SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO04140
Pre Gene Modal
BGIBMGA008712
Annotation
PREDICTED:_Bardet-Biedl_syndrome_5_protein_homolog_[Bombyx_mori]
Full name
Bardet-Biedl syndrome 5 protein homolog       + More
Bardet-Biedl syndrome 5 protein      
Location in the cell
PlasmaMembrane   Reliability : 0.952
 

Sequence

CDS
ATGTCGAAGGCTAAATCCGGTGCCGTTTGGGAAGACAGGGAAGTACTATTCGATCTGCCTTTCGCGTACTTAAAACTACGTCCAGGAGAGAAAATCTTCGACAGAATAGAGCCTATTGAGGATACGAAAGGGAACAGCGGTGTCAAAGGACGAATGGTCGTCACGAGTCTCAGGATTATATGGCACTCGTTGGCATCGCCCAGAATTAATATGTCTATTGGCTTGAACTGTCTCCTCTCGACGAGCACCAAGGTCGTGAACTCTGGTCTCCGTGGAACGACACAGGCTCTGCACGCGTTGGCAGCGTACCGAACTAACAGATACGAATTTATCTTCACGAATTTGTCGCCGAACTGCGTCCGCCATTACACCTCTGTTGTCGGAGTTCACAAAGCTTACATCAATTCGAGATTGTACAGAGATCTGAAGCTGCGTGGGGCGATCATACATAACAAACAACTGAGAATGGTGCCTCAGGAAAAGATTCTGCTTAACGAACACAGTATCTGGAATCTGTCTAGCGACTCCGGGAATCTTGGCACGATGCTGGTAACGAATATCAGAGTTGTATGGTACGCTGACGTGAACGAGGCTTTCAACGTGTCCATGCCGTACATAACTATTGATAGCATTTCAGTCAGAGCATCGAAATTCGGCGAGGCCTTAGTGTTCGTCATCAGACAAACATCGGGAGGTTATGTGCTCGGTTTCCGGGCGGACCCGCGGGATCGGCTGCCTCCATTGCTGTCTGAACTCCAAACACTCCATCGAGCTTATACCGAGAAACCCATATTTGGGGTCGAAATTAACTGGGAGAATGAGGCTCCAACTACAATCAATGATGAGATTGAAGAGCTAGAAGAGATAGGAGAACCTCGAGGGGAGATGGGGCCAAGTTTATATATGGCATCTCAATTGGCCAAACATCAAGAAGGCAAGGACGTTCAGCCAGTTTACAGCCCGTATTTAGGACTCGCTATAGAACCATTGAAAGAAGGTTTTACCCTCAAAAGCTTGTTTGAAGTTCAAAGTACAACTTAA
Protein
MSKAKSGAVWEDREVLFDLPFAYLKLRPGEKIFDRIEPIEDTKGNSGVKGRMVVTSLRIIWHSLASPRINMSIGLNCLLSTSTKVVNSGLRGTTQALHALAAYRTNRYEFIFTNLSPNCVRHYTSVVGVHKAYINSRLYRDLKLRGAIIHNKQLRMVPQEKILLNEHSIWNLSSDSGNLGTMLVTNIRVVWYADVNEAFNVSMPYITIDSISVRASKFGEALVFVIRQTSGGYVLGFRADPRDRLPPLLSELQTLHRAYTEKPIFGVEINWENEAPTTINDEIEELEEIGEPRGEMGPSLYMASQLAKHQEGKDVQPVYSPYLGLAIEPLKEGFTLKSLFEVQSTT

Summary

Description
Required for ciliogenesis.
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Subunit
PPart of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with PKD1 (By similarity).
Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with PKD1 (PubMed:24939912).
Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10 (By similarity). Binds to phosphoinositides (By similarity). Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (By similarity). Interacts with PKD1 (By similarity).
Miscellaneous
BBS5 may interact genetically with BBS1.
Similarity
Belongs to the BBS5 family.
Keywords
Cell membrane   Cell projection   Cilium   Complete proteome   Cytoplasm   Cytoskeleton   Membrane   Reference proteome   Protein transport   Transport   Alternative splicing   Bardet-Biedl syndrome   Ciliopathy   Disease mutation   Mental retardation   Obesity   Sensory transduction   Vision  
Feature
chain  Bardet-Biedl syndrome 5 protein homolog
splice variant  In isoform 2.
sequence variant  In BBS5; dbSNP:rs121908581.
EMBL
BABH01034340    RSAL01000020    RVE52595.1    ODYU01005753    SOQ46930.1    KZ149929    + More
PZC77470.1    NWSH01000446    PCG76354.1    KQ460720    KPJ12659.1    AGBW02010443    OWR48509.1    KQ459356    KPJ01276.1    JTDY01000046    KOB79199.1    KQ971307    EFA11133.1    GEDC01010844    JAS26454.1    NEDP02076645    OWF36293.1    KK853380    KDR08011.1    GG666498    EEN62236.1    PYGN01000536    PSN44632.1    JX053304    AFK11532.1    AKHW03006853    KYO17879.1    KL217611    KFO97086.1    AMQN01000650    AMQN01000651    KB293808    ELU15448.1    HAAF01001615    CCP73441.1    BC135573    AAI35574.1    BC049492    CM004482    OCT63563.1    IACK01194711    LAA96198.1    AFYH01086348    AFYH01086349    AEMK02000100    DQIR01216396    DQIR01299388    HDB71873.1    BT074553    ACO08977.1    ACTA01160968    AANG04001482    KK465770    KFQ81754.1    AK012283    AL929083    BC061031    KK423653    KFQ87219.1    JH880354    ELR62348.1    ADON01068760    ADON01068761    ADON01068762    AJFE02085449    AACZ04058509    GABC01005217    GABF01005804    GABD01004585    GABE01002475    JAA06121.1    JAA16341.1    JAA28515.1    JAA42264.1    KU178857    ALQ34315.1    AY604003    AY604004    AL834305    AC093899    CH471058    BC044593    BC147950    AAI47951.1    ABGA01089908    ABGA01164215    ABGA01287064    ABGA01287065    ADFV01058422    ADFV01058423    ADFV01058424    GAMT01001034    GAMS01006680    GAMR01004684    GAMQ01004786    GAMP01009584    JAB10827.1    JAB16456.1    JAB29248.1    JAB37065.1    JAB43171.1    KN124048    KFO22480.1    DS235881    EEB20011.1    AGTP01035491    CABD030016933    CABD030016934    CABD030016935    CABD030016936    AKCR02000010    PKK29554.1    AMGL01052775    LSYS01004331    OPJ80024.1    KZ505638    PKU49431.1    KL410194    KFQ94629.1    AABR07052473    BC167024    CH473949    AAI67024.1    EDL79059.1    AAPE02004773    AAPE02004774    AAPE02004775    NOWV01000295    RDD36915.1    DS985243    EDV26742.1    CM001287    EHH54926.1    AQIB01011524    AQIB01011525    AQIB01011526    AQIB01011527    AQIB01011528    AQIB01011529    AQIB01011530    AQIB01011531    AQIB01011532    AHZZ02004088    AHZZ02004089    JU322139    JU473186    AFE65895.1    AFH29990.1    AB169341    QUSF01000012    RLW04973.1    ABQF01010526    KL216733    KFV71119.1    PZQS01000005    PVD30948.1    AHAT01020077   
Proteomes
UP000005204    UP000283053    UP000218220    UP000053240    UP000007151    UP000053268    + More
UP000037510    UP000007266    UP000242188    UP000027135    UP000001554    UP000245037    UP000050525    UP000054308    UP000014760    UP000000437    UP000186698    UP000248482    UP000008672    UP000008227    UP000286640    UP000008912    UP000261680    UP000291021    UP000286642    UP000245341    UP000245340    UP000261681    UP000011712    UP000286641    UP000189704    UP000000589    UP000085678    UP000016666    UP000189706    UP000240080    UP000002277    UP000005640    UP000009136    UP000248484    UP000245300    UP000001595    UP000233020    UP000001073    UP000008225    UP000028990    UP000009046    UP000002279    UP000005215    UP000001519    UP000053872    UP000252040    UP000248483    UP000018467    UP000002356    UP000190648    UP000079721    UP000053283    UP000002494    UP000001074    UP000253843    UP000009022    UP000233120    UP000233180    UP000009130    UP000233140    UP000029965    UP000028761    UP000233200    UP000233060    UP000233100    UP000276834    UP000007754    UP000265300    UP000007646    UP000053875    UP000001038    UP000265140    UP000261440    UP000192224    UP000245119    UP000233040    UP000261600    UP000018468    UP000245320   
Pfam
PF07289   BBL5
Interpro
IPR014003   DM16_repeat        + More
IPR030804   BBS5/fem-3       
IPR006606   BBL5       

Ontologies

Topology

Subcellular location
Cell projection  
Cilium membrane  
Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Centriolar satellite  
Cilium basal body  
Length:
346
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.02837
Exp number, first 60 AAs:
0.00253
Total prob of N-in:
0.02918
outside
1  -  346
 
 

Population Genetic Test Statistics

Pi
181.78399
Theta
164.562603
Tajima's D
0.215632
CLR
0.733132
CSRT
0.43732813359332
Interpretation
Uncertain
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