Gene

KWMTBOMO04249  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014241

Annotation

PREDICTED:_transforming_growth_factor_beta-1-induced_transcript_1_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr8(-):988943-1020755      View in EpiBrowser

Full name

Transforming growth factor beta-1-induced transcript 1 protein      

Alternative Name

Androgen receptor-associated protein of 55 kDa
Hydrogen peroxide-inducible clone 5 protein
TGF beta-stimulated clone 5

Location in the cell

Extracellular   Reliability : 3.318

CDS

ATGTCAACAAAGGTTGAAGCCCCCGCCGTCTGTAACAGCTGCGACAAAGTGATTCAAGGCAGAATCGTGACGGCGCTGAACAAGAAATGGCATCCCGAGCACTTTGTCTGCAACACCTGCCGTAAGCCAATCGATGGAGCCAAGTTCCACCAGCACAACAACGGTGTCCATTGCGTGCCCTGCTTCACCAAACATCACAGCCCGCGGTGCCATGGATGCGGCGACCCCATCACTGACCGTGTGATCCAAGCTCTTGGCGTATCGTGGCACGCTCACCACTTCGTCTGCGGTGGATGCAAGAAGGAGCTTGGCGGTGGAGGGTTCATGGAACAGGCTGGCCGTCCCTATTGCTCCGATTGCTATGCAGACAAGTTCGCCACTCGCTGCAAGGGGTGCGGAAATCCAATCGTCGATAAAGCCATCATCGCGCTTGACGCTAAGTGGCACCGCGATTGCTTCACGTGCATGAAGTGCAGGAATCCAGTGACCGATTCGACATTCTCCGTGATGGAAAACCAGCCACTCTGCGGTAAATGCGCTTAA

Protein

MSTKVEAPAVCNSCDKVIQGRIVTALNKKWHPEHFVCNTCRKPIDGAKFHQHNNGVHCVPCFTKHHSPRCHGCGDPITDRVIQALGVSWHAHHFVCGGCKKELGGGGFMEQAGRPYCSDCYADKFATRCKGCGNPIVDKAIIALDAKWHRDCFTCMKCRNPVTDSTFSVMENQPLCGKCA

Description

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

Subunit

Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.

Similarity

Belongs to the paxillin family.

Keywords

Acetylation   Activator   Alternative splicing   Cell junction   Complete proteome   Cytoplasm   Cytoskeleton   Differentiation   LIM domain   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   Wnt signaling pathway   Zinc  

Feature

chain  Transforming growth factor beta-1-induced transcript 1 protein
splice variant  In isoform 7.

Uniprot

H9JXH5   E5G3X6   E5G3X5   Q9U6W9   A0A212FGS7   I4DR21   + More
A0A3S2NF33   A0A194Q2V3   A0A194QL85   A0A2A4IW40   A0A0L7KQ73   V5G618   A0A1B0A9X3   A0A1B0G8X4   A0A1A9VC76   A0A1B0BR22   B3MWB0   B4L2L2   A0A034VH27   B4IES3   A0A0K8VSU3   A0A0A1WH33   A0A1A9Y2X0   B4R613   B4Q1U2   A0A1L8EH08   B3NVL8   W8BBK2   A0A1W4VJE2   Q9VXC1   A0A1L8DLY1   A0A0Q9WPP1   A0A0L0C927   A0A1B0DJT5   B4NDS8   A0A3B0KUC8   T1PP03   D6WWV7   A0A0M4ERX6   A0A1W4VXE6   B4JL81   J3JW44   U4UYK6   U5EPZ9   A0A1Y1N131   B5DLF3   R4G8M1   A0A1W4XMK4   E0VDH5   A0A224XXW1   B4MW41   A0A1W4UWU6   B4LU08   A0A0A9XBA2   A0A023F9B1   A0A1B6BX93   A0A0K8TL13   A0A3B0JIX4   A0A182X191   A0A2C9GPQ9   A0A1B6DV35   A0A1B6DMJ3   A0A1B6CH08   A0A182U2G0   A0A1B6BX18   A0A1B6D472   A0A1B6DSG2   B4KF41   B3MN68   A0A2J7QZI5   A0A2J7QZI7   G3TPF2   A0A2J7QZI3   T1DQL1   A0A2J7QZI9   A0A2S2NLG4   A0A2P8YS99   A0A182VTP4   A0A182STZ6   A0A0A9YA80   A0A250YID9   A0A0A9Y2R2   Q62219-10   Q62219-7   A0A1S3EQY4   A0A1U8BHQ2   B4NSU7   B4IFM3   A0A3Q0CUA1   A0A1S3A6H4   Q8T0V8   N6UB94   A0A0P6JK87   A0A1U7QEC9   B4JAE8   A0A2J8TKW1   A0A061IGM5   Q62219-5  

Pubmed

19121390    10468589    22118469    22651552    26354079    26227816    + More
17994087    18057021    25348373    25830018    17550304    24495485    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26108605    25315136    18362917    19820115    22516182    23537049    28004739    15632085    23185243    20566863    25401762    26823975    25474469    26369729    29403074    28087693    7929412    10831843    16219310    16141072    15489334    9422762    9756887    9722648    10092676    10330411    9858471    10649439    11134073    10848625    11437454    11546764    11463817    11937715    12153727    11779876    11805099    12177201    12631731    14755691    16183059    15687259    15713747    16219691    16291758    16624805    16737959    17233630    17299801    17166536    21183079    22936249    23929341   

EMBL

BABH01032743    BABH01032744    HM748970    ADQ86007.1    HM748969    ADQ86006.1    + More
AF172845    AAD53751.1    AGBW02008598    OWR52946.1    AK404898    BAM20361.1    RSAL01000147    RVE45873.1    KQ459580    KPI99329.1    KQ461196    KPJ06297.1    NWSH01006346    PCG63494.1    JTDY01007081    KOB65468.1    GALX01002961    JAB65505.1    CCAG010017107    JXJN01018875    CH902625    EDV35255.1    CH933810    EDW07810.1    KRF94222.1    GAKP01017873    GAKP01017872    JAC41080.1    CH480832    EDW46177.1    GDHF01011299    GDHF01010743    GDHF01010353    JAI41015.1    JAI41571.1    JAI41961.1    GBXI01015978    GBXI01013647    GBXI01002009    JAC98313.1    JAD00645.1    JAD12283.1    CM000366    EDX18117.1    CM000162    EDX02517.1    GFDG01000841    JAV17958.1    CH954180    EDV46410.2    GAMC01016054    GAMC01016053    GAMC01016052    GAMC01016050    GAMC01016049    JAB90506.1    AE014298    BT132655    AAF48655.3    AEQ05557.1    GFDF01006618    JAV07466.1    CH940651    KRF82272.1    KRF82273.1    JRES01000728    KNC28933.1    AJVK01001054    CH964239    EDW81897.2    OUUW01000021    SPP89426.1    KA649459    KA649830    AFP64459.1    KQ971360    EFA09100.2    CP012528    ALC48952.1    CH916370    EDW00334.1    BT127462    AEE62424.1    KB632428    ERL95405.1    GANO01004536    JAB55335.1    GEZM01015490    GEZM01015487    GEZM01015486    JAV91612.1    CH379063    EDY72352.1    KRT06223.1    ACPB03014677    GAHY01000732    JAA76778.1    DS235078    EEB11431.1    GFTR01003517    JAW12909.1    CH963857    EDW75911.1    KRF98335.1    CH940649    EDW65061.1    GBHO01025607    GBRD01004687    GDHC01016025    JAG17997.1    JAG61134.1    JAQ02604.1    GBBI01000747    JAC17965.1    GEDC01031391    JAS05907.1    GDAI01002574    JAI15029.1    OUUW01000006    SPP82165.1    APCN01000737    GEDC01007761    JAS29537.1    GEDC01010404    JAS26894.1    GEDC01024512    GEDC01005748    JAS12786.1    JAS31550.1    GEDC01031466    JAS05832.1    GEDC01016852    JAS20446.1    GEDC01008705    JAS28593.1    CH933807    EDW13024.1    CH902620    EDV31025.1    KPU73190.1    NEVH01009069    PNF33999.1    PNF34000.1    PNF33996.1    GAMD01001100    JAB00491.1    PNF33998.1    GGMR01005349    MBY17968.1    PYGN01000391    PSN47130.1    GBHO01017159    JAG26445.1    GFFW01001380    JAV43408.1    GBHO01017160    JAG26444.1    L22482    AF083064    DQ143891    DQ143892    DQ143893    DQ143894    DQ143895    DQ143896    DQ143897    DQ143898    DQ143899    DQ143900    AK156423    AK158409    BC002049    BC056362    CM000361    CH982450    CM002910    EDX05721.1    EDX15279.1    KMY91302.1    CH480833    CH684345    EDW46445.1    EDW56474.1    AY069027    AE014134    AAL39172.1    AAN11104.1    AHN54636.1    APGK01035708    KB740928    ENN77926.1    GEBF01001621    JAO02012.1    CH916368    EDW03819.1    NDHI03003494    PNJ33684.1    PNJ33686.1    PNJ33687.1    KE671541    ERE80093.1   

Proteomes

UP000005204    UP000007151    UP000283053    UP000053268    UP000053240    UP000218220    + More
UP000037510    UP000092445    UP000092444    UP000078200    UP000092460    UP000007801    UP000009192    UP000001292    UP000092443    UP000000304    UP000002282    UP000008711    UP000192221    UP000000803    UP000008792    UP000037069    UP000092462    UP000007798    UP000268350    UP000095301    UP000007266    UP000092553    UP000001070    UP000030742    UP000001819    UP000015103    UP000192223    UP000009046    UP000076407    UP000075840    UP000075902    UP000235965    UP000007646    UP000245037    UP000075920    UP000075901    UP000000589    UP000081671    UP000189706    UP000079721    UP000019118    UP000030759   

PRIDE

H9JXH5    Q9VXC1    Q62219    Q8T0V8   

Pfam

PF00412   LIM

Interpro

IPR001781   Znf_LIM        + More
IPR017305   Tgfb1i1/Leupaxin/TGFB1I1       

ProteinModelPortal

H9JXH5   E5G3X6   E5G3X5   Q9U6W9   A0A212FGS7   I4DR21   + More
A0A3S2NF33   A0A194Q2V3   A0A194QL85   A0A2A4IW40   A0A0L7KQ73   V5G618   A0A1B0A9X3   A0A1B0G8X4   A0A1A9VC76   A0A1B0BR22   B3MWB0   B4L2L2   A0A034VH27   B4IES3   A0A0K8VSU3   A0A0A1WH33   A0A1A9Y2X0   B4R613   B4Q1U2   A0A1L8EH08   B3NVL8   W8BBK2   A0A1W4VJE2   Q9VXC1   A0A1L8DLY1   A0A0Q9WPP1   A0A0L0C927   A0A1B0DJT5   B4NDS8   A0A3B0KUC8   T1PP03   D6WWV7   A0A0M4ERX6   A0A1W4VXE6   B4JL81   J3JW44   U4UYK6   U5EPZ9   A0A1Y1N131   B5DLF3   R4G8M1   A0A1W4XMK4   E0VDH5   A0A224XXW1   B4MW41   A0A1W4UWU6   B4LU08   A0A0A9XBA2   A0A023F9B1   A0A1B6BX93   A0A0K8TL13   A0A3B0JIX4   A0A182X191   A0A2C9GPQ9   A0A1B6DV35   A0A1B6DMJ3   A0A1B6CH08   A0A182U2G0   A0A1B6BX18   A0A1B6D472   A0A1B6DSG2   B4KF41   B3MN68   A0A2J7QZI5   A0A2J7QZI7   G3TPF2   A0A2J7QZI3   T1DQL1   A0A2J7QZI9   A0A2S2NLG4   A0A2P8YS99   A0A182VTP4   A0A182STZ6   A0A0A9YA80   A0A250YID9   A0A0A9Y2R2   Q62219-10   Q62219-7   A0A1S3EQY4   A0A1U8BHQ2   B4NSU7   B4IFM3   A0A3Q0CUA1   A0A1S3A6H4   Q8T0V8   N6UB94   A0A0P6JK87   A0A1U7QEC9   B4JAE8   A0A2J8TKW1   A0A061IGM5   Q62219-5  

PDB

2MIU     E-value=1.26645e-06,     Score=120

KEGG

101747029    no KO assigned | (RefSeq) transforming growth factor beta-1-induced transcript 1 protein

GO

GO:0046872   GO:0003712   GO:0005925   GO:0005829   GO:0005886   GO:0005856   GO:0007160   GO:0050681   GO:0030855   GO:0010718   GO:0045165   GO:0016331   GO:0070411   GO:0030579   GO:0045893   GO:0045599   GO:0048495   GO:0003713   GO:0030512   GO:0030511   GO:0009408   GO:0016363   GO:0016055   GO:0008270   GO:0015074   GO:0006384   GO:0016021   GO:0042555   GO:0006260   GO:0004672   GO:0048384  

Subcellular location

Cell junction  
Focal adhesion  
Nucleus matrix  
Cytoplasm  
Cytoskeleton  

Length:

180

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00018

Exp number, first 60 AAs:

0

Total prob of N-in:

0.12282

outside

1  -  180

 

 

Pi

243.621674

Theta

177.127212

Tajima's D

0.622605

CLR

0.101719

CSRT

0.551122443877806

Interpretation

Uncertain