Gene

KWMTBOMO04164

Pre Gene Modal

BGIBMGA008722

Annotation

adipokinetic_hormone_1_precursor_[Bombyx_mori]

Location

Bomo_Chr7(+):12698283-12699276      View in EpiBrowser

Full name

Adipokinetic prohormone       + More
Adipokinetic prohormone type 1      
Hypertrehalosaemic prohormone      
Adipokinetic prohormone type 2      

Location in the cell

Extracellular   Reliability : 2.547

CDS

ATGTACAAATTCACGATTCTATTCCTTGTTTTGGCTTGCTTCATAATGGCCGAAGCCCAACTCACTTTCACATCCAGCTGGGGTGGAAAGAGGGCTGCCATCGCCGGCACTGTGTCCTGCAGGAACGATGAATCCTTGGCGTCTATTTATAAACTTATTCAGAATGAAGCTGAAAAACTCCTGCTATGCCAGAAGCCTTAA

Protein

MYKFTILFLVLACFIMAEAQLTFTSSWGGKRAAIAGTVSCRNDESLASIYKLIQNEAEKLLLCQKP

Description

This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
Cadherins are calcium-dependent cell adhesion proteins.

Subunit

Adipokinetic hormone precursor-related peptide (APRP) can form three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta), and p3 (beta-beta).

Similarity

Belongs to the AKH/HRTH/RPCH family.

Keywords

Amidation   Cleavage on pair of basic residues   Direct protein sequencing   Flight   Hormone   Neuropeptide   Pyrrolidone carboxylic acid   Secreted   Signal   Disulfide bond  

Feature

chain  Adipokinetic prohormone
peptide  Adipokinetic hormone

Uniprot

A8WFD9   H9JGS5   A0A2H1WI17   A0A0S1U0L9   M4QEK5   P67788   + More
C0HL91   A0A194RCE2   A0A194PWF9   A0A194RD19   A0A212FKQ9   A0A385H8T9   A0A0C5BEX1   A0A0U4EI00   C0HL92   A0A0C5BC69   B0LUE7   Q17128   A0A385H8U0   B3IUD5   A0A2J7QLY6   A0A1S3DUP8   A0A140F9Y0   A0A067RJ06   A0A0S1U082   A0A140F9Y6   C0HKR1   A0A1L4FNN3   M4QFY1   H2EUU6   A0A0N9SC48   A0A2H1VT60   A0A0N9SER0   A0A140F9Y7   A3RE77   C8Z3D5   B0W1A8   A0A023EB74   A0A1Q3FTJ2   A0A140F9Z1   Q5EY02   A0A182PMF7   T1DQQ2   A0A158N7M0   F4MJ53   B8K1Y2   A0A182K374   A0A140F9Y5   A0A140F9Z0   A0A140F9Y3   A0A2M3Z923   A0A2M4ANG7   Q16NE8   T1H5C7   A0A1L8DQ52   A0A2M4C507   A0A182FZY6   E0VV43   A0A182VPI3   A0A182TPX4   A0A182LR92   A0A182XUQ9   Q27Q78   A0A182IIN3   A0A140F9Y1   B6DE17   A0A140F9Y4   A0A182R1D8   A0A182NZ26   A0A140F9Y2   A0A140F9Y9   A0A140F9Y8   P35807   A0A182S506   A0A084VYF4   A0A345BED0   U5EY62   A0A182WR25   A0A3Q0IIP7   A0A182J042   D2J4T9   T1H8R7   N6UHE4   A0A182MX76   A0A3L8DIN6   A0A026W6Z0   E2C2C1   A0A1B0DLM1  

Pubmed

19121390    28756777    2753887    4074373    29466015    26354079    + More
22118469    30171635    25640113    9220026    3778476    24845553    22357169    26432101    18362917    19820115    24945155    15647592    20920257    21439292    17510324    20566863    20966253    12364791    14747013    16731343    17210077    19178717    2294116    3947348    24438588    25545120    23537049    30249741    24508170    20798317   

EMBL

EU263341    AB298930    ABW97444.1    BAG50369.1    BABH01034378    ODYU01008799    + More
SOQ52709.1    KT005945    RSAL01000020    ALM30296.1    RVE52577.1    KC340912    KZ149929    AGH25544.1    PZC77450.1    J04972    KQ460367    KPJ15513.1    KQ459589    KPI97662.1    KPJ15512.1    AGBW02007996    OWR54335.1    MH028060    AXY04229.1    KJ783476    AJM76765.1    KP979739    ALX27200.1    KJ783477    AJM76766.1    BABH01034377    EU373445    ABY81279.1    U35277    MH028061    AXY04230.1    AB298931    BAG50370.1    NEVH01013241    PNF29558.1    MG550150    AWT50584.1    KT805304    AML80822.1    KT805316    KK852478    AML80834.1    KDR23008.1    KT005946    ALM30297.1    RVE52578.1    KT805310    AML80828.1    KX096711    APJ36628.1    KC340913    AGH25545.1    PZC77451.1    ABLF02029129    JQ086350    AEY77127.1    KT456557    ALH44120.1    ODYU01003991    SOQ43414.1    KT456556    ALH44119.1    KT805311    AML80829.1    DQ232685    EF222289    KQ971343    ABB58740.1    ABN79649.1    EFA04704.2    FN391985    CAY77163.1    DS231821    EDS44978.1    GAPW01006752    GAPW01006751    GEHC01000512    JAC06847.1    JAV47133.1    GFDL01004125    JAV30920.1    KT805315    AML80833.1    AY622321    AAV41425.1    GAMD01002329    JAA99261.1    GGFL01015832    MBW80010.1    FJ943774    ADB91364.1    DQ232684    KQ971307    ABB58739.1    EFA11613.2    KT805309    AML80827.1    KT805314    AML80832.1    KT805307    AML80825.1    GGFM01004251    MBW25002.1    GGFK01009009    MBW42330.1    FN391987    CH477825    CAY77165.1    EAT35885.1    CAQQ02186890    GFDF01005476    JAV08608.1    GGFJ01011276    MBW60417.1    DS235802    EEB17249.1    DQ388479    AAAB01008984    ABD43194.1    EDO63368.1    APCN01003350    KT805305    AML80823.1    EU934386    ACI30164.1    KT805308    AML80826.1    AXCN02000734    KT805306    AML80824.1    KT805313    AML80831.1    KT805312    AML80830.1    L08775    L08774    J05171    ATLV01018364    KE525231    KFB42998.1    MF765462    AXF48182.1    GANO01002179    JAB57692.1    GQ888667    ACZ52614.1    ACPB03020720    KM283242    AJA32746.1    APGK01020368    KB740193    KB631602    ENN81145.1    ERL84541.1    AXCM01000044    QOIP01000007    RLU20186.1    KK107390    EZA51391.1    GL452124    EFN77871.1    AJVK01025142    AJVK01036518   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000235965    + More
UP000079169    UP000027135    UP000007819    UP000007266    UP000002320    UP000075885    UP000075881    UP000008820    UP000015102    UP000069272    UP000009046    UP000075903    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000075886    UP000075884    UP000075900    UP000030765    UP000075920    UP000075880    UP000015103    UP000019118    UP000030742    UP000075883    UP000279307    UP000053097    UP000008237    UP000092462   

PRIDE

A8WFD9    H9JGS5    B0LUE7    B3IUD5   

Pfam

PF06377   Adipokin_hormo        + More
PF04410   Gar1
PF00028   Cadherin
PF01049   Cadherin_C
PF02210   Laminin_G_2

Interpro

IPR010475   AKH/RPCH_hormone        + More
IPR002047   Adipokinetic_hormone_CS       
IPR009000   Transl_B-barrel_sf       
IPR040309   Naf1       
IPR038664   Gar1/Naf1_Cbf5-bd_sf       
IPR007504   H/ACA_rnp_Gar1/Naf1       
IPR020894   Cadherin_CS       
IPR013320   ConA-like_dom_sf       
IPR015919   Cadherin-like_sf       
IPR000233   Cadherin_cytoplasmic-dom       
IPR001791   Laminin_G       
IPR002126   Cadherin-like_dom       
IPR013032   EGF-like_CS       
IPR027397   Catenin_binding_dom_sf       

SUPFAM

SSF50447   SSF50447        + More
SSF49313   SSF49313       
SSF49899   SSF49899       

Gene 3D

2.40.10.230     4.10.900.10    

ProteinModelPortal

A8WFD9   H9JGS5   A0A2H1WI17   A0A0S1U0L9   M4QEK5   P67788   + More
C0HL91   A0A194RCE2   A0A194PWF9   A0A194RD19   A0A212FKQ9   A0A385H8T9   A0A0C5BEX1   A0A0U4EI00   C0HL92   A0A0C5BC69   B0LUE7   Q17128   A0A385H8U0   B3IUD5   A0A2J7QLY6   A0A1S3DUP8   A0A140F9Y0   A0A067RJ06   A0A0S1U082   A0A140F9Y6   C0HKR1   A0A1L4FNN3   M4QFY1   H2EUU6   A0A0N9SC48   A0A2H1VT60   A0A0N9SER0   A0A140F9Y7   A3RE77   C8Z3D5   B0W1A8   A0A023EB74   A0A1Q3FTJ2   A0A140F9Z1   Q5EY02   A0A182PMF7   T1DQQ2   A0A158N7M0   F4MJ53   B8K1Y2   A0A182K374   A0A140F9Y5   A0A140F9Z0   A0A140F9Y3   A0A2M3Z923   A0A2M4ANG7   Q16NE8   T1H5C7   A0A1L8DQ52   A0A2M4C507   A0A182FZY6   E0VV43   A0A182VPI3   A0A182TPX4   A0A182LR92   A0A182XUQ9   Q27Q78   A0A182IIN3   A0A140F9Y1   B6DE17   A0A140F9Y4   A0A182R1D8   A0A182NZ26   A0A140F9Y2   A0A140F9Y9   A0A140F9Y8   P35807   A0A182S506   A0A084VYF4   A0A345BED0   U5EY62   A0A182WR25   A0A3Q0IIP7   A0A182J042   D2J4T9   T1H8R7   N6UHE4   A0A182MX76   A0A3L8DIN6   A0A026W6Z0   E2C2C1   A0A1B0DLM1  

KEGG

100127025    no KO assigned | (RefSeq) AKH1; adipokinetic hormone 1

GO

GO:0005179   GO:0005576   GO:0007629   GO:0007218   GO:0016021   GO:0005732   GO:0000493   GO:0003723   GO:0042254   GO:0001522   GO:0005509   GO:0007156   GO:0005886   GO:0005230   GO:0006810   GO:0042555   GO:0006260   GO:0004672   GO:0048384  

PANTHER

PTHR31633  

Subcellular location

Secreted  
Cell membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.999033

 

 

Length:

66

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.18392

Exp number, first 60 AAs:

19.18392

Total prob of N-in:

0.60667

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  66

 

 

Pi

181.001112

Theta

158.529232

Tajima's D

0.05714

CLR

1.471263

CSRT

0.386130693465327

Interpretation

Uncertain