Gene

KWMTBOMO04057  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010294

Annotation

UDP-glycosyltransferase_UGT40A1_[Bombyx_mori]

Location

Bomo_Chr7(+):10037421-10046877      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 1.505

CDS

ATGTTAAGGGCAATTATATTGTGCTTGATATTAGTGACATGTAGTGCATACAAATTGTTAGCTGTTTTTCCGTTCCCTGGGAAGAGTCACATGATTTTAGGTGAAGGATATGTAAGGCTTCTCTTGGAGGCTAATCACGATGTAACGTACTTAACGCCTGCTCCACTAAAGATTGGTCATCCAAAATTAAGACAGATCGATGTATCTTCAACCGAAAAGGGTTTTGATTTCGATGGCCTGTTCAACTTTAAGAAGTTGATTAACAAAGAAGTCGATCTATCAGATACGAATCACAAGTATATCGTAATGCAATATGTAACCGAGTCATTGTTAATGCATCCCAACGTACAAAAACTGCTTTTGGATACAGATCAAACGTTTGATGCCGTGATTGTTGAGTGGATGTATAGCGACTTGTATTCTGGGTTTTCAACTGTCTTCAACTGTCCATTTATTTGGTCGTCATCGCTGGAGCCCCATCCCATGATCCTTAGGCTTATTGATTCTTTACCGAATCCAGCTTACTTTCCTGATCATACTTCATCCTTAGAACCTCCCTACACATTTCTAGAGCGTGTTGAACAATTATGGAACATTGCTAAAACTTTATACAACAGATGGAGATTGAAAGAAAAAGAAGAAAGTATTTACGAGAATGCGTTTGGACCAGCCGTTAAGAAACGAAACAGAGTTTTACCACCATACAACGAAGTGAAGTATAATGGATCATTGATTTTGGGAAATTCTCACGTGTCTACTGGAGTTGCTTTTAGTCTTCCTCAGAATTACAAGGCGATCTCAGGATATTATATACCGAAAAAAATACCACAGTTGCCCGATAAAATAAAAAATATCATGGACAAAGCAGAAAATGGTGTAATTTACTTCAGTATGGGAACAATGGTAAAAAGCAAAACATTACCAGAAGAATTGAAACGGAACCTAGTAGATATGTTTGGAAATCTAAAACAAACCGTTATATGGAAATTTGAGGAAGACTTAGATGGATTACCAAATAATGTGCATATTGTATCGTGGGCGCCGCAGCAAAGTATTCTTGCTCATCCCAACTGCGTGCTATTCATCACTCATGGCGGCTTACTGTCTACAACTGAGGCACTACACTATGGGGTCCCTATAATAGGGATCCCAGTTTTTGCCGACCAATTTCTCAACATCAAAAGAGCAACCACAAAAGGATTTGCCCTCGAAGTTGACATTAACTATGAAACACCAGGAAACTTAAAGTTGGCGATCGATGAAATTTTGAACAGCCCTAAATATCGTGAAAACATTAAGCAGCTATCGCTGGTCTACCACGATCGTCCGGTGTCTCCTGGTGCCGAGCTGGTCCACTGGGTGGAGCACGTCGTCAAGACTAAAGGAGCTCTCCATCTGCGCTCACCAGCACTGCACGTGCCTTTCTACCAGAAGCTGTACTTAGATCTTTTTGCTGTAATTTTAATGATGCCATTGGTTTTATGCATACTTCTGAGGTATATGAAAAATAAATTATTCGGTGTTATAAAAAAGAAGGGAAAGAAGACAAAAAAGAATCAGTAA

Protein

MLRAIILCLILVTCSAYKLLAVFPFPGKSHMILGEGYVRLLLEANHDVTYLTPAPLKIGHPKLRQIDVSSTEKGFDFDGLFNFKKLINKEVDLSDTNHKYIVMQYVTESLLMHPNVQKLLLDTDQTFDAVIVEWMYSDLYSGFSTVFNCPFIWSSSLEPHPMILRLIDSLPNPAYFPDHTSSLEPPYTFLERVEQLWNIAKTLYNRWRLKEKEESIYENAFGPAVKKRNRVLPPYNEVKYNGSLILGNSHVSTGVAFSLPQNYKAISGYYIPKKIPQLPDKIKNIMDKAENGVIYFSMGTMVKSKTLPEELKRNLVDMFGNLKQTVIWKFEEDLDGLPNNVHIVSWAPQQSILAHPNCVLFITHGGLLSTTEALHYGVPIIGIPVFADQFLNIKRATTKGFALEVDINYETPGNLKLAIDEILNSPKYRENIKQLSLVYHDRPVSPGAELVHWVEHVVKTKGALHLRSPALHVPFYQKLYLDLFAVILMMPLVLCILLRYMKNKLFGVIKKKGKKTKKNQ

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPU0   Q8WPG4   A0A2A4J6T0   A0A2H1V1W5   G9LPQ6   A0A140EA37   + More
A0A191T1M6   D6RUV0   G9LPU7   D6RUU6   G9LPU8   H9JL88   A0A194Q0G5   G9LPU3   A0A3S2LTQ3   A0A2H4WB58   G9LPU4   A0A024AGG4   A0A191T1M8   A0A2W1BQS6   A0A2H4WB67   A0A194R8C7   A0A024AH17   G9LPQ7   A0A2H1VVH6   A0A2H1WNF9   G9LPU6   A0A191T2J8   G9LPQ0   D6RUU7   D0PWZ6   A0A2A4K2B6   A0A2W1BXG7   A0A3S2LD93   A0A1L8D6H0   A0A191T2K2   A0A1L8D6R9   A0A2A4K0I8   A0A2W1BVZ0   A0A2H1W225   D6RUV2   A0A2H1X1Y8   A0A191T2G6   A0A140EA36   G9LPU2   A0A212FKT5   G9LPQ1   G9LPU1   A0A194RKU4   G9LPQ3   A0A024AHN0   A0A2H4WB53   A0A194RKA9   A0A2W1BQJ5   A0A191T1N5   A0A2A4J419   A0A3S2P0K8   A0A194Q5Q0   A0A191T1M1   A0A194Q1C7   A0A1L8D6E4   A0A191T1M3   D6RUU8   D6RUV1   G9LPQ5   A0A191T2G9   A0A2H4WB78   I4DN89   A0A0N1IN21   I4DR17   A0A2W1BX32   A0A2A4J0B4   H9JKP9   A0A3S2TLE9   A0A024AG04   A0A191T1P1   A0A3S2NJP8   A0A0L7L1M9   A0A2W1BSQ4   A0A212FD09   A0A2A4J325   A0A191T2K0   A0A194RDA8   A0A212ERW0   G9LPQ2   G9LPQ4   A0A2H1VVH4   A0A2H1WQL3   D6RUU9   G9LPV0   A0A2H1W5E5   A0A2W1BQJ6   A0A1L8D6G3   A0A0L7L448  

EC Number

2.4.1.17

Pubmed

22155036    11846783    26873292    20534444    19121390    26354079    + More
29027758    24698447    28756777    22118469    22651552    26227816   

EMBL

JQ070247    AEW43163.1    AF324465    AAL55994.1    NWSH01002698    PCG67661.1    + More
ODYU01000116    SOQ34342.1    JQ070213    AEW43129.1    KU214508    AMK97474.1    KU680302    ANI22008.1    AB539967    BAJ08157.1    JQ070254    AEW43170.1    AB539963    BAJ08153.1    JQ070255    AEW43171.1    BABH01011785    BABH01011786    BABH01011787    KQ459582    KPI98793.1    JQ070250    AEW43166.1    RSAL01000210    RVE44215.1    KY202932    AUC64276.1    JQ070251    AEW43167.1    KF777115    AHY99686.1    KU680303    ANI22009.1    KZ149930    PZC77368.1    KY202937    AUC64281.1    KQ460597    KPJ13897.1    KF777116    AHY99687.1    JQ070214    AEW43130.1    ODYU01004685    SOQ44830.1    ODYU01009829    SOQ54516.1    JQ070253    AEW43169.1    KU680294    ANI22000.1    JQ070207    AEW43123.1    JQ070252    AB539964    AEW43168.1    BAJ08154.1    FJ373022    ACQ66003.1    NWSH01000282    PCG77782.1    PZC77366.1    RVE44216.1    GEYN01000076    JAV02053.1    KU680304    ANI22010.1    GEYN01000085    JAV02044.1    PCG77781.1    PZC77367.1    ODYU01005852    SOQ47145.1    JQ070256    AB539969    AEW43172.1    BAJ08159.1    ODYU01012744    SOQ59206.1    KU680295    ANI22001.1    KU214507    AMK97473.1    JQ070249    AEW43165.1    AGBW02007992    OWR54346.1    JQ070208    AEW43124.1    JQ070248    AEW43164.1    KQ460075    KPJ17950.1    JQ070210    AEW43126.1    KF777113    AHY99684.1    KY202925    AUC64269.1    KPJ17977.1    PZC77369.1    KU680296    ANI22002.1    NWSH01003535    PCG66153.1    RSAL01000067    RVE49310.1    KPI98725.1    KU680297    ANI22003.1    KPI98794.1    GEYN01000100    JAV02029.1    KU680298    ANI22004.1    AB539965    BAJ08155.1    JQ070258    AB539968    AEW43174.1    BAJ08158.1    JQ070212    AEW43128.1    KU680300    ANI22006.1    KY202946    AUC64290.1    AK402777    BAM19379.1    KQ459356    KPJ01283.1    AK404892    BAM20357.1    PZC77370.1    NWSH01003979    PCG65597.1    RVE49311.1    KF777114    AHY99685.1    KU680301    ANI22007.1    RVE49308.1    JTDY01003683    KOB69154.1    PZC77371.1    AGBW02009118    OWR51610.1    NWSH01003818    PCG65793.1    KU680299    ANI22005.1    KPJ13896.1    AGBW02012922    OWR44215.1    JQ070209    AEW43125.1    JQ070211    AEW43127.1    SOQ44829.1    ODYU01010264    SOQ55252.1    AB539966    BAJ08156.1    JQ070257    AEW43173.1    ODYU01006413    SOQ48233.1    PZC77372.1    GEYN01000087    JAV02042.1    JTDY01003050    KOB70242.1   

Proteomes

UP000218220    UP000005204    UP000053268    UP000283053    UP000053240    UP000007151    + More
UP000037510   

PRIDE

G9LPU0    Q8WPG4    D6RUV0    G9LPU7    D6RUU6    G9LPU8    + More
H9JL88    G9LPU3    G9LPU4    G9LPU6    D6RUU7    D0PWZ6    D6RUV2    G9LPU2    G9LPU1    D6RUU8    D6RUV1    H9JKP9    D6RUU9    G9LPV0   

Pfam

PF00201   UDPGT

Interpro

IPR002213   UDP_glucos_trans        + More
IPR035595   UDP_glycos_trans_CS       

ProteinModelPortal

G9LPU0   Q8WPG4   A0A2A4J6T0   A0A2H1V1W5   G9LPQ6   A0A140EA37   + More
A0A191T1M6   D6RUV0   G9LPU7   D6RUU6   G9LPU8   H9JL88   A0A194Q0G5   G9LPU3   A0A3S2LTQ3   A0A2H4WB58   G9LPU4   A0A024AGG4   A0A191T1M8   A0A2W1BQS6   A0A2H4WB67   A0A194R8C7   A0A024AH17   G9LPQ7   A0A2H1VVH6   A0A2H1WNF9   G9LPU6   A0A191T2J8   G9LPQ0   D6RUU7   D0PWZ6   A0A2A4K2B6   A0A2W1BXG7   A0A3S2LD93   A0A1L8D6H0   A0A191T2K2   A0A1L8D6R9   A0A2A4K0I8   A0A2W1BVZ0   A0A2H1W225   D6RUV2   A0A2H1X1Y8   A0A191T2G6   A0A140EA36   G9LPU2   A0A212FKT5   G9LPQ1   G9LPU1   A0A194RKU4   G9LPQ3   A0A024AHN0   A0A2H4WB53   A0A194RKA9   A0A2W1BQJ5   A0A191T1N5   A0A2A4J419   A0A3S2P0K8   A0A194Q5Q0   A0A191T1M1   A0A194Q1C7   A0A1L8D6E4   A0A191T1M3   D6RUU8   D6RUV1   G9LPQ5   A0A191T2G9   A0A2H4WB78   I4DN89   A0A0N1IN21   I4DR17   A0A2W1BX32   A0A2A4J0B4   H9JKP9   A0A3S2TLE9   A0A024AG04   A0A191T1P1   A0A3S2NJP8   A0A0L7L1M9   A0A2W1BSQ4   A0A212FD09   A0A2A4J325   A0A191T2K0   A0A194RDA8   A0A212ERW0   G9LPQ2   G9LPQ4   A0A2H1VVH4   A0A2H1WQL3   D6RUU9   G9LPV0   A0A2H1W5E5   A0A2W1BQJ6   A0A1L8D6G3   A0A0L7L448  

PDB

2O6L     E-value=6.6114e-28,     Score=310

KEGG

692593    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT40A1; phenol UDP-glucosyltransferase

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0015020   GO:0016758   GO:0016740   GO:0008152   GO:0000166   GO:0016788   GO:0046872   GO:0006811   GO:0006032   GO:0004672   GO:0048384  

Subcellular location

Membrane  

SignalP

Position:   1 - 16,         Likelihood:  0.956859

 

 

Length:

520

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

42.54815

Exp number, first 60 AAs:

20.53795

Total prob of N-in:

0.93903

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  478

TMhelix

479  -  501

inside

502  -  520

 

 

Pi

202.071178

Theta

161.113387

Tajima's D

0.374871

CLR

149.486191

CSRT

0.470526473676316

Interpretation

Uncertain