Gene

KWMTBOMO04159

Pre Gene Modal

BGIBMGA008674

Annotation

unc-50-like_protein_[Bombyx_mori]

Location

Bomo_Chr7(-):12594860-12600642      View in EpiBrowser

Full name

Protein unc-50 homolog       + More
Mothers against decapentaplegic homolog      

Alternative Name

Uncoordinated-like protein
SMAD family member

Location in the cell

PlasmaMembrane   Reliability : 4.893

CDS

ATGAAGTATTCGACGTCGCCTACTCCAAATCTTCATAACTATCCTAGGAGCACTTCACCCCTGCCAGCCCCGGCTAATTATCAGCCAACAACAGCTAGCGCTTCAGTAAAACGCTACAAATACCTCAAGAGACTGTTCAAATTTAATCAAATGGACTTCGAATTCGCCGCTTGGCAAATGGTTTACTTGTTCATTGCCCCTCAGAAAGTATTCCGAAACTTTAACTATAGGAAGCATACAAAATCACAGTTTGCGAGAGACGACCCTGCATTCTTAGTGTTGCTCAGCATCTGGTTATTTTTGTCGTCAATATGTTTCGGATTGGCACTAGACCTGACTGTGGGCAAAGTTGCATTATTCATGCTGTTTGTGGTGTTCGTTGATTTCATCGGAGCAGGAATACTGGTCTCCACATTATTTTGGTACCTGAGCAACAAGCACCTGCGCCGCGACCCCGAGGGTCCGGACGTGGAGTGGGGCTACGCCTTCGACGTGCACATCAACGCGTTTTTCCCGCCGCTCTCGCTGCTGCACTGCTTCCAAATCGTACTATTCAACAGTATATTGTCTCAAGCGGGCTTCGTCTCGTGTCTGGTCTCAAACACCTTCTGGCTCGCCTCGATCATATACTACATGTACATTTCCTTCCTGGGATACAGCAACCTGCCGTTCCTGCAAAACACGAGGGTGTTCCTGCTGCCGCTGCCCGTGCTATTCGTGGTCTACCTGGCCACCCTGCTGGCCGGCTGGAACCTCAGCGAGCTGCTCATGTACTTCTATAGGTACAGGGTGTTGTAG

Protein

MKYSTSPTPNLHNYPRSTSPLPAPANYQPTTASASVKRYKYLKRLFKFNQMDFEFAAWQMVYLFIAPQKVFRNFNYRKHTKSQFARDDPAFLVLLSIWLFLSSICFGLALDLTVGKVALFMLFVVFVDFIGAGILVSTLFWYLSNKHLRRDPEGPDVEWGYAFDVHINAFFPPLSLLHCFQIVLFNSILSQAGFVSCLVSNTFWLASIIYYMYISFLGYSNLPFLQNTRVFLLPLPVLFVVYLATLLAGWNLSELLMYFYRYRVL

Description

May be required for cell surface expression of acetylcholine receptors.
May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).

Similarity

Belongs to the unc-50 family.
Belongs to the dwarfin/SMAD family.

Keywords

Complete proteome   Golgi apparatus   Membrane   Protein transport   Reference proteome   Transmembrane   Transmembrane helix   Transport   Acetylation   Alternative splicing   Nucleus   Phosphoprotein   RNA-binding  

Feature

chain  Protein unc-50 homolog
splice variant  In isoform 2.

Uniprot

Q2F641   A0A2H1W6L8   A0A2A4JQD8   A0A2W1BXP4   A0A194PWB2   I4DL67   + More
S4PME3   A0A023EM42   Q16HU6   B0W696   A0A1Q3FAF7   A0A182WMW6   A0A182LTQ7   A0A1I8NZS7   A0A1I8MHI8   A0A182QRM1   A0A0K8VNC1   A0A182TH78   A0A182JHJ6   A0A182VMP3   A0A182LG82   Q7PR08   W5JD79   B4LZN6   A0A2M4AK20   A0A2M3ZKY0   A0A0M4EST5   A0A182N549   D6W8C1   A0A0K8TMX9   Q294K8   B4GMY8   A0A2M4BWL6   B3LXG3   B4K7J3   A0A067R501   D0QWL5   A0A0L0CKJ0   A0A2M4BWT7   A0A0T6AWA0   A0A1W4XFD0   E0VHN0   A0A3B0JUI0   T1E8A1   A0A1B6DIF3   A0A210Q5J0   A0A1B6IS62   U5EV70   A0A1B6ERW1   A0A1W4W446   A0A1B0AA20   D3TNE3   B4NB00   Q9VHN5   A0A1A9YEQ4   E1ZYA3   B4QXZ7   B4PT86   B4HL34   B3P4U8   E9J004   A0A1A9VDZ5   A0A1B0BEV1   A0A1B6KPT4   A0A026W215   A0A0L8H648   A0A0V0G6V6   A0A182HTV9   B4JI03   A0A182JNI3   A0A088A0U2   A0A0M8ZXW0   A0A2R7WSH3   G1P116   A0A0L7QQB8   A0A2A3EMM7   A0A182XHI7   A0A182H6G8   A0A154PBX5   A0A151J4C6   B5DEV8   A0A0P6JC01   A0A195BTB8   A0A158NB45   R7UNM3   A0A195EW25   G5BMT5   A0A091KPV7   L8HP02   Q3ZBG6   W5KZ39   A0A2P2I278   F4WHB2   I3LLY5   A0A3L7INC0   A0A1U7QBG0   W5PVK2   A0A0A9YVQ2   A0A337SQ93  

Pubmed

19121390    28756777    26354079    22651552    23622113    24945155    + More
26483478    17510324    25315136    20966253    12364791    14747013    17210077    20920257    23761445    17994087    18362917    19820115    26369729    15632085    24845553    19859648    26108605    20566863    28812685    20353571    10731132    12537572    12537569    10980252    20798317    17550304    21282665    24508170    30249741    21993624    20431018    21347285    23254933    21993625    22751099    16305752    25329095    21719571    29704459    20809919    25401762    17975172   

EMBL

BABH01034372    DQ311231    ABD36176.1    ODYU01006674    SOQ48730.1    NWSH01000785    + More
PCG74211.1    KZ149929    PZC77456.1    KQ459589    KPI97666.1    AK402035    BAM18657.1    GAIX01003600    JAA88960.1    JXUM01090470    GAPW01003241    KQ563841    JAC10357.1    KXJ73185.1    CH478140    EAT33828.1    DS231847    EDS36443.1    GFDL01010494    JAV24551.1    AXCM01004558    AXCN02000174    GDHF01011935    JAI40379.1    AAAB01008859    EAA08030.4    ADMH02001856    ETN60850.1    CH940650    EDW68205.1    GGFK01007814    MBW41135.1    GGFM01008438    MBW29189.1    CP012526    ALC47860.1    KQ971307    EFA10930.1    GDAI01001899    JAI15704.1    CM000070    EAL28959.1    CH479185    EDW38212.1    GGFJ01008334    MBW57475.1    CH902617    EDV42807.1    CH933806    EDW15337.1    KK852747    KDR17270.1    FJ821033    ACN94714.1    JRES01000266    KNC32786.1    GGFJ01008333    MBW57474.1    LJIG01022715    KRT79086.1    DS235171    EEB12916.1    OUUW01000008    SPP84052.1    GAMD01002357    JAA99233.1    GEDC01030973    GEDC01011866    JAS06325.1    JAS25432.1    NEDP02004947    OWF43985.1    GECU01017983    JAS89723.1    GANO01002012    JAB57859.1    GECZ01029058    JAS40711.1    EZ422945    ADD19221.1    CH964232    EDW80964.1    AE014297    AY113422    GL435204    EFN73802.1    CM000364    EDX13734.1    CM000160    EDW96547.1    CH480815    EDW42998.1    CH954181    EDV49892.1    GL767291    EFZ13812.1    JXJN01013026    GEBQ01026525    JAT13452.1    KK107485    QOIP01000006    EZA50083.1    RLU21932.1    KQ419106    KOF84574.1    GECL01002382    JAP03742.1    APCN01000586    CH916369    EDV92911.1    KJ939605    AJE70276.1    KQ435830    KOX71799.1    KK855421    PTY22503.1    AAPE02034870    KQ414797    KOC60691.1    KZ288208    PBC33015.1    JXUM01027095    JXUM01027096    JXUM01027097    KQ560779    KXJ80923.1    KQ434869    KZC09419.1    KQ980151    KYN17491.1    AAMC01074123    AAMC01074124    BC168819    BC169164    AAI68819.1    GEBF01005543    JAN98089.1    KQ976417    KYM89681.1    ADTU01010875    AMQN01006852    AMQN01006853    KB299334    ELU08114.1    KQ981953    KYN32351.1    JH171109    EHB10596.1    KK751870    KFP42052.1    JH883698    ELR46035.1    BT021031    BC103305    IACF01002437    LAB68091.1    GL888158    EGI66389.1    AEMK02000020    RAZU01000007    RLQ79617.1    AMGL01078775    GBHO01007305    JAG36299.1    AANG04002548   

Proteomes

UP000005204    UP000218220    UP000053268    UP000069940    UP000249989    UP000008820    + More
UP000002320    UP000075920    UP000075883    UP000095300    UP000095301    UP000075886    UP000075902    UP000075880    UP000075903    UP000075882    UP000007062    UP000000673    UP000008792    UP000092553    UP000075884    UP000007266    UP000001819    UP000008744    UP000007801    UP000009192    UP000027135    UP000037069    UP000192223    UP000009046    UP000268350    UP000242188    UP000192221    UP000092445    UP000007798    UP000000803    UP000092443    UP000000311    UP000000304    UP000002282    UP000001292    UP000008711    UP000078200    UP000092460    UP000053097    UP000279307    UP000053454    UP000075840    UP000001070    UP000075881    UP000005203    UP000053105    UP000001074    UP000053825    UP000242457    UP000076407    UP000076502    UP000078492    UP000008143    UP000078540    UP000005205    UP000014760    UP000078541    UP000006813    UP000009136    UP000018467    UP000007755    UP000008227    UP000273346    UP000189706    UP000002356    UP000011712   

PRIDE

Q2F641    Q9VHN5    Q3ZBG6    I3LLY5   

Pfam

PF05216   UNC-50        + More
PF03166   MH2
PF03165   MH1

Interpro

IPR007881   UNC-50        + More
IPR003619   MAD_homology1_Dwarfin-type       
IPR013790   Dwarfin       
IPR008984   SMAD_FHA_dom_sf       
IPR036578   SMAD_MH1_sf       
IPR013019   MAD_homology_MH1       
IPR001132   SMAD_dom_Dwarfin-type       
IPR017855   SMAD-like_dom_sf       

SUPFAM

SSF56366   SSF56366        + More
SSF49879   SSF49879       

Gene 3D

2.60.200.10     3.90.520.10    

ProteinModelPortal

Q2F641   A0A2H1W6L8   A0A2A4JQD8   A0A2W1BXP4   A0A194PWB2   I4DL67   + More
S4PME3   A0A023EM42   Q16HU6   B0W696   A0A1Q3FAF7   A0A182WMW6   A0A182LTQ7   A0A1I8NZS7   A0A1I8MHI8   A0A182QRM1   A0A0K8VNC1   A0A182TH78   A0A182JHJ6   A0A182VMP3   A0A182LG82   Q7PR08   W5JD79   B4LZN6   A0A2M4AK20   A0A2M3ZKY0   A0A0M4EST5   A0A182N549   D6W8C1   A0A0K8TMX9   Q294K8   B4GMY8   A0A2M4BWL6   B3LXG3   B4K7J3   A0A067R501   D0QWL5   A0A0L0CKJ0   A0A2M4BWT7   A0A0T6AWA0   A0A1W4XFD0   E0VHN0   A0A3B0JUI0   T1E8A1   A0A1B6DIF3   A0A210Q5J0   A0A1B6IS62   U5EV70   A0A1B6ERW1   A0A1W4W446   A0A1B0AA20   D3TNE3   B4NB00   Q9VHN5   A0A1A9YEQ4   E1ZYA3   B4QXZ7   B4PT86   B4HL34   B3P4U8   E9J004   A0A1A9VDZ5   A0A1B0BEV1   A0A1B6KPT4   A0A026W215   A0A0L8H648   A0A0V0G6V6   A0A182HTV9   B4JI03   A0A182JNI3   A0A088A0U2   A0A0M8ZXW0   A0A2R7WSH3   G1P116   A0A0L7QQB8   A0A2A3EMM7   A0A182XHI7   A0A182H6G8   A0A154PBX5   A0A151J4C6   B5DEV8   A0A0P6JC01   A0A195BTB8   A0A158NB45   R7UNM3   A0A195EW25   G5BMT5   A0A091KPV7   L8HP02   Q3ZBG6   W5KZ39   A0A2P2I278   F4WHB2   I3LLY5   A0A3L7INC0   A0A1U7QBG0   W5PVK2   A0A0A9YVQ2   A0A337SQ93  

KEGG

692851    no KO assigned | (RefSeq) unc-50-like protein

GO

GO:0016021   GO:0030173   GO:0005840   GO:0000139   GO:0015031   GO:0005667   GO:0003700   GO:0005634   GO:0007179   GO:0005737   GO:0003677   GO:0005794   GO:0003723   GO:0005637  

PANTHER

PTHR12841   PTHR13703  

Subcellular location

Golgi apparatus membrane  
Cytoplasm  
Nucleus  
Nucleus inner membrane  

Length:

265

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

118.66136

Exp number, first 60 AAs:

5.79137

Total prob of N-in:

0.30262

outside

1  -  89

TMhelix

90  -  112

inside

113  -  118

TMhelix

119  -  141

outside

142  -  166

TMhelix

167  -  189

inside

190  -  193

TMhelix

194  -  216

outside

217  -  230

TMhelix

231  -  253

inside

254  -  265

 

 

Pi

54.291412

Theta

152.149784

Tajima's D

-1.587846

CLR

1282.739486

CSRT

0.0508474576271186

Interpretation

Uncertain