Gene

KWMTBOMO04154

Pre Gene Modal

BGIBMGA008717

Annotation

PREDICTED:_trafficking_protein_particle_complex_subunit_2_[Papilio_machaon]

Location

Bomo_Chr7(+):12560213-12561930      View in EpiBrowser

Full name

Trafficking protein particle complex subunit 2       + More
Trafficking protein particle complex subunit 2B      

Alternative Name

MBP-1-interacting protein 2A
Sedlin

Location in the cell

Cytoplasmic   Reliability : 1.847 Extracellular   Reliability : 1.406

CDS

ATGGCCGGCACATATTATTTTGTTATAGTCGGACATTCTGACAATCCTATCTTTGAAATGGATTTCATTCCTGTTACTAAAGAAACAAAGAAGGAAGATAACAGACATTTGAACCAGTTCATAGCCCATGCTGCCCTAGATCTAGTGGATGAACACATGTGGAAAGTACCAAATTGTTATTTAAAATCTGTTGACAAATTCAACCAGTGGTTCGTGTCTGCTTTTGTTACAGCAAGCCAGATGAGGTTCATAATAGTTCATGATACAAGAAATGAAGACAGTATAAAAAATTTCTTCACAGATGTCTATGAGTGTTACATTAAATTGATGCTGAATCCATTTTACAAAGAGGATACGCCAATCACAATGCCTGCTTTTGAAAAGAAAGTTCAATTTTTAGGAAAGAAATATTTAACTTAA

Protein

MAGTYYFVIVGHSDNPIFEMDFIPVTKETKKEDNRHLNQFIAHAALDLVDEHMWKVPNCYLKSVDKFNQWFVSAFVTASQMRFIIVHDTRNEDSIKNFFTDVYECYIKLMLNPFYKEDTPITMPAFEKKVQFLGKKYLT

Description

Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Subunit

Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1, PITX1, SF1, TRAPPC2L and TRAPPC3.
Interacts with PITX1, SF1, and TRAPPC3 (By similarity). Can homodimerize (By similarity). Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with ENO1 and TRAPPC2L.
Can homodimerize. Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with ENO1, PITX1 and SF1.

Miscellaneous

The gene encoding this protein appears to have arisen by retrotransposition of a cDNA from the X-linked locus TRAPPC2. The site of integration of this retrotransposed cDNA appears to lie within an intron of the ZNF547 gene, which provides a promoter and non-coding 5' exon. TRAPPC2 and this protein are indistinguishable at protein level, and both proteins have been identified and functionally characterized.
A paralogous gene encoding an identical protein appears to have arisen by retrotransposition of a cDNA from this locus and to have acquired a promoter and non-coding 5' UTR from the ZNF547 gene.

Similarity

Belongs to the TRAPP small subunits family. Sedlin subfamily.

Keywords

Complete proteome   Cytoplasm   ER-Golgi transport   Nucleus   Reference proteome   Transcription   Transport   Phosphoprotein   Alternative splicing   Disease mutation  

Feature

chain  Trafficking protein particle complex subunit 2
splice variant  In isoform 2 and isoform 3.
sequence variant  In SEDT; loss-of-function mutation.

Uniprot

H9JGS0   A0A2H1WFV7   I4DKA6   A0A2W1BSZ3   A0A2A4JQA3   A0A212EWR4   + More
A0A3S2P527   S4P863   A0A0L7L747   A0A067R175   A0A194RD30   A0A0N1PGY9   A0A1B6JBQ9   A0A1B6FDF6   A0A1B6KTV3   A0A146L8N3   A0A069DNT1   E0VPD4   A0A0P4VK01   T1IA30   A0A224Y0F7   A0A0V0G839   A0A1B6DDQ5   A0A1A9ZKG6   A0A1A9UG22   A0A1B0FBU5   H0ZD04   A0A1S2ZD41   U3JPD8   B5KFM3   A0A182LZE4   A0A2R7VRE0   A0A1Y1LQ39   A0A1U7TAR0   A0A1A9WTA7   Q16ZB8   A0A182YHN9   A0A1A9Y051   A0A1B0BC50   A0A0B8RTA1   A0A182RS40   A0A182VWT9   A0A1S3GFZ9   W5PP20   F1SRI0   Q3T0F2   A0A0F7Z927   E3TGK2   A0A1I8PE10   A0A0A0MXP8   A0A2J8RQ25   Q5RES6   A0A287D123   A0A250YA22   A0A286XNW4   A0A384CIG7   A0A341CAP8   A0A2U4AJI9   A0A3Q7N0V3   A0A340XDH8   A0A2Y9FK43   A0A3Q7RAH6   A0A2Y9MWZ2   A0A2U3WN45   A0A3Q7V7T6   A0A2Y9KKL1   E2QV03   G1PL13   A0A0A9Y587   A0A336LU60   A0A084VXW9   A0A2K6CSS0   G3QMD4   A0A2K5XM70   A0A0D9RRH6   A0A2R9BQ93   A0A2K5IBB9   A0A2R8MMX9   A0A2K6UCF0   A0A2J8W4J3   I7G790   F6Z6G0   A0A2J8JLP4   A0A1Y9H2V8   A0A182Q3N6   Q6IBE5   P0DI82   P0DI81   G9KUY4   A0A1I8M8H4   G1RD70   W5MV58   A0A2Y9MRP4   K9IQM0   A0A2Y9ML03   A0A2U3YVX9   U5EL85   A0A1A6HY81   A0A2K6P2H2   A0A240PLN3  

Pubmed

19121390    22651552    28756777    22118469    23622113    26227816    + More
24845553    26354079    26823975    26334808    20566863    27129103    20360741    17018643    28004739    17510324    25244985    25476704    20809919    15679890    14681463    20634964    28087693    21993624    24813606    16341006    25401762    24438588    22398555    22722832    17194215    17431167    22002653    25319552    16136131    11181995    11134351    15057824    15489334    10431248    11031107    11805826    19416478    21269460    23186163    14702039    15772651    21525244    25918224    14597397    20498720    11349230    11424925    23236062    25315136    25362486   

EMBL

BABH01034369    ODYU01008387    SOQ51941.1    AK401724    BAM18346.1    KZ149929    + More
PZC77461.1    NWSH01000785    PCG74217.1    AGBW02011906    OWR45942.1    RSAL01000020    RVE52585.1    GAIX01006081    JAA86479.1    JTDY01002598    KOB71131.1    KK852818    KDR15689.1    KQ460367    KPJ15522.1    KQ459356    KPJ01266.1    GECU01011121    JAS96585.1    GECZ01032389    GECZ01031363    GECZ01027973    GECZ01025365    GECZ01023297    GECZ01021766    GECZ01013910    GECZ01010307    GECZ01003124    GECZ01002527    GECZ01000935    JAS37380.1    JAS38406.1    JAS41796.1    JAS44404.1    JAS46472.1    JAS48003.1    JAS55859.1    JAS59462.1    JAS66645.1    JAS67242.1    JAS68834.1    GEBQ01025107    JAT14870.1    GDHC01015609    JAQ03020.1    GBGD01003409    JAC85480.1    DS235363    EEB15240.1    GDKW01001242    JAI55353.1    ACPB03012046    GFTR01002343    JAW14083.1    GECL01001849    JAP04275.1    GEDC01013526    JAS23772.1    CCAG010023541    ABQF01021745    AGTO01020707    EF191819    ACH46371.1    AXCM01001996    KK854041    PTY10102.1    GEZM01053531    JAV74025.1    CH477494    EAT39984.1    JXJN01011850    GBSH01002876    JAG66151.1    AMGL01113808    AY610478    AK344004    CU633939    BC102418    GBEX01003661    JAI10899.1    GU589488    ADO29438.1    ABGA01258473    NDHI03003661    PNJ10629.1    PNJ10630.1    CR857440    AGTP01001065    AGTP01001066    GFFW01004365    JAV40423.1    AAKN02052254    AAKN02052255    AAPE02017451    GBHO01016803    GBRD01012766    JAG26801.1    JAG53058.1    UFQS01000194    UFQT01000194    UFQT01000732    SSX01085.1    SSX21465.1    SSX26788.1    ATLV01018209    KE525224    KFB42813.1    CABD030122837    CABD030122838    CABD030122839    AQIB01143495    AJFE02015122    NDHI03003400    PNJ64686.1    PNJ64689.1    PNJ64690.1    AQIA01083425    AB173355    BAE90417.1    JSUE03044944    JU320833    CM001271    AFE64589.1    EHH30458.1    AACZ04014633    NBAG03000445    NBAG03000336    PNI23694.1    PNI23695.1    PNI38635.1    PNI38639.1    AXCN02000007    AK313736    CR456859    CH471135    CH471074    BAG36477.1    CAG33140.1    EAW72495.1    EAW98829.1    EAW98830.1    AF291676    AF058918    AC003002    BC008889    BC032809    AF157065    AF157062    AF157063    AF157064    AC003037    AK310542    DA542477    DB101396    BC016915    BC052618    JP020115    AES08713.1    ADFV01194347    ADFV01194348    AHAT01012851    GABZ01002842    JAA50683.1    GANO01001517    JAB58354.1    LZPO01007952    OBS83206.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000037510    UP000027135    + More
UP000053240    UP000053268    UP000009046    UP000015103    UP000092445    UP000078200    UP000092444    UP000007754    UP000079721    UP000016665    UP000075883    UP000189704    UP000091820    UP000008820    UP000076408    UP000092443    UP000092460    UP000075900    UP000075920    UP000081671    UP000002356    UP000008227    UP000009136    UP000221080    UP000095300    UP000001595    UP000005215    UP000005447    UP000261680    UP000291021    UP000252040    UP000245320    UP000286641    UP000265300    UP000248484    UP000286640    UP000248483    UP000245340    UP000286642    UP000248482    UP000002254    UP000001074    UP000030765    UP000233120    UP000001519    UP000233140    UP000029965    UP000240080    UP000233080    UP000008225    UP000233220    UP000233100    UP000006718    UP000002277    UP000075884    UP000075886    UP000005640    UP000095301    UP000001073    UP000018468    UP000245341    UP000092124    UP000233200    UP000075881   

PRIDE

H9JGS0    F1SRI0    Q3T0F2    Q5RES6    E2QV03    P0DI82    + More
P0DI81   

Pfam

PF04628   Sedlin_N

Interpro

IPR006722   Sedlin        + More
IPR011012   Longin-like_dom_sf       
IPR007233   TRAPPC       

SUPFAM

SSF64356   SSF64356       

ProteinModelPortal

H9JGS0   A0A2H1WFV7   I4DKA6   A0A2W1BSZ3   A0A2A4JQA3   A0A212EWR4   + More
A0A3S2P527   S4P863   A0A0L7L747   A0A067R175   A0A194RD30   A0A0N1PGY9   A0A1B6JBQ9   A0A1B6FDF6   A0A1B6KTV3   A0A146L8N3   A0A069DNT1   E0VPD4   A0A0P4VK01   T1IA30   A0A224Y0F7   A0A0V0G839   A0A1B6DDQ5   A0A1A9ZKG6   A0A1A9UG22   A0A1B0FBU5   H0ZD04   A0A1S2ZD41   U3JPD8   B5KFM3   A0A182LZE4   A0A2R7VRE0   A0A1Y1LQ39   A0A1U7TAR0   A0A1A9WTA7   Q16ZB8   A0A182YHN9   A0A1A9Y051   A0A1B0BC50   A0A0B8RTA1   A0A182RS40   A0A182VWT9   A0A1S3GFZ9   W5PP20   F1SRI0   Q3T0F2   A0A0F7Z927   E3TGK2   A0A1I8PE10   A0A0A0MXP8   A0A2J8RQ25   Q5RES6   A0A287D123   A0A250YA22   A0A286XNW4   A0A384CIG7   A0A341CAP8   A0A2U4AJI9   A0A3Q7N0V3   A0A340XDH8   A0A2Y9FK43   A0A3Q7RAH6   A0A2Y9MWZ2   A0A2U3WN45   A0A3Q7V7T6   A0A2Y9KKL1   E2QV03   G1PL13   A0A0A9Y587   A0A336LU60   A0A084VXW9   A0A2K6CSS0   G3QMD4   A0A2K5XM70   A0A0D9RRH6   A0A2R9BQ93   A0A2K5IBB9   A0A2R8MMX9   A0A2K6UCF0   A0A2J8W4J3   I7G790   F6Z6G0   A0A2J8JLP4   A0A1Y9H2V8   A0A182Q3N6   Q6IBE5   P0DI82   P0DI81   G9KUY4   A0A1I8M8H4   G1RD70   W5MV58   A0A2Y9MRP4   K9IQM0   A0A2Y9ML03   A0A2U3YVX9   U5EL85   A0A1A6HY81   A0A2K6P2H2   A0A240PLN3  

PDB

2J3W     E-value=1.46182e-51,     Score=506

KEGG

101743637    K20301 trafficking protein particle complex subunit 2 | (RefSeq) trafficking protein particle comple

GO

GO:0005737   GO:0006888   GO:0030008   GO:0005783   GO:0005654   GO:0048471   GO:0005793   GO:0005634   GO:0043231   GO:0048208   GO:0044325   GO:0008134   GO:0001501   GO:0006355   GO:0000139   GO:0005829   GO:0006810   GO:0005622   GO:0005975   GO:0006508   GO:0042555   GO:0006260   GO:0016021   GO:0004672   GO:0048384  

PANTHER

PTHR12403  

Subcellular location

Cytoplasm   Localized in perinuclear granular structures.   With evidence from 2 publications.
Perinuclear region   Localized in perinuclear granular structures.   With evidence from 2 publications.
Nucleus   Localized in perinuclear granular structures.   With evidence from 2 publications.
Endoplasmic reticulum-Golgi intermediate compartment   Localized in perinuclear granular structures.   With evidence from 2 publications.

Length:

139

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.58572

Exp number, first 60 AAs:

0.00531

Total prob of N-in:

0.15701

outside

1  -  139

 

 

Pi

190.415044

Theta

187.88218

Tajima's D

0.025161

CLR

394.23643

CSRT

0.379581020948953

Interpretation

Uncertain