Gene

KWMTBOMO04162

Pre Gene Modal

BGIBMGA008721

Annotation

glutamate_gated_chloride_channel_exon_3a_variant_[Bombyx_mori]

Location

Bomo_Chr7(+):12651233-12688459      View in EpiBrowser

Full name

Glutamate-gated chloride channel      

Location in the cell

PlasmaMembrane   Reliability : 3.891

CDS

ATGAATTCGGGCAAGATAAACTTCAGGGAGAAGGAGAAGCAGATCTTGGACCAGATCCTCGGGCCGGGGCGGTACGACGCCCGCATCAGACCGTCAGGCATCAACGGAACTGATGGGCCAGCGGTAGTCAGCGTCAATATATTTGTCAGGAGTATATCAAAGATCGATGACGTCACAATGGAATACTCTGTGCAACTCACGTTCAGAGAACAATGGCTGGACGAGAGACTGAAGTTTAACAATTTAGGAGGTCGTCTCAAATACTTGACCCTGACCGAGGCCAACAGGGTTTGGATGCCCGACCTGTTCTTCTCGAACGAGAAGGAAGGCCACTTTCACAACATCATCATGCCCAACGTGTACATCAGGATCTTTCCGAACGGGACCGTCCTGTACAGCATCCGTATCTCTCTCACTCTGTCGTGTCCCATGAACCTCAAGCTGTACCCGCTGGACAAGCAGACCTGCTCCTTGAGGATGGCCAGCTACGGCTGGACCACGGACGACCTCGTGTTCTTGTGGAAGGAAGGCGATCCTGTCCAGGTCGTGAAGAATCTCCATCTCCCAAGATTCACTCTGGAGAAGTTCCGCACCGATTATTGCAACAGCAAGACTAATACCGGCGAATACAGCTGCCTGAAGGTAGACCTGCTGTTCAAACGCGAGTTCAGCTACTACCTCATCCAGATCTACATCCCGTGCTGCATGCTCGTCATCGTCTCCTGGGTCTCCTTCTGGCTCGACCAGGGAGCAGTCCCGGCCCGAGTCTCTCTTGGCGTGACAACCCTGCTGACAATGGCCACTCAGTCATCAGGCATCAACGCCTCCCTACCGCCGGTATCGTATACAAAAGCCATCGACGTCTGGACGGGAGTCTGTCTGACCTTCGTCTTTGGAGCTCTACTGGAGTTCGCCCTCGTCAATTATGCGTCTCGCTCTGACATGCACAGAGAGAACATGAAAAAAACGAGACGGGAGATGGAGGCCGCCAGTATGGACGCTGCCTCGGATCTCTTGGACACGGATAGCAACGCCACCTTCGCTATGAAACCTCTGGTCCGCGGTGGCGTGGACACTAAGATGCGGCAGTGCGAGATCCACATCAGCCAGCCCAGGAAGAACTGCTGCCGGCTCTGGATGTCCAAGTTTCCCACGCGCTCCAAGAGGATCGACGTCATCTCCAGGATCACGTTTCCTCTTGTTTTCGCCATTTTCAATTTGGCTTACTGGTCAACATATTTGTTTCGCGACGAGGAGGAAGAGAAGTGA

Protein

MNSGKINFREKEKQILDQILGPGRYDARIRPSGINGTDGPAVVSVNIFVRSISKIDDVTMEYSVQLTFREQWLDERLKFNNLGGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGTVLYSIRISLTLSCPMNLKLYPLDKQTCSLRMASYGWTTDDLVFLWKEGDPVQVVKNLHLPRFTLEKFRTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQSSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSDMHRENMKKTRREMEAASMDAASDLLDTDSNATFAMKPLVRGGVDTKMRQCEIHISQPRKNCCRLWMSKFPTRSKRIDVISRITFPLVFAIFNLAYWSTYLFRDEEEEK

Description

Glutamate-gated chloride channel subunit. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration.

Subunit

Pentamer (By similarity). Homomultimer.

Miscellaneous

Channels desensitize rapidly in the continued presence of glutamate and are activated by the glutamate analog ibotenate. In Xenopus oocytes, avermectins and nodulisporic acid directly activate channel conductance.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.

Keywords

Alternative splicing   Cell junction   Cell membrane   Chloride   Chloride channel   Complete proteome   Disulfide bond   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Polymorphism   Postsynaptic cell membrane   Receptor   Reference proteome   RNA editing   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Glutamate-gated chloride channel
splice variant  In isoform C.

Uniprot

V9P9S1   V9P9T5   V9P9Q8   A0A2A4JRJ6   V9P9M0   X5IFF8   + More
A0A2A4JRY8   C6KI52   A0A3S2M6J8   A0A2A4JS55   V9P9T6   A0A194PY36   A0A194RDH4   I7B325   I7AHH8   A0A2A4JQG0   A0A3Q9DS29   A0A0L7LHS8   A0A3Q9DSY9   A0A1I8NSC5   A0A0Q9X376   A0A0Q9X8I2   I6PGU2   A0A0Q9X4M8   A0A0R3NKB4   A0A0P8XX27   A8DMU5   A0A0R3NKE2   A0A0P8XXA1   A0A1W4WFE2   A0A1I8NSC7   A0A1I8NSC1   F5HMR2   A0A0Q9XBI5   A0A1W4W899   A0A0Q9X6H4   A0A0R3NKI3   A0A0R1E0P8   A0A1I8NSB5   A0A0P8XX88   B4K4T2   A0A0B4LHB9   A0A1I8NSB2   A0A075EKP7   I5APY1   A0A0P8YK67   A0A075BUB3   A0A1I8NSB3   A8DMU4   A8DMU6   A0A1I8NSA4   A0A0Q9X1W2   A0A075BWQ5   A0A0Q9X1H1   A0A1W4WRN0   B4NEZ9   Q94900-5   Q94900-2   A0A3B0JNC0   A0A0R3NRA1   A0A0P8YCZ9   A0A336MUU0   A0A0B4LHB7   E1JIQ1   A0A0R1E0Q1   A0A1S4F3F3   A0A0R3NKF2   A0A0P9ANL8   A0A0Q9XC98   A0A1I8NSC8   A0A1W4W936   A0A0Q9X1C7   A0A075EIN4   A0A0R3NQP9   I5APY2   A0A0R1E5C5   A0A1Q2T825   A0A3B0KDB8   A0A0R1E4Z4   A0A0P8ZX56   A0A1I8NSC3   A0A1I8NSC4   A0A1B0FKY7   A0A1Y9H227   A0A1I8NSC2   F5HMR1   A0A0Q9W2C1   A0A0Q9XE11   A0A0B4LID6   A0A193BKY1   A0A0L0C937   A0A1W4W940   A0A3B0JNC2   A0A0R1E0P7   A0A336MVD8   A0A0Q9X220   A0A075BUZ5   A0A0A1XGD5   D5FTG8   A0A0A1WJG6  

Pubmed

26354079    30550974    26227816    17994087    15632085    17880682    + More
18362917    19820115    12364791    14747013    17210077    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    24929666    8702744    9886055    11095718    10966106    27302648    26108605    25830018   

EMBL

KC342244    AGW27405.1    KC342243    AGW27404.1    KC342245    AGW27406.1    + More
NWSH01000785    PCG74234.1    KC342247    AGW27408.2    AB857001    BAO58781.1    PCG74233.1    GQ221939    ACT09139.1    RSAL01000020    RVE52579.1    PCG74232.1    KC342248    AGW27409.1    KQ459589    KPI97664.1    KQ460367    KPJ15514.1    JX014231    AFO38419.1    JX014232    AFO38420.1    PCG74231.1    MH459002    AZQ00685.1    JTDY01001087    KOB74919.1    MH459003    AZQ00686.1    CH933806    KRG01913.1    KRG01914.1    JN966887    AFI80889.1    CH964251    KRF99782.1    CM000070    KRT01386.1    CH902617    KPU79319.1    EF545122    KQ971307    ABU63600.1    KYB29751.1    KRT01383.1    KPU79315.1    AAAB01008987    EGK97584.1    KRG01918.1    KRF99783.1    KRT01380.1    CM000160    KRK02876.1    KPU79318.1    EDW16085.2    AE014297    AHN57409.1    KJ725370    AIE48259.1    EIM53016.1    KPU79311.1    KC902521    AGS43092.1    EF545121    ABU63599.1    EFA11588.1    EF545123    ABU63601.1    KRG01917.1    KC902519    AGS43090.1    KRG01916.1    EDW83374.2    U58776    AJ002232    AF297500    AF297501    DQ665648    AAC47266.1    AAF55695.1    AAG40735.1    CAA05260.1    OUUW01000008    SPP83724.1    KRT01379.1    KPU79314.1    UFQT01002963    SSX34364.1    AHN57408.1    ACZ94952.2    KRK02877.1    KRT01378.1    KPU79317.1    KRG01911.1    KRG01910.1    KJ725371    AIE48260.1    KRT01381.1    EIM53017.2    KRK02882.1    LC171470    BAW87777.1    SPP83726.1    KRK02881.1    KPU79313.1    CCAG010001657    CCAG010001658    CCAG010001659    CCAG010001660    CCAG010001661    CCAG010001662    EGK97583.1    CH940652    KRF78966.1    KRG01907.1    AHN57407.1    KU589277    ANN12557.1    JRES01000752    KNC28765.1    SPP83727.1    KRK02875.1    SSX34362.1    KRG01909.1    KC902518    AGS43089.1    GBXI01004286    JAD10006.1    FJ851100    ACZ51432.1    GBXI01015295    JAC98996.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000053240    UP000037510    UP000095300    + More
UP000009192    UP000007798    UP000001819    UP000007801    UP000007266    UP000192223    UP000007062    UP000192221    UP000002282    UP000000803    UP000268350    UP000092444    UP000075884    UP000008792    UP000037069   

PRIDE

V9P9S1    V9P9T5    V9P9Q8    V9P9M0    X5IFF8    V9P9T6    + More
Q94900    E1JIQ1   

Pfam

PF02932   Neur_chan_memb        + More
PF02931   Neur_chan_LBD

Interpro

IPR006029   Neurotrans-gated_channel_TM        + More
IPR006028   GABAA/Glycine_rcpt       
IPR006202   Neur_chan_lig-bd       
IPR036734   Neur_chan_lig-bd_sf       
IPR036719   Neuro-gated_channel_TM_sf       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR015680   Glu_Cl_Channel       
IPR006201   Neur_channel       

SUPFAM

SSF90112   SSF90112        + More
SSF63712   SSF63712       

Gene 3D

2.70.170.10    

ProteinModelPortal

V9P9S1   V9P9T5   V9P9Q8   A0A2A4JRJ6   V9P9M0   X5IFF8   + More
A0A2A4JRY8   C6KI52   A0A3S2M6J8   A0A2A4JS55   V9P9T6   A0A194PY36   A0A194RDH4   I7B325   I7AHH8   A0A2A4JQG0   A0A3Q9DS29   A0A0L7LHS8   A0A3Q9DSY9   A0A1I8NSC5   A0A0Q9X376   A0A0Q9X8I2   I6PGU2   A0A0Q9X4M8   A0A0R3NKB4   A0A0P8XX27   A8DMU5   A0A0R3NKE2   A0A0P8XXA1   A0A1W4WFE2   A0A1I8NSC7   A0A1I8NSC1   F5HMR2   A0A0Q9XBI5   A0A1W4W899   A0A0Q9X6H4   A0A0R3NKI3   A0A0R1E0P8   A0A1I8NSB5   A0A0P8XX88   B4K4T2   A0A0B4LHB9   A0A1I8NSB2   A0A075EKP7   I5APY1   A0A0P8YK67   A0A075BUB3   A0A1I8NSB3   A8DMU4   A8DMU6   A0A1I8NSA4   A0A0Q9X1W2   A0A075BWQ5   A0A0Q9X1H1   A0A1W4WRN0   B4NEZ9   Q94900-5   Q94900-2   A0A3B0JNC0   A0A0R3NRA1   A0A0P8YCZ9   A0A336MUU0   A0A0B4LHB7   E1JIQ1   A0A0R1E0Q1   A0A1S4F3F3   A0A0R3NKF2   A0A0P9ANL8   A0A0Q9XC98   A0A1I8NSC8   A0A1W4W936   A0A0Q9X1C7   A0A075EIN4   A0A0R3NQP9   I5APY2   A0A0R1E5C5   A0A1Q2T825   A0A3B0KDB8   A0A0R1E4Z4   A0A0P8ZX56   A0A1I8NSC3   A0A1I8NSC4   A0A1B0FKY7   A0A1Y9H227   A0A1I8NSC2   F5HMR1   A0A0Q9W2C1   A0A0Q9XE11   A0A0B4LID6   A0A193BKY1   A0A0L0C937   A0A1W4W940   A0A3B0JNC2   A0A0R1E0P7   A0A336MVD8   A0A0Q9X220   A0A075BUZ5   A0A0A1XGD5   D5FTG8   A0A0A1WJG6  

PDB

4TNW     E-value=4.65744e-99,     Score=922

KEGG

101744220    K05273 glutamate receptor, anionic | (RefSeq) glutamate-gated chloride channel-like

GO

GO:0005886   GO:0005230   GO:0004888   GO:0016021   GO:0006811   GO:0008068   GO:0045211   GO:0034707   GO:0006821   GO:0030054   GO:0016020   GO:0006810   GO:0042555   GO:0006260   GO:0004672   GO:0048384   GO:0005216   GO:0034220  

PANTHER

PTHR18945   PTHR18945:SF754  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

422

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

82.1127

Exp number, first 60 AAs:

0.01156

Total prob of N-in:

0.37314

outside

1  -  224

TMhelix

225  -  247

inside

248  -  253

TMhelix

254  -  273

outside

274  -  287

TMhelix

288  -  310

inside

311  -  391

TMhelix

392  -  414

outside

415  -  422

 

 

Pi

202.110677

Theta

161.660463

Tajima's D

0.619739

CLR

12.146224

CSRT

0.552922353882306

Interpretation

Uncertain