Gene

KWMTBOMO04202

Pre Gene Modal

BGIBMGA008647

Annotation

hypothetical_protein_KGM_19575_[Danaus_plexippus]

Location

Bomo_Chr7(-):13427021-13458274      View in EpiBrowser

Full name

Dystrophin, isoforms A/C/F/G/H       + More
Dystrophin, isoform B      

Alternative Name

Protein detached

Location in the cell

Nuclear   Reliability : 2.742

CDS

ATGAGTAAGCTGGGAGAGCTTAAGGATCTGCAATCGGAGATCGAGACACACAGGAATGTGTACGCATCGCTCACTGGAACTGGCCGGCGTCTCCTGGGCAGCCTGTCTTCTCAGGAAGACGCTGTCATGCTGCAGAGGAGACTGGATGAGATGAATCAGAGATGGCATCACTTGAAAGCGAAGAGTATGGCTATCAGAAACCGCCTTGAGAGCAACGCCGAACATTGGTCCGCATTGCTGCTGTCTCTCCGGGAGTTAACTGAGTGGGTCATCAGGAAAGAGACAGAATTGAACGCTCTAGCACCTCCGAGGGGAGACCTCACCGCCCTCCTAAAGCAGCAAGATGATCATCGCGCCTTCAGGAGACAATTGGAAGACAAGCGTCCAGTGGTGGAGAGCAACCTCCTCAGCGGAAGGCAGTACATCGCCAACGAACCACCTCTCTCCGACACCAGTGATACTGAACCATCTCGGGACAGCGAAGGCGACTCCCGCGGCTACCGGTCTGCCGAGGAACAGGCCCGCGAGCTGGCCCGCTCTATCCGCCGCGAGGTGGCCAAGCTCGCTGACAAGTGGAACAACCTGGTCGACCGCAGCGACGCGTGGGGCAGGTGCTTGGATGATGCTGTACAGGTATGTCTAGAACTTAAGCTTACCTTTATTAATAAAACTAGCGGACCGTTCCGGCTCCGCTCGGGTCTTTAA

Protein

MSKLGELKDLQSEIETHRNVYASLTGTGRRLLGSLSSQEDAVMLQRRLDEMNQRWHHLKAKSMAIRNRLESNAEHWSALLLSLRELTEWVIRKETELNALAPPRGDLTALLKQQDDHRAFRRQLEDKRPVVESNLLSGRQYIANEPPLSDTSDTEPSRDSEGDSRGYRSAEEQARELARSIRREVAKLADKWNNLVDRSDAWGRCLDDAVQVCLELKLTFINKTSGPFRLRSGL

Description

Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane.
Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.

Subunit

Component of the dystrophin associated protein complex (DAPC). Interacts with Dg, via the Dg WW domain binding sites.

Keywords

Actin-binding   Alternative splicing   Calcium   Cell membrane   Complete proteome   Cytoplasm   Cytoskeleton   Membrane   Metal-binding   Phosphoprotein   Reference proteome   Repeat   Zinc   Zinc-finger  

Feature

chain  Dystrophin, isoforms A/C/F/G/H
splice variant  In isoform F.

Uniprot

A0A212EQW8   A0A194PWC9   A0A1E1WJ00   A0A194RDD7   A0A1B6EW19   A0A1B6KWY7   + More
A0A1B6LPQ0   A0A088AJ44   A0A1B6I1K0   A0A1B6IKG4   A0A310STA5   A0A232FMZ1   A0A1B6LEA1   A0A1B6KJ06   A0A158NE51   V9ICT2   A0A2A3EC27   E0VJZ9   A0A1B6HMA6   A0A0C9RVM7   A0A0L7R7U4   A0A0N0BDW7   A0A1B0G180   A0A336MUW4   A0A1A9X1L7   A0A1A9XP77   A0A336MMA3   A0A0K8TBX1   A0A0K8T9U8   A0A0K8T9F1   A0A0K8T9F7   A0A0K8TAJ4   A0A0A9YSD3   A0A0A9ZD72   A0A0A9YQV7   A0A0A9ZD78   A0A2J7PV18   A0A0A9Z5J2   A0A0A9Z8S5   A0A0K8T9D3   A0A0A9Z3C7   A0A0A9Z8T0   A0A0A9Z5J6   A0A0A9Z770   A0A0A9YLR0   A0A0A9Z766   A0A2J7PV24   A0A2J7PV58   A0A3L8DXZ2   A0A069DY06   A0A1L8E575   A0A224X947   A0A023F0P7   A0A0Q9WZ85   B4KCK7   B4GLW3   A0A0Q9X7F0   A0A0Q9X128   A0A0Q9WZ57   A0A0Q9X5Z0   A0A0Q9XB81   A0A0Q9WZP4   A0A0Q9X9Z4   A0A0Q9XBK8   A0A0Q9WZ87   A0A0B4KGB9   B4JYZ5   B4LZ03   A0A0Q9WGJ9   A0A0Q9WHH3   A0A0Q9WGH2   A0A0Q9WRQ6   A0A0Q9WSC2   A0A0Q9WGP2   A0A0B4KHR4   A0A0Q9WNZ9   A0A1W4W9F8   A0A0Q9WQI2   A0A0Q9WSU5   A0A0Q9WH19   Q9VDW6-2   A0A0B4KGH0   A0A0R3NKF7   A0A0Q9WU35   A0A0Q9WU41   A0A0R3NR30   Q9VDW3   A0A0Q9WIB5   A0A0Q9WGQ7   A0A0R3NK00   A0A0M4EJD4   A0A0R3NKA5   A0A0Q9WSF8   A0A0R3NPN5   Q9VDW6   A0A1W4W848   Q293M7  

Pubmed

22118469    26354079    28648823    21347285    20566863    25401762    + More
30249741    26334808    25474469    17994087    18057021    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    11018515    11223239    16399704    17355978    17543506    18093579    18327897    15632085    9499411   

EMBL

AGBW02013189    OWR43896.1    KQ459589    KPI97632.1    GDQN01004187    JAT86867.1    + More
KQ460367    KPJ15479.1    GECZ01027555    JAS42214.1    GEBQ01024019    JAT15958.1    GEBQ01014295    JAT25682.1    GECU01026907    JAS80799.1    GECU01020297    JAS87409.1    KQ760629    OAD59723.1    NNAY01000019    OXU31889.1    GEBQ01018143    JAT21834.1    GEBQ01028823    JAT11154.1    ADTU01012837    ADTU01012838    ADTU01012839    ADTU01012840    ADTU01012841    ADTU01012842    ADTU01012843    ADTU01012844    ADTU01012845    ADTU01012846    JR038061    AEY58099.1    KZ288290    PBC29240.1    DS235235    EEB13705.1    GECU01031869    JAS75837.1    GBYB01011751    JAG81518.1    KQ414637    KOC66952.1    KQ435851    KOX70714.1    CCAG010022463    UFQT01002783    SSX34056.1    UFQT01001358    SSX30199.1    GBRD01002769    JAG63052.1    GBRD01003655    JAG62166.1    GBRD01003657    JAG62164.1    GBRD01003638    JAG62183.1    GBRD01003651    JAG62170.1    GBHO01009596    JAG34008.1    GBHO01003854    JAG39750.1    GBHO01009598    JAG34006.1    GBHO01003849    JAG39755.1    NEVH01020989    PNF20188.1    GBHO01003850    JAG39754.1    GBHO01003851    JAG39753.1    GBRD01003659    JAG62162.1    GBHO01003847    JAG39757.1    GBHO01003846    JAG39758.1    GBHO01003845    JAG39759.1    GBHO01003848    JAG39756.1    GBHO01009597    JAG34007.1    GBHO01003853    JAG39751.1    PNF20189.1    PNF20190.1    QOIP01000002    RLU25330.1    GBGD01000006    JAC88883.1    GFDF01000226    JAV13858.1    GFTR01009002    JAW07424.1    GBBI01003645    JAC15067.1    CH933806    KRG01228.1    EDW14826.1    CH479185    EDW38537.1    KRG01220.1    KRG01221.1    KRG01225.1    KRG01222.1    KRG01226.1    KRG01224.1    KRG01229.1    KRG01223.1    KRG01219.1    KRG01227.1    AE014297    AGB96113.1    CH916378    EDV98610.1    CH940650    EDW68106.1    KRF83673.1    KRF83657.1    KRF83660.1    KRF83666.1    KRF83661.1    KRF83663.1    KRF83668.1    KRF83656.1    AGB96110.1    KRF83671.1    KRF83665.1    KRF83659.1    KRF83667.1    AF277386    AF297644    AF300456    AF302236    AAF55673.2    AGB96112.1    CM000070    KRT01348.1    KRF83669.1    KRF83664.1    KRT01360.1    AF300294    X99757    AAF55676.3    AAK15257.1    KRF83670.1    KRF83672.1    KRT01345.1    CP012526    ALC46996.1    KRT01342.1    KRF83662.1    KRT01343.1    EAL29187.4   

Proteomes

UP000007151    UP000053268    UP000053240    UP000005203    UP000215335    UP000005205    + More
UP000242457    UP000009046    UP000053825    UP000053105    UP000092444    UP000091820    UP000092443    UP000235965    UP000279307    UP000009192    UP000008744    UP000000803    UP000001070    UP000008792    UP000192221    UP000001819    UP000092553   

PRIDE

Q9VDW6    Q9VDW3   

Pfam

PF00435   Spectrin        + More
PF00569   ZZ
PF00397   WW
PF09069   EF-hand_3
PF09068   EF-hand_2
PF00361   Proton_antipo_M
PF00307   CH

Interpro

IPR018159   Spectrin/alpha-actinin        + More
IPR002017   Spectrin_repeat       
IPR011992   EF-hand-dom_pair       
IPR001202   WW_dom       
IPR036020   WW_dom_sf       
IPR000433   Znf_ZZ       
IPR015153   EF-hand_dom_typ1       
IPR015154   EF-hand_dom_typ2       
IPR001750   ND/Mrp_mem       
IPR035436   Dystrophin/utrophin       
IPR036872   CH_dom_sf       
IPR001589   Actinin_actin-bd_CS       
IPR001715   CH-domain       

SUPFAM

SSF47473   SSF47473        + More
SSF51045   SSF51045       
SSF47576   SSF47576       

Gene 3D

1.10.418.10    

CDD

cd00201  WW
cd00014  CH

ProteinModelPortal

A0A212EQW8   A0A194PWC9   A0A1E1WJ00   A0A194RDD7   A0A1B6EW19   A0A1B6KWY7   + More
A0A1B6LPQ0   A0A088AJ44   A0A1B6I1K0   A0A1B6IKG4   A0A310STA5   A0A232FMZ1   A0A1B6LEA1   A0A1B6KJ06   A0A158NE51   V9ICT2   A0A2A3EC27   E0VJZ9   A0A1B6HMA6   A0A0C9RVM7   A0A0L7R7U4   A0A0N0BDW7   A0A1B0G180   A0A336MUW4   A0A1A9X1L7   A0A1A9XP77   A0A336MMA3   A0A0K8TBX1   A0A0K8T9U8   A0A0K8T9F1   A0A0K8T9F7   A0A0K8TAJ4   A0A0A9YSD3   A0A0A9ZD72   A0A0A9YQV7   A0A0A9ZD78   A0A2J7PV18   A0A0A9Z5J2   A0A0A9Z8S5   A0A0K8T9D3   A0A0A9Z3C7   A0A0A9Z8T0   A0A0A9Z5J6   A0A0A9Z770   A0A0A9YLR0   A0A0A9Z766   A0A2J7PV24   A0A2J7PV58   A0A3L8DXZ2   A0A069DY06   A0A1L8E575   A0A224X947   A0A023F0P7   A0A0Q9WZ85   B4KCK7   B4GLW3   A0A0Q9X7F0   A0A0Q9X128   A0A0Q9WZ57   A0A0Q9X5Z0   A0A0Q9XB81   A0A0Q9WZP4   A0A0Q9X9Z4   A0A0Q9XBK8   A0A0Q9WZ87   A0A0B4KGB9   B4JYZ5   B4LZ03   A0A0Q9WGJ9   A0A0Q9WHH3   A0A0Q9WGH2   A0A0Q9WRQ6   A0A0Q9WSC2   A0A0Q9WGP2   A0A0B4KHR4   A0A0Q9WNZ9   A0A1W4W9F8   A0A0Q9WQI2   A0A0Q9WSU5   A0A0Q9WH19   Q9VDW6-2   A0A0B4KGH0   A0A0R3NKF7   A0A0Q9WU35   A0A0Q9WU41   A0A0R3NR30   Q9VDW3   A0A0Q9WIB5   A0A0Q9WGQ7   A0A0R3NK00   A0A0M4EJD4   A0A0R3NKA5   A0A0Q9WSF8   A0A0R3NPN5   Q9VDW6   A0A1W4W848   Q293M7  

KEGG

101738393    no KO assigned | (RefSeq) dystrophin, isoform B-like

GO

GO:0016021   GO:0008270   GO:0046872   GO:0003779   GO:0005737   GO:0050699   GO:0046928   GO:0008586   GO:0005856   GO:0007274   GO:0016010   GO:0007474   GO:0030010   GO:0048172   GO:0045202   GO:0046716   GO:0005938   GO:0008307   GO:0005198   GO:0008092   GO:0042383   GO:0007517  

Subcellular location

Cell membrane  
Sarcolemma  
Cytoplasm  
Cytoskeleton  

Length:

234

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

8e-05

Exp number, first 60 AAs:

8e-05

Total prob of N-in:

0.01980

outside

1  -  234

 

 

Pi

206.433919

Theta

164.816211

Tajima's D

0.045668

CLR

0.511106

CSRT

0.379531023448828

Interpretation

Possibly Positive selection