability : 1.731

CDS

ATGCTGAAAAGGTTGCAAATGGGCCTTCGCGCGTTCATGCTAGTAGCATCAAAAGTATGGAGTTGTATTTGTTATATGTTTAAGAAGCAATATCGTGCGTTGGCACAATACCAATCAGTGAAGTATGAAATCTACCCACTTTCCCCAGTATCTAGACACAGGCTGAGTCTAGTTAGAAGAAAAATCCTGGTTTTAGATTTAGATGAGACATTAATCCATTCGCATCATGATGCGATGGTCAGGCCCACTGTTAAGCCGGGTACGCCTCCGGACTTTGTCCTGAAAGTCACTATCGACAAACATCCAGTTAGATTTTTTGTTCATAAGAGGCCGCATGTAGACTACTTTTTGGATATAGTTTCACAGTGGTATGAGTTGGTTGTGTTTACTGCGTCTATGGAGATTTACGGCGCCGCTGTGGCTGACAAACTAGATAATGGACGAGGTATCCTGAGGAGACGTTTTTACAGGCAACACTGTACAGCAGAACATGGATCGTCATATACTAAAAATCTGTCATCAATATGTGACGATCTGAACAGAGTGTTCATACTGGACAATTCACCTGGAGCTTACCGAGATTTCCCGGATAACGCGATTCCAATAAAATCGTGGTTCTGCGATCCGCTGGACGTGTCCCTGCTGTCGCTGCTGCCCGTGCTCGACGCGCTGCGCTTCACGCACGACGTGCGCTCCGTGCTCTCGCGCAACCTGCACCTGCACAGGCTCTGGGACCCACCGGCTTTTGTACAAATGAAGGGCGTCGCCGGCACGCCGCAGTCTATTTATTTCCCACTCGTTAGGACGTTCAACGCTTTTCAAAATATAGATAATAATTATTATACTTAA

Protein

MLKRLQMGLRAFMLVASKVWSCICYMFKKQYRALAQYQSVKYEIYPLSPVSRHRLSLVRRKILVLDLDETLIHSHHDAMVRPTVKPGTPPDFVLKVTIDKHPVRFFVHKRPHVDYFLDIVSQWYELVVFTASMEIYGAAVADKLDNGRGILRRRFYRQHCTAEHGSSYTKNLSSICDDLNRVFILDNSPGAYRDFPDNAIPIKSWFCDPLDVSLLSLLPVLDALRFTHDVRSVLSRNLHLHRLWDPPAFVQMKGVAGTPQSIYFPLVRTFNAFQNIDNNYYT

Description

Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).

Catalytic Activity

H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Similarity

Belongs to the dullard family.

Keywords

Complete proteome   Hydrolase   Membrane   Protein phosphatase   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  CTD nuclear envelope phosphatase 1 homolog

Uniprot

Q1HQ92   A0A1E1W038   A0A2W1BPT7   A0A2H1V110   A0A3S2N8Z4   A0A194RGW2   + More
A0A222AJC1   H9JX52   A0A2P8YRZ2   A0A067RH29   E2BIZ4   A0A195CTH3   A0A151JNI5   A0A195B5T0   E2B029   A0A1B6GKG4   A0A1B6HTV3   A0A3L8DAC0   A0A232EM21   A0A1B6KT40   A0A1S4ELE8   K7J2Q1   A0A1Y1L048   A0A154PF11   E0VK35   A0A1Y1L054   V5IDG6   A0A1S4L4G3   B7Q367   V5HWQ3   A0A1E1XV31   A0A0C9SBB5   A0A1E1X6E1   A0A1Z5L5K0   A0A293LM45   A0A293LBS5   A0A131YNX7   A0A0C9RJ75   A0A026WKJ3   T1J4B5   A0A194Q2Y1   A0A1B6CCV0   A0A131X7B0   A0A0N0U3K6   L7MHX9   A0A1W4WM95   B4I6G4   Q9VRG7   A0A0L7R6R9   A0A0P4WG47   N6TUD6   U4TY55   B4PZ26   B3NYD0   Q29I63   A0A151JYW4   B3N0G3   A0A1W4VWT7   A0A2A3EEK2   A0A3B0K7Y6   A0A2M4CQP0   B4JLL8   B4N1H8   A0A1W4WB71   A0A1W4WLA3   E9FYK0   A0A0P5YKX9   B4M1V8   Q16T51   A0A1B6DA32   A0A0L0C260   X2JCV6   A0A1A9XX20   A0A1A9VNM3   A0A1B0A7P5   A0A0P5NHL9   A0A182UE25   A0A182LLK0   Q7Q5S6   A0A182X8K6   A0A240PP16   A0A0Q9WRS0   A0A0P8YEP3   A0A182QTL1   A0A0R3NZ59   A0A0R1ECC0   A0A0Q5TLD8   A0A1I8MLE9   A0A2M4AWW6   B4L8M8   A0A1W4VIK1   W5JEG0   A0A182FDT3   A0A212F6S5   A0A2M4AWN1   A0A1Q3G0P4   A0A1I8PF27   D6X3A1   A0A132AFB6   A0A0Q9WCE4  

EC Number

3.1.3.16

Pubmed

28756777    26354079    19121390    29403074    24845553    20798317    + More
30249741    28648823    20075255    28004739    20566863    25765539    29209593    26131772    28503490    28528879    26830274    24508170    28049606    25576852    17994087    10731132    12537572    12537569    23537049    17550304    15632085    21292972    17510324    26108605    12537568    12537573    12537574    16110336    17569856    17569867    20966253    12364791    25315136    18057021    20920257    23761445    22118469    18362917    19820115    26555130   

EMBL

DQ443160    ABF51249.1    GDQN01010707    JAT80347.1    KZ150021    PZC74886.1    + More
ODYU01000179    SOQ34535.1    RSAL01000190    RVE44704.1    KQ460211    KPJ16560.1    KY609677    ASO76454.1    BABH01031929    PYGN01000400    PSN47007.1    KK852510    KDR22343.1    GL448543    EFN84339.1    KQ977279    KYN03998.1    KQ978820    KYN28125.1    KQ976595    KYM79617.1    GL444372    EFN60955.1    GECZ01006986    JAS62783.1    GECU01029592    JAS78114.1    QOIP01000010    RLU17445.1    NNAY01003456    OXU19387.1    GEBQ01025389    JAT14588.1    GEZM01068298    GEZM01068296    GEZM01068295    JAV67032.1    KQ434890    KZC10431.1    DS235239    EEB13741.1    GEZM01068297    JAV67033.1    GANP01011972    JAB72496.1    ABJB010220444    ABJB010287002    ABJB010889996    ABJB010991774    DS847973    EEC13289.1    GANP01005570    JAB78898.1    GFAA01000361    JAU03074.1    GBZX01003062    JAG89678.1    GFAC01004404    JAT94784.1    GFJQ02004699    JAW02271.1    GFWV01005073    MAA29803.1    GFWV01000518    MAA25248.1    GEDV01008417    JAP80140.1    GBYB01013277    JAG83044.1    KK107167    EZA56503.1    JH431842    KQ459580    KPI99359.1    GEDC01026029    JAS11269.1    GEFH01005077    JAP63504.1    KQ435896    KOX69301.1    GACK01001469    JAA63565.1    CH480823    EDW56370.1    AE014298    AY094776    AY118321    KQ414646    KOC66543.1    GDRN01059520    JAI65493.1    APGK01018465    APGK01018466    APGK01018467    APGK01018468    KB740076    ENN81653.1    KB631643    ERL84923.1    CM000162    EDX03087.1    CH954180    EDV47609.1    CH379063    KQ981451    KYN41628.1    CH902640    EDV38367.2    KZ288277    PBC29712.1    OUUW01000021    SPP89443.1    GGFL01003459    MBW67637.1    CH916370    EDW00471.1    CH963925    EDW78217.1    GL732527    EFX87753.1    GDIP01057414    LRGB01001151    JAM46301.1    KZS13477.1    CH940651    EDW65662.1    CH477659    EAT37656.1    EAT37657.1    GEDC01014818    JAS22480.1    JRES01001107    KNC25509.1    AHN59985.1    GDIQ01152593    JAK99132.1    AAAB01008960    EAA10772.1    KRF98833.1    KPU77382.1    AXCN02000553    KRT06328.1    KRK07099.1    KQS30570.1    GGFK01011881    MBW45202.1    CH933815    EDW08003.1    KRG07540.1    ADMH02001746    ETN61214.1    AGBW02009971    OWR49446.1    GGFK01011882    MBW45203.1    GFDL01001678    JAV33367.1    KQ971372    EFA09780.2    JXLN01013336    KPM09255.1    KRF82332.1   

Proteomes

UP000283053    UP000053240    UP000005204    UP000245037    UP000027135    UP000008237    + More
UP000078542    UP000078492    UP000078540    UP000000311    UP000279307    UP000215335    UP000079169    UP000002358    UP000076502    UP000009046    UP000001555    UP000053097    UP000053268    UP000053105    UP000192223    UP000001292    UP000000803    UP000053825    UP000019118    UP000030742    UP000002282    UP000008711    UP000001819    UP000078541    UP000007801    UP000192221    UP000242457    UP000268350    UP000001070    UP000007798    UP000000305    UP000076858    UP000008792    UP000008820    UP000037069    UP000092443    UP000078200    UP000092445    UP000075902    UP000075882    UP000007062    UP000076407    UP000075880    UP000075886    UP000095301    UP000009192    UP000000673    UP000069272    UP000007151    UP000095300    UP000007266   

PRIDE

Q1HQ92    H9JX52    Q9VRG7    X2JCV6   

Pfam

PF03031   NIF

Interpro

IPR036412   HAD-like_sf        + More
IPR023214   HAD_sf       
IPR011948   Dullard_phosphatase       
IPR004274   FCP1_dom       

SUPFAM

SSF56784   SSF56784       

Gene 3D

3.40.50.1000    

ProteinModelPortal

Q1HQ92   A0A1E1W038   A0A2W1BPT7   A0A2H1V110   A0A3S2N8Z4   A0A194RGW2   + More
A0A222AJC1   H9JX52   A0A2P8YRZ2   A0A067RH29   E2BIZ4   A0A195CTH3   A0A151JNI5   A0A195B5T0   E2B029   A0A1B6GKG4   A0A1B6HTV3   A0A3L8DAC0   A0A232EM21   A0A1B6KT40   A0A1S4ELE8   K7J2Q1   A0A1Y1L048   A0A154PF11   E0VK35   A0A1Y1L054   V5IDG6   A0A1S4L4G3   B7Q367   V5HWQ3   A0A1E1XV31   A0A0C9SBB5   A0A1E1X6E1   A0A1Z5L5K0   A0A293LM45   A0A293LBS5   A0A131YNX7   A0A0C9RJ75   A0A026WKJ3   T1J4B5   A0A194Q2Y1   A0A1B6CCV0   A0A131X7B0   A0A0N0U3K6   L7MHX9   A0A1W4WM95   B4I6G4   Q9VRG7   A0A0L7R6R9   A0A0P4WG47   N6TUD6   U4TY55   B4PZ26   B3NYD0   Q29I63   A0A151JYW4   B3N0G3   A0A1W4VWT7   A0A2A3EEK2   A0A3B0K7Y6   A0A2M4CQP0   B4JLL8   B4N1H8   A0A1W4WB71   A0A1W4WLA3   E9FYK0   A0A0P5YKX9   B4M1V8   Q16T51   A0A1B6DA32   A0A0L0C260   X2JCV6   A0A1A9XX20   A0A1A9VNM3   A0A1B0A7P5   A0A0P5NHL9   A0A182UE25   A0A182LLK0   Q7Q5S6   A0A182X8K6   A0A240PP16   A0A0Q9WRS0   A0A0P8YEP3   A0A182QTL1   A0A0R3NZ59   A0A0R1ECC0   A0A0Q5TLD8   A0A1I8MLE9   A0A2M4AWW6   B4L8M8   A0A1W4VIK1   W5JEG0   A0A182FDT3   A0A212F6S5   A0A2M4AWN1   A0A1Q3G0P4   A0A1I8PF27   D6X3A1   A0A132AFB6   A0A0Q9WCE4  

PDB

2HHL     E-value=1.20529e-26,     Score=296

KEGG

733100    K17617 CTD nuclear envelope phosphatase 1 [EC:3.1.3.16] | (RefSeq) dullard-like protein

GO

GO:0016791   GO:0004721   GO:0016740   GO:0016021   GO:0030514   GO:0007474   GO:0004722   GO:0006470   GO:0005737   GO:0006998   GO:0005789   GO:0031965   GO:0005635   GO:0071595   GO:0010867   GO:0008047   GO:0043085   GO:0004637   GO:0009113   GO:0005524   GO:0046872   GO:0009058   GO:0016742   GO:0003824  

Subcellular location

Membrane  

Length:

282

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.8911

Exp number, first 60 AAs:

0.738559999999999

Total prob of N-in:

0.05399

outside

1  -  282

 

 

Pi

171.934773

Theta

175.762814

Tajima's D

-0.620409

CLR

0.666324

CSRT

0.219289035548223

Interpretation

Uncertain