Gene

KWMTBOMO04135  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008709

Annotation

PREDICTED:_chitinase_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr7(+):12052628-12064684      View in EpiBrowser

Full name

Chitinase A      

Location in the cell

Cytoplasmic   Reliability : 1.035

CDS

ATGGGGCATCGGATGATAGCGCTCGTATTCGCGGTGGCCGCGTTCGCCGTCGGCTCCTGCGGCCCGCCAGGGAAACCGAACCTCGGCTGGGGCGAGCGCACGTTCGCGATCGTCGAAGTCAACCAAGCGGCCACAGCTTACAACCAGCTCGTGACCAAGAAGGACGCCGCCGACGTCTCCGTCAACTGGAACGTGTGGACCGGCGACGCGGCCGACAAGTCCAGAGTCCTGCTCGATAAGAAGGAAGTCTGGAGCGGTGCCGGCAGCGCCACATCGGCCGCTTTCAAAGTGAAGAAGGGCGGAAGATACCAGATGCAGGTCGAGCTCTGCAACTCAGACGGATGCAGCTCTAGCGAGGGCGTCGAAATCGTAGTAGCTGACACTGATGGTAGCCATTTGAGGCCTCTCGATTATTCTATTGGTGAGAAAAATAAGCCCTTCAAGCAGACTTCGGGAAAAGTGGTGGGCGCTTACTTCGTCGAATGGGGTGTGTATCCTAGAAAGTTCCCTGTGGACCGCGTTCCGGTTCCGAACCTGACTCATTTGCTCTACGGCTTCATTCCGATTTGTGGTGGTGATGGCATCAATGACAGTTTGAAAGAAATTGAGGGCAGTTTTCAAGCACTACAACGTTCATGCAGCGGCCGTGAAGACTTCAAGGTTTCTATCCACGATCCCTGGGCGGCCCTGCAGAAACCTCAAAAGGGATTATCGTCCTGGAACGAGCCCTACAAAGGTAACTTCGGGCAGCTGATGCAGTTGAAACAAGCGAATACTGGCTTAAAGGTCTTACCTTCAATTGGTGGCTGGACATTGGCCGATCCCTTCTTCTTCTTCACCGACAAAACCAAGCGTGATCGTTTCGTTGCCTCCGTGAAAGACTTCCTCCAAACTTGGAAGTTCTTCGATGGTGTCGACATTGATTGGGAGTTCCCAGGTGGCAAAGGCGCTAACCCTGATCTCGGTAGTCCTAAAGACGGAGATGTATACGTTCAGCTCATGAAGGAATTACGTCAAATGTTGGATGAGCTGGCGGCTGAGACTGGTAGAACTTACGAGTTGACCTCTGCCATCAGCGCCGGTTGGGACAAGATCCAAGTCGTGAACTACAAGGAAGCCCAGAAATACATGGACCATATCTTCGTTATGAGTTACGACTTCAAGGGTGCCTGGTCTAACGACACTCTGGGACACCAGACTGCTCTATATGCTCCATCTTGGAGTCCTAAGGAAACTTACACCACCGACTTCGGTATCAGGTACCTGCTGACCCAAGGTGTCCAGCCCAAAAAGCTGGTTGTCGGTGTTGCTATGTACGGACGTGGTTGGACTGGAGTTCACGACTACAACGACGACATACCCTTCACTGGAGTTGCTAATGGTCCAGTTAAAGGAACTTGGCAGGACGGTGTGGTGGACTATAGGGAGATCGTGAATGGCATCACTTCAGGAACATGGCAGTACTTTTACGATAAAGTTGCTCAAGCTCCATACGTGTGGAATCCTACAACCGGCGATCTGGTGACTTATGATGACGCAAGATCAGTTATTGAGAAGGGGAAATACGTGAGGAACAATAAGCTTGGTGGACTGTTCGCTTGGGAAATAGACGCTGACAATGGCGATATCCTGAACGCTATGAATATGGGCTTAGGAAATTCCGCTTAG

Protein

MGHRMIALVFAVAAFAVGSCGPPGKPNLGWGERTFAIVEVNQAATAYNQLVTKKDAADVSVNWNVWTGDAADKSRVLLDKKEVWSGAGSATSAAFKVKKGGRYQMQVELCNSDGCSSSEGVEIVVADTDGSHLRPLDYSIGEKNKPFKQTSGKVVGAYFVEWGVYPRKFPVDRVPVPNLTHLLYGFIPICGGDGINDSLKEIEGSFQALQRSCSGREDFKVSIHDPWAALQKPQKGLSSWNEPYKGNFGQLMQLKQANTGLKVLPSIGGWTLADPFFFFTDKTKRDRFVASVKDFLQTWKFFDGVDIDWEFPGGKGANPDLGSPKDGDVYVQLMKELRQMLDELAAETGRTYELTSAISAGWDKIQVVNYKEAQKYMDHIFVMSYDFKGAWSNDTLGHQTALYAPSWSPKETYTTDFGIRYLLTQGVQPKKLVVGVAMYGRGWTGVHDYNDDIPFTGVANGPVKGTWQDGVVDYREIVNGITSGTWQYFYDKVAQAPYVWNPTTGDLVTYDDARSVIEKGKYVRNNKLGGLFAWEIDADNGDILNAMNMGLGNSA

Catalytic Activity

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Similarity

Belongs to the glycosyl hydrolase 18 family.
Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

Keywords

3D-structure   Carbohydrate metabolism   Chitin degradation   Direct protein sequencing   Glycosidase   Hydrolase   Polysaccharide degradation   Signal  

Feature

chain  Chitinase A

Uniprot

Q869E2   H9JGR2   Q2V6U4   Q4AE60   Q4AE58   Q4AE61   + More
A0A2W1BFK3   A0A2A4K0Q1   A0A2H1W7D1   U3MYV5   A0A0N1PEB3   Q3LS04   I4DIN5   D7PF26   Q4AE57   A0A194RJH1   Q3LRZ7   A0A0L7LKN3   Q4AE59   I4DMF3   A0A3S2M0R7   A0A212F3S4   A0A110BHA5   A0A2X2GLP0   A0A084YRD9   A0A1W5DGB0   A0A379ZED9   A8G807   A0A1Q4NX96   A0A1S6HQG7   A0A3R1DUU5   A0A379Y6D9   A2TC68   Q9ALZ0   A0A3G4SYG9   A0A383M1Z4   Q6T6I1   A0A2V4GNS9   O54328   Q4PZF3   B3VK60   Q8VQN2   Q2V8W9   A0A1B3FIT2   A0A379Y793   Q93LF1   A0A2G7ZKB4   E9NR88   A0A086G6J6   A0A1C0G3L8   A0A2V4FWV4   A0A3E2E9H0   F1C920   Q068W2   A0A1C3HLG1   A0A168GBA3   A0A0G3SSG7   A0A3Q0NKP7   A0A221DX62   Q2V9S9   A0A0D3QSW7   A0A161WM14   A0A3G6CIC0   A0A109Z469   M1E1V3   A0A240A944   Q5I4H6   Q6Q215   A0A142DUV4   P07254   A0A3F3KR79   Q3Y4D2   Q1HEB9   A0A2K9A7S9   E5FGC5   V5IV50   O83008   A0A089HM91   D0ELI2   W5U7W5   A0A1N6T079   A0A379YMJ9   A3D751   A7LHM5   D4ZGM8   F7RLD9   B1KH85   A0A2M7HP48   A0A3M3K2E7   S4YCJ6   A0A380A9L9   A0A0H3YHQ2   A0A318NYV9   A0A3Q9E657   A0A366J5P5   A0A2R3EWA6   G0APZ5   B8E8X7   Q12MA8   A9KYC7  

EC Number

3.2.1.14

Pubmed

12878222    19121390    16102417    28756777    26354079    22651552    + More
26227816    28053084    22118469    17404729    28536292    18565500    29067021    17112976    16170210    26817720    16453672    7851747    7704527    17927758    9371460    12554965    20153333    20458400    21868804    23929484    22328742   

EMBL

AB104488    BAC67246.1    BABH01034316    DQ288140    ABB88891.1    AB201280    + More
BAE16586.1    AB201282    BAE16588.1    AB201279    BAE16585.1    KZ150231    PZC71997.1    NWSH01000305    PCG77596.1    ODYU01006785    SOQ48957.1    KF218826    AGW23592.1    KQ459356    KPJ01281.1    DQ185387    ABA06504.1    AK401153    BAM17775.1    GU371869    ADI24347.1    AB201283    BAE16589.1    KQ460075    KPJ17978.1    DQ185397    ABA06506.1    JTDY01000754    KOB76002.1    AB201281    BAE16587.1    AK402471    BAM19093.1    RSAL01000082    RVE48506.1    AGBW02010497    OWR48385.1    FBSD01000002    CUW02024.1    UAUM01000015    SPZ55553.1    LT883155    SMZ54572.1    FWWG01000012    SMB27642.1    UGYN01000002    SUI60052.1    CP000826    ABV39247.1    MJAO01000018    OKB65483.1    CP014782    AQS37734.1    RCUE01000006    RCUO01000022    RCUN01000058    RCUS01000034    MMZ41110.1    MNB60146.1    MNH62195.1    MNL96932.1    UGYK01000002    SUI41371.1    EF151930    ABM69267.1    AF334683    AAK07482.1    CP033504    AYU92853.1    UIRQ01000031    SVK45853.1    AY433954    CP018926    LZOB01000022    AAR10884.1    ASM14310.1    OKP48996.1    QJPV01000003    QMDQ01000005    PYA41163.1    RAU88193.1    U35121    AAB97779.1    DQ013365    AAY67797.1    EU753246    ACE78180.1    AF454462    AAL57854.1    DQ285568    EF451957    ABB86291.1    ABO21767.1    CP016948    AOF01680.1    UGYL01000001    SUI41025.1    AY040610    AAK72610.2    MSTL01000020    PIJ13576.1    HQ699804    CP013046    ADW09324.1    ALL35928.1    JPUX01000001    KFF86810.1    LJDX02000223    OCO20217.1    QJPU01000008    PYA04588.1    QVOI01000008    RFT78583.1    HQ219075    ADX33318.1    DQ990373    ABI79317.1    LT575490    SAY45862.1    FKZE01000004    SAQ05998.1    FCGE01000007    CUY89242.1    LCWI01000017    KKZ16355.1    CP018917    CP021164    PPGF01000007    ASL90240.1    AWQ45898.1    PNU38901.1    DQ282126    ABB91448.1    KP065496    AJR10087.1    LWED01000060    KZK66143.1    CP033831    AYZ31032.1    CP014017    AMG99785.1    GU931689    ADM13645.1    LT906479    SNV79875.1    AY855211    AAW47932.1    AY566865    AAS68517.1    KT921885    KT921890    AMQ34972.1    AMQ34977.1    L01455    X03657    Z36294    DQ165083    AAZ86539.1    DQ493896    ABF48722.1    CP015194    AUD59657.1    HM473183    ADR30609.1    GU724601    ADW77626.1    AB015996    BAA31567.1    KM044038    AIP98317.1    GQ855217    ACX42071.1    KF823630    AHH32575.1    FTNN01000001    SIQ46516.1    UGYM01000002    SUI46614.1    CP000563    ABN62564.1    EU019911    ABS70983.1    AP011177    BAJ00827.1    AFOZ01000015    EGM70813.1    CP000961    ACA85393.1    PFGL01000063    PIW59447.1    RBOX01000163    RMN17269.1    CP006566    AGP42509.1    UGYV01000001    SUI76397.1    KP728831    AKN20311.1    PESE01000006    PYD37505.1    CP020373    AZQ09374.1    QNSC01000003    RBP81495.1    CP023019    AVI67008.1    CP002767    AEG10546.1    CP001252    ACK45793.1    CP000302    ABE55418.1    CP000891    ABX50398.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000283053    + More
UP000007151    UP000242817    UP000250791    UP000246092    UP000192912    UP000255529    UP000007074    UP000185770    UP000189545    UP000254765    UP000281251    UP000258172    UP000185968    UP000198289    UP000247670    UP000251655    UP000077316    UP000254742    UP000229306    UP000058492    UP000028708    UP000050507    UP000248086    UP000261108    UP000078180    UP000054899    UP000034361    UP000198428    UP000236556    UP000246645    UP000076650    UP000282317    UP000062490    UP000215134    UP000233830    UP000185718    UP000255196    UP000001557    UP000002350    UP000002956    UP000002168    UP000229079    UP000014900    UP000255061    UP000248196    UP000278437    UP000252468    UP000239498    UP000002249    UP000002507    UP000001982    UP000000770   

PRIDE

Q869E2    H9JGR2    Q4AE60    Q4AE58    Q4AE61    Q4AE57    + More
Q4AE59   

Pfam

PF08329   ChitinaseA_N        + More
PF00704   Glyco_hydro_18
PF02839   CBM_5_12

Interpro

IPR014756   Ig_E-set        + More
IPR017853   Glycoside_hydrolase_SF       
IPR011583   Chitinase_II       
IPR013783   Ig-like_fold       
IPR022409   PKD/Chitinase_dom       
IPR001223   Glyco_hydro18_cat       
IPR029070   Chitinase_insertion_sf       
IPR013540   ChitinaseA_N       
IPR001579   Glyco_hydro_18_chit_AS       
IPR036573   CBM_sf_5/12       
IPR003610   CBM_fam5/12       
IPR035986   PKD_dom_sf       

SUPFAM

SSF81296   SSF81296        + More
SSF51445   SSF51445       
SSF54556   SSF54556       
SSF51055   SSF51055       
SSF49299   SSF49299       

Gene 3D

2.60.40.10     3.10.50.10    

ProteinModelPortal

Q869E2   H9JGR2   Q2V6U4   Q4AE60   Q4AE58   Q4AE61   + More
A0A2W1BFK3   A0A2A4K0Q1   A0A2H1W7D1   U3MYV5   A0A0N1PEB3   Q3LS04   I4DIN5   D7PF26   Q4AE57   A0A194RJH1   Q3LRZ7   A0A0L7LKN3   Q4AE59   I4DMF3   A0A3S2M0R7   A0A212F3S4   A0A110BHA5   A0A2X2GLP0   A0A084YRD9   A0A1W5DGB0   A0A379ZED9   A8G807   A0A1Q4NX96   A0A1S6HQG7   A0A3R1DUU5   A0A379Y6D9   A2TC68   Q9ALZ0   A0A3G4SYG9   A0A383M1Z4   Q6T6I1   A0A2V4GNS9   O54328   Q4PZF3   B3VK60   Q8VQN2   Q2V8W9   A0A1B3FIT2   A0A379Y793   Q93LF1   A0A2G7ZKB4   E9NR88   A0A086G6J6   A0A1C0G3L8   A0A2V4FWV4   A0A3E2E9H0   F1C920   Q068W2   A0A1C3HLG1   A0A168GBA3   A0A0G3SSG7   A0A3Q0NKP7   A0A221DX62   Q2V9S9   A0A0D3QSW7   A0A161WM14   A0A3G6CIC0   A0A109Z469   M1E1V3   A0A240A944   Q5I4H6   Q6Q215   A0A142DUV4   P07254   A0A3F3KR79   Q3Y4D2   Q1HEB9   A0A2K9A7S9   E5FGC5   V5IV50   O83008   A0A089HM91   D0ELI2   W5U7W5   A0A1N6T079   A0A379YMJ9   A3D751   A7LHM5   D4ZGM8   F7RLD9   B1KH85   A0A2M7HP48   A0A3M3K2E7   S4YCJ6   A0A380A9L9   A0A0H3YHQ2   A0A318NYV9   A0A3Q9E657   A0A366J5P5   A0A2R3EWA6   G0APZ5   B8E8X7   Q12MA8   A9KYC7  

PDB

5GQB     E-value=0,     Score=2448

KEGG

100141460    no KO assigned | (RefSeq) Chi-h, BmChi-h; chitinase

GO

GO:0006032   GO:0004568   GO:0008061   GO:0005975   GO:0008152   GO:0016798   GO:0030246   GO:0005576   GO:0000272   GO:0004553   GO:0006508   GO:0042555   GO:0006260   GO:0016021   GO:0004672   GO:0048384  

SignalP

Position:   1 - 20,         Likelihood:  0.994980

 

 

Length:

555

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.31391

Exp number, first 60 AAs:

1.28403

Total prob of N-in:

0.06728

outside

1  -  555

 

 

Pi

2.460263

Theta

184.271547

Tajima's D

-2.043312

CLR

0.761818

CSRT

0.0111994400279986

Interpretation

Possibly Positive selection