Gene

KWMTBOMO04268

Pre Gene Modal

BGIBMGA014231

Annotation

serotonin_transporter_[Bombyx_mori]

Location

Bomo_Chr8(-):1423807-1459449      View in EpiBrowser

Full name

Transporter       + More
Sodium-dependent serotonin transporter      

Alternative Name

5HT transporter
Cocaine-sensitive serotonin transporter
dSERT1

Location in the cell

PlasmaMembrane   Reliability : 4.93

CDS

ATGCCGGCATCGGACGCGGCGTCTGCTCCTACTGTGCCCCCTGCCCCTTCTGCAACGCCACCAGACCCACCAGCCAACAACCTTACTGAGACCCAAAAACAACGCTCGGTAGTGGTGTCGCTCACACCGGCAAGGCAGCGGGAAACCTGGGCGAAGAAGGCGGAGTTCCTACTGGCGGTCGTCGGTTTTGCAGTTGACTTGGGGAATGTGTGGCGGTTTCCTTATATTTGCTACCAGAATGGAGGAGGCGCATTCCTGATACCTTACTGCGTGATGCTGCTGTTCGGAGGTCTTCCGTTGTTCTTCATGGAGCTGGCTTTGGGGCAGTATCATCGTTGCGGCTGCCTCACCCTTTGGAAGAGAATCTGTCCGGCTTTGAAAGGCGTCGGTTATGCAATCTGCATGATCGATATATACATGGGCATGTATTACAACACAATAATCGGCTGGGCTGTGTACTACTTGGTGGCGTCTCTGGCTTCCATCAACTCCGTGCTCCCTTGGACAAGCTGCAACAACGAGTGGAACACCCCGCTGTGCACACCTGTCACTGCGCCTCAGATCAACCCTAACAGTTCTACACCCGCGAAGGAGTTCTTTGAACGTAACGTCTTAGAACAGCACAGATCAAACGGCTTGGACTACATGGGTCCGATAAAACCTTCACTCGCTTTGTGCGTTTTTGGAGTCTTCGTGTTAGTTTATTTCTCGCTTTGGAAGGGCGTGAGGAGTGCTGGAAAGGTGGTTTGGGTCACAGCTTTAGCTCCGTATGTGGTTCTTTTAATTTTGCTCGCGAGAGGCGTCACTCTACCAGGTGCTACAGAAGGCATCCGTTATTATCTGACTCCTGAATGGCACAAGCTTCAGAATTCTAAGGTCTGGATTGACGCGGCCTCGCAGATATTCTTCTCTCTTGGTCCTGGATTCGGAACGCTCCTGGCTCTCTCAAGCTACAACAAGTTCAACAACAACTGCTATAGGGATGCCATCATCACCTCCTCTATAAACTGCCTCACAAGTTTCCTGGCCGGATTCGTAATCTTCTCCGTTTTGGGGTACATGGCACACGTTCAGAATAAAAGCATTGAGGAAGTGGGGCTCGAAGGACCAGGTCTGGTATTCATTGTATACCCTGAAGCTATTGCTACTATGACTGGATCCGTTTTCTGGGCCATTATATTCTTCCTAATGCTCATTACCCTTGGACTTGACAGTACTTTTGGAGGTCTTGAAGCGGTCACAACGGCCCTGTGTGACGAGTACCCGCGTGTGCTGGGCCGGAACCGGGAGATGTTCGTCGCAGTTCTGCTACTTTTCATCTATATCTGCGCTTTGCCTACCACTACTTATGGAGGAGTATTCCTGGTGGATCTTCTAAACGTGTACGGTCCTGGGCTGGCTATTCTGTTTGTGGTGTTCGCGGAGGCCGCTGGTGTCTGCTGGGTATACGGCGTGGATCGCTTCTCTGAAGACGTGAAGAGCATGCTAGGCCACAGCCCCGGCTGGTTCTGGAGAGCCTGCTGGTCTTATATCAGCCCCGTGTTCCTGCTAGTTCTTTTCGTGTTCTCCGTCCTCGCTCACCAGGAGATGCTTGGCGGGGAGTACACTTACCCACCCTGGTCTATCACGGTGGGCTGGGTGATGACCGGCACCACTGTATCTTGCATACCGCTCTACATCATTTACAAGTTCATAATCACTCCCGGCAGCTGCCTGCAGCGTATAAAAACGATCAAACGTCCCCAAGAAACATCCATACCTCCAGCGGATCCAGCAATCTGCACGCTGTGA

Protein

MPASDAASAPTVPPAPSATPPDPPANNLTETQKQRSVVVSLTPARQRETWAKKAEFLLAVVGFAVDLGNVWRFPYICYQNGGGAFLIPYCVMLLFGGLPLFFMELALGQYHRCGCLTLWKRICPALKGVGYAICMIDIYMGMYYNTIIGWAVYYLVASLASINSVLPWTSCNNEWNTPLCTPVTAPQINPNSSTPAKEFFERNVLEQHRSNGLDYMGPIKPSLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLLILLARGVTLPGATEGIRYYLTPEWHKLQNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDAIITSSINCLTSFLAGFVIFSVLGYMAHVQNKSIEEVGLEGPGLVFIVYPEAIATMTGSVFWAIIFFLMLITLGLDSTFGGLEAVTTALCDEYPRVLGRNREMFVAVLLLFIYICALPTTTYGGVFLVDLLNVYGPGLAILFVVFAEAAGVCWVYGVDRFSEDVKSMLGHSPGWFWRACWSYISPVFLLVLFVFSVLAHQEMLGGEYTYPPWSITVGWVMTGTTVSCIPLYIIYKFIITPGSCLQRIKTIKRPQETSIPPADPAICTL

Description

Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Similarity

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.

Keywords

Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Membrane   Metal-binding   Neurotransmitter transport   Reference proteome   Sodium   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Transporter

Uniprot

Q1ZYM3   Q8ITT6   A0A2W1BIK9   A0A2A4IX94   H9JXG5   A0A2H1VFJ0   + More
A0A0G3VGU2   A0A3S2LWJ8   A0A0N1PI33   A0A212EZ55   D7EJF2   A0A1W4XPX7   W8B9V2   B4LK63   B4MYF1   B4J4U5   A0A0L0CCA6   A0A1I8PGM9   A0A1I8MCM7   A0A1A9UVA4   A0A1B0FAW5   A0A1B0ACX2   A0A1A9YBG0   A0A1B0B2E7   B4KMJ5   A0A067R7F1   B3MFQ9   A0A0M4EF40   B4IHF5   A0A0J9RJY7   A0A0B4LHJ6   P51905   B3NQI6   B4PB89   Q179N7   A0A1S4FAZ9   A0A1W4WCH1   T1HNV9   B4H683   B5DZ75   A0A0A9Z0E6   A0A3B0JIX3   A0A0L7K5B2   A0A336LLZ3   A0A1J1HE86   J9JSJ1   A0A2S2P7F3   A0A2H8TMB2   E9G579   A0A0P5I101   A0A0P5WA44   A0A0N8ABX8   A0A0P5E0P6   A0A0P5DVR4   A0A0P4ZLK4   A0A0P5XE91   A0A0P6I3A8   A0A3Q0IU20   A0A2S2QG65   E0VCX5   A0A0P5DFY5   A0A226E7H7   U4UC00   A0A1D2NDT1   A0A1A9WDV2   A0A0Q9XKV8   A0A0P5RGG4   A0A0P5SC72   A0A0N8BEN8   R7VEB2   A0A182RR00   A0A182NPH7   A0A182FUE0   A0A182YA75   A0A0P5CI01   A0A182W2F5   W5JKL0   A0A1S3NMB9   A0A1S3PJQ5   A0A091RGN0   A0A3P8XA08   M7BYK9   A0A091I381   A0A2I0M8C2   A0A3N0XGY3   B3DJ31   G1N303  

Pubmed

16580636    12180970    28756777    19121390    26354079    22118469    + More
18362917    19820115    24495485    17994087    18057021    26108605    25315136    24845553    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8197200    12537569    8302852    17550304    17510324    15632085    23185243    25401762    26823975    26227816    21292972    20566863    23537049    27289101    23254933    25244985    20920257    23761445    25069045    23624526    23371554    23594743    20838655   

EMBL

DQ424889    ABD83661.1    AF384164    AAN59781.1    KZ150021    PZC74899.1    + More
NWSH01005698    PCG64038.1    BABH01032801    ODYU01002297    SOQ39597.1    KP657646    AKL78871.1    RSAL01000147    RVE45891.1    KQ460480    KPJ14348.1    AGBW02011366    OWR46770.1    DS497704    EFA12713.1    GAMC01008550    JAB98005.1    CH940648    EDW60652.1    KRF79531.1    CH963894    EDW77140.1    CH916367    EDW00641.1    JRES01000697    KNC29089.1    CCAG010012973    JXJN01007624    JXJN01007625    JXJN01007626    CH933808    EDW10842.2    KK852824    KDR15435.1    CH902619    EDV37749.2    CP012524    ALC41888.1    CH480838    EDW49179.1    CM002911    KMY96323.1    AE013599    AHN56634.1    U04809    AY071023    U02296    CH954179    EDV56989.2    CM000158    EDW92521.2    CH477348    EAT42921.1    ACPB03018083    CH479213    EDW33307.1    CM000071    EDY69546.1    KRT03174.1    GBHO01006263    GBRD01013944    GDHC01021060    JAG37341.1    JAG51882.1    JAP97568.1    OUUW01000001    SPP73379.1    JTDY01010779    KOB58024.1    UFQT01000063    SSX19264.1    CVRI01000001    CRK86271.1    ABLF02018602    ABLF02018603    GGMR01012731    MBY25350.1    GFXV01002613    MBW14418.1    GL732532    EFX85431.1    GDIQ01222204    JAK29521.1    GDIP01090232    JAM13483.1    GDIP01162513    JAJ60889.1    GDIP01154432    JAJ68970.1    GDIP01156828    JAJ66574.1    GDIP01211576    JAJ11826.1    GDIP01073538    JAM30177.1    GDIQ01035559    JAN59178.1    GGMS01007523    MBY76726.1    DS235068    EEB11231.1    GDIP01158031    JAJ65371.1    LNIX01000006    OXA52546.1    KB631957    ERL87475.1    LJIJ01000075    ODN03411.1    KRG05518.1    GDIQ01101870    JAL49856.1    GDIP01142027    JAL61687.1    GDIQ01185155    JAK66570.1    AMQN01017133    KB292772    ELU16974.1    GDIP01171124    JAJ52278.1    ADMH02001166    ETN63853.1    KK701838    KFQ27772.1    KB523138    EMP37173.1    KL218048    KFP01878.1    AKCR02000030    PKK25926.1    RJVU01074626    ROI16624.1    BX323811    BX547941    BC163340    BC163371    AAI63340.1   

Proteomes

UP000218220    UP000005204    UP000283053    UP000053240    UP000007151    UP000007266    + More
UP000192223    UP000008792    UP000007798    UP000001070    UP000037069    UP000095300    UP000095301    UP000078200    UP000092444    UP000092445    UP000092443    UP000092460    UP000009192    UP000027135    UP000007801    UP000092553    UP000001292    UP000000803    UP000008711    UP000002282    UP000008820    UP000192221    UP000015103    UP000008744    UP000001819    UP000268350    UP000037510    UP000183832    UP000007819    UP000000305    UP000079169    UP000009046    UP000198287    UP000030742    UP000094527    UP000091820    UP000014760    UP000075900    UP000075884    UP000069272    UP000076408    UP000075920    UP000000673    UP000087266    UP000265140    UP000031443    UP000054308    UP000053872    UP000000437    UP000001645   

PRIDE

Q1ZYM3    H9JXG5    P51905   

Pfam

PF00209   SNF        + More
PF03491   5HT_transport_N

Interpro

IPR000175   Na/ntran_symport        + More
IPR037272   SNS_sf       
IPR013086   Na/ntran_symport_serotonin_N       

SUPFAM

SSF161070   SSF161070       

ProteinModelPortal

Q1ZYM3   Q8ITT6   A0A2W1BIK9   A0A2A4IX94   H9JXG5   A0A2H1VFJ0   + More
A0A0G3VGU2   A0A3S2LWJ8   A0A0N1PI33   A0A212EZ55   D7EJF2   A0A1W4XPX7   W8B9V2   B4LK63   B4MYF1   B4J4U5   A0A0L0CCA6   A0A1I8PGM9   A0A1I8MCM7   A0A1A9UVA4   A0A1B0FAW5   A0A1B0ACX2   A0A1A9YBG0   A0A1B0B2E7   B4KMJ5   A0A067R7F1   B3MFQ9   A0A0M4EF40   B4IHF5   A0A0J9RJY7   A0A0B4LHJ6   P51905   B3NQI6   B4PB89   Q179N7   A0A1S4FAZ9   A0A1W4WCH1   T1HNV9   B4H683   B5DZ75   A0A0A9Z0E6   A0A3B0JIX3   A0A0L7K5B2   A0A336LLZ3   A0A1J1HE86   J9JSJ1   A0A2S2P7F3   A0A2H8TMB2   E9G579   A0A0P5I101   A0A0P5WA44   A0A0N8ABX8   A0A0P5E0P6   A0A0P5DVR4   A0A0P4ZLK4   A0A0P5XE91   A0A0P6I3A8   A0A3Q0IU20   A0A2S2QG65   E0VCX5   A0A0P5DFY5   A0A226E7H7   U4UC00   A0A1D2NDT1   A0A1A9WDV2   A0A0Q9XKV8   A0A0P5RGG4   A0A0P5SC72   A0A0N8BEN8   R7VEB2   A0A182RR00   A0A182NPH7   A0A182FUE0   A0A182YA75   A0A0P5CI01   A0A182W2F5   W5JKL0   A0A1S3NMB9   A0A1S3PJQ5   A0A091RGN0   A0A3P8XA08   M7BYK9   A0A091I381   A0A2I0M8C2   A0A3N0XGY3   B3DJ31   G1N303  

PDB

5I6Z     E-value=9.50993e-167,     Score=1508

KEGG

693007    K05037 solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 | (RefSeq) Sert; s

GO

GO:0005328   GO:0016021   GO:0015293   GO:0005335   GO:0051378   GO:0098793   GO:0051610   GO:0043005   GO:0005886   GO:0005261   GO:0043679   GO:0030424   GO:0006837   GO:0015844   GO:0046872   GO:0008504   GO:0005887   GO:0009636   GO:0045787   GO:0090067   GO:0048854   GO:0050998   GO:0035176   GO:0017137   GO:0012505   GO:0046621   GO:0071310   GO:0045121   GO:0010628   GO:0006836   GO:0005515   GO:0042555   GO:0006260   GO:0004672   GO:0048384  

PANTHER

PTHR11616  

Subcellular location

Cell membrane  

Length:

596

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

264.27634

Exp number, first 60 AAs:

5.31001

Total prob of N-in:

0.87740

inside

1  -  55

TMhelix

56  -  75

outside

76  -  84

TMhelix

85  -  107

inside

108  -  127

TMhelix

128  -  150

outside

151  -  216

TMhelix

217  -  239

inside

240  -  247

TMhelix

248  -  270

outside

271  -  293

TMhelix

294  -  316

inside

317  -  328

TMhelix

329  -  351

outside

352  -  387

TMhelix

388  -  410

inside

411  -  430

TMhelix

431  -  453

outside

454  -  462

TMhelix

463  -  485

inside

486  -  505

TMhelix

506  -  525

outside

526  -  539

TMhelix

540  -  562

inside

563  -  596

 

 

Pi

211.028418

Theta

175.845976

Tajima's D

0.96657

CLR

0.339727

CSRT

0.651117444127794

Interpretation

Uncertain