Gene

KWMTBOMO04031

Pre Gene Modal

BGIBMGA010276

Annotation

trypsin-like_proteinase_[Chilo_suppressalis]

Location

Bomo_Chr7(+):9391781-9396141      View in EpiBrowser

Full name

Trypsin, alkaline A       + More
Trypsin CFT-1      
Trypsin, alkaline C      
Trypsin, alkaline B      

Location in the cell

Extracellular   Reliability : 2.943

CDS

ATGAACAGTATCATTACATTGTTTTTCTTGTACGTGAGTGCAGTGTCTGCTACAGATGATCCAAGTCAGAGAATAGGAGGAGGGACGCTAGTTCCGATTACATCTTATCCATTTGCTACGGCTTTATTGAACAATCCCGGAAGCGGTGTGTTCACTCATAGATGCGGGGGCAGTATTCTAACGAGAAATGCAATTTTGTCGGCAGCTTCTTGTTTTTATACTGGAAACAATGCCCACGATGCGGTCTTGTGGCGGGCCAGAGTTGGCTCAGCCTACAGTAATTCTGGAGGAACGATGTACATCATAAGCCGCATCACGCCCCACACTAGCTTCTCTCCCACGACCCGGGCCAACGACATTGCCGTTCTCAGGACCAGATTCAACATTCAGTTCGTGGCTGGTCTCGTCGAAGCTGCAGGCCTTGTAGGCCGCACTTACACTTTCAGTAACGACCAAGCCGTTGAAGCGATTGGATGGGGAGCCGTATCTTCAACAGATCCAGTGTCTTCGATTCAGCTGAGGCGTACTGTTATATGGGTGGTGGACCAGCAAATATGTTCAAATAGGTACAGCGAACTAGGCTTCACGGTGGCTAGCAACATGGTCTGTCTTGGGTGGCTAGATGTCGGCGTCAGAGGACAATGTCAGGGTGACAATGGAAGCCCTATTCTGGATAACGGCGCAGTAGTGGGAGTGTTCTCTTGGGCCGAAGGTTGCGCACTGGGTCGGTACCCGGGCATCAATACCCGGCTCTCCCCGTACTTGCAATGGGTTGTGTCTACAGCTACTGCCGCGTAA

Protein

MNSIITLFFLYVSAVSATDDPSQRIGGGTLVPITSYPFATALLNNPGSGVFTHRCGGSILTRNAILSAASCFYTGNNAHDAVLWRARVGSAYSNSGGTMYIISRITPHTSFSPTTRANDIAVLRTRFNIQFVAGLVEAAGLVGRTYTFSNDQAVEAIGWGAVSSTDPVSSIQLRRTVIWVVDQQICSNRYSELGFTVASNMVCLGWLDVGVRGQCQGDNGSPILDNGAVVGVFSWAEGCALGRYPGINTRLSPYLQWVVSTATAA

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Disulfide bond   Hydrolase   Protease   Secreted   Serine protease   Signal   Zymogen   Direct protein sequencing  

Feature

propeptide  Activation peptide
chain  Trypsin, alkaline A

Uniprot

H9JL75   A0A2W1BZV8   A0A1E1WC82   A0A2A4JXV2   A0A3S2M1W1   I3UII3   + More
I6SJ34   A0A0L7LQY6   A0A2H1VBN8   T1QDI0   A0A3S2TNU2   Q961Y0   A0A194PVB6   A0A194PQQ5   A0A194PNR6   V9LL27   A0A194PNR3   Q56IB6   Q56IB4   G9F9K6   S5PVP1   Q6R561   Q56IB7   A0A0N1PHJ0   A0A194PQQ0   P35045   I3UII8   A0A194PP33   P35042   Q27540   A0A1E1WNA7   Q56IB5   P35047   Q56IB8   P35046   A0A3S2P336   A0A1E1WDA8   H9J243   I6TMW8   I3UIJ3   A0A2A4K747   O62598   A0A212EX29   A0A2H1VJ41   A0A2W1BKF9   W5X3N9   A0A2W1BP46   A0A0L7LB68   Q2I0D8   A0A0N1I947   A0A194PQ27   I6SJ30   A0A194PP38   H9J231   Q1HGK3   A0A212EX43   A0A2A4K636   A0A0L7LLK4   A0A3S2NM13   A0A2U8NFD7   I6TRT9   I7CHG6   I7E449   A0A2A4K5I4   A0A2W1BPN1   B4X995   A0A2A4K648   A0A2A4K5G7   Q9U4I7   B4X996   A0A2W1BQW9   H9J229   A0A2H1V0M1   J7IJ83   A0A2W1B1G1   A0A0L7LAY9   V9M0R7   A0A2W1BKV8   Q9U4I6   A0A2W1BF78   H9J230   O18442   I3UII6   A0A2H1V2A0   J7IF09   B4X9A1   A0A0L7KUC9   O18447   A0A089QDA2   A0A2A4K6E9   A0A2A4K5H6   A0A1C9M3A1   O18436   O18434   O18435   C9W8J5   A0A345H7U4   A0A1B0RHN7   Q9TXE6   J7IFG7  

EC Number

3.4.21.4

Pubmed

19121390    28756777    22432944    26227816    23955944    12110299    + More
26354079    16469064    23606528    15944081    8205142    8294037    8353523    7550246    10672067    22118469    22824002    10989289    23247047    9404008    19146482    20824821    8462672   

EMBL

BABH01011755    KZ149930    PZC77373.1    GDQN01006507    JAT84547.1    NWSH01000410    + More
PCG76596.1    RSAL01000067    RVE49320.1    JN315757    AFK64821.1    JQ904127    AFM77757.1    JTDY01000283    KOB77913.1    ODYU01001510    SOQ37822.1    JQ429438    AFW03963.1    RSAL01000038    RVE51123.1    AY040819    AAK81696.1    KQ459597    KPI95070.1    KPI95074.1    KPI95071.1    JQ340915    AFP74111.1    KPI95066.1    AY953061    AAX62034.1    AY953063    AAX62036.1    JN033751    JN315765    AEW46904.1    AFK64829.1    KC175562    AGR92345.1    AY513649    AAR98918.1    AY953060    AAX62033.1    KQ460226    KPJ16473.1    KPI95069.1    L16805    JN315762    AFK64826.1    KPI95067.1    L04749    U12917    AAA84423.1    GDQN01002626    JAT88428.1    AY953062    AAX62035.1    L16807    AY953059    AAX62032.1    L16806    RVE51121.1    GDQN01010607    GDQN01006137    JAT80447.1    JAT84917.1    BABH01007473    JQ904123    AFM77753.1    JN315767    AFK64831.1    NWSH01000106    PCG79472.1    AF064525    AF064526    AAC36247.1    AAC36248.1    AGBW02011836    OWR46056.1    ODYU01002655    SOQ40442.1    KZ149992    PZC75529.1    KF779933    AHI07442.1    KZ150104    PZC73453.1    JTDY01001849    KOB72722.1    DQ356009    ABC87051.1    KPJ16474.1    KPI95068.1    JQ904122    AFM77752.1    KPI95072.1    BABH01007514    BABH01007515    DQ486902    ABF47507.1    OWR46055.1    PCG79476.1    JTDY01000728    KOB76086.1    RVE51120.1    MF407317    AWL83213.1    JQ904126    AFM77756.1    JN793541    AFO68321.1    JX046916    AFO83992.1    PCG79487.1    PZC75525.1    EF531631    EF531633    ABR88242.1    ABR88244.1    PCG79486.1    PCG79485.1    AF173495    AAF24225.1    EF531632    ABR88243.1    PZC75527.1    BABH01007520    ODYU01000133    SOQ34395.1    JX195651    AFQ37934.1    KZ150747    PZC70338.1    JTDY01001906    KOB72570.1    JX866720    AGB93875.1    PZC75528.1    AF173496    AAF24226.1    PZC73448.1    BABH01007517    Y12277    CAA72956.1    JN315760    AFK64824.1    SOQ34394.1    JX195649    AFQ37932.1    EF531637    ABR88248.1    JTDY01005557    KOB66887.1    HM209426    Y12283    ADI32887.1    CAA72962.1    PZC73444.1    KM083777    AIR09758.1    PCG79488.1    PCG79495.1    KU302250    AOQ30448.1    EF104916    Y12271    ABP96918.1    CAA72950.1    Y12269    CAA72948.1    PZC73449.1    Y12270    CAA72949.1    FJ205445    ACR16008.2    MF770251    AXG72654.1    KM360188    AKH49604.1    JX195652    AFQ37935.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000037510    UP000053268    UP000053240    + More
UP000007151   

PRIDE

H9JL75    P35045    P35042    P35047    H9J243    H9J231    + More
H9J229    H9J230    Q9TXE6   

Pfam

PF00089   Trypsin

Interpro

IPR009003   Peptidase_S1_PA        + More
IPR001254   Trypsin_dom       
IPR001314   Peptidase_S1A       
IPR033116   TRYPSIN_SER       
IPR018114   TRYPSIN_HIS       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

H9JL75   A0A2W1BZV8   A0A1E1WC82   A0A2A4JXV2   A0A3S2M1W1   I3UII3   + More
I6SJ34   A0A0L7LQY6   A0A2H1VBN8   T1QDI0   A0A3S2TNU2   Q961Y0   A0A194PVB6   A0A194PQQ5   A0A194PNR6   V9LL27   A0A194PNR3   Q56IB6   Q56IB4   G9F9K6   S5PVP1   Q6R561   Q56IB7   A0A0N1PHJ0   A0A194PQQ0   P35045   I3UII8   A0A194PP33   P35042   Q27540   A0A1E1WNA7   Q56IB5   P35047   Q56IB8   P35046   A0A3S2P336   A0A1E1WDA8   H9J243   I6TMW8   I3UIJ3   A0A2A4K747   O62598   A0A212EX29   A0A2H1VJ41   A0A2W1BKF9   W5X3N9   A0A2W1BP46   A0A0L7LB68   Q2I0D8   A0A0N1I947   A0A194PQ27   I6SJ30   A0A194PP38   H9J231   Q1HGK3   A0A212EX43   A0A2A4K636   A0A0L7LLK4   A0A3S2NM13   A0A2U8NFD7   I6TRT9   I7CHG6   I7E449   A0A2A4K5I4   A0A2W1BPN1   B4X995   A0A2A4K648   A0A2A4K5G7   Q9U4I7   B4X996   A0A2W1BQW9   H9J229   A0A2H1V0M1   J7IJ83   A0A2W1B1G1   A0A0L7LAY9   V9M0R7   A0A2W1BKV8   Q9U4I6   A0A2W1BF78   H9J230   O18442   I3UII6   A0A2H1V2A0   J7IF09   B4X9A1   A0A0L7KUC9   O18447   A0A089QDA2   A0A2A4K6E9   A0A2A4K5H6   A0A1C9M3A1   O18436   O18434   O18435   C9W8J5   A0A345H7U4   A0A1B0RHN7   Q9TXE6   J7IFG7  

PDB

1FXY     E-value=3.2399e-21,     Score=249

KEGG

101737834    K01312 trypsin [EC:3.4.21.4] | (RefSeq) trypsin, alkaline A-like

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004252   GO:0008236   GO:0005615   GO:0006508   GO:0051013   GO:0005524   GO:0007179   GO:0006811   GO:0006032   GO:0016021   GO:0004672   GO:0048384  

Subcellular location

  

SignalP

Position:   1 - 17,         Likelihood:  0.987094

 

 

Length:

265

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0774800000000001

Exp number, first 60 AAs:

0.03275

Total prob of N-in:

0.00761

outside

1  -  265

 

 

Pi

214.811462

Theta

174.961252

Tajima's D

0.707244

CLR

0.006752

CSRT

0.576221188940553

Interpretation

Uncertain