Gene

KWMTBOMO04296  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014119

Annotation

PREDICTED:_trifunctional_purine_biosynthetic_protein_adenosine-3_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr8(-):2000081-2034989      View in EpiBrowser

Full name

Trifunctional purine biosynthetic protein adenosine-3      

Location in the cell

Cytoplasmic   Reliability : 1.932

CDS

ATGTCGGAAGCGAACGTTTTGGTAATAGGCGGAGGTGGTCGGGAACACGCTCTTTGCTGGAAGCTAGCGGATTCGCCTAATGTGAAAAAGATTTACTGCGCTCCAGGCAGTGTCGGTATTTCGACAACAAAAAAAGTTGAAAGCATCGAACTCGATATTAAAAACTACTCGGCATTAGCGCAATGGTGCAAAGATAACATAATAGACCTAGTTGTGATTGGCCCAGAAGATCCTCTTGCTCATGGTATTGTAGATGGCTTAGTTTCCTATGGAATTCCGTGCTTTGGGCCAAATAAAGCTGGTGCACAAATAGAGGCCAACAAGGACTGGGCAAAGAGGTTTATGAACAAATATCAGATACCGACTGCCAGACATAAGTCCTTCACTGATGCTGCAGCTGCCAAAGAGTTCATTAACAGTGCTACTTACCCGGCTTTGGTAGTGAAGGCTTCCGGGTTAGCGGCCGGCAAGGGTGTGGTTGTCGCTACATGCAAAGAAGAGGCCTGCAAAGCTGTTGATGAGATATTAACCGACGCCAAGTATGGTACAGCAGGACAGACCGTTGTCATTGAAGAGTTGTTGGAGGGCGATGAAGTTTCGGTCCTAGCATTCACCGATGGTGAAACCGTGTCGATGATGCCGCCCGCACAGGATCATAAACGCATCGGAGACGGCGACACCGGGCCCAACACCGGGGGCATGGGCGCCTACTCGCCTTGTCCACTGATAACACCAGACCAACTCGCTGACGTCAAGGACCAGGTGCTGCAGAGAGCCGTCGACGGACTTAAAGCGGAGGGCATCAAATATGTGGGTGTTCTCTACGCCGGCATGATGGTCACCAAATCAGGCCCCATGACGCTGGAGTTCAACTGTCGTTTCGGTGACCCTGAAACCCAGGTTCTGATGACCTTAATGGACTCTGACCTTTATAAAGTGATGAAGGCCTGCGTCAACGGCACCCTGAAACAAATGCAAGTGCAATGGAACACCAAGATGTCTGCCGTGGGGGTGGTCATCTCTTCCAAGGGCTACCCTGAAACTTCGACCAAGGGATGCGTGATTAGCGGATTGTCCCAAGTGCAAGCGAACCCGGAAATAGTAGTGTTCCATAGCGGCGTGGGGCGCGGCGCCAACGGGTCGCTGGTGACGTGGGGGGGGCGCGTGCTGCTGGCGTGCGCGCGGGCCGCCTCGCTGCGCGCCGCCGCCGCCGCCGCCACCGCCGCCGCCTCCATGATCGACTTCCCCGGCGCGCACTACCGGAAGGACATCGCACACCGCGCCTTCACCAAGATCAACGGCCTCTCGTACCTTCAAAGCGGAGTAGACATAGACGCGGCCGCGACCCTGGTCCGCCAGATGGAGCCGCTGGCCACCGCCACGCACCGGCGCGGCGTGCTGGGCAGGCTCGGCTGCTTCAGTGGCCTGTTCCAGCTCTCCGCCATGGGGGAGAAGTGGGAGGACCCCGTCCTAGTGCAGGGAACCGACGGGGTTGGCACTAAGCTGAAGATAGCTGAGCTAATGCAGAAGTACGACACGATCGGCCAGGACCTGGTGGCCATGTGCGTCAACGACATCCTGTGCGCCGGCGCCGAGCCCTTCGCCTTCCTGGACTACATGGCGTGCGGGCGCCTGCAGCTGGACGTGGCCACCGCCGTGGTCCGGGGCATCGCCGACGCCTGCATCGCGTCCGGCTGCGCGCTGCTGGGCGGCGAAACGGCGGAGATGCCGTCGATGTACGAGGTGGGCAAGTACGACCTGGCGGGGTTCGCGGTGGGCGTGGTGGACAACCGCAAGCAGCTGCCGCGCGCCGCCGCGCCGCCGGACGTGCTGCTGGCGCTGCCCTCCACCGGCGCGCACAGCAACGGGTACAGCCTCGTGCAGAAGATCATGGCGGAGACGGGCCACAAGTATGAGGAGCCGGCTCCGTTCAGCACTTCAAACAAGAGTTTCGGAGAAGAATTCCTGGTGCCCACGGGCCTGTACGTCAACGCGCTCCTGCCCTCGATAAAGAAAGGCCTAGTGAAGGGCCTGGCTCACATCACCGGCGGCGGCCTGCTGGAGAACATCCCCAGGATCCTGCCGCCCAACGTGAAGGCCAAGCTAGACGCCACCAAGTTCCGCATCAAGCCGATCTTTGGCTGGCTCCAGGCTAAGGGCGTCGTTTCAGACTTCGAGATGCTTCGCACGTTCAACTGCGGGGTGGGCATGGTGGTCATAGCTGACCCTGAGCTGGTGGACGAGCTGCTGGCGTCCGTCGAAGATCTACACGTCATCGGGGTACTCGAGGAGATGGGGGCTGAAGGAGGGCACCAAGTGGTCGTGGAGAAGTTCTCGGAGGCCATGGCCCCTCTGAAAGCTCCGTACCTGTCTGATCGCGAGCTGCCCAAGAAGTCGCTTTCGTACAAGGACAGCGGGGTCGATATCGAAGCTGGAGACTCCTTGGTCTCCATGATCAAACCCTTGGCAAGGTCGACGACGCGGTCGGGCGTTATCGGAGGTCTGGGCGGCTTCGGGGGCTGCTTCCAGCTCAAGGCCGTGGAACAGGAGTTTAAGGACCCGGTGTTGGTGCTGGCAGCAGATGGGGTGGGCACCAAGCTGAAAATAGCGCAAGAGATTAACAAGCACGACAGCATCGGCTTGGACCTGGTGGCCATGTGCGTCAACGACATCGTGTGCAACGGGGGCGCGCCGCTCACCTTCCTGGACTACTTCGCGTGCGGCTCCCTGCAGGTGTCCGTCGCGTCCAGCGTCGTGGCCGGGGTGGCCGCCGGCTGCAGGCAGGCCGGCGCCGCGCTCATCGGCGGCGAGACGGCGGAGATGCCCGGCATGTACGAGCCTGGCGTGTACGACGTGGCGGGCTTCGCGCTGGGCGTCGTGGAGCGCGCCAACATACTGCCCAAGATCAACGACATCAACGTGGGCGATATTGTGATCGGTTTGCCTTCCAACGGTGTACACAGCAACGGGTTCAGCCTCATACACAAGCTGATGAAGAAGGCCGGACTCACGCTCAACGACAAAGCTCCGTTCAGTGCAGAGGGACTCACTCTGGGCGAGGAGCTGATCAAGCCGACTCGCATATACGCGCGCGCGGTGCTGGCGGGCGTGCAGCGCGGGCTGGTAAAGGCGGCGGCGCACGTGACGGGCGGCGGACTGCTGCACAATCTGCCGCGCGTCATGCCCGACCACGTGCGCGCGCGCCTCAACGCGCACTGGTGGCACGTGCACCCGGTGTTCGCGTGGATAGCGGACGCGGGCGCGGTCCAGGACGAGGAGATGCTGCAGACCTTCAACTGCGGCATCGGGATGGTGCTCATCGTGTCGCCAGAGCACCAGGCTGATGTGATGAACATAAGCCGGTCGTACGGCGCGATGGTGATCGGCTCGCTGCAGGCGCGGCCGCCGGGGGGCGCGCGCGTGCTCGTCGACAACTTCGCCTCCGCCGTGGACTTCACGCGCAGGATGCCGCTCATGCACAACAAGAAGGTGGCAGTCCTAGTATCCGGCAACGGTAGTAACCTGCAGGCGCTCATCGACACGACCCGCGAGCCCGCGCACTGCATGTGCGCCGAAATAACCCTTGTGGTCTCTAACAAGAAGGACGCTTTTGCTTTGCAACGAGCCGAGAAGGCGGGGATACCTACGCTGGTGCTGAGCCACCAGCAGTTCGCGTCGCGCGAGGAGTTCGACCGCGCGGTGTCGGGCGCGCTGGAGCAGCACCGCATCGACATCGTGTGCCTGGCCGGCTACATGAGGATGCTCTCCGCAGAGTTCGTGCACAAGTGGCGCGGGCGGCTGGTGAACATCCACCCGTCGCTGCTGCCGCGGCACCCGGGCCTGCGCGCGCAGCGGCAGTGCCTGGAGGCCGGGGACGCCGAGTCGGGCTGCACTGTGCACTTCGTCGATGAGGGCATGGACACGGGTCCAATCATAGTCCAAGAGCGCGTGCCAGTGTTGCGGGACGACACGGAGGAGACCCTCACGCAGCGCATCCTGGAGGCCGAGCACCGCGCCTACCCGCGCGCGCTGCGCCTGCTCGCCACCGGCCGCGTGCGGCTCACGGCGCAGGGCGTGCTGCTCTGGCACTCGTAA

Protein

MSEANVLVIGGGGREHALCWKLADSPNVKKIYCAPGSVGISTTKKVESIELDIKNYSALAQWCKDNIIDLVVIGPEDPLAHGIVDGLVSYGIPCFGPNKAGAQIEANKDWAKRFMNKYQIPTARHKSFTDAAAAKEFINSATYPALVVKASGLAAGKGVVVATCKEEACKAVDEILTDAKYGTAGQTVVIEELLEGDEVSVLAFTDGETVSMMPPAQDHKRIGDGDTGPNTGGMGAYSPCPLITPDQLADVKDQVLQRAVDGLKAEGIKYVGVLYAGMMVTKSGPMTLEFNCRFGDPETQVLMTLMDSDLYKVMKACVNGTLKQMQVQWNTKMSAVGVVISSKGYPETSTKGCVISGLSQVQANPEIVVFHSGVGRGANGSLVTWGGRVLLACARAASLRAAAAAATAAASMIDFPGAHYRKDIAHRAFTKINGLSYLQSGVDIDAAATLVRQMEPLATATHRRGVLGRLGCFSGLFQLSAMGEKWEDPVLVQGTDGVGTKLKIAELMQKYDTIGQDLVAMCVNDILCAGAEPFAFLDYMACGRLQLDVATAVVRGIADACIASGCALLGGETAEMPSMYEVGKYDLAGFAVGVVDNRKQLPRAAAPPDVLLALPSTGAHSNGYSLVQKIMAETGHKYEEPAPFSTSNKSFGEEFLVPTGLYVNALLPSIKKGLVKGLAHITGGGLLENIPRILPPNVKAKLDATKFRIKPIFGWLQAKGVVSDFEMLRTFNCGVGMVVIADPELVDELLASVEDLHVIGVLEEMGAEGGHQVVVEKFSEAMAPLKAPYLSDRELPKKSLSYKDSGVDIEAGDSLVSMIKPLARSTTRSGVIGGLGGFGGCFQLKAVEQEFKDPVLVLAADGVGTKLKIAQEINKHDSIGLDLVAMCVNDIVCNGGAPLTFLDYFACGSLQVSVASSVVAGVAAGCRQAGAALIGGETAEMPGMYEPGVYDVAGFALGVVERANILPKINDINVGDIVIGLPSNGVHSNGFSLIHKLMKKAGLTLNDKAPFSAEGLTLGEELIKPTRIYARAVLAGVQRGLVKAAAHVTGGGLLHNLPRVMPDHVRARLNAHWWHVHPVFAWIADAGAVQDEEMLQTFNCGIGMVLIVSPEHQADVMNISRSYGAMVIGSLQARPPGGARVLVDNFASAVDFTRRMPLMHNKKVAVLVSGNGSNLQALIDTTREPAHCMCAEITLVVSNKKDAFALQRAEKAGIPTLVLSHQQFASREEFDRAVSGALEQHRIDIVCLAGYMRMLSAEFVHKWRGRLVNIHPSLLPRHPGLRAQRQCLEAGDAESGCTVHFVDEGMDTGPIIVQERVPVLRDDTEETLTQRILEAEHRAYPRALRLLATGRVRLTAQGVLLWHS

Catalytic Activity

(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate
5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate

Similarity

In the C-terminal section; belongs to the GART family.
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.

Keywords

ATP-binding   Ligase   Manganese   Metal-binding   Multifunctional enzyme   Nucleotide-binding   Purine biosynthesis   Transferase   Alternative splicing   Complete proteome   Phosphoprotein   Reference proteome  

Feature

chain  Trifunctional purine biosynthetic protein adenosine-3
splice variant  In isoform Short.

Uniprot

A0A194Q198   A0A212F6U9   H9JX54   A0A2H1W1D8   A0A182K5Z2   Q16SB2   + More
A0A182XUE2   A0A1J1I1K5   A0A1Q3G1V3   Q7Q1H5   A0A2C9GR12   A0A182NBU5   A0A182GMG1   A0A182ULV5   A0A182UKN4   A0A182KTY7   A0A182QP91   A0A182P4C4   W4VRN4   A0A182REX7   A0A182WGM1   A0A182YDE4   A0A182LW43   W5JAT6   A0A2M4A0P2   A0A2M4A0Q3   Q26255   A0A182F2X5   T1PHC3   A0A1I8MCL5   A0A0A1WVA5   X2J516   P00967   F3YDH3   A0A1B0AWW8   A0A1A9Y4Z7   A0A1W4WDU8   B3MKX0   B4JQ39   B4LV26   B4KFE3   W8APA0   A0A3B0K9P1   P16340   B4MUE3   A0A2C9JGI9   A0A182SNS9   A0A182G4G9   A0A182J4J4   A0A1L8E235   A0A3S1BU38   T1GB75  

Pubmed

26354079    22118469    19121390    17510324    12364791    14747013    + More
17210077    26483478    20966253    25244985    20920257    23761445    1518084    25315136    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    3123310    6413075    6300768    18327897    17994087    24495485    15632085    15545653    15562597   

EMBL

KQ459580    KPI99357.1    AGBW02009971    OWR49448.1    BABH01031924    BABH01031925    + More
BABH01031926    ODYU01005441    SOQ46304.1    CH477677    EAT37357.1    CVRI01000037    CRK93468.1    GFDL01001248    JAV33797.1    AAAB01008980    EAA14291.4    APCN01001747    JXUM01074668    KQ562844    KXJ75023.1    AXCN02000691    GANO01001277    JAB58594.1    AXCM01002017    ADMH02001647    ETN61567.1    GGFK01001056    MBW34377.1    GGFK01001042    MBW34363.1    S43653    KA647515    AFP62144.1    GBXI01011979    JAD02313.1    AE014134    AHN54213.1    J02527    X00041    BT126334    AEB72014.1    JXJN01004959    CH902620    EDV30628.1    CH916372    EDV99019.1    CH940649    EDW63275.1    CH933807    EDW12043.1    GAMC01020223    GAMC01020222    JAB86333.1    OUUW01000006    SPP82366.1    X06285    CH379058    AY754390    CH963857    EDW76069.1    JXUM01143724    KQ569652    KXJ68564.1    GFDF01001509    JAV12575.1    RQTK01000075    RUS88726.1    CAQQ02199923   

Proteomes

UP000053268    UP000007151    UP000005204    UP000075881    UP000008820    UP000076407    + More
UP000183832    UP000007062    UP000075840    UP000075884    UP000069940    UP000249989    UP000075903    UP000075902    UP000075882    UP000075886    UP000075885    UP000075900    UP000075920    UP000076408    UP000075883    UP000000673    UP000069272    UP000095301    UP000000803    UP000092460    UP000092443    UP000192221    UP000007801    UP000001070    UP000008792    UP000009192    UP000268350    UP000001819    UP000007798    UP000076420    UP000075901    UP000075880    UP000271974    UP000015102   

PRIDE

H9JX54    Q26255    X2J516    P00967    P16340   

Pfam

PF00551   Formyl_trans_N        + More
PF01071   GARS_A
PF02844   GARS_N
PF02769   AIRS_C
PF02843   GARS_C
PF00586   AIRS
PF12901   SUZ-C
PF12752   SUZ

Interpro

IPR000115   PRibGlycinamide_synth        + More
IPR020561   PRibGlycinamid_synth_ATP-grasp       
IPR020559   PRibGlycinamide_synth_CS       
IPR020560   PRibGlycinamide_synth_C-dom       
IPR010918   PurM-like_C_dom       
IPR011761   ATP-grasp       
IPR004607   GART       
IPR036477   Formyl_transf_N_sf       
IPR016185   PreATP-grasp_dom_sf       
IPR037123   PRibGlycinamide_synth_C_sf       
IPR011054   Rudment_hybrid_motif       
IPR004733   PurM_cligase       
IPR002376   Formyl_transf_N       
IPR001555   GART_AS       
IPR036676   PurM-like_C_sf       
IPR016188   PurM-like_N       
IPR020562   PRibGlycinamide_synth_N       
IPR036921   PurM-like_N_sf       
IPR013815   ATP_grasp_subdomain_1       
IPR024771   SUZ       
IPR024642   SUZ-C       

SUPFAM

SSF52440   SSF52440        + More
SSF53328   SSF53328       
SSF51246   SSF51246       
SSF56042   SSF56042       
SSF55326   SSF55326       

Gene 3D

3.30.1330.10     3.30.1490.20     3.90.600.10     3.90.650.10    

CDD

cd02196  PurM
cd08645  FMT_core_GART

ProteinModelPortal

A0A194Q198   A0A212F6U9   H9JX54   A0A2H1W1D8   A0A182K5Z2   Q16SB2   + More
A0A182XUE2   A0A1J1I1K5   A0A1Q3G1V3   Q7Q1H5   A0A2C9GR12   A0A182NBU5   A0A182GMG1   A0A182ULV5   A0A182UKN4   A0A182KTY7   A0A182QP91   A0A182P4C4   W4VRN4   A0A182REX7   A0A182WGM1   A0A182YDE4   A0A182LW43   W5JAT6   A0A2M4A0P2   A0A2M4A0Q3   Q26255   A0A182F2X5   T1PHC3   A0A1I8MCL5   A0A0A1WVA5   X2J516   P00967   F3YDH3   A0A1B0AWW8   A0A1A9Y4Z7   A0A1W4WDU8   B3MKX0   B4JQ39   B4LV26   B4KFE3   W8APA0   A0A3B0K9P1   P16340   B4MUE3   A0A2C9JGI9   A0A182SNS9   A0A182G4G9   A0A182J4J4   A0A1L8E235   A0A3S1BU38   T1GB75  

PDB

2QK4     E-value=1.25077e-121,     Score=1122

KEGG

101744981    K11787 phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphori

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00670    One carbon pool by folate - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0006189   GO:0005524   GO:0004637   GO:0004644   GO:0009113   GO:0004641   GO:0006164   GO:0046084   GO:0005829   GO:0008168   GO:0005737   GO:0009058   GO:0016742   GO:0003824  

PANTHER

PTHR10520  

Length:

1364

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0135399999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00026

outside

1  -  1364

 

 

Pi

227.340749

Theta

177.3943

Tajima's D

0.847285

CLR

0.038273

CSRT

0.615419229038548

Interpretation

Uncertain