SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO04080  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA008625
Annotation
PREDICTED:_DNA_replication_licensing_factor_Mcm2_isoform_X1_[Bombyx_mori]
Full name
DNA helicase       + More
CTP synthase      
DNA replication licensing factor Mcm2      
Alternative Name
UTP--ammonia ligase
Minichromosome maintenance 2 protein
Location in the cell
Nuclear   Reliability : 2.802
 

Sequence

CDS
ATGGCGGCGGCGATCATGCGCTCTATTGCTGCCTTTAGTAGAACAGGGCGCGGAGTGGACGAGAACTTGGTCCCATTGTCTCACGTTTGTCCCTGTCTGACCTGTAGGGAGTGGACGCTGGAAGCCGGTGCGCTAGTACTGGCGGACCGCGGCGTCTGTCTCATCGACGAGTTCGACAAAATGAATGACCAGGACCGGACCTCCATACACGAAGCGATGGAGCAACAGTCCATATCCATATCCAAGGCAGGGATCGTCACGTCACTGCACGCCAGGTGTTCCGTGATAGCGGCGGCCAATCCCATCGGCGGGCGCTACGACGCCTCGCTCACGTTCTCAGAGAACGTGGCCCTCTCCGAGCCCATCCTGTCGCGTTTCGACGTGCTGTGCGTCGTGCGCGACGAGCCCGACCCCATGCGGGACGCGCACCTCGCCAGATTCGTGGTGAGCTCGCACATGCGGCACCACCCGAGCTCGCCCGCGACGTCACTAGACCACGCCGCCCCCGACCCCGACTTCGTGCTGCCCCAGGACCTCTTCAAGAAGTACATCGTGTACTCCAGGGAGAACGTGCACCCCAAGCTGCAGAATATGGATCAGGACAAAGTCGCGAAAATGTACAGTCAGCTCCGGCAGGAGTCCCTCGCGACGGGAAGCCTGCCCATCACCGTGCGACACATCGAATCAGTGATCCGCATGTGCGAGGCTCACGCCCGCATGCACCTACGGAGCCAGGTCAGCGAGGAGGACGTGAACGTGGCCATCCGCACCATGCTGGAGAGCTTCGTCGACACGCAGAAGTACAGCGTCATGCGAGCCATGAGACAGACGTTCCAAAAGTATTTATCCTACAAAAAGGATCACAGTGAGCTGCTTTATTACATCCTGAGGCAGCTGACCATAGACCAACTGGCCTACATGAGAGGCCTCCACAACCATTCACAATCAACAATAGAAATCTCCGAGAGAGATCTGCTCGAGAGGGCCCGTCAAATAAACATAACGGATCTGAAACCATTTTATGACAGTTACATATTTAAAATCAATAATTTCAGTTATGATCAAAAGAGGAAGGTAATTGTGCACTTACTACCCGAAGTGCCCAGTGCTTCATAA
Protein
MAAAIMRSIAAFSRTGRGVDENLVPLSHVCPCLTCREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLHARCSVIAAANPIGGRYDASLTFSENVALSEPILSRFDVLCVVRDEPDPMRDAHLARFVVSSHMRHHPSSPATSLDHAAPDPDFVLPQDLFKKYIVYSRENVHPKLQNMDQDKVAKMYSQLRQESLATGSLPITVRHIESVIRMCEAHARMHLRSQVSEEDVNVAIRTMLESFVDTQKYSVMRAMRQTFQKYLSYKKDHSELLYYILRQLTIDQLAYMRGLHNHSQSTIEISERDLLERARQINITDLKPFYDSYIFKINNFSYDQKRKVIVHLLPEVPSAS

Summary

Description
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate
Subunit
Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable). Interacts with Mcm10.
Similarity
Belongs to the MCM family.
Belongs to the CTP synthase family.
Keywords
ATP-binding   Cell cycle   Cell division   Complete proteome   DNA replication   DNA-binding   Helicase   Hydrolase   Metal-binding   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Zinc   Zinc-finger  
Feature
chain  DNA helicase
EC Number
3.6.4.12
6.3.4.2
EMBL
BABH01039421    BABH01039422    BABH01039423    BABH01039424    BABH01039425    NWSH01000139    + More
PCG79153.1    ODYU01007344    SOQ50024.1    KQ459600    KPI94294.1    AGBW02014538    OWR41481.1    GAIX01005777    JAA86783.1    GECU01036054    GECU01009935    JAS71652.1    JAS97771.1    KQ435037    KZC14122.1    KQ971380    EEZ97575.1    LJIG01022556    KRT79946.1    KZ288206    PBC33109.1    LBMM01006018    KMQ91014.1    GL446721    EFN87325.1    QOIP01000008    RLU19179.1    KQ981864    KYN34214.1    GEDC01026389    JAS10909.1    KQ979568    KYN20930.1    KK107109    EZA59244.1    KQ414697    KOC63500.1    GL888818    EGI57938.1    ADTU01014870    KQ982911    KYQ49335.1    GEBQ01016385    GEBQ01008553    JAT23592.1    JAT31424.1    KQ976662    KYM78597.1    APGK01040543    KB740983    ENN76347.1    KB632410    ERL95212.1    KK852777    KDR16761.1    GECZ01028772    JAS40997.1    GBYB01011577    GBYB01014685    GBYB01014686    JAG81344.1    JAG84452.1    JAG84453.1    KQ977104    KYN05793.1    PYGN01002802    PSN29948.1    DS231847    EDS36437.1    JXUM01027084    KQ560777    KXJ80931.1    KQ459995    KPJ18533.1    JXUM01088166    KQ563684    KXJ73497.1    CH477416    EAT41359.1    JXJN01015972    GFDL01015764    JAV19281.1    JRES01000936    KNC27056.1    KA648321    AFP62950.1    ADMH02001267    ETN63293.1    CH479179    EDW24506.1    CCAG010004927    GDHF01025324    JAI26990.1    GL439602    EFN66971.1    APCN01005029    AAAB01008880    EAA08670.5    GBXI01005942    JAD08350.1    BC000300    AAH00300.2    ATLV01024815    KE525361    KFB51958.1    AEFK01070797    GBRD01004521    JAG61300.1    GEBQ01015835    JAT24142.1    GBHO01024500    JAG19104.1    GAMC01003180    JAC03376.1    GBHO01035774    JAG07830.1    CH954181    EDV49954.1    CM000160    EDW96488.1    L42762    AE014297    AY069702    CH480815    EDW43062.1    AXCN02000084    HAAF01004839    CCP76664.1    CH940650    EDW67538.1    CH964232    EDW80817.1    GEZM01053963    JAV73893.1    GFTR01008220    JAW08206.1    CH902617    EDV44088.1    ACPB03005149    KK854039    PTY10046.1    ABLF02033582    KV971180    PIO23009.1    GBBI01002389    JAC16323.1    GFJQ02002239    JAW04731.1    OUUW01000007    SPP82812.1    CP012526    ALC46999.1    JU327597    AFE71353.1   
Pfam
PF14551   MCM_N        + More
PF17207   MCM_OB
PF00493   MCM
PF12619   MCM2_N
PF17855   MCM_lid
PF00117   GATase
PF06418   CTP_synth_N
PF03153   TFIIA
Interpro
IPR012340   NA-bd_OB-fold        + More
IPR001208   MCM_dom       
IPR008045   MCM2       
IPR031327   MCM       
IPR033762   MCM_OB       
IPR027417   P-loop_NTPase       
IPR041562   MCM_lid       
IPR027925   MCM_N       
IPR018525   MCM_CS       
IPR003593   AAA+_ATPase       
IPR017926   GATASE       
IPR029062   Class_I_gatase-like       
IPR004468   CTP_synthase       
IPR033828   GATase1_CTP_Synthase       
IPR017456   CTP_synthase_N       
IPR004855   TFIIA_asu/bsu       
IPR009088   TFIIA_b-brl       
SUPFAM
SSF52540   SSF52540        + More
SSF50249   SSF50249       
SSF52317   SSF52317       
SSF50784   SSF50784       
Gene 3D
PDB
6HV9     E-value=9.43228e-78,     Score=738

Ontologies

Topology

Subcellular location
Nucleus  
Length:
371
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00408999999999999
Exp number, first 60 AAs:
0.0002
Total prob of N-in:
0.01740
outside
1  -  371
 
 

Population Genetic Test Statistics

Pi
317.144906
Theta
174.283768
Tajima's D
3.809012
CLR
0.11818
CSRT
0.99790010499475
Interpretation
Uncertain
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