Gene

KWMTBOMO04068

Pre Gene Modal

BGIBMGA010092

Annotation

receptor_type_guanylyl_cyclase_[Bombyx_mori]

Location

Bomo_Chr7(-):10414877-10498760      View in EpiBrowser

Full name

Guanylate cyclase      

Location in the cell

Nuclear   Reliability : 1.558 PlasmaMembrane   Reliability : 2.092

CDS

ATGTTAGTGGAGATCGTGCAAGCGATTCTCCCCCTTATCGTTAAGAGACTAAAGTGCAAAAAACGTTCATACGGATATCGAGCGGATTACAGGAAGAGACGAAGCGAATACGCTACCGATACTCATGTTGTTTGTGACCATGTTCAAACACAGAAGATTAAAACGAGATCTGTAATTAATCATGAAACACCAATATTATTCACATTCCTGGTTCTTTACGTGTGTATTTTGAATGTCATTATTAAATGTGACGTTAGTGTTAATGATGTAAATAATAAAGACGGTTTTATTAAACATGGATACGATACGCACGTGAATTTGAGGAACAAGTCTAAATGGTTAGGGCATAGGCACGAAGATAGAGTGTACGGAAAGAATATGCGCAAAGGACATGTGTCGATGAAAAGACACACCGGTGAGAAGAAAGACGATAATTTTAGTCCAGACGAACAAGACTTCGATAAGTTTAACGATTTTTATAAGAGCAACGAAGATTTGACCAACGTTACTGAGTACCCGGATATATTTGAGATGTCGCGATACGTTTACGATGATACCCGCGCCATTGGCCATCCCCATGACTTGGCCAAAAATCCTTATTACGTGAAGAATATTAATTTTAATTTACGCCCAGAGAGGCACCAGTTCCACCGGAAGATCGTGAAACTGGGCGTTCTGTTGCCCGCCGACCCAAATCAAGTGTTTTCGTTGGTCAAGGTTCTGCCAATATTGGAAATGGCCATACCGGCTGTTACAAAGCAGGACGGACCCCTTCCTGGTTGGAAAATACTGGTGGACTACAGAGATACCCTGTGTTCTTCTGTGGAAGGACCACTGGCGGCCTTCGAGTTTTACGTTAATGGATCAGCTGATGCTTTTATTGGTCCCGGTTGCGAGTACGTCATTGCTCCGGTGGCAAGGTATGCTGGACCTTGGGGTATACCGGTGTTGACAGCGGGCGCTCAGGCTGAAGCTTTTTTCTACAAACACCCAAGTTACGCAACTCTGACCAGAATGATGGGTAGCTACACTCAAGCAGGCGTCGCTATTCGCAATATCTTCGAGGAGTTCAACTGGCGTCGCTTAGGGATGCTCTACCACAACAACGACCCCTCGTCGGGGAAGGGAAACAGCCCGTGCTTCTTGACACTGAGCGCCGTGTTCACGGTGTTGAACAAGAAAACGAGCGGATCCGACAACATTATAACGGCCCAGTTCGACGAGACGAACACGACAAATACGAAATTCAAGGAGCTCCTTCACAAACTGTCCCTGAGCACGAGAATTGTCGTGTTATGTGCGAACCCGGCTACAGTAAGAGAAATAATGCTGGCAGCCGACGATCTCAACATGGTGTCGTCCGGAGAATACGTGTTCTTTAATATTGAACTTTTTTCTAATTTAGCATCAGCTTCATCCAAGGAACCCTGGAAATCTGAGAACGACACGGAGGAAAGAAACGAAAGAGCAAGGAGGGCCTATAGTGCTGTGCTGACCGTGACGAGTCCGGCTCCAGAGAAAAAGGAATACCTTGAGTTTTCTGATCAGGTCAAAGAGCTCGCCGCAACGAAGTACAACTACACGTTCGGGAAAGGCGAAGTTGTTTCAACTTTCGTGGCTGCCTTTTACGATGCGGTCCTTCTGTACGCTCTGGCGCTGAACGACACTCTGCAGCAGGCGACCGATCCTCGAGGGCAGCTGGACGGCGCTGCGGTAATGAGGAATATGTGGAATAGGACTTTTCAAGGTATAACCGGCGAGGTTGTAATAAACAGCAACGGTGATCGCGTCGCCTCTTATTCGTTGCTCGATATGAACCCAAATACCAGCAAATTTGAGGTGGTAGCAACATACGTGGCCGCAAATAAAACACTACAGTTCACCGAGAATAGACCTATTTACTGGGCTGGCGGCCGAACCACTCCGCCCCCTGACACACCGGAATGCGGCTTCGATGGTTCGCTTTGTCCGGATAACTCACTCCCGGTTTACGCGATTCTCAGTATTGTATTGAGTTCCGTCGTTGTGATCTTGGCGATACTATCAGTCTTCATATACAGGCATTATAAACTTGAGGCGGAAATCGCGATGATGACCTGGAGGGTTAGCTGGAGTGATGTCCTGCAGCCTGGCGGTCGACTCAGAGGCAGTCTGCATTCAATAACCAGACGCTACAGCACTGGAACCACGTTCTCCGACGAAGCGACATCATTGGCTGGAGATCGCCAAGTGTACACTCCATGTGGATTCTACAAGGGCTGCAGAGTCGCAATCAAACTAGTGGACAAACAGCGAATAGACCTCACCAGGCCGTTACTGCTGGAGCTGAAGAAAATGAAAGATCTCGAGCACGACCATTTGGCGAGGTTCTATGGGGCCTGCGTTGATCCGCCGCACTGCTGCTTGTTGACCGAATACTGTCCGAAAGGATCTTTGCAGGATATCCTTGAGAATGAATCTATCAAACTAGATTGGATGTTCAAAGTCAGTTTGATGCACGATATAGTAAAGGGCATGCATTACTTACACAATTCCGACATAAAATCGCATGGAGCACTCAAGTCGAGCAATTGTGTAGTTGATTCGAGATTTGTATTAAAAATAACCGACTTCGGAATACACGCCTTAAGAACTTCGGAAAAGGACTCGAGCGCTCACAGTTATTGGACTCGTCTCCTCTGGACAGCTCCGGAACTATTGAGAATGCCAGAGCCGCCGCCGGAGGGCACACAGAAAGGCGACGTTTATTCCTTTGCTATTGTCATGCACGAGATAGTGAATAGGCAGGGAGTATTTTGGCTCGGACCCGGCATAGAATTCTCACCTAAAGAAATCATTGAAACGATCAGGGCGAGTTGTCTACGGCCTAATACGTCTCATCACCGATCTTGCGAAGCTGATGACGCGGCAGAGCTGATGCGTCGGTGCTGGGCAGAGGATCCAACTGAAAGACCTGACTTTGGAAACCTTAAGGGTGCCATAAGGAGGCTCAACAAAACTCAAGAAAGTAGCAATATTTTAGACAACCTGCTTTCCCGTATGGAACAATATGCGAATAATTTGGAGACTCTAGTTAGCGAGAGAACTCAGGACTATTTAGAAGAAAAGAAAAAATGCGAAGAGCTACTGTACCAGTTACTGCCTAAGTCAGTGGCCTCCCAGCTAATCAACGGGCAGTCAGTGGTAGCGGAAACCTTCGAACAAGTCACAATCTACTTTTCAGATATAGTTGGTTTCACTGCTCTCTCAGCTTCCTCCACTCCTATGCAAGTGGTGGACCTCCTCAATGATCTGTATACCTGTTTTGATTCCATTGTGGAAAACTATGACGTCTATAAGGTGGAAACCATAGGTGATGCGTACATGGTGGTATCTGGTCTGCCTGAACGCAACGGGACCAGACATGCGTGCGAAGTGGCGAGGATGGCTCTCGCTTTACTGGATGCCGTCAGGAGATTCCGCATCAGGCATCGGCCTATGGACCAGCTGAGACTTCGGATCGGATTACATTCTGGTCCCTGTGTTGCTGGAGTGGTGGGCTTGAAGATGCCGCGCTACTGCTTGTTCGGTGACACAGTAAACACCGCGTCTCGTATGGAATCCAACGGAGAAGCTCTGAAGATACACGTGTCTCCGGACACGAAAGCTCTGCTGGATACATTCGGGACGTTCCATTTGGAGTGCAGAGGGGAGGTCGCCATGAAGGGTAAAGGAATTCTAGTCACATATTGGTTATTGGGTGAAAAAACGGACCCAAATGCTCCGAAGGAAAAACCTTCGCTGGTCAAAAACCAAACACTTTCAACCGAAAGCGGTTCACTTTCGCATCTCACACCATTTCGGCAGAGAATGGATCAAAACTCCAGGTCTTCAAGTAGGCGTGGGTCAGGAGTTTTCCAGCAGAGGTCTATAGACGTCACCAAGCTAGAAAAAGAAACACAGCCGTTGCTTCAAAGCCTCGCGATTCAAAGGCAGCTCTCAGACCCTACGGAACCAGTAGCTAATGGTATAGACAACGAGGAATCAGACAAACTATCAGTAACTAATTCAATATCGTTAAATGTAAACTCTCTAAGCCACAATCACCAGGGGCATCCACGGGTCAAACTGAAGGAAGCCAACTCGATCAACCACAAGTCAAAAGTTGGTAATAATAATTGGATTTCAAAACTGCCTACAGCCAGTAATTCCTTTGACAACGGAACCAAGAAAGCCAGTGAGCGTCTTAAAGATTACAGCAGTGTACCGCTTCTTTCGAAGGCCGATACACCTAATGATTCTATAGTGTAA

Protein

MLVEIVQAILPLIVKRLKCKKRSYGYRADYRKRRSEYATDTHVVCDHVQTQKIKTRSVINHETPILFTFLVLYVCILNVIIKCDVSVNDVNNKDGFIKHGYDTHVNLRNKSKWLGHRHEDRVYGKNMRKGHVSMKRHTGEKKDDNFSPDEQDFDKFNDFYKSNEDLTNVTEYPDIFEMSRYVYDDTRAIGHPHDLAKNPYYVKNINFNLRPERHQFHRKIVKLGVLLPADPNQVFSLVKVLPILEMAIPAVTKQDGPLPGWKILVDYRDTLCSSVEGPLAAFEFYVNGSADAFIGPGCEYVIAPVARYAGPWGIPVLTAGAQAEAFFYKHPSYATLTRMMGSYTQAGVAIRNIFEEFNWRRLGMLYHNNDPSSGKGNSPCFLTLSAVFTVLNKKTSGSDNIITAQFDETNTTNTKFKELLHKLSLSTRIVVLCANPATVREIMLAADDLNMVSSGEYVFFNIELFSNLASASSKEPWKSENDTEERNERARRAYSAVLTVTSPAPEKKEYLEFSDQVKELAATKYNYTFGKGEVVSTFVAAFYDAVLLYALALNDTLQQATDPRGQLDGAAVMRNMWNRTFQGITGEVVINSNGDRVASYSLLDMNPNTSKFEVVATYVAANKTLQFTENRPIYWAGGRTTPPPDTPECGFDGSLCPDNSLPVYAILSIVLSSVVVILAILSVFIYRHYKLEAEIAMMTWRVSWSDVLQPGGRLRGSLHSITRRYSTGTTFSDEATSLAGDRQVYTPCGFYKGCRVAIKLVDKQRIDLTRPLLLELKKMKDLEHDHLARFYGACVDPPHCCLLTEYCPKGSLQDILENESIKLDWMFKVSLMHDIVKGMHYLHNSDIKSHGALKSSNCVVDSRFVLKITDFGIHALRTSEKDSSAHSYWTRLLWTAPELLRMPEPPPEGTQKGDVYSFAIVMHEIVNRQGVFWLGPGIEFSPKEIIETIRASCLRPNTSHHRSCEADDAAELMRRCWAEDPTERPDFGNLKGAIRRLNKTQESSNILDNLLSRMEQYANNLETLVSERTQDYLEEKKKCEELLYQLLPKSVASQLINGQSVVAETFEQVTIYFSDIVGFTALSASSTPMQVVDLLNDLYTCFDSIVENYDVYKVETIGDAYMVVSGLPERNGTRHACEVARMALALLDAVRRFRIRHRPMDQLRLRIGLHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSPDTKALLDTFGTFHLECRGEVAMKGKGILVTYWLLGEKTDPNAPKEKPSLVKNQTLSTESGSLSHLTPFRQRMDQNSRSSSRRGSGVFQQRSIDVTKLEKETQPLLQSLAIQRQLSDPTEPVANGIDNEESDKLSVTNSISLNVNSLSHNHQGHPRVKLKEANSINHKSKVGNNNWISKLPTASNSFDNGTKKASERLKDYSSVPLLSKADTPNDSIV

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Feature

chain  Guanylate cyclase

Uniprot

A0A0M3VH92   Q9BPR0   A0A212FC80   A0A194PLI8   A0A2A4IYS3   A0A158P0M1   + More
A0A0L7QKK7   A0A3L8DRY2   A0A195F401   K7J4N4   A0A1B6ME96   A0A1B6L105   A0A023F0L0   A0A224XIJ1   A0A1Q3G4K8   A0A2M4CVF3   A0A2M4CVA2   A0A2M3YZQ2   A0A151WKN4   Q7PTP9   A0A1Y9GKX4   A0A2M4B9V1   A0A2M4BA30   A0A2M4A0W1   A0A2M4B9R9   A0A2M4BA27   A0A2M4A6J1   A0A182V1G5   A0A2M4CIX2   A0A026WB13   Q174S2   A0A0P4ZZF4   A0A0N8DFN2   A0A0P5W112   A0A0P6GQV3   T1KF53   A0A0F7VJB8   A0A1B6JNQ5   A0A146M109   A0A0A9WYA7   E9H6U6   A0A0C9QYW7   A0A034VF88   A0A0K8VHK8   G1FKY1   W8B2G3   A0A0A1X716   A0A0F7VHC5   A0A2S2NHF4   A0A1B0AAF2   B4NBA6   A0A1A9YK51   A0A1A9UTM4   A0A1J1IEB7   A0A0L0CC40   A0A1I8MLJ8   A0A1J1IG90   B4JT47   Q296Q0   B4GEV1   A0A3B0JPZ6   B3M388   A0A0P4XYS6   Q9VF17   B4PRJ3   B4QXT4   B4HLG9   A0A1W4VFT6   B3P3W6   B4K5Q8   B4LX87   A0A210PTL8   V4AEX2   A0A1B0G6S3   V4AZ64   A0A0Q9WE85   A0A336LM52   A0A1S3IRF8   A0A0A1X5Z0   V4BNJ3   A0A1S4G740   A0A1I8PRN8   R7U0U2   A0A1W4VFG5   A0A0P9CAM4   K1QPS4  

EC Number

4.6.1.2

Pubmed

11483433    22118469    26354079    21347285    30249741    20075255    + More
25474469    12364791    14747013    17210077    24508170    17510324    26823975    25401762    21292972    25348373    24495485    25830018    17994087    26108605    25315136    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    18057021    28812685    23254933    22992520   

EMBL

LC081227    BAS31078.1    AB047558    BAB32672.1    AGBW02009215    OWR51328.1    + More
KQ459600    KPI94301.1    NWSH01005377    PCG64263.1    ADTU01000999    ADTU01001000    ADTU01001001    ADTU01001002    ADTU01001003    ADTU01001004    ADTU01001005    ADTU01001006    ADTU01001007    ADTU01001008    KQ414940    KOC59164.1    QOIP01000005    RLU22558.1    KQ981855    KYN34897.1    AAZX01000462    AAZX01000467    AAZX01003821    GEBQ01005731    JAT34246.1    GEBQ01022656    JAT17321.1    GBBI01003690    JAC15022.1    GFTR01008565    JAW07861.1    GFDL01000300    JAV34745.1    GGFL01005071    MBW69249.1    GGFL01005072    MBW69250.1    GGFM01000984    MBW21735.1    KQ983002    KYQ48418.1    AAAB01008794    EAA03567.6    APCN01002156    GGFJ01000665    MBW49806.1    GGFJ01000774    MBW49915.1    GGFK01001070    MBW34391.1    GGFJ01000664    MBW49805.1    GGFJ01000773    MBW49914.1    GGFK01002927    MBW36248.1    GGFL01001106    MBW65284.1    KK107293    EZA53250.1    CH477406    EAT41579.1    GDIP01206411    JAJ16991.1    GDIP01038391    GDIP01024551    JAM65324.1    GDIP01093526    JAM10189.1    GDIQ01040342    JAN54395.1    CAEY01000034    LN830672    CFW94181.1    GECU01006994    JAT00713.1    GDHC01005166    JAQ13463.1    GBHO01031198    JAG12406.1    GL732598    EFX72574.1    GBYB01005872    JAG75639.1    GAKP01016966    JAC41986.1    GDHF01014393    GDHF01013971    JAI37921.1    JAI38343.1    JN225448    AEL97641.1    GAMC01011230    JAB95325.1    GBXI01013066    GBXI01007611    JAD01226.1    JAD06681.1    LN830669    CFW94178.1    GGMR01004005    MBY16624.1    CH964232    EDW81070.1    CVRI01000047    CRK98555.1    JRES01000623    KNC29816.1    CRK98556.1    CH916373    EDV94937.1    CM000070    EAL28393.2    CH479182    EDW34136.1    OUUW01000008    SPP84277.1    CH902617    EDV43549.1    GDIP01235910    JAI87491.1    AE014297    AAF55244.2    CM000160    EDW97393.2    CM000364    EDX12758.1    CH480815    EDW41989.1    CH954181    EDV49072.1    CH933806    EDW15120.1    KRG01394.1    CH940650    EDW66739.1    KRF82885.1    NEDP02005508    OWF39796.1    KB200170    ESP02584.1    CCAG010013864    KB200718    ESP00406.1    KRF82888.1    UFQT01000054    SSX19066.1    GBXI01008204    JAD06088.1    KB202408    ESO90424.1    AMQN01002234    KB308725    ELT96795.1    KPU80309.1    JH815886    EKC33099.1   

Proteomes

UP000007151    UP000053268    UP000218220    UP000005205    UP000053825    UP000279307    + More
UP000078541    UP000002358    UP000075809    UP000007062    UP000075840    UP000075903    UP000053097    UP000008820    UP000015104    UP000000305    UP000092445    UP000007798    UP000092443    UP000078200    UP000183832    UP000037069    UP000095301    UP000001070    UP000001819    UP000008744    UP000268350    UP000007801    UP000000803    UP000002282    UP000000304    UP000001292    UP000192221    UP000008711    UP000009192    UP000008792    UP000242188    UP000030746    UP000092444    UP000085678    UP000095300    UP000014760    UP000005408   

PRIDE

Q9BPR0    Q9VF17   

Pfam

PF00211   Guanylate_cyc        + More
PF07714   Pkinase_Tyr
PF01094   ANF_receptor
PF00005   ABC_tran
PF16185   MTABC_N
PF00664   ABC_membrane

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR001170   ANPR/GUC       
IPR001828   ANF_lig-bd_rcpt       
IPR018297   A/G_cyclase_CS       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR000719   Prot_kinase_dom       
IPR029787   Nucleotide_cyclase       
IPR001054   A/G_cyclase       
IPR028082   Peripla_BP_I       
IPR003593   AAA+_ATPase       
IPR032410   MTABC_N       
IPR003439   ABC_transporter-like       
IPR017871   ABC_transporter_CS       
IPR036640   ABC1_TM_sf       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       

SUPFAM

SSF55073   SSF55073        + More
SSF53822   SSF53822       
SSF56112   SSF56112       
SSF90123   SSF90123       
SSF52540   SSF52540       

Gene 3D

3.30.70.1230     1.20.1560.10    

ProteinModelPortal

A0A0M3VH92   Q9BPR0   A0A212FC80   A0A194PLI8   A0A2A4IYS3   A0A158P0M1   + More
A0A0L7QKK7   A0A3L8DRY2   A0A195F401   K7J4N4   A0A1B6ME96   A0A1B6L105   A0A023F0L0   A0A224XIJ1   A0A1Q3G4K8   A0A2M4CVF3   A0A2M4CVA2   A0A2M3YZQ2   A0A151WKN4   Q7PTP9   A0A1Y9GKX4   A0A2M4B9V1   A0A2M4BA30   A0A2M4A0W1   A0A2M4B9R9   A0A2M4BA27   A0A2M4A6J1   A0A182V1G5   A0A2M4CIX2   A0A026WB13   Q174S2   A0A0P4ZZF4   A0A0N8DFN2   A0A0P5W112   A0A0P6GQV3   T1KF53   A0A0F7VJB8   A0A1B6JNQ5   A0A146M109   A0A0A9WYA7   E9H6U6   A0A0C9QYW7   A0A034VF88   A0A0K8VHK8   G1FKY1   W8B2G3   A0A0A1X716   A0A0F7VHC5   A0A2S2NHF4   A0A1B0AAF2   B4NBA6   A0A1A9YK51   A0A1A9UTM4   A0A1J1IEB7   A0A0L0CC40   A0A1I8MLJ8   A0A1J1IG90   B4JT47   Q296Q0   B4GEV1   A0A3B0JPZ6   B3M388   A0A0P4XYS6   Q9VF17   B4PRJ3   B4QXT4   B4HLG9   A0A1W4VFT6   B3P3W6   B4K5Q8   B4LX87   A0A210PTL8   V4AEX2   A0A1B0G6S3   V4AZ64   A0A0Q9WE85   A0A336LM52   A0A1S3IRF8   A0A0A1X5Z0   V4BNJ3   A0A1S4G740   A0A1I8PRN8   R7U0U2   A0A1W4VFG5   A0A0P9CAM4   K1QPS4  

PDB

3A3K     E-value=7.8552e-60,     Score=589

KEGG

692412    K12323 atrial natriuretic peptide receptor A [EC:4.6.1.2] | (RefSeq) Gcy, Bm-GCY, BmGC-I; receptor t

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0035556   GO:0016021   GO:0004383   GO:0004672   GO:0000166   GO:0001653   GO:0007168   GO:0006182   GO:0005886   GO:0007165   GO:0042626   GO:0038023   GO:0005887   GO:0006468   GO:0019934   GO:0009190   GO:0016849   GO:0006032   GO:0048384  

Length:

1429

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

49.8363900000003

Exp number, first 60 AAs:

0.69179

Total prob of N-in:

0.35933

outside

1  -  533

TMhelix

534  -  553

inside

554  -  663

TMhelix

664  -  686

outside

687  -  1429

 

 

Pi

222.088659

Theta

167.452358

Tajima's D

1.129907

CLR

0.31382

CSRT

0.691665416729164

Interpretation

Uncertain