Gene

KWMTBOMO04277

Annotation

PREDICTED:_phosphatidylinositol-glycan_biosynthesis_class_X_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr8(+):1702270-1706759      View in EpiBrowser

Full name

Phosphatidylinositol-glycan biosynthesis class X protein      

Location in the cell

PlasmaMembrane   Reliability : 2.275

CDS

ATGTTGACAAATATTTTTAGTTTTCGAATATGTATCGTTGTTTTTGTTGCAATCAAAGTTTTTTCGGCCAGTAAATGTGATTATGATGTGAAAATAGCTCAGATACTCATCAATGATGGATATCACAGGCATCATTACAGGAACCTAACCTACCACATAATTTTCAATGAGGATTCAGAGTCAAAAGGTATATACAATGGATGCAGAATTGGCCTCGACCAGTACCTGCCTGCTGGGGTGTTTGTTAATCCTAATGAACTGAATGAGTTCAATCGTCTGGAAAGGTTGAATGCATTTCCGAGGGGTCGGGTCAACATAGAGCTACCAACTGAAGAAGCAGAACCTATAAATGTGTTCATTATAAGTGAATTGACTGATGATGAAATACAAATGTGGCTACCAGTTCATGCTCGGTATCACGAATCTGTATCTGGTGGAGGGATGGTACAGTATGACATAGGACCCCCGAAAATGTACCTATATTGTGCTGATCGTAGACTGGACGTGTGCGACCGCAGTGTGTCACCATCTGTCACTTTGACATGTAACGGTGGTGTCAAGATGTGCTCGTGGAGAGATATACCTTACACTGTGTTGACAGATCCTCTCGTGTGGCGCGTTCCAGTCGGGAACTCCAACCACTTCTACATCATCGGCATAGGTACAGCATTCGCCATAATGGTCGGCACCACAATGGTGATCAGAGCGATGCATGACCACATTTTGAAGCACCGACGTCTGATTATACGATGA

Protein

MLTNIFSFRICIVVFVAIKVFSASKCDYDVKIAQILINDGYHRHHYRNLTYHIIFNEDSESKGIYNGCRIGLDQYLPAGVFVNPNELNEFNRLERLNAFPRGRVNIELPTEEAEPINVFIISELTDDEIQMWLPVHARYHESVSGGGMVQYDIGPPKMYLYCADRRLDVCDRSVSPSVTLTCNGGVKMCSWRDIPYTVLTDPLVWRVPVGNSNHFYIIGIGTAFAIMVGTTMVIRAMHDHILKHRRLIIR

Description

Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity).

Subunit

Interacts with PIGM.

Similarity

Belongs to the PIGX family.

Keywords

Alternative splicing   Complete proteome   Endoplasmic reticulum   Glycoprotein   GPI-anchor biosynthesis   Membrane   Reference proteome   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Phosphatidylinositol-glycan biosynthesis class X protein
splice variant  In isoform 2.

Uniprot

A0A2W1BMQ1   A0A2H1VC44   A0A194RGK0   A0A194Q192   A0A1E1W9Q6   A0A1B6BZ57   + More
A0A1B6EKN5   A0A1B6KZA0   A0A1Y1K8M4   A0A0V0GBL8   A0A3Q0JKE3   A0A1S4E713   A0A069DQK5   T1I1R7   A0A067QQI7   A0A2P8YBV0   E2AE44   A0A088AJP6   A0A2G9QKP5   H3A3C4   A0A0L0CP74   A0A154PBW0   F4WEN9   B4KQ38   K9IR82   A0A026W3C6   A0A0K8SN19   Q28YB4   B4GD50   A0A0A9YDD3   A0A195FM55   J3JWE6   A0A195E7W8   A0A2R7WCY1   A0A232F0S5   A0A195C664   A0A3B0J6T6   A0A146M4Y8   G1Q8N8   W5JW65   K7IRT5   A0A0L7R1F2   F6RKI9   U6DYQ3   M3XXL1   A0A0M4EEZ5   A0A2Y9KNF1   N6STZ1   A0A2Y9SMT5   S7N4P1   A0A2M4CMR8   B4P255   A0A2M4BY56   A0A084VL22   A0A2Y9NY62   G3T1M3   G3UEV2   A0A3Q7NM60   G1LAP0   A0A182MVH5   A0A2K5ZZL4   A0A341C037   A0A091KA67   A0A1A9XIV1   A0A384DHW4   B4MR01   A0A383Z9I2   M3WNE3   A0A1W4WB87   A0A1I8M2T3   G5ALC7   A0A195AVL9   A0A158NF05   B3N9C6   A0A099ZS15   A0A1U8DWA6   A0A3Q0FT40   A0A3Q7V1X3   A0A091DLV8   A0A3Q0FPT1   A0A2Y9HF86   A0A087WSN5   F6YX19   A0A182JK25   A0A2U3YGU5   A0A2U4A9P9   F7DFD7   Q99LV7   A0A1Q3F3K8   A0A2K6GSB4   H9ZAK0   F1LRM6   A0A1J1J015   A0A2J8RG78   H9F2G9   A0A182MZ47  

Pubmed

28756777    26354079    28004739    26334808    24845553    29403074    + More
20798317    9215903    26108605    21719571    17994087    24508170    30249741    15632085    25401762    22516182    28648823    26823975    21993624    20920257    23761445    20075255    19892987    23537049    17550304    24438588    20010809    17975172    25315136    21993625    21347285    19468303    16141072    15489334    15635094    25319552    15057822   

EMBL

KZ150021    PZC74894.1    ODYU01001758    SOQ38397.1    KQ460211    KPJ16569.1    + More
KQ459580    KPI99352.1    GDQN01007375    JAT83679.1    GEDC01030747    GEDC01024603    GEDC01002031    JAS06551.1    JAS12695.1    JAS35267.1    GECZ01031280    GECZ01018174    JAS38489.1    JAS51595.1    GEBQ01023200    JAT16777.1    GEZM01096141    JAV55127.1    GECL01000636    JAP05488.1    GBGD01002923    JAC85966.1    ACPB03018229    ACPB03018230    KK853091    KDR11544.1    PYGN01000719    PSN41742.1    GL438827    EFN68277.1    KV961180    PIO16164.1    AFYH01210524    AFYH01210525    AFYH01210526    JRES01000105    KNC34071.1    KQ434858    KZC08904.1    GL888103    EGI67402.1    CH933808    EDW08140.1    GABZ01002455    JAA51070.1    KK107455    QOIP01000010    EZA50528.1    RLU17700.1    GBRD01011082    GBRD01011081    JAG54742.1    CM000071    EAL26051.3    CH479181    EDW32545.1    GBHO01013980    GBHO01013979    GBHO01013978    JAG29624.1    JAG29625.1    JAG29626.1    KQ981490    KYN41337.1    BT127564    AEE62526.1    KQ979479    KYN21310.1    KK854561    PTY16890.1    NNAY01001375    OXU24192.1    KQ978287    KYM95666.1    OUUW01000001    SPP75552.1    GDHC01004140    JAQ14489.1    AAPE02025167    ADMH02000203    ETN67380.1    KQ414668    KOC64621.1    HAAF01015367    CCP87187.1    AEYP01017513    AEYP01017514    AEYP01017515    CP012524    ALC42740.1    APGK01056839    KB741277    KB632028    ENN71154.1    ERL88115.1    KE163428    EPQ12029.1    GGFL01002387    MBW66565.1    CM000157    EDW89256.2    GGFJ01008801    MBW57942.1    ATLV01014397    KE524970    KFB38666.1    ACTA01042684    ACTA01050684    ACTA01058684    AXCM01007649    KK502098    KFP20651.1    CH963849    EDW74540.1    AANG04001815    JH165776    EHA97837.1    KQ976736    KYM76070.1    ADTU01013693    CH954177    EDV59613.2    KL896584    KGL83555.1    KN122104    KFO33119.1    AC135962    AK008583    BC002202    GFDL01012893    JAV22152.1    JU476162    AFH32966.1    AABR07034444    CVRI01000061    CRL04185.1    NDHI03003699    PNJ07506.1    PNJ07509.1    JU325072    AFE68828.1   

Proteomes

UP000053240    UP000053268    UP000079169    UP000015103    UP000027135    UP000245037    + More
UP000000311    UP000005203    UP000008672    UP000037069    UP000076502    UP000007755    UP000009192    UP000053097    UP000279307    UP000001819    UP000008744    UP000078541    UP000078492    UP000215335    UP000078542    UP000268350    UP000001074    UP000000673    UP000002358    UP000053825    UP000002281    UP000000715    UP000092553    UP000248482    UP000019118    UP000030742    UP000002282    UP000030765    UP000248483    UP000007646    UP000286641    UP000008912    UP000075883    UP000233140    UP000252040    UP000053119    UP000092443    UP000261680    UP000007798    UP000261681    UP000011712    UP000192221    UP000095301    UP000006813    UP000078540    UP000005205    UP000008711    UP000053641    UP000189705    UP000286642    UP000028990    UP000248481    UP000000589    UP000075880    UP000245341    UP000245320    UP000233160    UP000002494    UP000183832    UP000075884   

PRIDE

F6YX19    F7DFD7    Q99LV7    F1LRM6   

Pfam

PF08320   PIG-X        + More
PF08423   Rad51
PF07973   tRNA_SAD
PF02824   TGS
PF03129   HGTP_anticodon
PF00587   tRNA-synt_2b

Interpro

IPR040039   PIGX        + More
IPR013233   PIG-X/PBN1       
IPR027417   P-loop_NTPase       
IPR030547   XRCC2       
IPR020588   RecA_ATP-bd       
IPR013632   DNA_recomb/repair_Rad51_C       
IPR012676   TGS-like       
IPR033728   ThrRS_core       
IPR004154   Anticodon-bd       
IPR006195   aa-tRNA-synth_II       
IPR018163   Thr/Ala-tRNA-synth_IIc_edit       
IPR004095   TGS       
IPR002320   Thr-tRNA-ligase_IIa       
IPR002314   aa-tRNA-synt_IIb       
IPR012675   Beta-grasp_dom_sf       
IPR036621   Anticodon-bd_dom_sf       
IPR012947   tRNA_SAD       

SUPFAM

SSF52540   SSF52540        + More
SSF55186   SSF55186       
SSF81271   SSF81271       

Gene 3D

3.10.20.30     3.40.50.800    

CDD

cd00771  ThrRS_core

ProteinModelPortal

A0A2W1BMQ1   A0A2H1VC44   A0A194RGK0   A0A194Q192   A0A1E1W9Q6   A0A1B6BZ57   + More
A0A1B6EKN5   A0A1B6KZA0   A0A1Y1K8M4   A0A0V0GBL8   A0A3Q0JKE3   A0A1S4E713   A0A069DQK5   T1I1R7   A0A067QQI7   A0A2P8YBV0   E2AE44   A0A088AJP6   A0A2G9QKP5   H3A3C4   A0A0L0CP74   A0A154PBW0   F4WEN9   B4KQ38   K9IR82   A0A026W3C6   A0A0K8SN19   Q28YB4   B4GD50   A0A0A9YDD3   A0A195FM55   J3JWE6   A0A195E7W8   A0A2R7WCY1   A0A232F0S5   A0A195C664   A0A3B0J6T6   A0A146M4Y8   G1Q8N8   W5JW65   K7IRT5   A0A0L7R1F2   F6RKI9   U6DYQ3   M3XXL1   A0A0M4EEZ5   A0A2Y9KNF1   N6STZ1   A0A2Y9SMT5   S7N4P1   A0A2M4CMR8   B4P255   A0A2M4BY56   A0A084VL22   A0A2Y9NY62   G3T1M3   G3UEV2   A0A3Q7NM60   G1LAP0   A0A182MVH5   A0A2K5ZZL4   A0A341C037   A0A091KA67   A0A1A9XIV1   A0A384DHW4   B4MR01   A0A383Z9I2   M3WNE3   A0A1W4WB87   A0A1I8M2T3   G5ALC7   A0A195AVL9   A0A158NF05   B3N9C6   A0A099ZS15   A0A1U8DWA6   A0A3Q0FT40   A0A3Q7V1X3   A0A091DLV8   A0A3Q0FPT1   A0A2Y9HF86   A0A087WSN5   F6YX19   A0A182JK25   A0A2U3YGU5   A0A2U4A9P9   F7DFD7   Q99LV7   A0A1Q3F3K8   A0A2K6GSB4   H9ZAK0   F1LRM6   A0A1J1J015   A0A2J8RG78   H9F2G9   A0A182MZ47  

KEGG

101736799    K07541 GPI mannosyltransferase 1 subunit X | (RefSeq) phosphatidylinositol-glycan biosynthesis class

PATHWAY

00563    Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006506   GO:0016021   GO:0005789   GO:0005657   GO:0000724   GO:0033063   GO:0005524   GO:0003677   GO:0008094   GO:0004829   GO:0006435   GO:0016459   GO:0042555   GO:0006260   GO:0004672   GO:0048384  

PANTHER

PTHR28650   PTHR46644   PTHR11451  

Subcellular location

Endoplasmic reticulum membrane  

SignalP

Position:   1 - 22,         Likelihood:  0.914401

 

 

Length:

250

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

36.36377

Exp number, first 60 AAs:

14.0409

Total prob of N-in:

0.14681

POSSIBLE N-term signal

sequence

outside

1  -  214

TMhelix

215  -  237

inside

238  -  250

 

 

Pi

217.377977

Theta

171.996048

Tajima's D

0.920989

CLR

0

CSRT

0.637618119094045

Interpretation

Uncertain