Gene

KWMTBOMO04156  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008718

Annotation

hypothetical_protein_KGM_20880_[Danaus_plexippus]

Location

Bomo_Chr7(+):12569723-12577544      View in EpiBrowser

Full name

DNA-directed RNA polymerase III subunit RPC4      

Alternative Name

DNA-directed RNA polymerase III subunit D

Location in the cell

Nuclear   Reliability : 3.066

CDS

ATGTCCGGTGATAAATCATCTAAACCGAATGGACTGGGTACAGATCCCATGCAGAGGCTCGCTTCATTAAAAGCACCCAGAGATCTTATGCTTGGAGGAGTCAAACCAAACAAAAAAGTCTTCACACCTAACTTGAACGTAGCTCGGAGTAAAAATAAAGGACAAGCAACAACAAGTGCCAAAGAAACAAGGAATGAAGAGAAGAACAGCAGGGATTCAAACAGGAACCGGAATTTTAACAGGAATCAGAGAAATGGGCCAACACTAATAAAATCTGCTGGTGTCTTCTCTGAAGGCATCGGTTCATCAGAGAGGCATTCTTCAAGTCGCTCGTACTACGGGCGGGACACAGAAAAAACTACAAACATTATGAAGAAGCCAGCTATCAGAGTAAAGGATTTCGTGAAGATCGACAAAGAACTGGAGGAGAAGAAGATAAATATGATTTTAAGAGGAGGCGATACTGACGAGCTGGAGTCCATCGACTTTAAGGACATCCTCGACAGGGACGCACCCATCAAACTACCCATGGATGATGGGAACTGGGCCAAGACTCATGCGAAACCGAAAGTCAAGGTTAAAGAAGAGATTGTTGTCAAGACAGAACCCCGGGAAGATGGCGACTGTGTTATAAGCACACCAGAACGAAAGCCAGACGTGAAGGAAGCGTTTGAAGATACCGACTTAGTGAACTTACTTAATAACGACAAATCAACATTAATTATGTTGCAGCTTCCCTCGAGTCTCCCGGGCAGAGGCGGCCGCGTCGAGGACGACGTTCCCCGGAGGAGGACCAAGAACGAGCCCGGCCCGTCCGCCGGGGGGGGCGCGGACCCCGGCGCGGCGGACGAGCAGGAGGAGGACAACAAGTGTCGCCTGACGGACCTCGAGGAGGGTAGGATCGGCAAGCTGCAGCTCCACAGGTCGGGGAGGGTCACCCTGGCTTTAGGAGAAACTGTATTTGAGGTATCGATGGGCACAAAAGCTGCGTTCCACCAAGAACTGGTTTCTGTAAGTACTGATGACGCGTCACGCTCAGCCAAGGTGACCTCCTTAGGCGCTCTCCGACATAAACTAAACGTGATCCCGGATTGGGAAACAATGTTTCGGGATATTCCTCTATAG

Protein

MSGDKSSKPNGLGTDPMQRLASLKAPRDLMLGGVKPNKKVFTPNLNVARSKNKGQATTSAKETRNEEKNSRDSNRNRNFNRNQRNGPTLIKSAGVFSEGIGSSERHSSSRSYYGRDTEKTTNIMKKPAIRVKDFVKIDKELEEKKINMILRGGDTDELESIDFKDILDRDAPIKLPMDDGNWAKTHAKPKVKVKEEIVVKTEPREDGDCVISTPERKPDVKEAFEDTDLVNLLNNDKSTLIMLQLPSSLPGRGGRVEDDVPRRRTKNEPGPSAGGGADPGAADEQEEDNKCRLTDLEEGRIGKLQLHRSGRVTLALGETVFEVSMGTKAAFHQELVSVSTDDASRSAKVTSLGALRHKLNVIPDWETMFRDIPL

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Subunit

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. Interacts with RPC5 (By similarity).

Similarity

Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.

Keywords

Acetylation   Antiviral defense   Complete proteome   DNA-directed RNA polymerase   Immunity   Innate immunity   Isopeptide bond   Methylation   Nucleus   Phosphoprotein   Reference proteome   Transcription   Ubl conjugation  

Feature

chain  DNA-directed RNA polymerase III subunit RPC4

Uniprot

H9JGS1   A0A2A4JQ70   A0A2H1W6S1   A0A2A4JRI3   A0A194PY41   A0A212FPJ4   + More
A0A1E1W2A5   A0A1E1WPD6   A0A1E1WQH3   A0A2W1BQT0   Q16XP6   A0A1Q3F2I1   B0WKN9   A0A084VRH5   A0A067QV31   A0A182JWD6   A0A182V4W7   A0A182NSF5   Q5TSX9   A0A182PP91   A0A2M3ZBA8   A0A182KZL2   A0A182XFD4   A0A182RZL3   A0A182W3E6   A0A182HYM7   A0A182Y8T8   A0A182JDW8   A0A2M4ATE8   A0A2M4AUN6   A0A182SJA4   W5JDB9   A0A2M4BS17   A0A182FQV6   A0A088AHL1   A0A2A3EBK7   A0A1A9X101   A0A151XCG1   A0A182Q487   A0A1B6KUG5   A0A0V0G870   A0A1B6CWU7   A0A0K8V9D8   A0A0K8UI44   A0A151NBL1   A0A1A9YCK7   A0A1B0AQM1   A0A1U7RTF6   A0A2K6LHE7   A0A2K6QE16   A0A1U7SE94   A0A2K5KFE9   A0A1U7S492   A0A2K5YG24   A0A096NU72   A0A2K5L6N0   G7PCV0   A0A2K6D862   G7N0N3   F7E6W4   K7FF32   L5L739   Q5E9Z7   K7FF40   A0A2U3W2Q6   A0A0D9RVE8   F1MTH4   A0A0L0C8C4   A0A1S3A4C7   A0A3B4X8E0   A0A034VCN0   A0A3Q1JRD4   A0A2K6TA70   A0A034VDA6   A0A2K5PLN3   A0A3Q7P6Y6   W5PKZ9   A0A2D0QX22   A0A1V4KHM4   A0A1A8Q6T2   A0A1A8LBM2   A0A1A8FZZ0   A0A2D0QX25   A0A1V4KHP6   A0A1A8RXU9   Q58D98  

Pubmed

19121390    26354079    22118469    28756777    17510324    24438588    + More
24845553    12364791    14747013    17210077    20966253    25244985    20920257    23761445    22293439    25362486    22002653    25319552    17431167    17381049    23258410    16305752    19393038    26108605    25348373    20809919    11282978   

EMBL

BABH01034370    NWSH01000785    PCG74215.1    ODYU01006674    SOQ48733.1    PCG74214.1    + More
KQ459589    KPI97669.1    AGBW02002137    OWR55664.1    GDQN01009934    JAT81120.1    GDQN01002202    JAT88852.1    GDQN01001983    JAT89071.1    KZ149929    PZC77459.1    CH477534    EAT39396.1    GFDL01013308    JAV21737.1    DS231974    EDS29970.1    ATLV01015669    KE525026    KFB40569.1    KK852982    KDR12904.1    AAAB01008898    EAL40548.4    GGFM01005041    MBW25792.1    APCN01005389    GGFK01010729    MBW44050.1    GGFK01010987    MBW44308.1    ADMH02001863    ETN60809.1    GGFJ01006708    MBW55849.1    KZ288310    PBC28566.1    KQ982314    KYQ58045.1    AXCN02000237    GEBQ01024892    JAT15085.1    GECL01002019    JAP04105.1    GEDC01019326    GEDC01004884    JAS17972.1    JAS32414.1    GDHF01017134    JAI35180.1    GDHF01025965    JAI26349.1    AKHW03003565    KYO34214.1    JXJN01001971    AHZZ02033108    AQIA01066973    CM001283    EHH64036.1    JU336032    JU476897    JV048007    CM001260    AFE79785.1    AFH33701.1    AFI38078.1    EHH28335.1    JSUE03040998    AGCU01168936    AGCU01168937    KB030270    ELK19250.1    BT020772    BC118212    AQIB01116627    JRES01000760    KNC28521.1    GAKP01019407    JAC39545.1    GAKP01019409    JAC39543.1    AMGL01048564    LSYS01003090    OPJ83949.1    HAEI01004473    SBR88957.1    HAEF01004630    HAEG01013787    SBR42012.1    HAEB01017814    HAEC01008101    SBQ64341.1    OPJ83948.1    HAEH01020275    SBS10537.1    BT021699    AAX46546.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000008820    UP000002320    + More
UP000030765    UP000027135    UP000075881    UP000075903    UP000075884    UP000007062    UP000075885    UP000075882    UP000076407    UP000075900    UP000075920    UP000075840    UP000076408    UP000075880    UP000075901    UP000000673    UP000069272    UP000005203    UP000242457    UP000091820    UP000075809    UP000075886    UP000050525    UP000092443    UP000092460    UP000189705    UP000233180    UP000233200    UP000233080    UP000233140    UP000028761    UP000233060    UP000009130    UP000233100    UP000233120    UP000006718    UP000007267    UP000010552    UP000009136    UP000245340    UP000029965    UP000037069    UP000079721    UP000261360    UP000265040    UP000233220    UP000233040    UP000286641    UP000002356    UP000221080    UP000190648   

PRIDE

H9JGS1    Q5E9Z7   

Pfam

PF05132   RNA_pol_Rpc4

Interpro

IPR007811   RPC4       

ProteinModelPortal

H9JGS1   A0A2A4JQ70   A0A2H1W6S1   A0A2A4JRI3   A0A194PY41   A0A212FPJ4   + More
A0A1E1W2A5   A0A1E1WPD6   A0A1E1WQH3   A0A2W1BQT0   Q16XP6   A0A1Q3F2I1   B0WKN9   A0A084VRH5   A0A067QV31   A0A182JWD6   A0A182V4W7   A0A182NSF5   Q5TSX9   A0A182PP91   A0A2M3ZBA8   A0A182KZL2   A0A182XFD4   A0A182RZL3   A0A182W3E6   A0A182HYM7   A0A182Y8T8   A0A182JDW8   A0A2M4ATE8   A0A2M4AUN6   A0A182SJA4   W5JDB9   A0A2M4BS17   A0A182FQV6   A0A088AHL1   A0A2A3EBK7   A0A1A9X101   A0A151XCG1   A0A182Q487   A0A1B6KUG5   A0A0V0G870   A0A1B6CWU7   A0A0K8V9D8   A0A0K8UI44   A0A151NBL1   A0A1A9YCK7   A0A1B0AQM1   A0A1U7RTF6   A0A2K6LHE7   A0A2K6QE16   A0A1U7SE94   A0A2K5KFE9   A0A1U7S492   A0A2K5YG24   A0A096NU72   A0A2K5L6N0   G7PCV0   A0A2K6D862   G7N0N3   F7E6W4   K7FF32   L5L739   Q5E9Z7   K7FF40   A0A2U3W2Q6   A0A0D9RVE8   F1MTH4   A0A0L0C8C4   A0A1S3A4C7   A0A3B4X8E0   A0A034VCN0   A0A3Q1JRD4   A0A2K6TA70   A0A034VDA6   A0A2K5PLN3   A0A3Q7P6Y6   W5PKZ9   A0A2D0QX22   A0A1V4KHM4   A0A1A8Q6T2   A0A1A8LBM2   A0A1A8FZZ0   A0A2D0QX25   A0A1V4KHP6   A0A1A8RXU9   Q58D98  

PDB

6F44     E-value=0.0092743,     Score=91

KEGG

101743929    K03026 DNA-directed RNA polymerase III subunit RPC4 | (RefSeq) DNA-directed RNA polymerase III subun

PATHWAY

03020    RNA polymerase - Bombyx mori (domestic silkworm)

GO

GO:0006383   GO:0005666   GO:0003899   GO:0003677   GO:0000790   GO:0045089   GO:0005829   GO:0003682   GO:0032728   GO:0016607   GO:0045087   GO:0051607   GO:0006508   GO:0042555   GO:0006260   GO:0016021   GO:0004672   GO:0048384  

PANTHER

PTHR13408  

Subcellular location

Nucleus  

Length:

374

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00058

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01483

outside

1  -  374

 

 

Pi

274.65568

Theta

195.363185

Tajima's D

0.497639

CLR

253.318595

CSRT

0.513924303784811

Interpretation

Uncertain